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References from Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of VEGF gene. Local targets link to admitted publications; unresolved targets remain external evidence.
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
10.1016/s2214-109x(13)70145-1 · 2014 · External reference
Global estimates of visual impairment: 2010
10.1136/bjophthalmol-2011-300539 · 2012 · External reference
Causes and prevalence of visual impairment among adults in the United States
10.1001/archopht.122.4.477 · 2004 · External reference
Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
10.1186/1471-2415-10-31 · 2010 · External reference
Genomic aspects of age-related macular degradation
10.1016/j.bbrc.2014.08.013 · 2014 · External reference
Diabetes mellitus and early age-related macular degeneration
10.1001/archophthalmol.2010.355 · 2011 · External reference
Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence
2013 · External reference
Effects of hydroquinone on retinal and vascular cells in vitro
10.4103/0301-4738.95869 · 2012 · External reference
Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration
10.1152/ajpcell.00126.2009 · 2009 · External reference
Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis
10.1167/iovs.04-0311 · 2004 · External reference
Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling
10.1016/j.neurobiolaging.2011.09.039 · 2012 · External reference
RAGE biology, atherosclerosis and diabetes
10.1042/cs20100501 · 2011 · External reference
RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin
10.2337/db06-0221 · 2006 · External reference
Regulation of RAGE for attenuating progression of diabetic vascular complications
10.1155/2012/894605 · 2012 · External reference
Receptor for advanced glycation end products and age-related macular degeneration
10.1167/iovs.04-0404 · 2004 · External reference
Ten-year incidence of age-related macular degeneration according to diabetic retinopathy classification among Medicare beneficiaries
10.1097/iae.0b013e3182831248 · 2013 · External reference
Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy
10.1136/bjo.2003.032466 · 2004 · External reference
Increased expression of tight junctions in ARPE-19 cells under endoplasmic reticulum stress
10.3109/02713683.2011.606592 · 2011 · External reference
Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats
10.1073/pnas.171266298 · 2001 · External reference
Expression of REG III and prognosis in head and neck cancer
10.3892/or.2013.2521 · 2013 · External reference
Intermittent hypoxia induces the proliferation of rat vascular smooth muscle cell with the increases in epidermal growth factor family and erbB2 receptor
10.1016/j.yexcr.2013.08.014 · 2013 · External reference
Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene
10.1016/j.lfs.2013.09.001 · 2013 · External reference
Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs
10.7164/antibiotics.55.552 · 2002 · External reference
Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure−activity relationships, and antitumor activities of N-phenyl-Nʹ-{4-(4-quinolyloxy)phenyl}ureas
10.1021/jm030427r · 2005 · External reference
Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor
10.1074/jbc.m304435200 · 2003 · External reference
Identification of a receptor for Reg (Regenerating Gene) protein, a pancreatic β-cell regeneration factor
10.1074/jbc.275.15.10723 · 2000 · External reference
Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients
10.1111/j.1365-2362.2004.01419.x · 2004 · External reference
Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38
10.1016/j.lfs.2011.11.011 · 2012 · External reference
Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation
1833 · External reference
Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren's syndrome
10.1111/cei.12142 · 2013 · External reference
Expression of Ins1 and Ins2 genes in mouse fetal liver
10.1007/s00441-013-1741-4 · 2014 · External reference
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
10.1016/s0021-9258(18)99049-6 · 1991 · External reference
Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6
10.1016/j.gene.2005.07.004 · 2005 · External reference
Activation of Reg gene, a gene for insulin-producing β-cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation
2001 · External reference
Cyclin D1 activation through ATF-2 in Reg-induced pancreatic β-cell regeneration
10.1016/j.febslet.2005.12.070 · 2006 · External reference
Activation of REG Iα and REG Iβ genes in human pancreatic β cells by combined addition of IL-6 and dexamethasone through JAK/STAT pathway,
2015 · External reference
Vascular endothelial growth factors and angiogenesis in eye disease
10.1016/s1350-9462(02)00043-5 · 2003 · External reference
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice
10.1172/jci11771 · 2001 · External reference
Molecular identity and cellular distribution of advanced glycation endproduct receptors: Relationship of p60 to OST-48 and p90 to 80K-H membrane proteins
10.1073/pnas.93.20.11047 · 1996 · External reference
Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex
10.1007/bf03401604 · 1995 · External reference
Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction
10.1111/j.1432-1033.1995.0408h.x · 1995 · External reference
CD36, a member of class B scavenger receptor family, is a receptor for advanced glycation end products
10.1111/j.1749-6632.2001.tb03961.x · 2001 · External reference
CD36, serves as a receptor for advanced glycation endproducts (AGE)
10.1016/s1056-8727(01)00208-2 · 2002 · External reference
Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products
10.1074/jbc.m011613200 · 2001 · External reference
Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE)
10.1016/s0014-5793(01)03325-7 · 2002 · External reference
FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products
10.1074/jbc.m210211200 · 2003 · External reference
Smoking and the risk of age-related macular degeneration: a meta-analysis
10.1016/j.annepidem.2008.04.002 · 2008 · External reference
Genetic factors in AMD study, smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation
10.1136/bjo.2005.073643 · 2006 · External reference
Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio
10.1001/archopht.121.6.785 · 2003 · External reference
Hypertension, cardiovascular disease, and age-related macular degeneration
10.1001/archopht.118.3.351 · 2000 · External reference
Blood pressure, atherosclerosis, and the incidence of age-related maculopathy; the Rotterdam Study
10.1167/iovs.03-0121 · 2003 · External reference
Interaction between VEGF and calcium-independent phospholipase A2 in proliferation and migration of retinal pigment epithelium
10.3109/02713683.2012.663855 · 2012 · External reference
Vascular endothelial growth factor expression in choroidal neovascularization in rats
10.1007/bf01739641 · 1997 · External reference
Induction of VEGF gene expression by retinoic acid through Sp1-binding sites in retinoblastoma Y79 cells
2002 · External reference
Transcription factors having impact on vascular endothelial growth factor (VEGF) gene expression in angiogenesis
2004 · External reference
Sp1 and Sp3 regulate basal transcription of the human APOBEC3G gene
10.1093/nar/gkm340 · 2007 · External reference
Inducible expression of manganese superoxide dismutase by phorbol 12-myristate 13-acetate is mediated by Sp1 in endothelial cells
10.1161/01.atv.20.2.392 · 2000 · External reference
Sp1 mediates glucose activation of the acetyl-CoA carboxylase promoter
10.1074/jbc.271.3.1385 · 1996 · External reference
Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells
10.1074/jbc.273.14.8225 · 1998 · External reference
Induction of vascular endothelial growth factor by tumor necrosis factor α in human glioma cells: possible roles of SP-1
10.1074/jbc.271.45.28220 · 1996 · External reference
