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References from Model structures of inactive and peptide agonist bound C5aR: Insights into agonist binding, selectivity and activation. Local targets link to admitted publications; unresolved targets remain external evidence.
The chemotactic receptor for human C5a anaphylatoxin
10.1038/349614a0 · 1991 · External reference
Role of C5a in inflammatory responses
10.1146/annurev.immunol.23.021704.115835 · 2005 · External reference
Complement-targeted therapeutics
10.1038/nbt1342 · 2007 · External reference
Crystal structure of rhodopsin: A G protein-coupled receptor
10.1126/science.289.5480.739 · 2000 · External reference
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
10.1126/science.1150577 · 2007 · External reference
Crystal structure of opsin in its G-protein-interacting conformation
10.1038/nature07330 · 2008 · External reference
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
10.1126/science.1194396 · 2010 · External reference
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist
10.1126/science.1197410 · 2010 · External reference
Structure of an agonist-bound human A2A adenosine receptor
10.1126/science.1202793 · 2011 · External reference
Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor
10.1038/nature09648 · 2011 · External reference
Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
10.1016/j.str.2011.06.014 · 2011 · External reference
Structure of the human histamine H1 receptor complex with doxepin
10.1038/nature10236 · 2011 · External reference
Crystal structure of the micro-opioid receptor bound to a morphinan antagonist
10.1038/nature10954 · 2012 · External reference
Structure of the chemokine receptor CXCR1 in phospholipid bilayers
10.1038/nature11580 · 2012 · External reference
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
10.1038/nature10753 · 2012 · External reference
Structure of the delta-opioid receptor bound to naltrindole
10.1038/nature11111 · 2012 · External reference
Crystal structure of a lipid G protein-coupled receptor
10.1126/science.1215904 · 2012 · External reference
Structure and dynamics of the M3 muscarinic acetylcholine receptor
10.1038/nature10867 · 2012 · External reference
Activation and allosteric modulation of a muscarinic acetylcholine receptor
10.1038/nature12735 · 2013 · External reference
High-resolution crystal structure of human protease-activated receptor 1
10.1038/nature11701 · 2012 · External reference
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex
10.1126/science.1241475 · 2013 · External reference
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875
10.1038/nature13494 · 2014 · External reference
Agonist-bound structure of the human P2Y12 receptor
10.1038/nature13288 · 2014 · External reference
Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors
10.1073/pnas.91.4.1214 · 1994 · External reference
Essential role for the second extracellular loop in C5a receptor activation
10.1038/nsmb913 · 2005 · External reference
Determination of structural elements related to the biological activities of a potent decapeptide agonist of human C5a anaphylatoxin
10.1034/j.1399-3011.1999.00087.x · 1999 · External reference
Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy
10.1002/(sici)1097-0134(199706)28:2<261::aid-prot13>3.0.co;2-g · 1997 · External reference
Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site
10.1074/jbc.m410797200 · 2005 · External reference
The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein
10.1074/jbc.m206169200 · 2003 · External reference
Structural and functional characterization of human and murine C5a anaphylatoxins
10.1107/s139900471400844x · 2014 · External reference
Mapping the ligand-binding site on the C5a receptor: arginine74 of C5a contacts aspartate282 of the C5a receptor
10.1021/bi011055w · 2001 · External reference
The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding
10.1074/jbc.m609178200 · 2007 · External reference
Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand
10.1021/bi990139q · 1999 · External reference
The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)
10.1074/jbc.c100714200 · 2002 · External reference
Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor
10.1021/bi702321a · 2008 · External reference
Ligand binding and micro-switches in 7TM receptor structures
10.1016/j.tips.2009.02.006 · 2009 · External reference
Three-dimensional representations of G protein-coupled receptor structures and mechanisms
10.1016/s0076-6879(02)43145-x · 2002 · External reference
Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
10.1074/jbc.m206801200 · 2002 · External reference
Location of the retinal chromophore in the activated state of rhodopsin*
10.1074/jbc.m805725200 · 2009 · External reference
Two protonation switches control rhodopsin activation in membranes
10.1073/pnas.0804541105 · 2008 · External reference
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
10.1074/jbc.m103747200 · 2001 · External reference
Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region
10.1074/jbc.m110.129213 · 2010 · External reference
Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation
10.1074/jbc.m806987200 · 2009 · External reference
Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fit
10.1073/pnas.1407545111 · 2014 · External reference
