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References from Nucleoside antitumor drugs: From molecular mechanisms and adaptive resistance to clinical translation. Local targets link to admitted publications; unresolved targets remain external evidence.
Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
10.1038/nrd4010 · 2013 · External reference
Unraveling resistance mechanisms to the novel nucleoside analog RX-3117 in lung cancer: insights into DNA repair, cell cycle dysregulation and targeting PKMYT1 for improved therapy
10.1186/s13046-025-03470-z · 2025 · External reference
AP1M2 Drives Gemcitabine‐Cisplatin Chemoresistance by Enhancing RAD54B‐Associated DNA Repair in Bladder Cancer
10.1096/fj.202500423r · 2025 · External reference
Epigenetic Drivers of Chemoresistance in Nucleobase and Nucleoside Analog Therapies
10.3390/biology14070838 · 2025 · External reference
Epigenetic Biomarkers for predicting Nucleoside Analog Drug Response and Resistance in Cancer
10.3390/biom16040587 · 2026 · External reference
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
10.1038/s41392-023-01480-x · 2023 · External reference
Exploring viral mimicry combined with epigenetics and tumor immunity: new perspectives in cancer therapy
10.7150/ijbs.103877 · 2025 · External reference
Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
10.3389/fcell.2023.1173432 · 2023 · External reference
Advancing Epigenetic Combination Therapy in Oncology: Multifunctional Nano-Drug delivery Systems for Synergistic Efficacy and Precision Modulation
2025 · External reference
The Role of SAMHD1 in Viral Resistance and Transduction Efficiency challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives
2025 · External reference
Unresolved reference
2025 · External reference
Microbial metabolites in tumor metabolic reprogramming and immunotherapy: new insights
10.3389/fcimb.2025.1706040 · 2025 · External reference
Intratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer
10.3389/fphar.2024.1510851 · 2025 · External reference
Current and emerging prodrug strategies
10.1021/acs.jmedchem.5c00826 · 2025 · External reference
Prodrug-based drug delivery systems: strategic approaches and emerging challenges in targeted therapeutics
2025 · External reference
The ProTide Prodrug Technology: from the Concept to the Clinic: Miniperspective
10.1021/acs.jmedchem.7b00734 · 2017 · External reference
Is monitoring of the intracellular active metabolite levels of nucleobase and nucleoside analogs ready for precision medicine applications?
10.1007/s13318-022-00786-5 · 2022 · External reference
Cell and tissue specific metabolism of nucleoside and nucleotide drugs: case studies and implications for precision medicine
10.1124/dmd.122.000856 · 2023 · External reference
Clinical translation of Self‐Assembled cancer nanomedicines
2021 · External reference
Prodrug-based combinational nanomedicine remodels lipid metabolism for reinforced ferroptosis and immune activation
10.1016/j.apsb.2025.03.016 · 2025 · External reference
Is it still worth renewing nucleoside anticancer drugs nowadays?
