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References from Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
Immediate modulation of transcutaneous Auricular vagus nerve stimulation in patients with treatment-resistant depression: a resting-state functional magnetic resonance imaging study
2022 · External reference
Ferroptosis: a new target for depression prevention and treatment
10.1007/s00702-025-02912-4 · 2025 · External reference
Ferroptosis-associated signaling pathways and therapeutic approaches in depression
10.3389/fnins.2025.1559597 · 2025 · External reference
Quercetin inhibits neuronal ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression
10.1016/j.phymed.2024.155560 · 2024 · External reference
Quercetin alleviates depressive-like behavior by modulating Acetyl-H3K9 mediated ferroptosis pathway in hypothalamus of perimenopausal depression rat model
10.1016/j.biopha.2024.117369 · 2024 · External reference
Untargeted metabolomics reveals that Quercetin Alleviates depressive‐like symptoms in perimenopausal depression rat model by regulating metabolic disorders and inhibiting ferroptosis in the prefrontal cortex
10.1111/ejn.70358 · 2025 · External reference
Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis
10.1016/j.biopha.2024.116425 · 2024 · External reference
Sinensetin attenuates post-stroke depression via dual modulation of TLR4/NF-κB–NRF2/GPX4 pathways
2026 · External reference
Comprehensive metagenomic and lipidomic analysis showed that Baicalin could improve depressive behaviour in atherosclerotic mice by inhibiting nerve cell ferroptosis
10.3389/fimmu.2025.1599570 · 2025 · External reference
Resveratrol alleviates depression-like behaviors by inhibiting ferroptosis via AKT/NRF2 pathway
10.1016/j.brainresbull.2024.111136 · 2025 · External reference
Gallic acid improves Comorbid chronic pain and depression behaviors by inhibiting P2X7 receptor-mediated ferroptosis in the spinal cord of rats
10.1021/acschemneuro.2c00532 · 2023 · External reference
Pellitorine protects chronic restraint stress-induced cognitive deficits via inhibiting neural inflammation and ferroptosis
10.1016/j.intimp.2025.115166 · 2025 · External reference
Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress
10.1016/j.jep.2023.116729 · 2023 · External reference
Asiaticoside attenuates chronic restraint stress-induced hippocampal CA1 neuronal ferroptosis via activating BDNF/Nrf2/GPX4 signaling pathway
10.2147/dddt.s509208 · 2025 · External reference
Gypenosides attenuates CORT-induced ferroptosis via inhibiting TNF-α/NF-κB signaling pathway in PC12 cells
10.3390/molecules30102103 · 2025 · External reference
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression
10.1007/s11418-025-01930-6 · 2025 · External reference
Activation of SIRT1 by Hydroxysafflor Yellow a attenuates chronic unpredictable mild stress‐induced microglia activation and iron death in depressed rats
2025 · External reference
Bufotenidine attenuates astrocyte ferroptosis in depressive-like behaviors through targeting GluA1 to reduce neuronal lipid synthesis
10.1016/j.freeradbiomed.2026.03.024 · 2026 · External reference
Role of PTP1B in coordinating synaptic plasticity and ferroptosis: a mechanism underlying the antidepressant effect of spinosin from Ziziphus Jujuba mill. Var. Spinosa (Bunge) Hu Ex H. F. Chou
10.1016/j.jep.2026.121428 · 2026 · External reference
Lycium Barbarum (Wolfberry) glycopeptide prevents stress-induced anxiety disorders by regulating oxidative stress and ferroptosis in the medial prefrontal cortex
10.1016/j.phymed.2023.154864 · 2023 · External reference
Atractylodes Macrocephala koidz. Polysaccharide alleviates chemotherapy-induced depression-like behaviors through the gut–brain axis
10.3390/ijms262010189 · 2025 · External reference
Seahorse attenuated DSS ‐induced depression in mice by inhibiting neuroinflammation and ferroptosis
10.1002/fsn3.70482 · 2025 · External reference
