Research graph
References from The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops. Local targets link to admitted publications; unresolved targets remain external evidence.
HIV-1 antiretroviral resistance: scientific principles and clinical applications
10.2165/11633630-000000000-00000 · 2012 · External reference
Changes in darunavir/r resistance score after previous failure to tipranavir/r in HIV-1-infected multidrug-resistant patients
10.1097/qai.0b013e31819367fc · 2009 · External reference
Factors associated with the selection of mutations conferring resistance to protease inhibitors (PIs) in PI-experienced patients displaying treatment failure on darunavir
10.1128/aac.00909-07 · 2008 · External reference
Human immunodeficiency virus reverse transcriptase and protease sequence database
10.1093/nar/gkg100 · 2003 · External reference
The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynami
10.15190/d.2014.19 · 2014 · External reference
10.1128/aac.46.3.731-738.2002
10.1128/aac.46.3.731-738.2002 · 2002 · External reference
Update of the drug resistance mutations in HIV-1
2014 · External reference
Prototypical recombinant multi-protease inhibitor resistant infectious molecular clones of human immunodeficiency virus type-1
10.1128/aac.00614-13 · 2013 · External reference
HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements
10.1021/bi2018317 · 2012 · External reference
“Wide-open” 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target
10.1016/j.str.2005.11.005 · 2005 · External reference
Higher desolvation energy reduces molecular recognition in multi-drug resistant HIV-1 protease
2012 · External reference
HIV-1 protease variants from 100-fold drug resistant clinical isolates: expression, purification, and crystallization
10.1016/s1046-5928(02)00650-2 · 2003 · External reference
Phaser crystallographic software
10.1107/s0021889807021206 · 2007 · External reference
PHENIX: a comprehensive python-based system for macromolecular structure solution
10.1107/s0907444909052925 · 2010 · External reference
Coot: model-building tools for molecular graphics
10.1107/s0907444904019158 · 2004 · External reference
PDB_REDO: automated re-refinement of X-ray structure models in the PDB
10.1107/s0021889809008784 · 2009 · External reference
MolProbity: all-atom structure validation for macromolecular crystallography
10.1107/s0907444909042073 · 2010 · External reference
Unresolved reference
External reference
LigPlot+: multiple ligand-protein interaction diagrams for drug discovery
10.1021/ci200227u · 2011 · External reference
X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes
10.1038/342299a0 · 1989 · External reference
Scalable molecular dynamics with NAMD
10.1002/jcc.20289 · 2005 · External reference
VMD: visual molecular dynamics
10.1016/0263-7855(96)00018-5 · 1996 · External reference
Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants
10.1107/s0907444911011541 · 2011 · External reference
Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir
10.1016/j.jmb.2008.05.062 · 2008 · External reference
Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes
10.1016/j.bbrc.2012.12.045 · 2013 · External reference
A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV
10.1128/aac.00107-14 · 2014 · External reference
Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease
10.1021/ja504096m · 2014 · External reference
Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir
10.1128/jvi.00451-09 · 2009 · External reference
Unresolved reference
2014 · External reference
