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References from Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD. Local targets link to admitted publications; unresolved targets remain external evidence.
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
10.1097/hep.0000000000000004 · 2023 · External reference
Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical Bayesian approach
10.3350/cmh.2022.0239 · 2022 · External reference
Hepatocytic ballooning in non-alcoholic steatohepatitis: bridging the knowledge gap and charting future avenues
2023 · External reference
Hepatocytic ballooning in non-alcoholic steatohepatitis: dilemmas and future directions
10.1111/liv.15571 · 2023 · External reference
Hepatocellular ballooning in NASH
10.1016/j.jhep.2010.04.031 · 2010 · External reference
Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings
10.1002/hep.24127 · 2011 · External reference
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
10.1111/j.1572-0241.1999.01377.x · 1999 · External reference
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
10.1002/hep.20701 · 2005 · External reference
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients
10.1002/hep.25889 · 2012 · External reference
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
10.3748/wjg.v20.i42.15539 · 2014 · External reference
Hepatic transcriptome signature correlated with HOMA-IR explains early nonalcoholic fatty liver disease pathogenesis
10.1016/j.aohep.2020.06.009 · 2020 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
Limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
Regularization paths for generalized linear models via coordinate descent
10.18637/jss.v033.i01 · 2010 · External reference
Gene expression predicts histological severity and reveals distinct molecular profiles of nonalcoholic fatty liver disease
10.1038/s41598-019-48746-5 · 2019 · External reference
Regression modeling strategies: with applications to linear models
2015 · External reference
Decision curve analysis: a novel method for evaluating prediction models
10.1177/0272989x06295361 · 2006 · External reference
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
10.1016/j.ebiom.2024.105232 · 2024 · External reference
Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival
10.1186/s13073-022-01055-5 · 2022 · External reference
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease
10.1016/j.ebiom.2023.104620 · 2023 · External reference
Acquisition of epithelial plasticity in human chronic liver disease
10.1038/s41586-024-07465-2 · 2024 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
Doublet identification in single-cell sequencing data using scDblFinder
10.12688/f1000research.73600.1 · 2021 · External reference
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
10.1002/hep.23998 · 2011 · External reference
Intermediate filament cytoskeleton of the liver in health and disease
10.1007/s00418-008-0431-x · 2008 · External reference
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration
10.1038/ncomms13369 · 2016 · External reference
Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers
10.1016/j.cmet.2013.11.018 · 2014 · External reference
Annexins: from structure to function
10.1152/physrev.00030.2001 · 2002 · External reference
Variants of core histones and their roles in cell fate decisions, development and cancer
10.1038/nrm.2016.166 · 2017 · External reference
Metabolic functions of FABPs — mechanisms and therapeutic implications
10.1038/nrendo.2015.122 · 2015 · External reference
The single-cell transcriptional landscape of mammalian organogenesis
10.1038/s41586-019-0969-x · 2019 · External reference
Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level
10.1158/2159-8290.cd-21-0316 · 2022 · External reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · 2017 · External reference
A scalable SCENIC workflow for single-cell gene regulatory network analysis
10.1038/s41596-020-0336-2 · 2020 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Comprehensive and integrative genomic characterization of hepatocellular carcinoma
10.1016/j.cell.2017.05.046 · 2017 · External reference
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
10.1016/0003-2697(87)90021-2 · 1987 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method
10.1006/meth.2001.1262 · 2001 · External reference
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
10.1016/0003-2697(76)90527-3 · 1976 · External reference
Growth of human hepatoma cell lines with differentiated functions in chemically defined medium
1982 · External reference
Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
10.1111/j.1440-1746.2008.05733.x · 2009 · External reference
Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis
10.1194/jlr.r066357 · 2016 · External reference
Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis
10.1016/j.molcel.2019.07.028 · 2019 · External reference
Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53