Traditional Chinese formula xiaoyaosan alleviates depressive-like behavior in CUMS mice by regulating PEBP1-GPX4-Mediated ferroptosis in the hippocampus
10.2147/ndt.s302443 · 2021 · External reference
Di-Huang-Yin-Zi regulates P53/SLC7A11 signaling pathway to improve the mechanism of post-stroke depression
10.1016/j.jep.2023.117226 · 2024 · External reference
Yi-Nao-Jie-Yu prescription relieves post-stroke depression by mitigating ferroptosis in hippocampal neurons via activating the Nrf2/GPX4/SLC7A11 pathway
10.1007/s11481-024-10167-1 · 2025 · External reference
[Kaixinsan Alleviates Adriamycin-Induced Depression-like Behaviors in Mice by Reducing Ferroptosis]
2024 · External reference
Bushen shugan huayu formula improves depressive-like behavior in perimenopausal mice by modulating neuronal ferroptosis through the GPER1/Nrf2 pathway
10.1016/j.phymed.2025.157464 · 2026 · External reference
Baihe Dihuang Danshen decoction alleviates myocardial ischemia-reperfusion injury in depression-induced rats by inhibiting ferroptosis
10.2174/0113862073387437250803043736 · 2025 · External reference
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis
10.1016/j.brainres.2023.148715 · 2024 · External reference
Electroacupuncture ameliorates chronic inflammatory pain and depression comorbidity by inhibiting Nrf2-Mediated ferroptosis in hippocampal neurons
10.1007/s11064-025-04401-2 · 2025 · External reference
Electroacupuncture alleviates depression-like behavior after spinal cord injury via SIRT1/HMGB1 signaling axis mediated ferroptosis
10.1016/j.bbr.2026.116052 · 2026 · External reference
["shugan Tiaoshen" Acupuncture Improves Chronic Inflammatory Pain and Depression Comorbidity by Inhibiting Ferroptosis]
2025 · External reference
Traditional pediatric massage exerted an antidepressant effect and activated IGF-1/Nrf2 pathway in CUMS-exposed adolescent rats
10.1016/j.jneuroim.2025.578554 · 2025 · External reference
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
10.1186/s12974-022-02400-6 · 2022 · External reference
Melatonin alleviates LPS-induced depression-like behavior in mice by inhibiting ferroptosis by regulating RNA methylation-mediated SIRT6/Nrf2/HO-1 pathway
10.1007/s00394-024-03495-8 · 2024 · External reference
Nicorandil ameliorates depression‐like behaviors after traumatic brain injury by suppressing ferroptosis through the SLC7A11/GPX4 axis in the hippocampus
2024 · External reference
Repurposing of rebamipide as a neuroprotective agent to alleviate letrozole-induced depressive-like behaviors in female rats: Targeting SIRT1/FoxO1/Wnt/β-Catenin, and related ferroptosis pathways
10.1016/j.lfs.2025.123941 · 2025 · External reference
Ketamine may exert rapid antidepressant effects through modulation of neuroplasticity, autophagy, and ferroptosis in the habenular nucleus
10.1016/j.neuroscience.2022.10.015 · 2022 · External reference
Etomidate improves the antidepressant effect of electroconvulsive therapy by suppressing hippocampal neuronal ferroptosis via upregulating BDNF/Nrf2
10.1007/s12035-023-03499-1 · 2023 · External reference
Inhibition of ferroptosis alleviates chronic unpredictable mild stress-induced depression in mice via tsRNA-3029b
10.1016/j.brainresbull.2023.110773 · 2023 · External reference
Realistic-NPs trigger depression-like behaviors via mitochondrial iron overload mediating ferroptosis
10.1016/j.cbi.2026.111970 · 2026 · External reference
GLX351322-Loaded nanoparticles alleviate chronic stress-induced depressive behaviors through inhibition of ferroptosis and oxidative stress
10.2147/ijn.s555165 · 2025 · External reference
Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis
10.1016/j.lfs.2021.119551 · 2021 · External reference
Se-Methylselenocysteine alleviates iron deposit-induced Anxiety- and depression-like behaviors in chronic renal failure rats receiving iron therapy via Nrf2/GPX4 activation
