Research graph
References from Nab-paclitaxel exacerbates PD-1 antibody-associated immune myocarditis via the STAT1/Egr-1/Trp53-mediated ferroptosis pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Immune checkpoint inhibitors: Unravelling atherosclerotic cardiovascular risk
10.1016/j.atherosclerosis.2025.119147 · 2025 · External reference
Atherosclerosis with Immune Checkpoint Inhibitor Therapy: evidence, Diagnosis, and Management: JACC: CardioOncology State-of-the-Art Review
10.1016/j.jaccao.2022.11.011 · 2022 · External reference
The good (Tumor Killing) and the bad (Cardiovascular Complications) of Immunologic Checkpoint Inhibitors
10.1007/s11886-024-02147-x · 2024 · External reference
Risk Factors for Immune Checkpoint Inhibitor-Mediated Cardiovascular Toxicities
10.1007/s11912-023-01414-4 · 2023 · External reference
Cardiovascular Toxicity with PD-1/PD-L1 Inhibitors in Cancer patients: a Systematic Review and Meta-Analysis
2022 · External reference
Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis
10.1161/circulationaha.122.062551 · 2024 · External reference
Distinct Inflammatory responses of hiPSC-derived Endothelial Cells and Cardiomyocytes to Cytokines involved in Immune Checkpoint Inhibitor-Associated Myocarditis
10.3390/cells14171397 · 2025 · External reference
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue damage, and Mortality in SARS-CoV-2 Infection and Cytokine shock Syndromes
10.1016/j.cell.2020.11.025 · 2021 · External reference
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine responses
10.1016/j.immuni.2019.06.007 · 2019 · External reference
Interferon-γ induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK/STAT1-mediated inhibition of system Xc−
10.1016/j.freeradbiomed.2023.05.027 · 2023 · External reference
Protosappanin a Protects DOX-Induced Myocardial Injury and Cardiac Dysfunction by Targeting ACSL4/FTH1 Axis-Dependent Ferroptosis
2024 · External reference
Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα
10.1080/13880209.2023.2212700 · 2023 · External reference
Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation
10.1016/j.redox.2024.103066 · 2024 · External reference
TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation
10.1038/s41418-023-01239-5 · 2024 · External reference
Targeted xCT-mediated Ferroptosis and Protumoral Polarization of Macrophages is Effective against HCC and Enhances the Efficacy of the Anti-PD-1/L1 Response
2023 · External reference
Tumor-Associated Antigen xCT and mutant-p53 as Molecular Targets for New Combinatorial Antitumor strategies
10.3390/cells10010108 · 2021 · External reference
STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
10.1038/s41419-022-04971-x · 2022 · External reference
Ferroptosis as a p53-mediated activity during tumour suppression
10.1038/nature14344 · 2015 · External reference
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis
2023 · External reference
Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice
10.1016/j.bbadis.2022.166556 · 2022 · External reference
Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network
10.1080/07357907.2018.1533965 · 2018 · External reference
Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis
10.1074/jbc.m008454200 · 2001 · External reference
Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
10.1073/pnas.2628034100 · 2003 · External reference
Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53
10.1158/0008-5472.can-04-3742 · 2005 · External reference
JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis
10.1007/s10495-022-01714-3 · 2022 · External reference
miR-30e-3p Promotes Cardiomyocyte Autophagy and Inhibits Apoptosis via Regulating Egr-1 during Ischemia/Hypoxia
10.1155/2020/7231243 · 2020 · External reference
Irf1- and Egr1-activated transcription plays a key role in macrophage polarization: a multiomics sequencing study with partial validation
10.1016/j.intimp.2021.108072 · 2021 · External reference
The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin
10.1038/sj.cgt.7700896 · 2006 · External reference
Egr1 mediates retinal vascular dysfunction in diabetes mellitus via promoting p53 transcription
10.1111/jcmm.14225 · 2019 · External reference
A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells
10.1038/sj.cdd.4402029 · 2007 · External reference
ISCU-p53 axis orchestrates macrophage polarization to dictate immunotherapy response in esophageal squamous cell carcinoma
10.1038/s41419-025-07787-7 · 2025 · External reference
STAT5B Suppresses Ferroptosis by Promoting DCAF13 Transcription to Regulate p53/xCT Pathway to Promote Mantle Cell Lymphoma Progression
2024 · External reference
Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8(+) Effector T Cells in Acute Myocarditis
10.1161/circulationaha.125.073836 · 2025 · External reference
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation
10.1038/s41392-025-02216-9 · 2025 · External reference
Ferroptosis as a novel therapeutic target for cardiovascular disease
10.7150/thno.54113 · 2021 · External reference
Cardiac fibroblast-derived IGFBP6 orchestrates cardiac remodeling by coupling the EGR1-MFAP4 axis
10.7150/ijbs.114417 · 2025 · External reference
