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References from A bis(benzimidazolyl)-based anion transporter triggers chloride-initiated pyroptosis of MDA-MB-468 and 4T1 triple-negative breast cancer cells in vitro and in vivo. Local targets link to admitted publications; unresolved targets remain external evidence.
Amino acid metabolism in breast cancer: pathogenic drivers and therapeutic opportunities
10.1093/procel/pwaf011 · 2025 · External reference
The evolving landscape of immune checkpoint inhibitors and antibody drug conjugates in the treatment of early-stage breast cancer
10.1093/oncolo/oyad233 · 2023 · External reference
Adjuvant capecitabine with docetaxel and cyclophosphamide plus epirubicin for triple-negative breast cancer (CBCSG010): an open-label, randomized, multicenter, phase III trial
10.1200/jco.19.02474 · 2020 · External reference
Molecular design of a pathogen-activated, self-assembling mechanopharmaceutical device
10.1016/j.jconrel.2022.05.029 · 2022 · External reference
Monitoring the changes of pH in lysosomes during autophagy and apoptosis by plasmon enhanced raman imaging
10.1021/acs.analchem.9b01250 · 2019 · External reference
Inhibition of lysosomal degradation of clusterin by protein kinase D3 promotes triple-negative breast cancer tumor growth
10.1002/advs.202003205 · 2021 · External reference
Glutathione-programmed mitochondria-targeted delivery of lonidamine for triple-negative breast cancer
10.2147/ijn.s413217 · 2023 · External reference
Chloride transport through supramolecular barrel-rosette ion channels: lipophilic control and apoptosis-inducing activity
10.1021/jacs.6b10379 · 2016 · External reference
Determinants of ion-transporter cancer cell death
10.1016/j.chempr.2019.05.001 · 2019 · External reference
Synthesis, anionophoric activity, and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters
10.1016/j.ejmech.2018.04.036 · 2018 · External reference
Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells
10.1038/nchem.2021 · 2014 · External reference
A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations
10.1038/nchem.2706 · 2017 · External reference
A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy
10.1021/jacs.3c01451 · 2023 · External reference
Near-infrared triggered anion transport induces cancer cell death
10.1002/anie.202523734 · 2026 · External reference
Perenosins: a new class of anion transporter with anti-cancer activity
10.1039/c6ob00002a · 2016 · External reference
Inhibition of autophagic flux by cyclometalated iridium(iii) complexes through anion transportation
10.1039/c8sc04520h · 2019 · External reference
Platinum-based metal complexes as chloride transporters that trigger apoptosis
10.1039/d4sc02115k · 2024 · External reference
Ferroptosis of cancer cells via tubulin degradation and mitochondrial dysfunction: a novel mechanism of anticancer effect for small-molecule anion transporters
10.1021/acs.jmedchem.4c03227 · 2025 · External reference
Design, synthesis, and antitumor efficacy of substituted 2-amino[1,2,4] triazolopyrimidines and related heterocycles as dual inhibitors for microtubule polymerization and Janus kinase 2
10.1021/acs.jmedchem.3c01690 · 2023 · External reference
Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: design, synthesis, and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates
10.1016/j.bioorg.2024.107421 · 2024 · External reference
10.1021/acs.jmedchem.5c01888
10.1021/acs.jmedchem.5c01888 · External reference
In vitro elimination of epidermal growth factor receptor-overexpressing cancer cells by CD32A-chimeric receptor T cells in combination with cetuximab or panitumumab
10.1002/ijc.32663 · 2020 · External reference
Targeting oncogenic MAGEA6 sensitizes triple negative breast cancer to doxorubicin through its autophagy and ferroptosis by stabling AMPKα1
10.1038/s41420-024-02196-9 · 2024 · External reference
Design, synthesis, and biological evaluation of Golgi-targeting anion transporters as inducers of Golgiphagy and apoptosis in cancer cells
10.1016/j.ejmech.2025.117519 · 2025 · External reference
GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis
10.1038/s41418-025-01505-8 · 2025 · External reference
Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs
10.1038/s41418-023-01117-0 · 2023 · External reference
Cell autonomous functions of CD47 in regulating cellular and metabolic plasticity
10.1038/s41418-024-01347-w · 2024 · External reference
Two-photon fluorescence lifetime imaging of intracellular chloride in cockroach salivary glands
10.1039/b813797h · 2009 · External reference
Hypoosmotic and glutamate-induced swelling of bipolar cells in the rat retina: comparison with swelling of Müller glial cells
10.1111/jnc.12307 · 2013 · External reference
Porcine spleen deoxyribonuclease II. Covalent structure, cDNA sequence, molecular cloning, and gene expression
10.1074/jbc.273.27.17192 · 1998 · External reference
A review of pathophysiology, molecular mechanisms, and omics approaches of spinal cord injury
10.3390/ijms26167895 · 2025 · External reference
Synergistic antitumor immunotherapy via mitochondria regulation in macrophages and tumor cells by an iridium photosensitizer
10.1021/acscentsci.4c02156 · 2025 · External reference
Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break
10.1073/pnas.2002126117 · 2020 · External reference
Activated SIRT1 contributes to DPT-induced glioma cell parthanatos by upregulation of NOX2 and NAT10
10.1038/s41401-023-01109-3 · 2023 · External reference
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis, and pyroptosis by activating NLRP3
10.1016/j.redox.2019.101215 · 2019 · External reference
The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
10.1016/j.immuni.2024.11.017 · 2025 · External reference
Cyclic GMP-AMP synthase recognizes the physical features of DNA
10.1038/s41401-024-01369-7 · 2025 · External reference
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
10.1016/j.immuni.2021.03.011 · 2021 · External reference
TANK-binding kinase 1 in the pathogenesis and treatment of inflammation-related diseases
10.3390/ijms26051941 · 2025 · External reference
Investigations of potential therapeutic targets from high-throughput, label-free, quantitative proteomic studies in MDA-MB-468 cells treated with metformin and electrical pulses
10.1016/j.bioelechem.2025.109153 · 2026 · External reference
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting caspase-1-induced pyroptosis
10.1016/j.intimp.2021.107496 · 2021 · External reference
The interplay of the cGAS–STING pathway with the lysosome
10.1016/j.tibs.2025.08.010 · 2025 · External reference
Multi-responsive nanofibers composite gel for local drug delivery to inhibit recurrence of glioma after operation
10.1186/s12951-021-00943-z · 2021 · External reference
Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling
2023 · External reference
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
10.1111/imr.12534 · 2017 · External reference
Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage
10.1186/s13048-025-01887-w · 2025 · External reference
Molecular mechanisms and cellular functions of cGAS–STING signalling
10.1038/s41580-020-0244-x · 2020 · External reference
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
10.1038/s41573-023-00822-2 · 2024 · External reference
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
10.1038/nature15514 · 2015 · External reference