10.1016/j.freeradbiomed.2026.03.003 · 2026 · External reference
Regulation of Nrf2/GPX4 signaling pathway by hyperbaric oxygen protects against depressive behavior and cognitive impairment in a spinal cord injury rat model
2025 · External reference
Butyric acid and valeric acid attenuate stress-induced ferroptosis and depressive-like behaviors by suppressing hippocampal neuroinflammation
10.1186/s12967-025-06950-0 · 2025 · External reference
Decreased gut microbiome-derived Indole-3-Propionic acid mediates the exacerbation of myocardial Ischemia/reperfusion injury following depression via the brain-gut-heart axis
10.1016/j.redox.2025.103580 · 2025 · External reference
DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis
10.1016/j.freeradbiomed.2024.10.298 · 2024 · External reference
DHA and EPA prevent seizure and depression‐like behavior by inhibiting ferroptosis and neuroinflammation via different mode‐of‐actions in a pentylenetetrazole‐induced kindling model in mice
2022 · External reference
Ferroptosis, pathogenesis and therapy in AS Co-Depression disease
2025 · External reference
Natural products targeting ferroptosis in depression: research progress and therapeutic prospects
10.1016/j.phymed.2025.156818 · 2025 · External reference
Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders
2022 · External reference
The cell biology of ferroptosis
10.1038/s41580-024-00703-5 · 2024 · External reference
Signaling pathways and defense mechanisms of ferroptosis
10.1111/febs.16059 · 2021 · External reference
Ferroptosis: a new antidepressant pharmacological mechanism
10.3389/fphar.2023.1339057 · 2024 · External reference
The role of ferroptosis in nervous system disorders
10.31083/j.jin2201019 · 2023 · External reference
The vicious cycle of neuroinflammation and ferroptosis in depression: mechanisms and therapeutic targets
10.3389/fnins.2026.1819436 · 2026 · External reference
Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6
10.1002/ajh.24888 · 2017 · External reference
Zebrafish kidney stromal cell lines support multilineage hematopoiesis
10.1182/blood-2009-02-203638 · 2009 · External reference
Uncoupling of CD71 shedding with mitochondrial clearance in reticulocytes in a subset of myelodysplastic syndromes
10.1038/s41375-018-0204-z · 2018 · External reference
Snapshots of iron speciation: tracking the fate of iron nanoparticle drugs via a liquid chromatography–inductively coupled plasma–mass spectrometric approach
10.1021/acs.molpharmaceut.8b01215 · 2019 · External reference
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
10.1073/pnas.0606424103 · 2006 · External reference
Role of Intracellular Labile Iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide
10.1016/j.freeradbiomed.2013.12.006 · 2014 · External reference
Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells
10.1080/15548627.2021.1911016 · 2021 · External reference
Iron administration overcomes resistance to erastin-mediated ferroptosis in ovarian cancer cells
10.3389/fonc.2022.868351 · 2022 · External reference
Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed
10.1182/bloodadvances.2020002198 · 2020 · External reference
Decreased Ferroportin promotes myeloma cell growth and osteoclast differentiation
10.1158/0008-5472.can-14-3804 · 2015 · External reference
Dietary Iron overload differentially modulates chemically-induced liver injury in rats
10.3390/nu12092784 · 2020 · External reference
Quantitative susceptibility mapping reveals an Association between brain iron load and depression severity
10.3389/fnhum.2017.00442 · 2017 · External reference
Quantitative susceptibility mapping of brain iron deposition in patients with recurrent depression
10.30773/pi.2022.0110 · 2022 · External reference
Cranial electrotherapy stimulation alleviates depression-like behavior of post-stroke depression rats by upregulating GPX4-Mediated BDNF expression
10.1016/j.bbr.2022.114117 · 2023 · External reference