Fibroblast growth factor 21 inhibited ischemic arrhythmias via targeting miR-143/EGR1 axis
10.1007/s00395-019-0768-4 · 2020 · External reference
IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice
10.1038/s41467-023-40639-6 · 2023 · External reference
Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling
10.1186/s40364-024-00558-0 · 2024 · External reference
Fibroblast growth factor 21 inhibited ischemic arrhythmias via targeting miR-143/EGR1 axis
10.1007/s00395-019-0768-4 · ExternalCitation · doi-reference
JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis
10.1007/s10495-022-01714-3 · ExternalCitation · doi-reference
The good (Tumor Killing) and the bad (Cardiovascular Complications) of Immunologic Checkpoint Inhibitors
10.1007/s11886-024-02147-x · ExternalCitation · doi-reference
Risk Factors for Immune Checkpoint Inhibitor-Mediated Cardiovascular Toxicities
10.1007/s11912-023-01414-4 · ExternalCitation · doi-reference
Immune checkpoint inhibitors: Unravelling atherosclerotic cardiovascular risk
10.1016/j.atherosclerosis.2025.119147 · ExternalCitation · doi-reference
Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice
10.1016/j.bbadis.2022.166556 · ExternalCitation · doi-reference
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue damage, and Mortality in SARS-CoV-2 Infection and Cytokine shock Syndromes
10.1016/j.cell.2020.11.025 · ExternalCitation · doi-reference
Interferon-γ induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK/STAT1-mediated inhibition of system Xc−
10.1016/j.freeradbiomed.2023.05.027 · ExternalCitation · doi-reference
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine responses
10.1016/j.immuni.2019.06.007 · ExternalCitation · doi-reference
Irf1- and Egr1-activated transcription plays a key role in macrophage polarization: a multiomics sequencing study with partial validation
10.1016/j.intimp.2021.108072 · ExternalCitation · doi-reference
Atherosclerosis with Immune Checkpoint Inhibitor Therapy: evidence, Diagnosis, and Management: JACC: CardioOncology State-of-the-Art Review
10.1016/j.jaccao.2022.11.011 · ExternalCitation · doi-reference
Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation
10.1016/j.redox.2024.103066 · ExternalCitation · doi-reference
Ferroptosis as a p53-mediated activity during tumour suppression
10.1038/nature14344 · ExternalCitation · doi-reference
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation
10.1038/s41392-025-02216-9 · ExternalCitation · doi-reference
TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation
10.1038/s41418-023-01239-5 · ExternalCitation · doi-reference
STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
10.1038/s41419-022-04971-x · ExternalCitation · doi-reference
ISCU-p53 axis orchestrates macrophage polarization to dictate immunotherapy response in esophageal squamous cell carcinoma
10.1038/s41419-025-07787-7 · ExternalCitation · doi-reference
IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice
10.1038/s41467-023-40639-6 · ExternalCitation · doi-reference
A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells
10.1038/sj.cdd.4402029 · ExternalCitation · doi-reference
The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin
10.1038/sj.cgt.7700896 · ExternalCitation · doi-reference
Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
10.1073/pnas.2628034100 · ExternalCitation · doi-reference
Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis
10.1074/jbc.m008454200 · ExternalCitation · doi-reference
Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network
10.1080/07357907.2018.1533965 · ExternalCitation · doi-reference
Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα
10.1080/13880209.2023.2212700 · ExternalCitation · doi-reference
Egr1 mediates retinal vascular dysfunction in diabetes mellitus via promoting p53 transcription
10.1111/jcmm.14225 · ExternalCitation · doi-reference
miR-30e-3p Promotes Cardiomyocyte Autophagy and Inhibits Apoptosis via Regulating Egr-1 during Ischemia/Hypoxia
10.1155/2020/7231243 · ExternalCitation · doi-reference
Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53
10.1158/0008-5472.can-04-3742 · ExternalCitation · doi-reference
Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis
10.1161/circulationaha.122.062551 · ExternalCitation · doi-reference
Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8(+) Effector T Cells in Acute Myocarditis
10.1161/circulationaha.125.073836 · ExternalCitation · doi-reference
Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling
10.1186/s40364-024-00558-0 · ExternalCitation · doi-reference
Tumor-Associated Antigen xCT and mutant-p53 as Molecular Targets for New Combinatorial Antitumor strategies
10.3390/cells10010108 · ExternalCitation · doi-reference
Distinct Inflammatory responses of hiPSC-derived Endothelial Cells and Cardiomyocytes to Cytokines involved in Immune Checkpoint Inhibitor-Associated Myocarditis
10.3390/cells14171397 · ExternalCitation · doi-reference
Cardiac fibroblast-derived IGFBP6 orchestrates cardiac remodeling by coupling the EGR1-MFAP4 axis
10.7150/ijbs.114417 · ExternalCitation · doi-reference
Ferroptosis as a novel therapeutic target for cardiovascular disease
10.7150/thno.54113 · ExternalCitation · doi-reference