10.1016/s0092-8674(03)00042-4 · 2003 · External reference
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
10.1002/hep.20701 · ExternalCitation · doi-reference
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
10.1002/hep.23998 · ExternalCitation · doi-reference
Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings
10.1002/hep.24127 · ExternalCitation · doi-reference
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients
10.1002/hep.25889 · ExternalCitation · doi-reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method
10.1006/meth.2001.1262 · ExternalCitation · doi-reference
Intermediate filament cytoskeleton of the liver in health and disease
10.1007/s00418-008-0431-x · ExternalCitation · doi-reference
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
10.1016/0003-2697(76)90527-3 · ExternalCitation · doi-reference
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
10.1016/0003-2697(87)90021-2 · ExternalCitation · doi-reference
Hepatic transcriptome signature correlated with HOMA-IR explains early nonalcoholic fatty liver disease pathogenesis
10.1016/j.aohep.2020.06.009 · ExternalCitation · doi-reference
Comprehensive and integrative genomic characterization of hepatocellular carcinoma
10.1016/j.cell.2017.05.046 · ExternalCitation · doi-reference
Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers
10.1016/j.cmet.2013.11.018 · ExternalCitation · doi-reference
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease
10.1016/j.ebiom.2023.104620 · ExternalCitation · doi-reference
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
10.1016/j.ebiom.2024.105232 · ExternalCitation · doi-reference
Hepatocellular ballooning in NASH
10.1016/j.jhep.2010.04.031 · ExternalCitation · doi-reference
Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis
10.1016/j.molcel.2019.07.028 · ExternalCitation · doi-reference
Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53
10.1016/s0092-8674(03)00042-4 · ExternalCitation · doi-reference
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration
10.1038/ncomms13369 · ExternalCitation · doi-reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · ExternalCitation · doi-reference
Metabolic functions of FABPs — mechanisms and therapeutic implications
10.1038/nrendo.2015.122 · ExternalCitation · doi-reference
Variants of core histones and their roles in cell fate decisions, development and cancer
10.1038/nrm.2016.166 · ExternalCitation · doi-reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · ExternalCitation · doi-reference
The single-cell transcriptional landscape of mammalian organogenesis
10.1038/s41586-019-0969-x · ExternalCitation · doi-reference
Acquisition of epithelial plasticity in human chronic liver disease
10.1038/s41586-024-07465-2 · ExternalCitation · doi-reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · ExternalCitation · doi-reference
A scalable SCENIC workflow for single-cell gene regulatory network analysis
10.1038/s41596-020-0336-2 · ExternalCitation · doi-reference
Gene expression predicts histological severity and reveals distinct molecular profiles of nonalcoholic fatty liver disease
10.1038/s41598-019-48746-5 · ExternalCitation · doi-reference
Limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · ExternalCitation · doi-reference
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
10.1097/hep.0000000000000004 · ExternalCitation · doi-reference
Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
10.1111/j.1440-1746.2008.05733.x · ExternalCitation · doi-reference
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
10.1111/j.1572-0241.1999.01377.x · ExternalCitation · doi-reference
Hepatocytic ballooning in non-alcoholic steatohepatitis: dilemmas and future directions
10.1111/liv.15571 · ExternalCitation · doi-reference
Annexins: from structure to function
10.1152/physrev.00030.2001 · ExternalCitation · doi-reference
Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level
10.1158/2159-8290.cd-21-0316 · ExternalCitation · doi-reference
Decision curve analysis: a novel method for evaluating prediction models
10.1177/0272989x06295361 · ExternalCitation · doi-reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · ExternalCitation · doi-reference
Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival
10.1186/s13073-022-01055-5 · ExternalCitation · doi-reference
Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis
10.1194/jlr.r066357 · ExternalCitation · doi-reference
Doublet identification in single-cell sequencing data using scDblFinder
10.12688/f1000research.73600.1 · ExternalCitation · doi-reference
Regularization paths for generalized linear models via coordinate descent
10.18637/jss.v033.i01 · ExternalCitation · doi-reference
Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical Bayesian approach
10.3350/cmh.2022.0239 · ExternalCitation · doi-reference
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
10.3748/wjg.v20.i42.15539 · ExternalCitation · doi-reference