Ferroptosis response segregates Small Cell Lung Cancer (SCLC) neuroendocrine subtypes
10.1038/s41467-021-22336-4 · 2021 · External reference
Active steroid hormone synthesis renders adrenocortical cells highly susceptible to type II ferroptosis induction
10.1038/s41419-020-2385-4 · 2020 · External reference
Resolving the role of lipoxygenases in the initiation and execution of ferroptosis
10.1021/acscentsci.7b00589 · 2018 · External reference
Protein kinase C epsilon is a key regulator of mitochondrial redox homeostasis in Acute Myeloid leukemia
10.1158/1078-0432.ccr-17-2684 · 2018 · External reference
Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis
10.1126/sciadv.aba8968 · 2020 · External reference
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
10.1038/s41422-019-0263-3 · 2020 · External reference
Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease
10.1016/j.metabol.2024.155953 · 2024 · External reference
BACH1 encourages ferroptosis by activating KDM4C‐mediated COX2 demethylation after cerebral ischemia–reperfusion injury
10.1111/ejn.16035 · 2023 · External reference
Lipid peroxidation and immune biomarkers are associated with major depression and its phenotypes, including treatment-resistant depression and melancholia
10.1007/s12640-017-9835-5 · 2017 · External reference
Membrane phospholipid peroxidation promotes loss of dopaminergic neurons in psychological stress‐induced parkinson's disease susceptibility
10.1111/acel.13970 · 2023 · External reference
Nlrp6 protects from Corticosterone-induced NSPC ferroptosis by modulating RIG-1/MAVS-Mediated mitophagy
10.1016/j.redox.2024.103196 · 2024 · External reference
LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination
2022 · External reference
The Glutamate/Cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
10.1038/ncomms15074 · 2017 · External reference
GPX4 alleviates diabetes mellitus-induced erectile dysfunction by inhibiting ferroptosis
10.3390/antiox11101896 · 2022 · External reference
Role of uL3 in multidrug resistance in P53-Mutated lung cancer cells
10.3390/ijms18030547 · 2017 · External reference
DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway
10.1038/s41388-021-01676-x · 2021 · External reference
Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
10.1038/s41416-019-0660-x · 2019 · External reference
Solasonine causes redox imbalance and mitochondrial oxidative stress of ferroptosis in lung adenocarcinoma
2022 · External reference
Astragaloside IV attenuates ferroptosis after Subarachnoid Hemorrhage via Nrf2/HO-1 signaling pathway
2022 · External reference
P53 in ferroptosis regulation: the new weapon for the old guardian
10.1038/s41418-022-00943-y · 2022 · External reference
ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer
10.1016/j.redox.2024.103118 · 2024 · External reference
Hydrogen sulfide protects cardiomyocytes from Doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-Sulfhydration and Nrf2 activation
10.1016/j.redox.2024.103066 · 2024 · External reference
Nrf2 and ferroptosis: exploring translational avenues for therapeutic approaches to neurological diseases
10.2174/0113894501320839240918110656 · 2025 · External reference
Glutathione alterations in depression: a meta-analysis and systematic review of Proton magnetic resonance spectroscopy studies
10.1007/s00213-024-06735-1 · 2024 · External reference
Alterations in iron metabolism and the erythron in major depression: further evidence for a chronic inflammatory process
10.1016/0165-0327(96)00038-9 · 1996 · External reference
A meta-analysis of lipid peroxidation markers in major depression
2015 · External reference
Abnormality in peripheral and brain iron contents and the relationship with Grey matter volumes in major depressive disorder
10.3390/nu16132073 · 2024 · External reference
Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia
10.1038/s41398-024-02862-7 · 2024 · External reference
