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References from Transthyretin chemical chaperoning by flavonoids: Structure–activity insights towards the design of potent amyloidosis inhibitors. Local targets link to admitted publications; unresolved targets remain external evidence.
Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8Å
10.1016/0022-2836(78)90368-6 · 1978 · External reference
Three-dimensional structure of the transthyretin-retinol-binding protein complex
10.1515/cclm.2002.213 · 2002 · External reference
Neurodegeneration in familial amyloid polyneuropathy: from pathology to molecular signaling
10.1016/j.pneurobio.2003.11.002 · 2003 · External reference
Endoplasmic reticulum stress associated with extracellular aggregates. Evidence from transthyretin deposition in familial amyloid polyneuropathy
10.1074/jbc.m602302200 · 2006 · External reference
Studies on plasma transthyretin (prealbumin) in familial amyloidotic polyneuropathy, Portuguese type
1983 · External reference
Familial amyloid polyneuropathy: an electron microscope study of the peripheral nerve in five cases. II. Nerve fibre changes
10.1093/brain/94.2.207 · 1971 · External reference
Tafamidis
10.1038/nrd3675 · 2012 · External reference
Transthyretin-related amyloidoses and the heart: a clinical overview
10.1038/nrcardio.2010.67 · 2010 · External reference
Alzheimer’s disease: the amyloid cascade hypothesis
10.1126/science.1566067 · 1992 · External reference
The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics
10.1126/science.1072994 · 2002 · External reference
Wanker EE EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
10.1038/nsmb.1437 · 2008 · External reference
Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity
10.1016/j.febslet.2009.10.062 · 2009 · External reference
Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils
10.1021/bi2012383 · 2011 · External reference
How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro
10.1074/jbc.m114.554667 · 2014 · External reference
Polyphenols as therapeutic molecules in Alzheimer’s disease through modulating amyloid pathways
2014 · External reference
Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism
10.1111/j.1747-0285.2005.00318.x · 2006 · External reference
Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity
10.1021/bi00096a024 · 1993 · External reference
Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative
10.1042/bj20040011 · 2004 · External reference
Specific detection of quinoproteins by redox-cycling staining
10.1016/s0021-9258(17)35225-0 · 1991 · External reference
Electrically neutral microheterogeneity of human plasma transthyretin (prealbumin) detected by isoelectric focusing in urea gradients
10.1002/(sici)1522-2683(19990601)20:7<1349::aid-elps1349>3.0.co;2-5 · 1999 · External reference
Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation
10.1016/j.febslet.2011.06.030 · 2011 · External reference
Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design
10.1042/bj20070689 · 2007 · External reference
Covalent modification of proteins by green tea polyphenol [-]-epigallocatechin-3-gallate through autoxidation
10.1016/j.freeradbiomed.2008.07.023 · 2008 · External reference
Transthyretin oligomers induce calcium influx via voltage-gated calcium channels
10.1111/j.1471-4159.2006.04210.x · 2007 · External reference
Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates
10.1016/s0002-9440(10)63050-7 · 2001 · External reference
Recent advances in transthyretin amyloidosis therapy
10.1186/2047-9158-3-19 · 2014 · External reference
Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro
10.1016/j.bbadis.2004.06.008 · 2004 · External reference
Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis
10.1073/pnas.0501609102 · 2005 · External reference
Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP
10.1111/j.1471-4159.2008.05611.x · 2008 · External reference
The crystal structure of the green tea polyphenol [-]-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site
10.1021/bi1004409 · 2010 · External reference
Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity
10.1111/j.1460-9568.2005.04532.x · 2006 · External reference
Radical scavenging activity of tea catechins and their related compounds
10.1271/bbb.63.1621 · 1999 · External reference
Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)
10.1038/sj.bjc.6600295 · 2002 · External reference
Structure-activity relationship of bis-galloyl derivatives related to [-]-epigallocatechin gallate
10.1248/cpb.57.190 · 2009 · External reference
Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate
10.1248/bpb.31.816 · 2008 · External reference
Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases
10.1111/j.1755-5949.2008.00060.x · 2008 · External reference
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
10.1093/ajcn/81.1.230s · 2005 · External reference
Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans
10.1021/jf9032975 · 2010 · External reference
Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises?
10.3390/ijms12095592 · 2011 · External reference
Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate
10.1016/j.ejps.2010.06.010 · 2010 · External reference
Design, semisynthesis, and evaluation of O-acyl derivatives of (-)-epigallocatechin-3-gallate as antitumor agents
10.1021/jf070519f · 2007 · External reference
Piperine enhances thebioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice
10.1093/jn/134.8.1948 · 2004 · External reference
Parkinson’s disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake
10.1093/aje/155.8.732 · 2002 · External reference
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
10.1523/jneurosci.1521-05.2005 · 2005 · External reference
Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties
10.1016/j.jnutbio.2012.06.011 · 2013 · External reference
Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: “in vivo” evidence from FAP mice models
10.1371/journal.pone.0029933 · 2012 · External reference
Green tea halts progression of cardiac transthyretin amyloidosis: an observational report
10.1007/s00392-012-0463-z · 2012 · External reference