Structure of the complement factor 5a receptor–ligand complex studied by disulfide trapping and molecular modeling
10.1074/jbc.m709467200 · 2008 · External reference
Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop
10.1074/jbc.m600548200 · 2006 · External reference
Probing the message:address sites for chemoattractant binding to the C5a receptor. Mutagenesis of hydrophilic and proline residues within the transmembrane segments
10.1074/jbc.270.30.18077 · 1995 · External reference
C5L2, a nonsignaling C5A binding protein
10.1021/bi034489v · 2003 · External reference
Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg
10.4049/jimmunol.134.5.3325 · 1985 · External reference
Response of human neutrophils to C5a: a role for the oligosaccharide moiety of human C5ades Arg-74 but not of C5a in biologic activity
10.4049/jimmunol.127.5.1978 · 1981 · External reference
MOLMOL: a program for display and analysis of macromolecular structures
10.1016/0263-7855(96)00009-4 · 1996 · External reference
Clustal W and Clustal X version 2.0
10.1093/bioinformatics/btm404 · 2007 · External reference
Unresolved reference
1993 · External reference
Potential energy curves for cation−π interactions: off-axis configurations are also attractive
10.1021/jp906086x · 2009 · External reference
Comparative protein modelling by satisfaction of spatial restraints
10.1006/jmbi.1993.1626 · 1993 · External reference
GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation
10.1021/ct700301q · 2008 · External reference
Torsion angle dynamics for NMR structure calculation with the new program DYANA
10.1006/jmbi.1997.1284 · 1997 · External reference
The membrane-bound state of K2P potassium channels
10.1021/ja102191s · 2010 · External reference
Chromophore channeling in the G-protein coupled receptor rhodopsin
10.1021/ja0691977 · 2007 · External reference
Setting up and running molecular dynamics simulations of membrane proteins
10.1016/j.ymeth.2006.08.006 · 2007 · External reference
Structure of fully hydrated fluid phase lipid bilayers with monounsaturated chains
10.1007/s00232-005-7006-8 · 2005 · External reference
Lipid properties and the orientation of aromatic residues in OmpF, influenza M2, and alamethicin systems: molecular dynamics simulations
10.1021/bi981802y · 1998 · External reference
Molecular characterization of gel and liquid-crystalline structures of fully hydrated POPC and POPE bilayers
10.1021/jp0686339 · 2007 · External reference
Peptide folding: when simulation meets experiment
10.1002/(sici)1521-3773(19990115)38:1/2<236::aid-anie236>3.0.co;2-m · 1999 · External reference
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility
10.1002/jcc.21256 · 2009 · External reference
Structure of the tyrosine-sulfated C5a receptor N terminus in complex with chemotaxis inhibitory protein of Staphylococcus aureus
10.1074/jbc.m808179200 · 2009 · External reference
Common folding mechanism of a beta-hairpin peptide via non-native turn formation revealed by unbiased molecular dynamics simulations
10.1021/ja9064365 · 2009 · External reference
Direct observation of the folding and unfolding of a beta-hairpin in explicit water through computer simulation
10.1021/ja0257321 · 2002 · External reference
The free energy landscape for beta hairpin folding in explicit water
10.1073/pnas.201543998 · 2001 · External reference
Molecular dynamics simulations of unfolding and refolding of a beta-hairpin fragment of protein G
10.1073/pnas.96.16.9062 · 1999 · External reference
Folding simulations of a three-stranded antiparallel beta-sheet peptide
10.1073/pnas.190324897 · 2000 · External reference
Diversity and modularity of G protein-coupled receptor structures
10.1016/j.tips.2011.09.003 · 2012 · External reference
Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity
10.1124/mol.65.4.868 · 2004 · External reference
Induction of an antigen-specific CTL response by a conformationally biased agonist of human C5a anaphylatoxin as a molecular adjuvant
10.4049/jimmunol.164.10.5492 · 2000 · External reference
Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity
10.1021/jm960727r · 1997 · External reference
Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat
10.1038/sj.bjp.0702847 · 1999 · External reference
Differential activities of decapeptide agonists of human C5a: the conformational effects of backbone N-methylation
10.1016/s1567-5769(01)00141-2 · 2001 · External reference
The influence of Lys68 in decepeptide agonists of C5a on C5a receptor binding, activation and selectivity
10.1111/j.1399-3011.1999.tb01612.x · 1999 · External reference
The Cation−π Interaction
10.1021/cr9603744 · 1997 · External reference
The NH2-terminal region of C5aR but not that of FPR is critical for both protein transport and ligand binding
10.1016/s0021-9258(17)41884-9 · 1994 · External reference
Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes
10.1124/pr.110.002667 · 2010 · External reference
C5a receptor activation. Genetic identification of critical residues in four transmembrane helices
10.1074/jbc.274.22.15757 · 1999 · External reference
Conformational complexity of G-protein-coupled receptors
10.1016/j.tips.2007.06.003 · 2007 · External reference
A G protein-coupled receptor at work: the rhodopsin model
10.1016/j.tibs.2009.07.005 · 2009 · External reference
Biased signaling pathways in beta2-adrenergic receptor characterized by 19F-NMR
10.1126/science.1215802 · 2012 · External reference