Alterations in magnetic susceptibility correlate with higher cerebral blood flow in the right amygdala of patients with major depressive disorder
10.1016/j.jad.2025.03.070 · 2025 · External reference
Alterations in brain iron deposition with progression of late-life depression measured by magnetic resonance imaging (MRI)-Based quantitative susceptibility mapping
10.21037/qims-21-1137 · 2022 · External reference
Dissecting immune cell ferroptosis via single-cell multi-omics identifies RPL8 as a potential therapeutic target for depression
2026 · External reference
Hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression
10.1016/j.bbr.2021.113261 · 2021 · External reference
The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology
10.1016/j.biopsych.2018.09.031 · 2019 · External reference
Sestrin2 attenuates depressive-like behaviors and neuroinflammation in CUMS mice through inhibiting ferroptosis
10.1097/wnr.0000000000001988 · 2023 · External reference
Electroacupuncture ameliorates depression-like behaviors in rats with post-stroke depression by inhibiting ferroptosis in the prefrontal cortex
10.3389/fnins.2024.1422638 · 2024 · External reference
Driving factors of neuronal ferroptosis
10.1016/j.tcb.2024.01.010 · 2024 · External reference
Neuron stem cell NLRP6 sustains Hippocampal neurogenesis to resist stress-induced depression
10.1016/j.apsb.2023.03.010 · 2023 · External reference
Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis
10.1186/s13287-025-04511-2 · 2025 · External reference
Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression
10.1186/s12974-022-02492-0 · 2022 · External reference
Microglial NLRP3 inflammasome activation mediates IL-1β-Related inflammation in prefrontal cortex of depressive rats
10.1016/j.bbi.2014.04.007 · 2014 · External reference
Ferroptosis in microglial activation: a systematic review and multidata comparison
10.1093/braincomms/fcag109 · 2026 · External reference
AEBP1 targets DDR2 to induce ferroptosis and microglial activation through the STAT3/P53 signaling pathway, exacerbating depression risk
10.1016/j.abb.2025.110632 · 2025 · External reference
When the stars misfire: astrocytic dysfunctions in major depressive disorder
10.1007/s11064-025-04483-y · 2025 · External reference
Neuroinflammation and major depressive disorder: astrocytes at the crossroads
10.3389/fncel.2024.1504555 · 2024 · External reference
Astrocytic PCBP1 suppresses ferroptosis to restore glutamatergic homeostasis and mitigate stress‐induced depression in Male mice
2025 · External reference
Astrocyte metabolism and signaling pathways in the CNS
2023 · External reference
Ferroptosis: molecular mechanisms and health implications
10.1038/s41422-020-00441-1 · 2021 · External reference
Lead binds HIF-1α contributing to depression-like behaviour through modulating Mitochondria-associated Astrocyte ferroptosis
10.1038/s42003-025-08824-z · 2025 · External reference
Markers of elevated oxidative stress in oligodendrocytes captured from the brainstem and occipital cortex in major depressive disorder and suicide
2022 · External reference
P23 protects against ferroptosis of brain microvascular endothelial cells in ischemic stroke
2025 · External reference
The gut Microbiota metabolite Butyrate modulates acute stress-induced ferroptosis in the prefrontal cortex via the gut–brain axis
10.3390/ijms26041698 · 2025 · External reference
Exosome-based modulation of ferroptosis in neurological disorders: mechanisms, therapeutic potential, and translational challenges
10.3389/fimmu.2025.1677808 · 2025 · External reference
Aerobic exercise improves the overall outcome of type 2 diabetes mellitus among people with mental disorders
10.1155/da/6651804 · 2024 · External reference
Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6
10.1002/ajh.24888 · ExternalCitation · doi-reference
Seahorse attenuated DSS ‐induced depression in mice by inhibiting neuroinflammation and ferroptosis
