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References from Protein tyrosine sulfation: from molecular mechanisms and pathophysiology to analytical advances and therapeutic translation. Local targets link to admitted publications; unresolved targets remain external evidence.
The biology and enzymology of protein tyrosine O-sulfation
10.1074/jbc.r300008200 · 2003 · External reference
Sulfoproteomics workflow with precursor ion accurate mass shift analysis reveals novel tyrosine sulfoproteins in the Golgi
10.1021/acs.jproteome.3c00323 · 2024 · External reference
The structural role of receptor tyrosine sulfation in chemokine recognition
10.1111/bph.12455 · 2014 · External reference
Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2
10.1074/jbc.m508991200 · 2006 · External reference
Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter
10.1074/jbc.m302439200 · 2003 · External reference
Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases
10.1016/j.pharmthera.2023.108540 · 2023 · External reference
Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins
10.1073/pnas.95.6.2896 · 1998 · External reference
Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans
10.1074/jbc.273.38.24770 · 1998 · External reference
Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
10.1016/s0092-8674(00)80577-2 · 1999 · External reference
Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC)
10.1111/j.1365-2958.2004.04478.x · 2005 · External reference
Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer
10.18632/oncotarget.10046 · 2016 · External reference
Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy
10.1186/s12943-024-02068-x · 2024 · External reference
Distinguishing sulfotyrosine containing peptides from their phosphotyrosine counterparts using mass spectrometry
10.1007/s13361-017-1854-1 · 2018 · External reference
Development of a sample-preparation workflow for sulfopeptide enrichment: from target analysis to challenges in shotgun sulfoproteomics
10.1021/acs.analchem.0c01342 · 2020 · External reference
MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics
10.1038/nmeth.4256 · 2017 · External reference
Direct mapping of tyrosine sulfation states in native peptides by nanopore
10.1038/s41589-024-01734-x · 2025 · External reference
Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells
10.1096/fasebj.14.2.345 · 2000 · External reference
Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms
10.1042/bj20020044 · 2002 · External reference
Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm
10.1371/journal.pone.0029559 · 2012 · External reference
Sulfotransferases in glycosaminoglycan biosynthesis
10.1016/j.sbi.2003.08.002 · 2003 · External reference
Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2
10.1016/j.str.2023.04.012 · 2023 · External reference
Inactivating PAPSS2 mutations in a patient with premature pubarche
10.1056/nejmoa0810489 · 2009 · External reference
Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2
10.1073/pnas.95.19.11134 · 1998 · External reference
Sulfotyrosine residues: Interaction specificity determinants for extracellular protein-protein interactions
10.1016/j.jbc.2022.102232 · 2022 · External reference
A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production
10.3389/fimmu.2022.1072702 · 2022 · External reference
Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction
10.1038/ncomms2593 · 2013 · External reference
Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1
10.1038/s41598-017-07141-8 · 2017 · External reference
Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2
10.1016/j.jasms.2008.06.021 · 2008 · External reference
Structural characterization of metal binding in human tyrosylprotein sulfotransferase 2, TPST2
10.1038/s41598-026-37189-4 · 2026 · External reference
Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase-1
10.1111/febs.70597 · 2026 · External reference
Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence
10.1073/pnas.172380899 · 2002 · External reference
PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus
10.1016/0092-8674(95)90174-4 · 1995 · External reference
PredSulSite: prediction of protein tyrosine sulfation sites with multiple features and analysis
10.1016/j.ab.2012.06.003 · 2012 · External reference
The Sulfinator: predicting tyrosine sulfation sites in protein sequences
10.1093/bioinformatics/18.5.769 · 2002 · External reference
Computational characterization of the binding properties of the HIV1-neutralizing antibody PG16 and design of PG16-derived CDRH3 peptides
2023 · External reference
Evidence for differences in erythrocyte surface receptors for the malarial parasites, Plasmodium falciparum and Plasmodium knowlesi
10.1084/jem.146.1.277 · 1977 · External reference
Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice
10.1074/jbc.m202420200 · 2002 · External reference
Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility
10.1074/jbc.m513768200 · 2006 · External reference
Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency
10.1016/j.ygcen.2007.12.006 · 2008 · External reference
TPST2-mediated tyrosine sulfation orchestrates porcine preimplantation development
10.1186/s12915-026-02525-7 · 2026 · External reference
Uncommon posttranslational modifications in proteomics: ADP-ribosylation, tyrosine nitration, and tyrosine sulfation
10.1002/mas.21811 · 2024 · External reference
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
10.1042/bcj20180266 · 2018 · External reference
Mass spectrometry and enzyme assays refute histone tyrosine sulfation
10.1038/s41589-025-01994-1 · 2025 · External reference
Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription
10.1038/s41589-023-01267-9 · 2023 · External reference
GAL3ST1-mediated histone tyrosine sulfation induced by cancer-associated fibroblasts promotes gastric cancer metastasis
10.1158/0008-5472.can-25-2452 · 2026 · External reference
Karyopherins: from nuclear-transport mediators to nuclear-function regulators
10.1016/j.tcb.2004.09.004 · 2004 · External reference
Giantin mediates Golgi localization of Gal3-O-sulfotransferases and affects salivary mucin sulfation in patients with Sjogren's disease
10.1172/jci.insight.171585 · 2024 · External reference
Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis
10.1073/pnas.261704098 · 2002 · External reference
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling
10.1073/pnas.1106083108 · 2011 · External reference
Discovery of (4-phenyl-cyclohexyl)acetate-derived tyrosylprotein sulfotransferase 2 (TPST2) inhibitors with potent anti-tumor activity for immuno-oncology applications
10.1021/acs.jmedchem.5c01391 · 2025 · External reference
R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5
10.1371/journal.pone.0040976 · 2012 · External reference
CXCL12 (SDF-1)/CXCR4 pathway in cancer
10.1158/1078-0432.ccr-09-2329 · 2010 · External reference
Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma
10.1371/journal.pone.0056114 · 2013 · External reference
Sulfate metabolism is abnormal in patients with rheumatoid arthritis. Confirmation by in vivo biochemical findings
1994 · External reference
Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis
10.1186/s12915-023-01641-y · 2023 · External reference
Autoimmunity and tyrosine sulfation
10.1016/j.autrev.2005.03.004 · 2005 · External reference
Dysfunctional HDL as a diagnostic and therapeutic target
10.1161/atvbaha.108.179226 · 2010 · External reference
Lack of tyrosylprotein sulfotransferase activity in hematopoietic cells drastically attenuates atherosclerosis in Ldlr-/- mice
10.1161/atvbaha.109.192963 · 2009 · External reference
Distinct, autosomal recessive form of spondyloepimetaphyseal dysplasia segregating in an inbred Pakistani kindred
10.1002/(sici)1096-8628(19980806)78:5<468::aid-ajmg13>3.0.co;2-d · 1998 · External reference
Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse
10.1038/2458 · 1998 · External reference
The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping
10.1016/0092-8674(94)90281-x · 1994 · External reference
A member of a family of sulfate-activating enzymes causes murine brachymorphism
10.1073/pnas.95.15.8681 · 1998 · External reference
Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization
10.1006/bbrc.2000.2123 · 2000 · External reference
Site-selective solid-phase synthesis of a CCR5 sulfopeptide library to interrogate HIV binding and entry
10.1021/cb500337r · 2014 · External reference
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
10.1073/pnas.0308527100 · 2004 · External reference
Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71
10.1038/nm.1961 · 2009 · External reference
Scavenger receptor B2 is a cellular receptor for enterovirus 71
10.1038/nm.1992 · 2009 · External reference
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry
10.1016/s0092-8674(00)80058-6 · 1999 · External reference
SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2
10.1016/j.cell.2020.09.033 · 2020 · External reference
The effects of sulglycotide on the adhesion and the inflammation of helicobacter pylori
10.3390/ijerph17082918 · 2020 · External reference
Adherence of pilus- Opa+ gonococci to epithelial cells in vitro involves heparan sulfate
10.1084/jem.182.2.511 · 1995 · External reference
Mucin glycan foraging in the human gut microbiome
10.3389/fgene.2015.00081 · 2015 · External reference
2'-fucosyllactose promotes colonization of akkermansia muciniphila and prevents colitis in vitro and in mice
10.1021/acs.jafc.3c08305 · 2024 · External reference
Antiviral strategies using natural source-derived sulfated polysaccharides in the light of the COVID-19 pandemic and major human pathogenic viruses
10.3390/v14010035 · 2021 · External reference
Host-receptor post-translational modifications refine staphylococcal leukocidin cytotoxicity
10.3390/toxins12020106 · 2020 · External reference
TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection
10.3389/fimmu.2023.1242330 · 2023 · External reference
