Research graph
References from PDCD1 SNPs and alloimmune transplant outcomes: mechanistic basis and human evidence across solid organ transplantation and allogeneic hematopoietic stem cell transplantation. Local targets link to admitted publications; unresolved targets remain external evidence.
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
10.1002/j.1460-2075.1992.tb05481.x · 1992 · External reference
Structure and chromosomal localization of the human PD-1 gene (PDCD1)
10.1006/geno.1994.1562 · 1994 · External reference
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
10.1093/intimm/8.5.765 · 1996 · External reference
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
10.1084/jem.192.7.1027 · 2000 · External reference
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
10.1038/85330 · 2001 · External reference
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
10.1016/s1074-7613(00)80089-8 · 1999 · External reference
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
10.1126/science.291.5502.319 · 2001 · External reference
PD-1 and its ligands in tolerance and immunity
10.1146/annurev.immunol.26.021607.090331 · 2008 · External reference
The PD-1 pathway in tolerance and autoimmunity
10.1111/j.1600-065x.2010.00923.x · 2010 · External reference
Role of the PD-1 pathway in the immune response
10.1111/j.1600-6143.2012.04224.x · 2012 · External reference
PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection
10.4049/jimmunol.179.8.5204 · 2007 · External reference
T-cell activation and transplantation tolerance
10.1016/j.trre.2011.09.002 · 2012 · External reference
PD-L1/PD-1 signal deficiency promotes allogeneic immune responses and accelerates heart allograft rejection
10.1097/tp.0b013e3181861932 · 2008 · External reference
PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft
10.1111/j.1600-6143.2009.02859.x · 2010 · External reference
Blockade or deficiency of PD-L1 expression in intestinal allograft accelerates graft tissue injury in mice
10.1111/ajt.16873 · 2022 · External reference
Mechanisms of rejection: current perspectives
10.1097/tp.0b013e31823cab44 · 2012 · External reference
Origin and biology of the allogeneic response
10.1101/cshperspect.a014993 · 2013 · External reference
Allorecognition pathways in transplant rejection and tolerance
10.1097/tp.0b013e31829853ce · 2013 · External reference
T cell allorecognition pathways in solid organ transplantation
10.3389/fimmu.2018.02548 · 2018 · External reference
Current concepts and advances in graft-versus-host disease immunology
10.1146/annurev-immunol-102119-073227 · 2021 · External reference
Graft-versus-host disease
10.1016/s0140-6736(09)60237-3 · 2009 · External reference
Acute graft-versus-host disease - biologic process, prevention, and therapy
10.1056/nejmra1609337 · 2017 · External reference
The association between single-nucleotide polymorphisms of Co-Stimulatory genes within Non-HLA region and the prognosis of leukemia patients with hematopoietic stem cell transplantation
2021 · External reference
LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors
10.3389/fimmu.2023.1066393 · 2023 · External reference
Preliminary data on SNP of transplantation-related genes after haploidentical stem cell transplantation
10.3390/jcm13164681 · 2024 · External reference
Single-Nucleotide polymorphisms within Non-HLA regions are associated with engraftment effectiveness for patients with unrelated cord blood transplantation
2022 · External reference
SNPs: impact on gene function and phenotype
10.1007/978-1-60327-411-1_1 · 2009 · External reference
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
10.1038/ng1020 · 2002 · External reference
PD-1 and cancer: molecular mechanisms and polymorphisms
10.1007/s00251-017-1015-5 · 2018 · External reference
Exploring the bio-functional effect of single nucleotide polymorphisms in the promoter Region of the TNFSF4, CD28, and PDCD1 genes
10.3390/jcm12062157 · 2023 · External reference
Exhaustion of T cells after renal transplantation
2024 · External reference
Lack of association between CTLA-4 and PDCD1 polymorphisms and acute rejection in German liver transplant recipients
10.1016/j.humimm.2013.04.021 · 2013 · External reference
Association of programmed cell death 1 and programmed cell death 1 ligand gene polymorphisms with delayed graft function and acute rejection in kidney allograft recipients
2015 · External reference
The association between viral infections and Co-stimulatory gene polymorphisms in kidney transplant outcomes
10.5812/jjm.31338 · 2016 · External reference
Association between co-stimulatory molecule gene polymorphism and acute rejection of allograft
10.1016/j.trim.2014.06.003 · 2014 · External reference
Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction
10.1016/j.jhep.2016.02.034 · 2016 · External reference
Identification of PDCD1 as a potential biomarker in acute rejection after kidney transplantation via comprehensive bioinformatic analysis
2022 · External reference
Clinical validation of an immune quiescence gene expression signature in kidney transplantation
10.34067/kid.0005062021 · 2021 · External reference
Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
10.4049/jimmunol.171.3.1272 · 2003 · External reference
Regulation of GVHD and GVL activity via PD-L1 interaction with PD-1 and CD80
10.3389/fimmu.2018.03061 · 2018 · External reference