10.1002/fsn3.70482 · ExternalCitation · doi-reference
Glutathione alterations in depression: a meta-analysis and systematic review of Proton magnetic resonance spectroscopy studies
10.1007/s00213-024-06735-1 · ExternalCitation · doi-reference
Melatonin alleviates LPS-induced depression-like behavior in mice by inhibiting ferroptosis by regulating RNA methylation-mediated SIRT6/Nrf2/HO-1 pathway
10.1007/s00394-024-03495-8 · ExternalCitation · doi-reference
Ferroptosis: a new target for depression prevention and treatment
10.1007/s00702-025-02912-4 · ExternalCitation · doi-reference
Electroacupuncture ameliorates chronic inflammatory pain and depression comorbidity by inhibiting Nrf2-Mediated ferroptosis in hippocampal neurons
10.1007/s11064-025-04401-2 · ExternalCitation · doi-reference
When the stars misfire: astrocytic dysfunctions in major depressive disorder
10.1007/s11064-025-04483-y · ExternalCitation · doi-reference
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression
10.1007/s11418-025-01930-6 · ExternalCitation · doi-reference
Yi-Nao-Jie-Yu prescription relieves post-stroke depression by mitigating ferroptosis in hippocampal neurons via activating the Nrf2/GPX4/SLC7A11 pathway
10.1007/s11481-024-10167-1 · ExternalCitation · doi-reference
Etomidate improves the antidepressant effect of electroconvulsive therapy by suppressing hippocampal neuronal ferroptosis via upregulating BDNF/Nrf2
10.1007/s12035-023-03499-1 · ExternalCitation · doi-reference
Lipid peroxidation and immune biomarkers are associated with major depression and its phenotypes, including treatment-resistant depression and melancholia
10.1007/s12640-017-9835-5 · ExternalCitation · doi-reference
Alterations in iron metabolism and the erythron in major depression: further evidence for a chronic inflammatory process
10.1016/0165-0327(96)00038-9 · ExternalCitation · doi-reference
AEBP1 targets DDR2 to induce ferroptosis and microglial activation through the STAT3/P53 signaling pathway, exacerbating depression risk
10.1016/j.abb.2025.110632 · ExternalCitation · doi-reference
Neuron stem cell NLRP6 sustains Hippocampal neurogenesis to resist stress-induced depression
10.1016/j.apsb.2023.03.010 · ExternalCitation · doi-reference
Microglial NLRP3 inflammasome activation mediates IL-1β-Related inflammation in prefrontal cortex of depressive rats
10.1016/j.bbi.2014.04.007 · ExternalCitation · doi-reference
Hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression
10.1016/j.bbr.2021.113261 · ExternalCitation · doi-reference
Cranial electrotherapy stimulation alleviates depression-like behavior of post-stroke depression rats by upregulating GPX4-Mediated BDNF expression
10.1016/j.bbr.2022.114117 · ExternalCitation · doi-reference
Electroacupuncture alleviates depression-like behavior after spinal cord injury via SIRT1/HMGB1 signaling axis mediated ferroptosis
10.1016/j.bbr.2026.116052 · ExternalCitation · doi-reference
Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis
10.1016/j.biopha.2024.116425 · ExternalCitation · doi-reference
Quercetin alleviates depressive-like behavior by modulating Acetyl-H3K9 mediated ferroptosis pathway in hypothalamus of perimenopausal depression rat model
10.1016/j.biopha.2024.117369 · ExternalCitation · doi-reference
The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology
10.1016/j.biopsych.2018.09.031 · ExternalCitation · doi-reference
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis
10.1016/j.brainres.2023.148715 · ExternalCitation · doi-reference
Inhibition of ferroptosis alleviates chronic unpredictable mild stress-induced depression in mice via tsRNA-3029b
10.1016/j.brainresbull.2023.110773 · ExternalCitation · doi-reference
Resveratrol alleviates depression-like behaviors by inhibiting ferroptosis via AKT/NRF2 pathway
10.1016/j.brainresbull.2024.111136 · ExternalCitation · doi-reference