Tyrosine sulfation as a protein post-translational modification
10.3390/molecules20022138 · 2015 · External reference
Sulfation of chondroitin and bile acids converges to antagonize Wnt/beta-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis
10.1016/j.apsb.2023.12.006 · 2024 · External reference
Intestinal sulfation is essential to protect against colitis and colonic carcinogenesis
10.1053/j.gastro.2021.03.048 · 2021 · External reference
Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis
10.1038/s41418-018-0147-y · 2019 · External reference
Inhibition of the SLC35B2-TPST2 axis of tyrosine sulfation attenuates the growth and metastasis of pancreatic ductal adenocarcinom
10.1016/j.jcmgh.2023.05.003 · 2023 · External reference
Histone H3Y99sulf regulates hepatocellular carcinoma responding to hypoxia
10.1016/j.jbc.2024.105721 · 2024 · External reference
Heparan sulfate proteoglycans
10.1101/cshperspect.a004952 · 2011 · External reference
Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer
10.1038/s41467-022-32530-7 · 2022 · External reference
Glycan-lectin interactions as novel immunosuppression drivers in glioblastoma
10.3390/ijms23116312 · 2022 · External reference
The IFN gamma receptor: a paradigm for cytokine receptor signaling
10.1146/annurev.immunol.15.1.563 · 1997 · External reference
Effect of sulfotyrosine and negatively charged amino acid of leech-derived peptides on binding and inhibitory activity against thrombin
10.1002/cbic.202300744 · 2024 · External reference
Kinetics of the inhibition of thrombin by hirudin
10.1021/bi00364a025 · 1986 · External reference
Direct thrombin inhibitors
10.1111/j.1365-2125.2011.03916.x · 2011 · External reference
Physiological roles and regulation of mammalian sulfate transporters
10.1152/physrev.2001.81.4.1499 · 2001 · External reference
Inhibition of p53 sulfoconjugation prevents oxidative hepatotoxicity and acute liver failure
10.1053/j.gastro.2021.12.260 · 2022 · External reference
Regulation of p53 localization
10.1046/j.1432-1327.2001.02227.x · 2001 · External reference
Biological actions of cholecystokinin
10.1016/0196-9781(94)90104-x · 1994 · External reference
Cholecystokinin-from local gut hormone to ubiquitous messenger
10.3389/fendo.2017.00047 · 2017 · External reference
Premises for cholecystokinin and gastrin peptides in diabetes therapy
10.1177/1179551419883608 · 2019 · External reference
3-O-sulfation of Heparan sulfate enhances tau interaction and cellular uptake
10.1002/anie.201913029 · 2020 · External reference
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus alpha-synuclein and beta-amyloid aggregates
10.1074/jbc.ra117.000378 · 2018 · External reference
10.64898/2026.05.19.725324
10.64898/2026.05.19.725324 · External reference
Custom workflow for the confident identification of sulfotyrosine-containing peptides and their discrimination from phosphopeptides
10.1021/acs.jproteome.3c00425 · 2023 · External reference
Direct identification of tyrosine sulfation by using ultraviolet photodissociation mass spectrometry
10.1007/s13361-014-0910-3 · 2014 · External reference
Engineering of SH2 Domains for the recognition of protein tyrosine O-sulfation sites
10.1007/978-1-0716-3393-9_16 · 2023 · External reference
Characterization of O-sulfopeptides by negative ion mode tandem mass spectrometry: superior performance of negative ion electron capture dissociation
10.1021/ac301536r · 2012 · External reference
MSFragger-labile: a flexible method to improve labile PTM analysis in proteomics
10.1016/j.mcpro.2023.100538 · 2023 · External reference
The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics
10.1038/nchem.1889 · 2014 · External reference
Online parallel accumulation-serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer
10.1074/mcp.tir118.000900 · 2018 · External reference
Characterization and optimization of multiplexed quantitative analyses using high-field asymmetric-waveform ion mobility mass spectrometry
10.1021/acs.analchem.8b05399 · 2019 · External reference
Searching for sulfotyrosines (sY) in a HA(pY)STACK
10.1021/acs.jproteome.4c00907 · 2025 · External reference
Simultaneous identification of tyrosine phosphorylation and sulfation sites utilizing tyrosine-specific bromination
10.1007/s13361-011-0214-9 · 2011 · External reference
Resolving sulfation posttranslational modifications on a peptide hormone using nanopores
10.1021/acsnano.4c09872 · 2024 · External reference
Multiple rereads of single proteins at single-amino acid resolution using nanopores
10.1126/science.abl4381 · 2021 · External reference
Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody
10.1074/jbc.m609398200 · 2006 · External reference
Engineering of Src homology 2 domain leading to sulfotyrosine recognition with a high affinity by integrating a distinctive selection theme and next-generation sequencing
2022 · External reference
Specific recognition mechanism of an antibody to sulfated tyrosine and its potential use in biological research
10.1016/j.jbc.2025.108176 · 2025 · External reference
