Research graph
References from Preclinical evaluation of SLC35D3-targeted CAR-T cells for tumor-selective immunotherapy. Local targets link to admitted publications; unresolved targets remain external evidence.
CAR T cell immunotherapy for human cancer
10.1126/science.aar6711 · 2018 · External reference
CAR T-cell therapies for T-cell malignancies: does cellular immunotherapy represent the best chance of cure?
10.1182/bloodadvances.2023012263 · 2025 · External reference
CAR-T cell therapy: current limitations and potential strategies
10.1038/s41408-021-00459-7 · 2021 · External reference
CAR-T cell therapy for cancer: current challenges and future directions
10.1038/s41392-025-02269-w · 2025 · External reference
CAR-T therapy in solid tumors
10.1016/j.ccell.2025.03.019 · 2025 · External reference
Pan-cancer analysis identifies tumor cell surface targets for CAR-T cell therapies and antibody drug conjugates
10.3390/cancers14225674 · 2022 · External reference
Tumor-associated antigen prediction using a single-sample gene expression state inference algorithm
2024 · External reference
Integrated transcriptomic and proteomic validation identifies SLC35D3 as a tumor-selective surface antigen for colorectal and neuroendocrine carcinomas
2026 · External reference
The pharmacology of second-generation chimeric antigen receptors
10.1038/nrd4597 · 2015 · External reference
Raludotatug deruxtecan, a CDH6-Targeting antibody–drug conjugate with a DNA topoisomerase I inhibitor DXd, is efficacious in human ovarian and kidney cancer models
10.1158/1535-7163.mct-23-0287 · 2024 · External reference
Modulation of target antigen density improves CAR T-cell functionality and persistence
10.1158/1078-0432.ccr-18-3784 · 2019 · External reference
Tumor antigen and receptor densities regulate efficacy of a chimeric antigen receptor targeting anaplastic lymphoma kinase
10.1016/j.ymthe.2017.06.008 · 2017 · External reference
Development of a novel Anti-CD19 chimeric antigen receptor: a paradigm for an affordable CAR T cell production at academic institutions
10.1016/j.omtm.2018.11.010 · 2019 · External reference
Systematic single amino acid affinity tuning of CD229 CAR T cells retains efficacy against multiple myeloma and eliminates on-target off-tumor toxicity
10.1126/scitranslmed.add7900 · 2023 · External reference
Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice
10.1158/0008-5472.can-15-0159 · 2015 · External reference
The IgG4 Hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer
10.1038/s41467-023-37616-4 · 2023 · External reference
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
10.1073/pnas.0813101106 · 2009 · External reference
Toll-like receptor 4 signaling activation domains promote CAR T cell function against solid tumors
2024 · External reference
IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor
10.1038/nbt.4086 · 2018 · External reference