10.1016/j.ejmech.2023.115987 · 2024 · External reference
A general nanoplatform for nucleotide drug delivery: from molecular binding to antiviral therapy
2025 · External reference
Application of artificial intelligence in drug discovery
10.2174/1381612828666220608141049 · 2022 · External reference
Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs
10.1021/acs.chemrev.6b00209 · 2016 · External reference
Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy
10.1186/s13045-022-01263-x · 2022 · External reference
Nucleoside-based anticancer drugs: Mechanism of action and drug resistance
10.1016/j.bcp.2023.115741 · 2023 · External reference
Emerging roles of nucleotide metabolism in cancer
10.1016/j.trecan.2023.04.008 · 2023 · External reference
Nucleosides with fluorinated nucleobases for antiviral and anticancer therapies
10.1016/j.fmre.2025.06.002 · 2025 · External reference
Enhancing the Nucleoside Analog Response with Translational Therapeutic Approaches to Overcome Resistance
10.3390/cells15020130 · 2026 · External reference
5-fluorouracil: mechanisms of action and clinical strategies
10.1038/nrc1074 · 2003 · External reference
Defective expression of deoxycytidine kinase in cytarabine-resistant acute myeloid leukemia cells
2009 · External reference
APOBEC3 upregulation drives gemcitabine resistance
10.1038/s43018-024-00755-8 · 2024 · External reference
A novel gemcitabine derivative-loaded liposome with great pancreas-targeting ability
10.1038/s41401-019-0227-7 · 2019 · External reference
Unlocking the potential of cytarabine: a comprehensive review from molecular insights to advanced nanoformulations and Co-delivery strategies for enhanced drug efficacy
10.1016/j.jddst.2024.106346 · 2024 · External reference
Gemcitabine alters phosphatidylcholine metabolism in mouse pancreatic tumors
10.1021/acs.jproteome.4c00839 · 2025 · External reference
Recent progress in gemcitabine-loaded nanoparticles for pancreatic cancer therapy: a review
10.1039/d5nr02005k · 2025 · External reference
Inhibitory effect and related mechanism of decitabine combined with gemcitabine on proliferation of NK/T cell lymphoma cells
10.3389/fphar.2023.1134895 · 2023 · External reference
Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer
10.1021/cr900028p · 2009 · External reference
DNA replication stress induced by trifluridine determines tumor cell fate according to p53 status
10.1158/1541-7786.mcr-19-1051 · 2020 · External reference
TAS-102, a novel antitumor agent: a review of the mechanism of action
10.1016/j.ctrv.2015.06.001 · 2015 · External reference
5-fluorouracil and other fluoropyrimidines in colorectal cancer
2020 · External reference
Xianglian Pill combined with 5-fluorouracil enhances antitumor activity and reduces gastrointestinal toxicity in gastric cancer by regulating the p38 MAPK/NF-κB signaling pathway
10.1016/j.jep.2024.117988 · 2024 · External reference
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance
10.1038/s41467-021-27847-8 · 2022 · External reference
Inhibitors of the cancer target ribonucleotide reductase, past and present
10.3390/biom12060815 · 2022 · External reference
Preclinical Toxicology of Antimetabolite Drugs used in Cancer Therapy–Literary Review
2024 · External reference
Cellular responses to widespread DNA replication stress
10.3390/ijms242316903 · 2023 · External reference
DNA methylation, methyltransferases, and cancer
10.1038/sj.onc.1204341 · 2001 · External reference
Recent progress in DNA methyltransferase inhibitors as anticancer agents
10.3389/fphar.2022.1072651 · 2022 · External reference
Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
10.1016/j.celrep.2023.113098 · 2023 · External reference
Decitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines; the impact of DCK overexpression
10.3389/fphar.2022.991751 · 2022 · External reference
DNA hypomethylating drugs in cancer therapy
10.1101/cshperspect.a026948 · 2017 · External reference
DNMT1-mediated epigenetic silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability
10.1038/s41388-022-02404-9 · 2022 · External reference
Unresolved reference
2022 · External reference
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity
10.1038/s41401-025-01639-y · 2026 · External reference
Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma
10.1158/2159-8290.cd-25-0587 · 2025 · External reference
Nucleoside-based anticancer drugs: Mechanism of action and drug resistance
10.1016/j.bcp.2023.115741 · 2023 · External reference
Nucleoside analogs: molecular mechanisms signaling cell death
10.1038/onc.2008.316 · 2008 · External reference
Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
10.3390/cancers10070240 · 2018 · External reference
Drug resistance in cancer: molecular mechanisms and emerging treatment strategies
10.1186/s43556-025-00352-w · 2025 · External reference
Multi-omics dissection of tumor microenvironment-mediated drug resistance: mechanisms and therapeutic reprogramming
