Research graph
References from Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG Iα, a new auto-antigen in Sjögren׳s syndrome patients, in salivary duct epithelial cells. Local targets link to admitted publications; unresolved targets remain external evidence.
A novel gene activated in regenerating islets
10.1016/s0021-9258(18)69176-8 · 1988 · External reference
Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in β-cells
10.2337/diabetes.51.2007.s462 · 2002 · External reference
Reg gene family and human diseases
10.3748/wjg.v9.i12.2635 · 2003 · External reference
Activation of Reg gene, a gene for insulin-producing β-cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation
2001 · External reference
Neutrophil chemoattractant 2β regulates expression of the Reg gene in injured gastric mucosa in rats
10.1053/gast.2000.20262 · 2000 · External reference
Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes; role of IFNβ
10.1007/s00125-006-0365-6 · 2006 · External reference
Interleukin-8 regulates expression of Reg protein in Helicobacter pylori-infected gastric mucosa
10.1111/j.1572-0241.2005.41915.x · 2005 · External reference
Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3γ via gastric STAT3 activation
10.1371/journal.pone.0030786 · 2012 · External reference
Involvement of the IL-22/REG Iα axis in ulcerative colitis
10.1038/labinvest.2009.147 · 2010 · External reference
Possible role of REG Iα protein in ulcerative colitis and colitic cancer
10.1136/gut.2004.053587 · 2005 · External reference
Cytokines in Sjögren׳s syndrome: potential therapeutic targets
10.1136/ard.2009.115378 · 2010 · External reference
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
10.1038/sj.onc.1203551 · 2000 · External reference
Stat proteins and oncogenesis
10.1172/jci0215617 · 2002 · External reference
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
10.1073/pnas.97.8.4227 · 2000 · External reference
STAT signaling in head and neck cancer
10.1038/sj.onc.1203483 · 2000 · External reference
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
10.1038/sj.onc.1206047 · 2002 · External reference
REG Iα protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells
10.1093/carcin/bgm250 · 2008 · External reference
Novel aspects of Sjögren׳s syndrome in 2012
10.1186/1741-7015-11-93 · 2013 · External reference
Cytokines in Sjögren׳s syndrome
10.1111/j.1601-0825.2009.01582.x · 2009 · External reference
Pathogenesis of Sjögren׳s syndrome
10.1097/bor.0b013e32832eba21 · 2009 · External reference
Pathogenesis of Sjögren׳s syndrome and therapeutic consequences
10.1097/bor.0b013e32833c36c5 · 2010 · External reference
Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren׳s syndrome
10.1111/cei.12142 · 2013 · External reference
Morphogenesis of normal human salivary gland cells in vitro
1994 · External reference
Including the p53 ELAV-like protein-binding site in vector cassettes enhances transgene expression in rat submandibular gland
10.1111/j.1601-0825.2011.01895.x · 2012 · External reference
Construction and function of a recombinant adenovirus encoding a human aquaporin 1-green fluorescent protein fusion product
10.1038/sj.cgt.7700146 · 2000 · External reference
Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38
10.1016/j.lfs.2011.11.011 · 2012 · External reference
A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene
10.1016/j.bbrc.2010.05.051 · 2010 · External reference
Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells
10.1016/j.bbrc.2008.12.113 · 2009 · External reference
Cyclin D1 activation through ATF-2 in Reg-induced pancreatic β-cell regeneration
10.1016/j.febslet.2005.12.070 · 2006 · External reference
Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation
1833 · External reference
Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene
10.1016/j.lfs.2013.09.001 · 2013 · External reference
New Aspects of Mechanism of Salivary Gland Dysfunction in Sjögren׳s Syndrome
2014 · External reference
Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjögren׳s syndrome and correlate with the clinical manifestations of the disease
10.1093/rheumatology/40.6.656 · 2001 · External reference
Circulating cytokines in primary Sjögren׳s syndrome determined by a multiplex cytokine array system
10.1111/j.0300-9475.2004.01432.x · 2004 · External reference
Janus kinases in immune cell signaling
10.1111/j.1600-065x.2008.00754.x · 2009 · External reference
Synergistic activations of REG I α and REG I β promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic β cells
10.1155/2015/173058 · 2015 · External reference
The interleukin-8 pathway in cancer
10.1158/1078-0432.ccr-07-4843 · 2008 · External reference
Chemokine expression and leucocyte infiltration in Sjögren׳s syndrome
10.1093/rheumatology/37.7.779 · 1998 · External reference
Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients
10.1111/j.1365-2362.2004.01419.x · 2004 · External reference
Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment
10.1210/endo.139.5.5997 · 1998 · External reference
Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III
10.1016/j.gene.2004.06.010 · 2004 · External reference
Implications of long-term medication of oral steroids and antimalarial drugs in primary Sjögren׳s syndrome
10.1016/j.intimp.2011.09.006 · 2011 · External reference
A double blind placebo controlled trial of azathioprine in the treatment of primary Sjögren׳s syndrome
1998 · External reference
Methotrexate in primary Sjögren׳s syndrome
1996 · External reference
Efficacy and safety of mizoribine for the treatment of Sjögren׳s syndrome: a multicenter open-label clinical trial
10.3109/s10165-007-0627-2 · 2007 · External reference
What is the future of targeted therapy in rheumatology: biologics or small molecules
10.1186/1741-7015-12-43 · 2014 · External reference
OPTION investigators, Effects of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomized trial
10.1016/s0140-6736(08)60453-5 · 2008 · External reference
Effectiveness of rituximab treatment in primary Sjögren׳s syndrome: a randomized, double-blind, placebo-controlled trial
10.1002/art.27314 · 2010 · External reference
Efficacy and safety of rituximab treatment in early primary Sjögren׳s syndrome: a prospective, multi-center, follow-up study
10.1186/ar4359 · 2013 · External reference
REFLEX Trial Group, Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
10.1002/art.22025 · 2006 · External reference
Improved health-related quality of life for patients with active rheumatoid arthritis receiving rituximab: results of the dose-ranging assessment: international clinical evaluation of Rituximab in rheumatoid arthritis (DANCER) trial
2008 · External reference
Longterm effects of rituximab on B cell counts and autoantibody production in rheumatoid arthritis: use of high-sensitivity flow cytometry for more sensitive assessment of B cell depletion
10.3899/jrheum.111488 · 2013 · External reference