Realistic-NPs trigger depression-like behaviors via mitochondrial iron overload mediating ferroptosis
10.1016/j.cbi.2026.111970 · ExternalCitation · doi-reference
Role of Intracellular Labile Iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide
10.1016/j.freeradbiomed.2013.12.006 · ExternalCitation · doi-reference
DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis
10.1016/j.freeradbiomed.2024.10.298 · ExternalCitation · doi-reference
Se-Methylselenocysteine alleviates iron deposit-induced Anxiety- and depression-like behaviors in chronic renal failure rats receiving iron therapy via Nrf2/GPX4 activation
10.1016/j.freeradbiomed.2026.03.003 · ExternalCitation · doi-reference
Bufotenidine attenuates astrocyte ferroptosis in depressive-like behaviors through targeting GluA1 to reduce neuronal lipid synthesis
10.1016/j.freeradbiomed.2026.03.024 · ExternalCitation · doi-reference
Pellitorine protects chronic restraint stress-induced cognitive deficits via inhibiting neural inflammation and ferroptosis
10.1016/j.intimp.2025.115166 · ExternalCitation · doi-reference
Alterations in magnetic susceptibility correlate with higher cerebral blood flow in the right amygdala of patients with major depressive disorder
10.1016/j.jad.2025.03.070 · ExternalCitation · doi-reference
Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress
10.1016/j.jep.2023.116729 · ExternalCitation · doi-reference
Di-Huang-Yin-Zi regulates P53/SLC7A11 signaling pathway to improve the mechanism of post-stroke depression
10.1016/j.jep.2023.117226 · ExternalCitation · doi-reference
Role of PTP1B in coordinating synaptic plasticity and ferroptosis: a mechanism underlying the antidepressant effect of spinosin from Ziziphus Jujuba mill. Var. Spinosa (Bunge) Hu Ex H. F. Chou
10.1016/j.jep.2026.121428 · ExternalCitation · doi-reference
Traditional pediatric massage exerted an antidepressant effect and activated IGF-1/Nrf2 pathway in CUMS-exposed adolescent rats
10.1016/j.jneuroim.2025.578554 · ExternalCitation · doi-reference
Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis
10.1016/j.lfs.2021.119551 · ExternalCitation · doi-reference
Repurposing of rebamipide as a neuroprotective agent to alleviate letrozole-induced depressive-like behaviors in female rats: Targeting SIRT1/FoxO1/Wnt/β-Catenin, and related ferroptosis pathways
10.1016/j.lfs.2025.123941 · ExternalCitation · doi-reference
Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease
10.1016/j.metabol.2024.155953 · ExternalCitation · doi-reference
Ketamine may exert rapid antidepressant effects through modulation of neuroplasticity, autophagy, and ferroptosis in the habenular nucleus
10.1016/j.neuroscience.2022.10.015 · ExternalCitation · doi-reference
Lycium Barbarum (Wolfberry) glycopeptide prevents stress-induced anxiety disorders by regulating oxidative stress and ferroptosis in the medial prefrontal cortex
10.1016/j.phymed.2023.154864 · ExternalCitation · doi-reference
Quercetin inhibits neuronal ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression
10.1016/j.phymed.2024.155560 · ExternalCitation · doi-reference
Natural products targeting ferroptosis in depression: research progress and therapeutic prospects
10.1016/j.phymed.2025.156818 · ExternalCitation · doi-reference
Bushen shugan huayu formula improves depressive-like behavior in perimenopausal mice by modulating neuronal ferroptosis through the GPER1/Nrf2 pathway
10.1016/j.phymed.2025.157464 · ExternalCitation · doi-reference
Hydrogen sulfide protects cardiomyocytes from Doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-Sulfhydration and Nrf2 activation
10.1016/j.redox.2024.103066 · ExternalCitation · doi-reference
ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer
10.1016/j.redox.2024.103118 · ExternalCitation · doi-reference
Nlrp6 protects from Corticosterone-induced NSPC ferroptosis by modulating RIG-1/MAVS-Mediated mitophagy
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