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References from Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Local targets link to admitted publications; unresolved targets remain external evidence.
Caspases: enemies within
10.1126/science.281.5381.1312 · 1998 · External reference
Apoptosis: controlled demolition at the cellular level
10.1038/nrm2312 · 2008 · External reference
Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death
10.1038/cdd.2011.96 · 2012 · External reference
CASH, a novel caspase homologue with death effector domains
10.1074/jbc.272.32.19641 · 1997 · External reference
MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death
10.1073/pnas.94.21.11333 · 1997 · External reference
I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD- 95-induced apoptosis
10.1074/jbc.272.28.17255 · 1997 · External reference
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
10.1073/pnas.94.20.10717 · 1997 · External reference
Inhibition of death receptor signals by cellular FLIP
10.1038/40657 · 1997 · External reference
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
10.1038/sj.cdd.4400370 · 1998 · External reference
Casper is a FADD- and caspase-related inducer of apoptosis
10.1016/s1074-7613(00)80450-1 · 1997 · External reference
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
10.1074/jbc.272.30.18542 · 1997 · External reference
c-FLIPR, a new regulator of death receptor-induced apoptosis
10.1074/jbc.m414425200 · 2005 · External reference
FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis
10.1128/mcb.21.24.8247-8254.2001 · 2001 · External reference
Activation of NF-kappaB by FADD, Casper, and caspase-8
10.1074/jbc.275.15.10838 · 2000 · External reference
The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways
10.1016/s0960-9822(00)00512-1 · 2000 · External reference
Conserved function of caspase-8 in apoptosis during bony fish evolution
10.1016/j.gene.2007.03.010 · 2007 · External reference
Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire
10.1093/molbev/msn012 · 2008 · External reference
Caspases: evolutionary aspects of their functions in vertebrates
10.1111/j.1095-8649.2009.02184.x · 2009 · External reference
Evolutionary analyses of caspase-8 and its paralogs: deep origins of the apoptotic signaling pathways
10.1002/bies.201500010 · 2015 · External reference
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
10.1073/pnas.91.22.10255 · 1994 · External reference
Unresolved reference
1967 · External reference
Unresolved reference
1994 · External reference
Stages of embryonic development of the zebrafish
10.1002/aja.1002030302 · 1995 · External reference
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
10.1084/jem.169.5.1747 · 1989 · External reference
Composition-based statistics and translated nucleotide searches: improving the TBLASTN module of BLAST
10.1186/1741-7007-4-41 · 2006 · External reference
The apoptotic initiator Caspase-8: its functional ubiquity and genetic diversity during animal evolution
10.1093/molbev/msu260 · 2014 · External reference
and PSI-BLAST: a new generation of protein database search programs
10.1093/nar/25.17.3389 · 1997 · External reference
MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform
10.1093/nar/gkf436 · 2002 · External reference
RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
10.1093/bioinformatics/btl446 · 2006 · External reference
Mechanism of procaspase-8 activation by c-FLIPL
10.1073/pnas.0812453106 · 2009 · External reference
FORTE: a profile–profile comparison tool for protein fold recognition
10.1093/bioinformatics/btg474 · 2004 · External reference
Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation
10.1002/j.1460-2075.1992.tb05437.x · 1992 · External reference
Transgenic frogs expressing the highly fluorescent protein Venus under the control of a strong mammalian promoter suitable for monitoring living cells
10.1002/dvdy.20350 · 2005 · External reference
The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity
10.1111/j.1365-2443.2004.00802.x · 2004 · External reference
Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus
10.1074/jbc.m112475200 · 2002 · External reference
and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation
10.1002/dvdy.22099 · 2009 · External reference
Suppression of head formation by Xmsx-1 through the inhibition of intracellular nodal signaling
10.1242/dev.128.14.2769 · 2001 · External reference
Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8
10.1016/s0925-4773(03)00003-0 · 2003 · External reference
Caspases: keys in the ignition of cell death
10.1021/cr010183n · 2002 · External reference
Molecular phylogeny and divergence time estimates for major rodent groups: evidence from multiple genes
10.1093/oxfordjournals.molbev.a003860 · 2001 · External reference
Estimation of divergence times from multiprotein sequences for a few mammalian species and several distantly related organisms
10.1073/pnas.051611498 · 2001 · External reference
Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions
10.1016/j.yexcr.2012.01.019 · 2012 · External reference
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
10.1038/nbt0102-87 · 2002 · External reference
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
10.1016/s0092-8674(00)81265-9 · 1996 · External reference
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death–inducing signaling complex
10.1016/s0092-8674(00)81266-0 · 1996 · External reference
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death
10.1074/jbc.m104837200 · 2001 · External reference
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway
10.1128/mcb.24.7.2627-2636.2004 · 2004 · External reference
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development
10.1016/s1074-7613(00)80214-9 · 2000 · External reference
The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation
10.1084/jem.20051556 · 2006 · External reference
Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons
10.1126/science.291.5507.1279 · 2001 · External reference
Identification of candidate genes encoding the core components of the cell death machinery in the Ciona intestinalis genome
10.1038/sj.cdd.4401223 · 2003 · External reference
Death receptors
10.1042/bse0390053 · 2003 · External reference
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
10.1038/nature09852 · 2011 · External reference
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
10.1038/nature09857 · 2011 · External reference
The diverse role of RIP kinases in necroptosis and inflammation
10.1038/ni.3206 · 2015 · External reference
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
10.1038/82732 · 2000 · External reference
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
10.1038/nchembio711 · 2005 · External reference
A new kind of cell suicide: mechanisms and functions of programmed necrosis
10.1016/j.tibs.2014.10.003 · 2014 · External reference
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
10.1038/nrm3737 · 2014 · External reference
Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1
10.1111/imr.12304 · 2015 · External reference
RIPK1 and RIPK3: critical regulators of inflammation and cell death
10.1016/j.tcb.2015.01.001 · 2015 · External reference
The FLIP side of life
10.1126/scisignal.2003845 · 2013 · External reference
The initiator caspase, caspase-10β, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways
10.1111/j.1365-2443.2006.00983.x · 2006 · External reference
Expression of cellular FLICE-inhibitory protein in human coronary arteries and in a rat vascular injury model
10.1016/s0002-9440(10)64712-8 · 2000 · External reference
TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2
10.1159/000086599 · 2005 · External reference
Synergistic interactions between interferon-gamma and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis
10.1182/blood-2007-10-119552 · 2008 · External reference
Molecular mechanisms that control endothelial cell contacts
10.1002/(sici)1096-9896(200002)190:3<281::aid-path527>3.0.co;2-z · 2000 · External reference
New lives for old: evolution of pseudoenzyme function illustrated by iRhoms
10.1038/nrm3392 · 2012 · External reference
Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling
10.1128/mcb.24.19.8418-8427.2004 · 2004 · External reference
TimeTree: a public knowledge-base of divergence times among organisms
10.1093/bioinformatics/btl505 · 2006 · External reference
