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References from Structural alterations by five disease-causing mutations in the low-pH conformation of human dihydrolipoamide dehydrogenase (hLADH) analyzed by molecular dynamics – Implications in functional loss and modulation of reactive oxygen species generation by pathogenic hLADH forms. Local targets link to admitted publications; unresolved targets remain external evidence.
Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid
10.1111/j.1471-4159.2009.05942.x · 2009 · External reference
Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase
10.1523/jneurosci.1842-04.2004 · 2004 · External reference
Mechanisms of generation of oxygen radicals and reductive mobilization of ferritin iron by lipoamide dehydrogenase
10.1093/oxfordjournals.jbchem.a123402 · 1991 · External reference
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species
10.1523/jneurosci.1899-04.2004 · 2004 · External reference
Bioenergetics and the formation of mitochondrial reactive oxygen species
10.1016/j.tips.2006.10.005 · 2006 · External reference
Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources
10.1089/ars.2005.7.1140 · 2005 · External reference
Alpha-ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ
10.1016/j.neuroscience.2008.10.015 · 2009 · External reference
Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging
10.1096/fj.06-6686com · 2007 · External reference
The role of mitochondrial dehydrogenases in the generation of oxidative stress
10.1016/j.neuint.2013.01.012 · 2013 · External reference
An update on the role of mitochondrial alpha-ketoglutarate dehydrogenase in oxidative stress
10.1016/j.mcn.2012.07.005 · 2013 · External reference
The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I
10.1074/jbc.m113.545301 · 2014 · External reference
Novel mutations in dihydrolipoamide dehydrogenase deficiency in two cousins with borderline-normal PDH complex activity
10.1002/ajmg.a.31313 · 2006 · External reference
Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase
10.1093/hmg/ddr202 · 2011 · External reference
Mutations in the dimer interface of dihydrolipoamide dehydrogenase promote site-specific oxidative damages in yeast and human cells
10.1074/jbc.m111.274415 · 2011 · External reference
A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process
10.1186/2049-3002-2-4 · 2014 · External reference
Calcium and mitochondrial reactive oxygen species generation: how to read the facts
10.3233/jad-2010-100465 · 2010 · External reference
Molecular dynamics study of the structural basis of dysfunction and the modulation of reactive oxygen species generation by pathogenic mutants of human dihydrolipoamide dehydrogenase
10.1016/j.abb.2013.08.015 · 2013 · External reference
A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency
10.1002/humu.9319 · 2005 · External reference
Deficiency of dihydrolipoamide dehydrogenase due to two mutant alleles (E340K and G101del) – analysis of a family and prenatal testing
10.1016/s0925-4439(97)00073-2 · 1997 · External reference
Dihydrolipoamide dehydrogenase (DLD) deficiency in a Spanish patient with myopathic presentation due to a new mutation in the interface domain
10.1007/s10545-010-9169-4 · 2010 · External reference
Leigh syndrome in a girl with a novel DLD mutation causing E3 deficiency
10.1016/j.pediatrneurol.2012.09.013 · 2013 · External reference
Using Xplor-NIH for NMR molecular structure determination
10.1016/j.pnmrs.2005.10.001 · 2006 · External reference
VMD: visual molecular dynamics
10.1016/0263-7855(96)00018-5 · 1996 · External reference
Stochastic boundary conditions for molecular dynamics simulations of ST2 water
10.1016/0009-2614(84)80098-6 · 1984 · External reference
Deformable stochastic boundaries in molecular dynamics
10.1063/1.445724 · 1983 · External reference
Molecular dynamics with coupling to an external bath
10.1063/1.448118 · 1984 · External reference
Crystal structure of human dihydrolipoamide dehydrogenase: NAD(+)/NADH binding and the structural basis of disease-causing mutations
10.1016/j.jmb.2005.05.014 · 2005 · External reference
Spectroscopic studies of the characterization of recombinant human dihydrolipoamide dehydrogenase and its side-directed mutants
10.1074/jbc.270.26.15545 · 1995 · External reference
Characterization of 2 site specifically mutated human dihydrolipoamide dehydrogenases (His-452-]Gln and Glu-457-]Gln)
10.1016/s0021-9258(18)42740-8 · 1992 · External reference
Detailed kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase
10.1186/1471-2091-12-53 · 2011 · External reference
Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase
10.1074/jbc.m108264200 · 2002 · External reference
10.1007/s008940050133 · 1998 · Admitted local publication
Oligomerization of nitrophorins
10.1016/j.ab.2006.02.003 · 2006 · External reference
Diffusion-ordered nuclear magnetic resonance spectroscopy for analysis of DNA secondary structural elements
10.1016/j.ab.2007.04.025 · 2007 · External reference
Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate
10.1074/jbc.m114.591073 · 2014 · External reference
