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References from Insights into the inhibitory mechanism of triazole-based small molecules on phosphatidylinositol-4,5-bisphosphate binding pleckstrin homology domain. Local targets link to admitted publications; unresolved targets remain external evidence.
Building signaling complexes at the membrane
10.1126/stke.3212006pe7 · 2006 · External reference
Membrane–protein interactions in cell signaling and membrane trafficking
10.1146/annurev.biophys.33.110502.133337 · 2005 · External reference
Membrane recognition by phospholipid-binding domains
10.1038/nrm2328 · 2008 · External reference
Lipid traffic: floppy drives and a superhighway
10.1038/nrm1591 · 2005 · External reference
PI3K pathway alterations in cancer: variations on a theme
10.1038/onc.2008.245 · 2008 · External reference
Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility
10.1038/srep02035 · 2013 · External reference
Targeting phosphoinositide 3-kinase delta for the treatment of respiratory diseases
10.1111/nyas.12039 · 2013 · External reference
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains
10.1073/pnas.1004522107 · 2010 · External reference
PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels
10.1085/jgp.201311033 · 2014 · External reference
High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate
10.1074/jbc.272.3.1799 · 1997 · External reference
Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes
10.1073/pnas.1201658110 · 2013 · External reference
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
10.1084/jem.20131459 · 2014 · External reference
Myristoylated alanine-rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5-bisphosphate and protein kinase C in vascular smooth muscle
10.1096/fj.13-238022 · 2014 · External reference
Low hippocampal PI(4,5)P(2) contributes to reduced cognition in old mice as a result of loss of MARCKS
10.1038/nn.3342 · 2013 · External reference
PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism
10.1007/978-94-007-6331-9_6 · 2013 · External reference
Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly
10.3389/fmicb.2014.00234 · 2014 · External reference
Inhibition of phospholipase C-delta 1 catalytic activity by sphingomyelin
10.1021/bi961072z · 1996 · External reference
Protein kinase C and phospholipase C: bilayer interactions and regulation
10.1016/s0959-440x(97)80122-4 · 1997 · External reference
The PI3K pathway As drug target in human cancer
10.1200/jco.2009.25.3641 · 2010 · External reference
Discovery of a novel class of AKT pleckstrin homology domain inhibitors
10.1158/1535-7163.mct-07-2276 · 2008 · External reference
In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316
10.3727/0965040042380487 · 2004 · External reference
Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains
10.1074/jbc.m703517200 · 2007 · External reference
Small-molecule inhibitors of the PI3K signaling network
10.4155/fmc.11.12 · 2011 · External reference
PI3K signalling: the path to discovery and understanding
10.1038/nrm3290 · 2012 · External reference
Effects of ortho substituent groups of protocatechualdehyde derivatives on binding to the C1 domain of novel protein kinase C
10.1021/jp304787j · 2012 · External reference
Alkyl cinnamates as regulator for the C1 domain of protein kinase C isoforms
10.1016/j.chemphyslip.2012.02.010 · 2012 · External reference
Membrane interaction and protein kinase C-C1 domain binding properties of 4-hydroxy-3-(hydroxymethyl) phenyl ester analogues
10.1021/jp5044305 · 2014 · External reference
Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor
10.1158/1535-7163.mct-09-0985 · 2010 · External reference
Binding of PLCdelta1PH-GFP to PtdIns(4,5)P2 prevents inhibition of phospholipase C-mediated hydrolysis of PtdIns(4,5)P2 by neomycin
10.1111/j.1745-7254.2005.00223.x · 2005 · External reference
Small chemicals with inhibitory effects on PtdIns(3,4,5) P-3 binding of Btk PH domain
10.1016/j.bmcl.2014.03.068 · 2014 · External reference
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate
10.1016/s0960-9822(02)00972-7 · 2002 · External reference
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain
10.1016/0092-8674(95)90219-8 · 1995 · External reference
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
10.1042/bj20031229 · 2003 · External reference
Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities
10.1111/j.1742-4658.2009.07477.x · 2010 · External reference
Bilayer interaction and protein kinase C-C1 domain binding studies of kojic acid esters
10.1039/c4ra02352h · 2014 · External reference
Physicochemical characterization of diacyltetrol-based lipids consisting of both diacylglycerol and phospholipid headgroups
10.1039/c4ra02495h · 2014 · External reference
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain
10.1073/pnas.92.23.10472 · 1995 · External reference
The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain
10.1021/bi000902c · 2000 · External reference
Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3
10.1242/jcs.02325 · 2005 · External reference
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer
10.1146/annurev.cellbio.17.1.615 · 2001 · External reference
Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model
10.1016/j.exphem.2007.03.020 · 2007 · External reference
Drugging the PI3 kinome: from chemical tools to drugs in the clinic
10.1158/0008-5472.can-09-4355 · 2010 · External reference
AKT crystal structure and AKT-specific inhibitors
10.1038/sj.onc.1209087 · 2005 · External reference
Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin
10.1002/anie.201302207 · 2013 · External reference
Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells
10.1124/mol.109.060475 · 2010 · External reference
Small molecule inhibitors of phospholipase C from a novel high-throughput screen
10.1074/jbc.m112.422501 · 2013 · External reference
Phospholipase Cgamma1 is required for metastasis development and progression
10.1158/0008-5472.can-08-1181 · 2008 · External reference
Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes
10.1074/jbc.m111.231993 · 2011 · External reference
Signaling and subcellular targeting by membrane-binding domains
10.1146/annurev.biophys.29.1.49 · 2000 · External reference
Recyclable catalytic dendrimer nanoreactor for part-per-million Cu(I) catalysis of “click” chemistry in water
10.1021/ja5061388 · 2014 · External reference
Copper oxide nanoparticle mediated ‘click chemistry’ for the synthesis of mono-, bis- and tris-triazole derivatives from 10,10-dipropargyl-9-anthrone as a key building block
10.1039/c3ra44869j · 2014 · External reference
Functionalization of 2-(S)-isopropyl-5-iodo-pyrimidin-4-ones through Cu(I)-mediated 1,3-dipolar azide-alkyne cycloadditions
10.1016/j.tetlet.2011.10.011 · 2011 · External reference
Membrane lipids: where they are and how they behave
10.1038/nrm2330 · 2008 · External reference
Differential roles of phosphatidylserine, PtdIns(4,5)P2, and PtdIns(3,4,5)P3 in plasma membrane targeting of C2 domains. Molecular dynamics simulation, membrane binding, and cell translocation studies of the PKCalpha C2 domain
10.1074/jbc.m802617200 · 2008 · External reference
The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-d ione) spontaneously forms conjugates with common components of cell culture medium
10.1124/dmd.106.014498 · 2007 · External reference
Direct activation of human phospholipase C by its well known inhibitor u73122
10.1074/jbc.m110.191783 · 2011 · External reference