2025 · External reference
Nanomedicines for overcoming cancer drug resistance
10.3390/pharmaceutics14081606 · 2022 · External reference
Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy‐naïve pT2 gallbladder adenocarcinoma patients
10.1111/his.12805 · 2016 · External reference
Role of human nucleoside transporters in pancreatic cancer and chemoresistance
10.3748/wjg.v27.i40.6844 · 2021 · External reference
“Open Sesame?”: Biomarker status of the human equilibrative nucleoside transporter-1 and molecular mechanisms influencing its expression and activity in the uptake and cytotoxicity of gemcitabine in pancreatic cancer
10.3390/cancers12113206 · 2020 · External reference
hENT1 expression predicts response to gemcitabine and nab-paclitaxel in advanced pancreatic ductal adenocarcinoma
10.1158/1078-0432.ccr-22-2576 · 2022 · External reference
Elucidation of the gemcitabine transporters of escherichia coli K-12 and gamma-proteobacteria linked to gemcitabine-related chemoresistance
10.3390/ijms25137012 · 2024 · External reference
Nanoparticle-based delivery strategies for combating drug resistance in cancer therapeutics
10.3390/cancers17162628 · 2025 · External reference
MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells
10.1016/j.bbamcr.2020.118824 · 2020 · External reference
Multidrug resistance protein 5 affects cell proliferation, migration and gemcitabine sensitivity in pancreatic cancer MIA Paca‑2 and PANC‑1 cells
10.3892/or.2023.8666 · 2023 · External reference
Unresolved reference
2025 · External reference
The role of various collagen types in tumor biology: a review
2025 · External reference
Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug delivery in a 3D Model of Pancreatic Cancer Fibrosis
10.1002/smll.202506926 · 2025 · External reference
Decitabine/cedazuridine: first approval
10.1007/s40265-020-01389-7 · 2020 · External reference
Oral decitabine–cedazuridine versus intravenous decitabine for myelodysplastic syndromes and chronic myelomonocytic leukaemia (ASCERTAIN): a registrational, randomised, crossover, pharmacokinetics, phase 3 study
10.1016/s2352-3026(23)00338-1 · 2024 · External reference
FDA approval summary: decitabine and cedazuridine tablets for myelodysplastic syndromes
10.1158/1078-0432.ccr-21-4498 · 2022 · External reference
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
10.1016/j.isci.2024.108907 · 2024 · External reference
The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342
10.1080/15257770.2024.2325439 · 2024 · External reference
Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase activity and Nucleic Acid Binding
10.1021/acschembio.3c00118 · 2023 · External reference
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
10.1038/nm.4265 · 2017 · External reference
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses
10.1038/s41392-025-02523-1 · 2025 · External reference
Precision medicine engaging nucleoside analogues: New advances to a conventional arsenal
10.1007/s13596-024-00747-0 · 2025 · External reference
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
10.1038/s41467-017-01582-5 · 2017 · External reference
Clinical use of biomarkers in the field of cytotoxic nucleoside analogues
10.1080/15257770.2023.2272640 · 2024 · External reference
Epigenetic changes in nucleoside transporter hENT1 and dCK, as mechanism for gemcitabine-aquired resistance in cervical cancer cell lines
10.1200/jco.2010.28.15_suppl.e13633 · 2010 · External reference
Acquired Resistance to Decitabine Associated with the Deoxycytidine Kinase A180P Mutation: Implications for the Order of Hypomethylating Agents in Myeloid Malignancies Treatment
10.3390/ijms26115083 · 2025 · External reference
Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
10.1038/nsb942 · 2003 · External reference
Development and preclinical pharmacology of a novel dCK inhibitor, DI-87
10.1016/j.bcp.2019.113742 · 2020 · External reference
Ribonucleotide reductases: structure, chemistry, and metabolism suggest new therapeutic targets
10.1146/annurev-biochem-013118-111843 · 2020 · External reference
Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
10.1038/onc.2014.155 · 2015 · External reference
mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer
10.1016/j.neo.2021.05.007 · 2021 · External reference
Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment
10.3390/cancers13164200 · 2021 · External reference
Cytidine deaminase enzyme activity is a predictive biomarker in gemcitabine-treated cancer patients
10.1007/s00280-023-04579-8 · 2023 · External reference
Design optimization of Fucoidan-coating Cationic Liposomes for enhance Gemcitabine delivery
10.1007/s10637-024-01455-x · 2024 · External reference
Structure of human cytidine deaminase bound to a potent inhibitor
10.1021/jm0496279 · 2005 · External reference
The Emerging Role of Cytidine Deaminase in Human Diseases: a New Opportunity for Therapy?