PD-1 genotype of the donor is associated with acute graft-versus-host disease after HLA-identical sibling donor stem cell transplantation
10.1007/s00277-018-3438-y · 2018 · External reference
Polymorphisms of the costimulatory genes CTLA-4, CD28, PD-1, and ICOS and outcome of kidney transplants in Iranian patients
2017 · External reference
Beyond cancer: regulation and function of PD-L1 in health and immune-related diseases
10.3390/ijms23158599 · 2022 · External reference
The role of PD-1 signaling in health and immune-related diseases
2023 · External reference
Programmed cell death-1 and its ligands: current knowledge and possibilities in immunotherapy
10.1016/j.clinsp.2023.100177 · 2023 · External reference
Evolving landscape of PD-L2: bring new light to checkpoint immunotherapy
10.1038/s41416-022-02084-y · 2023 · External reference
PD-L1's role in preventing alloreactive T cell responses following hematopoietic and organ transplant
10.3390/cells12121609 · 2023 · External reference
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
10.1126/science.aaf1292 · 2017 · External reference
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
10.1038/ncomms7692 · 2015 · External reference
PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue
10.4049/jimmunol.181.8.5313 · 2008 · External reference
Endothelial stromal PD-L1 (programmed death ligand 1) modulates CD8(+) T-Cell infiltration after heart transplantation
10.1161/circheartfailure.120.007982 · 2021 · External reference
Programmed death-1 targeting can promote allograft survival
10.4049/jimmunol.169.11.6546 · 2002 · External reference
PD-1 blockade for relapsed lymphoma post-allogeneic hematopoietic cell transplant: high response rate but frequent GVHD
10.1182/blood-2017-01-761346 · 2017 · External reference
Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma
10.1182/blood-2016-09-738385 · 2017 · External reference
Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantation
10.1136/jmg.2009.068841 · 2010 · External reference
The ensembl variant effect predictor
10.1186/s13059-016-0974-4 · 2016 · External reference
A joint NCBI and EMBL-EBI transcript set for clinical genomics and research
10.1038/s41586-022-04558-8 · 2022 · External reference
Database resources of the national center for biotechnology information in 2026
10.1093/nar/gkaf1060 · 2026 · External reference
The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors
10.1016/s0378-1119(97)00260-6 · 1997 · External reference
Revisiting the PD-1 pathway
10.1126/sciadv.abd2712 · 2020 · External reference
A putative regulatory polymorphism in PD-1 is associated with nephropathy in a population-based cohort of systemic lupus erythematosus patients
10.1191/0961203303lu1052oa · 2004 · External reference
Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes
10.1111/cei.12603 · 2015 · External reference
PDCD1 polymorphisms may predict response to Anti-PD-1 blockade in patients with metastatic Melanoma
10.3389/fimmu.2021.672521 · 2021 · External reference
Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in East Asian
10.1007/s00592-018-1152-9 · 2018 · External reference
rs10204525 binding to miR-4717-3p modulates PD-1 expression and predicts the development of immune-related adverse events in patients with advanced cancer treated with anti-PD-1/PD-L1 therapy
10.1136/jitc-2025-012207 · 2025 · External reference
PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves' and Hashimoto's diseases
10.1080/08916934.2021.1946796 · 2021 · External reference
Association between PD-1 and PD-L1 polymorphisms and the risk of cancer: a meta-analysis of case-control studies
10.3390/cancers11081150 · 2019 · External reference
Association between hepatitis B viral burden in chronic infection and a functional single nucleotide polymorphism of the PDCD1 gene
10.1007/s10875-010-9450-1 · 2010 · External reference
SNP-SNP interaction in genes encoding PD-1/PD-L1 axis as a potential risk factor for clear cell renal cell carcinoma
10.3390/cancers12123521 · 2020 · External reference
Impact of CD 28, CD86, CTLA-4 and PD-1 genes polymorphisms on acute renal allograft rejection and graft survival among Egyptian recipients
10.1038/s41598-024-52195-0 · 2024 · External reference
The predictive and prognostic role of single nucleotide gene variants of PD-1 and PD-L1 in patients with advanced melanoma treated with PD-1 inhibitors
2023 · External reference
A clinician's guide to HLA matching in allogeneic hematopoietic stem cell transplant
10.1016/j.humimm.2022.03.002 · 2022 · External reference
KIR in allogeneic hematopoietic stem cell transplantation: need for a unified paradigm for donor selection
10.3389/fimmu.2022.821533 · 2022 · External reference
CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors
10.1182/blood-2007-01-069781 · 2007 · External reference
Immune suppression in allogeneic hematopoietic stem cell transplantation
10.1007/164_2021_544 · 2022 · External reference
A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation
10.3324/haematol.2012.067140 · 2012 · External reference
Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis
10.1056/nejmoa2215943 · 2023 · External reference
Immunosuppression and kidney transplantation
10.1007/164_2021_546 · 2022 · External reference
A global reference for human genetic variation
10.1038/nature15393 · 2015 · External reference