Nanobodies: natural single-domain antibodies
10.1146/annurev-biochem-063011-092449 · 2013 · External reference
Analysis of tyrosine-O-sulfation
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Fluorescent peptide sensors for tyrosylprotein sulfotransferase activity
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Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120
10.1073/pnas.97.11.5762 · 2000 · External reference
Chlorate–a potent inhibitor of protein sulfation in intact cells
10.1016/s0006-291x(86)80253-4 · 1986 · External reference
3'-Phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) knockdown sensitizes non-small cell lung cancer cells to DNA damaging agents
10.18632/oncotarget.3635 · 2015 · External reference
Human genetic disorders caused by mutations in genes encoding biosynthetic enzymes for sulfated glycosaminoglycans
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Chondrodysplasias due to proteoglycan defects
10.1093/glycob/12.4.57r · 2002 · External reference
Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120
10.1016/s0092-8674(03)00508-7 · 2003 · External reference
Tyrosine sulfation at antibody light chain CDR-1 increases binding affinity and neutralization potency to interleukine-4
2024 · External reference
Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry
10.1016/j.ebiom.2016.06.037 · 2016 · External reference
Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation
10.1016/j.chembiol.2023.06.013 · 2023 · External reference
Semisynthesis of an evasin from tick saliva reveals a critical role of tyrosine sulfation for chemokine binding and inhibition
10.1073/pnas.2000605117 · 2020 · External reference
Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry
10.1016/j.bmc.2008.10.005 · 2008 · External reference
Fluorosulfate as a latent sulfate in peptides and proteins
10.1021/jacs.3c07937 · 2023 · External reference
Tyrosine phosphorylation of recombinant hirudin increases affinity to thrombin and antithrombotic activity
10.1002/prot.26616 · 2024 · External reference
3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) is a potential diagnostic and prognostic biomarker in colon adenocarcinoma
10.1038/s41598-026-36388-3 · 2026 · External reference
Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library
10.1073/pnas.1806660115 · 2018 · External reference
Genetically encoding fluorosulfate-l-tyrosine to react with lysine, histidine, and tyrosine via suFEx in proteins in vivo
10.1021/jacs.8b01087 · 2018 · External reference
Immunogenicity of biotherapeutics: causes and association with posttranslational modifications
10.1155/2016/1298473 · 2016 · External reference
Tyrosine sulfation: a modulator of extracellular protein-protein interactions
10.1016/s1074-5521(00)00093-4 · 2000 · External reference
Structural insights into endobiotic reactivation by human gut microbiome-encoded sulfatases
10.1021/acs.biochem.0c00711 · 2020 · External reference
A radiometric method for the measurement of adenosine 3'-phosphate 5'-phosphosulfate in rat and mouse liver
10.1016/s0090-9556(25)07813-4 · 1985 · External reference
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10.1096/fasebj.11.1.9034160 · 1997 · External reference
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10.1016/j.bbapap.2006.07.002 · 2006 · External reference
Desulfovibrio in the gut: the enemy within?
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Acetaminophen hepatotoxicity: the first 35 years
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Efficient proximity labeling in living cells and organisms with TurboID
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Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging
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A secreted tyrosine kinase acts in the extracellular environment
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Accurate structure prediction of biomolecular interactions with AlphaFold 3
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Functional genetic encoding of sulfotyrosine in mammalian cells
10.1038/s41467-020-18629-9 · 2020 · External reference
Preparation of tyrosylprotein sulfotransferases for in vitro one-pot enzymatic synthesis of sulfated proteins/peptides
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Engineering of a small protein scaffold to recognize sulfotyrosine with high specificity
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Nanobodies right in the middle: intrabodies as toolbox to visualize and modulate antigens in the living cell
10.3390/biom10121701 · 2020 · External reference
Overexpression of the 3'-phosphoadenosine 5'-phosphosulfate (PAPS) transporter 1 increases sulfation of chondroitin sulfate in the apical pathway of MDCK II cells
10.1093/glycob/cwm121 · 2008 · External reference
Crystal structure of Saccharomyces cerevisiae 3'-phosphoadenosine-5'-phosphosulfate reductase complexed with adenosine 3',5'-bisphosphate
10.1021/bi801118f · 2008 · External reference