10.1016/j.ymthe.2019.11.026 · 2020 · External reference
Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase
10.1038/onc.2013.357 · 2014 · External reference
Cytidine Deaminase Resolves Replicative stress and Protects Pancreatic Cancer from DNA-Targeting Drugs
10.1158/0008-5472.can-22-3219 · 2024 · External reference
Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML
10.1038/s41419-022-05023-0 · 2022 · External reference
Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
10.1038/ncomms3722 · 2013 · External reference
GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state
10.1073/pnas.1401706111 · 2014 · External reference
Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis
10.1038/s41467-024-48237-w · 2024 · External reference
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
10.1038/nm.4255 · 2017 · External reference
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
10.1073/pnas.1805593115 · 2018 · External reference
Targeting the DNA damage response and repair in cancer through nucleotide metabolism
10.1002/1878-0261.13227 · 2022 · External reference
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
10.1038/nm.4265 · 2017 · External reference
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
2020 · External reference
Targeting WEE1 kinase in gynecological malignancies
10.2147/dddt.s462056 · 2024 · External reference
dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells
10.1111/cas.14718 · 2021 · External reference
Replication stress in Cancer: Mechanistic Insights and Therapeutic Opportunities for Radiosensitization
10.3390/cimb48010067 · 2026 · External reference
Overcoming Microbiome-acquired gemcitabine resistance in pancreatic ductal adenocarcinoma
10.3390/biomedicines12010227 · 2024 · External reference
Microbiota and their metabolites potentiate cancer immunotherapy: Therapeutic target or resource for small molecule drug discovery?
10.3389/fphar.2022.1091124 · 2022 · External reference
Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer
10.1186/s13046-018-0985-y · 2019 · External reference
Fecal microbiota transplantation augments 5-fluorouracil efficacy in pancreatic cancer via gut microbiota modulation
2025 · External reference
Abstract C032: NUC-7738 in combination with pembrolizumab in patients with metastatic melanoma: phase 2 results from the NuTide: 701 study
10.1158/1535-7163.targ-23-c032 · 2023 · External reference
Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effects
10.20517/cdr.2022.136 · 2023 · External reference
Problems related to resistance to cytarabine in acute myeloid leukemia
10.1080/1042819032000159861 · 2004 · External reference
Drug resistance to cytotoxic nucleoside analogues
10.2174/1389450033490957 · 2003 · External reference
Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies
10.1038/s41375-021-01218-0 · 2021 · External reference
Mechanisms of resistance to hypomethylating agents and BCL-2 inhibitors
10.1016/j.beha.2023.101521 · 2023 · External reference
Review of transporter substrate, inhibitor, and inducer characteristics of cladribine
10.1007/s40262-021-01065-3 · 2021 · External reference
Cellular pharmacology of fludarabine: molecular determinants of transport and metabolism
10.3389/fphar.2026.1818501 · 2026 · External reference
Nelarabine in T-cell acute lymphoblastic leukemia: intracellular metabolism and molecular mode-of-action
10.1038/s41375-025-02529-2 · 2025 · External reference
Targeted therapy combined with immunotherapy vs trifluridine/tipiracil with bevacizumab as late-line therapy in metastatic colorectal cancer
10.3748/wjg.v31.i29.109947 · 2025 · External reference
Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models
10.3892/or.2014.3487 · 2014 · External reference
Trifluridine–tipiracil and bevacizumab in refractory metastatic colorectal cancer
10.1056/nejmoa2214963 · 2023 · External reference
10.1016/j.clcc.2024.12.002
10.1016/j.clcc.2024.12.002 · External reference
The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia
10.1038/sj.bjc.6602881 · 2005 · External reference
The Role of CPX-351 in the Acute Myeloid Leukemia Treatment Landscape: Mechanism of Action, Efficacy, and Safety: L. Pagano et al
10.1007/s40265-025-02194-w · 2025 · External reference
