Research graph
References from Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular identification of a renal urate anion exchanger that regulates blood urate levels
10.1038/nature742 · 2002 · External reference
Kidney-specific expression of a novel mouse organic cation transporter-like protein
10.1016/s0014-5793(97)01325-2 · 1997 · External reference
Hominoid Evolution, and the Pathogenesis of Salt-Sensitivity
2002 · External reference
Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease
10.1038/sj.ki.5000391 · 2006 · External reference
A Risk Factor and a Target for Treatment?
10.1681/asn.2005121331 · 2006 · External reference
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
10.1371/journal.pgen.1000504 · 2009 · External reference
SLC2A9 is a high-capacity urate transporter in humans
10.1371/journal.pmed.0050197 · 2008 · External reference
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
10.1038/ng.106 · 2008 · External reference
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
10.1038/ng.107 · 2008 · External reference
Regulation of Uric Acid Excretion by the Kidney
10.1007/s11926-012-0240-z · 2012 · External reference
Genetics of hyperuricemia and gout: implications for the present and future
10.1007/s11926-012-0309-8 · 2013 · External reference
The Molecular Physiology of Uric Acid Homeostasis
10.1146/annurev-physiol-021113-170343 · 2015 · External reference
Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology
10.1002/bdd.693 · 2010 · External reference
The molecular pharmacology of organic anion transporters: From DNA to FDA?
10.1124/mol.65.3.479 · 2004 · External reference
Function and Localization of Urate Transporter 1 in Mouse Kidney
10.1097/01.asn.0000107560.80107.19 · 2004 · External reference
Organic anion and cation transporters occur in pairs of similar and similarly expressed genes
10.1016/s0006-291x(02)02853-x · 2003 · External reference
Multiple organic anion transporters contribute to net renal excretion of uric acid
10.1152/physiolgenomics.00207.2007 · 2008 · External reference
Linkage of organic anion transporter-1 to metabolic pathways through integrated “omics”-driven network and functional analysis
10.1074/jbc.m111.272534 · 2011 · External reference
Multispecific Drug Transporter Slc22a8 (Oat3) Regulates Multiple Metabolic and Signaling Pathways
10.1124/dmd.113.052647 · 2013 · External reference
Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters
10.1152/physiolgenomics.00014.2004 · 2004 · External reference
Striking Differences between Knockout and Wild-Type Mice in Global Gene Expression Variability
10.1371/journal.pone.0097734 · 2014 · External reference
Interaction of organic cations with organic anion transporters
10.1074/jbc.m109.024489 · 2009 · External reference
Organic anion transporter 3 contributes to the regulation of blood pressure
10.1681/asn.2008020180 · 2008 · External reference
Analysis of mutations in the urate transporter 1 (URAT1) gene of Japanese patients with hypouricemia in northern Japan and review of the literature
10.1080/08860220600580365 · 2006 · External reference
URAT1 mutations cause renal hypouricemia type 1 in Iraqi Jews
10.1093/ndt/gfq722 · 2011 · External reference
Clinical and functional characterization of URAT1 variants
10.1371/journal.pone.0028641 · 2011 · External reference
Novel allelic variants and evidence for a prevalent mutation in URAT1 causing renal hypouricemia: biochemical, genetics and functional analysis
10.1038/ejhg.2013.3 · 2013 · External reference
Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia
10.1253/circj.cj-14-1267 · 2015 · External reference
A’‘complexity’ of urate transporters
10.1038/ki.2010.206 · 2010 · External reference
Genetics of gout
10.1097/bor.0b013e32833645e8 · 2010 · External reference
Overview of glycoconjugate analysis, Curr Protoc Protein Sci
2009 · External reference
Unresolved reference
2009 · External reference
Growth factor-heparan sulfate “switches” regulating stages of branching morphogenesis
10.1007/s00467-013-2725-z · 2014 · External reference
Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence
10.1001/jama.290.7.932 · 2003 · External reference
Defective pantothenate metabolism and neurodegeneration
10.1042/bst20140098 · 2014 · External reference
Coenzyme A and its derivatives: renaissance of a textbook classic
10.1042/bst20140176 · 2014 · External reference
Coenzyme A, more than’‘just’ a metabolic cofactor
10.1042/bst20140125 · 2014 · External reference
What do drug transporters really do?
10.1038/nrd4461 · 2015 · External reference
The Organic Anion Transporter (OAT) Family: A Systems Biology
2015 · External reference
Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis
10.1124/mol.109.056564 · 2009 · External reference
Initial sequencing and comparative analysis of the mouse genome
2002 · External reference
