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References from The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity. Local targets link to admitted publications; unresolved targets remain external evidence.
Tube travel: the role of proteases in individual and collective cancer cell invasion
10.1158/0008-5472.can-08-0784 · 2008 · External reference
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited
10.1083/jcb.200807195 · 2009 · External reference
Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer
10.1593/neo.04349 · 2005 · External reference
Pericellular cathepsin B and malignant progression
10.1023/a:1023007717757 · 2003 · External reference
Immunohistochemical localization of cathepsin B in neoplastic human prostate
10.1002/pros.2990260402 · 1995 · External reference
Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts
10.1158/0008-5472.can-07-5127 · 2008 · External reference
Lysosomal involvement in cell death and cancer
10.1016/j.bbamcr.2008.09.008 · 2009 · External reference
Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes
10.1091/mbc.12.12.4013 · 2001 · External reference
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion
10.1371/journal.pone.0045910 · 2012 · External reference
Thiazolidinediones induce Rab7-RILP-MAPK-dependent juxtanuclear lysosome aggregation and reduce tumor cell invasion
10.1111/j.1600-0854.2009.01012.x · 2010 · External reference
Supporting a role for the GTPase Rab7 in prostate cancer progression
10.1371/journal.pone.0087882 · 2014 · External reference
Na+/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells
10.1111/j.1600-0854.2009.00904.x · 2009 · External reference
HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+–H+ exchangers
10.1242/jcs.063644 · 2010 · External reference
Extracellular acidification alters lysosomal trafficking in human breast cancer cells
10.1016/s1476-5586(03)80037-4 · 2003 · External reference
MRI of the tumor microenvironment
10.1002/jmri.10181 · 2002 · External reference
Acidic pH enhances the invasive behavior of human melanoma cells
10.1007/bf00121214 · 1996 · External reference
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
10.1158/0008-5472.can-06-0983 · 2006 · External reference
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
10.1073/pnas.0911325107 · 2010 · External reference
The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration
10.1038/onc.2013.549 · 2013 · External reference
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
10.1038/35001622 · 2000 · External reference
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
10.1158/0008-5472.can-05-3617 · 2006 · External reference
The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors
10.1016/s0960-9822(01)00531-0 · 2001 · External reference
Phenotypic and cytogenetic characterization of a cell line derived from primary prostatic carcinoma
10.1002/ijc.2910440525 · 1989 · External reference
Knockdown of core binding factorbeta alters sphingolipid metabolism
10.1002/jcp.24406 · 2013 · External reference
Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells
10.1152/ajpregu.00506.2001 · 2002 · External reference
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
10.1074/jbc.m412357200 · 2005 · External reference
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
10.1111/j.1474-9726.2007.00304.x · 2007 · External reference
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
10.1128/mcb.26.1.28-38.2006 · 2006 · External reference
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease
10.1126/science.1143780 · 2007 · External reference
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
10.1074/jbc.m205670200 · 2002 · External reference
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
10.1016/j.molcel.2005.02.022 · 2005 · External reference
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
10.1016/s0021-9258(17)44885-x · 1990 · External reference
Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin
10.1083/jcb.200606077 · 2007 · External reference
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
10.1126/science.1411546 · 1992 · External reference
Active erk regulates microtubule stability in H-ras-transformed cells
10.1038/sj.neo.7900180 · 2001 · External reference
Autophagy: cellular and molecular mechanisms
10.1002/path.2697 · 2010 · External reference
Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes
10.1247/csf.08005 · 2008 · External reference
A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1
10.1074/jbc.m109.026013 · 2009 · External reference
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
10.1093/emboj/19.21.5720 · 2000 · External reference
Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study
10.1186/1476-4598-9-207 · 2010 · External reference
Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
10.1186/bcr3058 · 2011 · External reference
Cathepsin B inhibition limits bone metastasis in breast cancer
10.1158/0008-5472.can-11-2759 · 2012 · External reference
Tumour microenvironment-opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
10.1038/nrc1821 · 2006 · External reference
Acetylation and deacetylation of non-histone proteins
10.1016/j.gene.2005.09.010 · 2005 · External reference
Deacetylation of cortactin by SIRT1 promotes cell migration
10.1038/onc.2008.388 · 2009 · External reference
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
10.1016/s1097-2765(03)00038-8 · 2003 · External reference
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington’s disease by increasing tubulin acetylation
10.1523/jneurosci.0037-07.2007 · 2007 · External reference
The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock
10.1016/j.bbamcr.2013.03.004 · 2013 · External reference
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
10.1371/journal.pgen.1002135 · 2011 · External reference
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes
10.1038/emboj.2008.308 · 2009 · External reference
Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport
10.1523/jneurosci.5599-11.2012 · 2012 · External reference
Role of PI3K/Akt/mTOR and MEK/ERK pathway in Concanavalin A induced autophagy in HeLa cells
10.1016/j.cbi.2014.01.003 · 2014 · External reference
ERK and cell death: mechanisms of ERK-induced cell death—apoptosis, autophagy and senescence
10.1111/j.1742-4658.2009.07366.x · 2010 · External reference
New and emerging HDAC inhibitors for cancer treatment
10.1172/jci69738 · 2014 · External reference