The Clinical Safety and Efficacy of Cytarabine and Daunorubicin Liposome (CPX‐351) in Acute Myeloid Leukemia patients: a Systematic Review
10.1002/cnr2.70199 · 2025 · External reference
CPX-351: from preclinical studies to future directions
2026 · External reference
Response and toxicity to cytarabine therapy in leukemia and lymphoma: from dose puzzle to pharmacogenomic biomarkers
10.3390/cancers13050966 · 2021 · External reference
Quality-adjusted Time without Symptoms of disease or Toxicity (Q-TWiST) analysis of CPX-351 versus 7+ 3 in older adults with newly diagnosed high-risk/secondary AML
10.1186/s13045-021-01119-w · 2021 · External reference
First-in-man study of CPX-351: a liposomal carrier containing cytarabine and daunorubicin in a fixed 5: 1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia
10.1200/jco.2010.30.5961 · 2011 · External reference
Transplant outcomes after CPX-351 vs 7+ 3 in older adults with newly diagnosed high-risk and/or secondary AML
10.1182/bloodadvances.2021006468 · 2022 · External reference
Application of ProTide technology to gemcitabine: a successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development
10.1021/jm401853a · 2014 · External reference
Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells
10.1593/neo.10576 · 2010 · External reference
NUC-3373 targets the DNA-directed pathway more effectively than 5-FU
10.1158/1538-7445.am2022-1835 · 2022 · External reference
O-2 phase III study of NUC-1031+ cisplatin vs gemcitabine+ cisplatin for first-line treatment of patients with advanced biliary tract cancer (NuTide: 121)
10.1016/j.annonc.2023.04.017 · 2023 · External reference
A phase III randomized study of first-line NUC-1031/cisplatin vs. gemcitabine/cisplatin in advanced biliary tract cancer
10.1016/j.jhep.2025.01.040 · 2025 · External reference
NUC-1031, use of ProTide technology to circumvent gemcitabine resistance: current status in clinical trials
10.1007/s12032-020-01386-6 · 2020 · External reference
A phase Ib study of NUC-3373 in combination with standard therapies in advanced/metastatic colorectal cancer (NuTide: 302)
10.1200/jco.2021.39.3_suppl.93 · 2021 · External reference
The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human phase I clinical trial
10.1158/1078-0432.ccr-21-1652 · 2021 · External reference
Unresolved reference
2022 · External reference
455MO NUC-7738 in patients with advanced solid tumours: phase I results from the NuTide: 701 phase I/II study
10.1016/j.annonc.2022.07.584 · 2022 · External reference
1530P Patient derived organoids reveal synergy between NUC-7738 and PD-1 inhibition in renal cell carcer
10.1016/j.annonc.2025.08.2161 · 2025 · External reference
“Open Sesame?”: Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and activity in the Uptake and Cytotoxicity of Gemcitabine in Pancreatic Cancer
10.3390/cancers12113206 · 2020 · External reference
Dihydropyrimidine Dehydrogenase Deficiency and Implementation of Upfront DPYD Genotyping
10.1002/cpt.2667 · 2022 · External reference
Fluoropyrimidine Dosage and Toxicity
2025 · External reference
Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS
10.1016/j.apsb.2019.06.008 · 2020 · External reference
Membrane‐permeable triphosphate prodrugs of nucleoside analogues
10.1002/anie.201511808 · 2016 · External reference
Innovative nanomedicine delivery: targeting tumor microenvironment to defeat drug resistance
10.3390/pharmaceutics16121549 · 2024 · External reference
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy
10.1080/17425247.2023.2292678 · 2023 · External reference
Antibody–drug conjugates: recent advances in payloads
10.1016/j.apsb.2023.06.015 · 2023 · External reference
Novel telomere-targeting dual-pharmacophore dinucleotide prodrugs for anticancer therapy
10.1093/nar/gkaf591 · 2025 · External reference
Chemotherapeutic Spherical Nucleic Acids
10.1021/acsnano.5c16609 · 2025 · External reference
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway
10.1016/j.apsb.2025.05.008 · 2025 · External reference
N-trimethyl chitosan nanoparticles and CSKSSDYQC peptide: N-trimethyl chitosan conjugates enhance the oral bioavailability of gemcitabine to treat breast cancer
10.1016/j.jconrel.2018.03.013 · 2018 · External reference
CD123/CD33 dual-antibody modified liposomes effectively target acute myeloid leukemia cells and reduce antigen-negative escape
10.1016/j.ijpharm.2019.118518 · 2019 · External reference
Co-administration of iRGD enhances tumor-targeted delivery and anti-tumor effects of paclitaxel-loaded PLGA nanoparticles for colorectal cancer treatment
10.1201/9780429065767 · 2019 · External reference
Self-assembled lipid–prodrug nanoparticles
10.1038/s44222-023-00082-0 · 2023 · External reference
Orally delivered berberine derivatives for dual therapy in diabetic complications with MRSA infections
10.1016/j.cclet.2024.109917 · 2025 · External reference
Gemcitabine and Pin1 siRNA co-delivery with fucoidan-coated nano-liposomes for therapy of pancreatic cancer
10.1016/j.jddst.2023.104872 · 2023 · External reference
Advancing pancreatic cancer therapy by mesothelin-specific nanobody conjugation
10.1186/s12943-025-02325-7 · 2025 · External reference
Unresolved reference
2025 · External reference
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis
10.1016/j.apsb.2023.03.004 · 2023 · External reference
A bioinspired supramolecular nanoprodrug for precision therapy of B-cell non-Hodgkin’s lymphoma
10.1186/s12951-024-02745-5 · 2024 · External reference
Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy
10.1016/j.jcis.2016.10.041 · 2017 · External reference
Collagenase-functionalized liposomes overcome stromal barriers in pancreatic cancer
10.1021/acsnano.5c20618 · 2026 · External reference
Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer
10.1002/advs.202507118 · 2025 · External reference
FU-coating pH-sensitive liposomes for improving the release of gemcitabine by endosome escape in pancreatic cancer cells
10.1016/j.jddst.2022.104135 · 2023 · External reference
Rational formulation and industrial manufacturing of lipid-based complex injectables: Landmarks and trends
10.1016/j.jconrel.2024.07.021 · 2024 · External reference
Barrier permeation and improved nanomedicine delivery in tumor microenvironments
10.1016/j.canlet.2023.216166 · 2023 · External reference
Supramolecular nanomedicine in the intelligent cancer therapy: recent advances and future
2024 · External reference
Unresolved reference
2020 · External reference
nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer
10.1158/2159-8290.cd-11-0242 · 2012 · External reference
Reverse intratumor bacteria-induced gemcitabine resistance with carbon nanozymes for enhanced tumor catalytic-chemo therapy
10.1016/j.nantod.2022.101395 · 2022 · External reference
Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia
10.1186/s12935-023-03057-8 · 2023 · External reference
Wee1 inhibition by MK1775 potentiates gemcitabine through accumulated replication stress leading to apoptosis in biliary tract cancer
10.1016/j.biopha.2023.115389 · 2023 · External reference
A phase I/II trial of oral SRA737 (a Chk1 Inhibitor) given in combination with low-dose gemcitabine in patients with advanced cancer
10.1158/1078-0432.ccr-22-2074 · 2023 · External reference
A polymeric nanovesicle delivers sulfopin and gemcitabine to remodel tumor microenvironment for enhanced chemoimmunotherapy against orthotopic pancreatic cancer
2025 · External reference
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma
10.1186/s12943-020-01297-0 · 2021 · External reference
5-FU@ HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia
10.1186/s12951-025-03335-9 · 2025 · External reference
Macrophage membrane-coated nano-gemcitabine promotes lymphocyte infiltration and synergizes AntiPD-L1 to restore the tumoricidal function
10.1021/acsnano.2c07861 · 2022 · External reference
Targeting PD‐L1 with DNA Aptamers and Conjugated with Gemcitabine as a Novel Therapeutic Strategy for Bladder Cancer Chemotherapy combined with Immunotherapy
10.1002/smsc.202370023 · 2023 · External reference
Transformer-based Molecular Generative Model for Antiviral Drug Design
10.1021/acs.jcim.3c00536 · 2024 · External reference
Transfer learning with multiomics integration and deep neural networks reveals drug resistance mechanisms in cancer
10.1038/s41598-025-23435-8 · 2025 · External reference
Clinical application and drug resistance mechanism of gemcitabine
10.3389/fcell.2025.1702720 · 2025 · External reference