Research graph
References from GRK2–JAK1 binding represses hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting STAT3 activation. Local targets link to admitted publications; unresolved targets remain external evidence.
Cellular interactions in maintaining an inflammatory microenvironment in rheumatoid arthritis
10.1016/j.molimm.2025.06.008 · 2025 · External reference
Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
10.1016/s2665-9913(23)00211-4 · 2023 · External reference
What is Rheumatoid Arthritis?
10.1001/jama.2022.0786 · 2022 · External reference
Targeting fibroblast-like synoviocytes in rheumatoid arthritis
10.1016/j.coph.2022.102304 · 2022 · External reference
Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
10.1038/s41584-020-0413-5 · 2020 · External reference
The JAK-STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms
10.1093/eurheartj/ehab447 · 2021 · External reference
Efficacy and safety of JAK inhibitors in rheumatoid arthritis: update for the practising clinician
10.1038/s41584-023-01062-9 · 2024 · External reference
Peficitinib Inhibits the Chemotactic activity of Monocytes via Proinflammatory Cytokine Production in Rheumatoid Arthritis Fibroblast-like Synoviocytes
10.3390/cells8060561 · 2019 · External reference
Safety signal detection and evaluation in clinical development programs: a case study of tofacitinib
10.1002/prp2.371 · 2018 · External reference
Recurrent herpes zoster in a rheumatoid arthritis patient treated with tofacitinib: a case report and review of the literature
10.12998/wjcc.v10.i24.8703 · 2022 · External reference
JAK inhibitor selectivity: new opportunities, better drugs?
10.1038/s41584-024-01153-1 · 2024 · External reference
Joint Location-specific JAK-STAT Signaling in Rheumatoid Arthritis Fibroblast-like Synoviocytes
10.1002/acr2.11093 · 2019 · External reference
MicroRNA-17-5p Reduces Inflammation and Bone Erosions in mice with Collagen-Induced Arthritis and Directly Targets the JAK/STAT Pathway in Rheumatoid Arthritis Fibroblast-like Synoviocytes
10.1002/art.41441 · 2020 · External reference
Janus kinases in cytokine signalling
10.1098/rstb.1996.0012 · 1996 · External reference
Structural basis of recognition of interferon-α receptor by tyrosine kinase 2
10.1038/nsmb.2807 · 2014 · External reference
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
10.1136/annrheumdis-2014-206028 · 2015 · External reference
Janus kinase inhibitors in autoimmune diseases
2013 · External reference
The JAK-STAT pathway: impact on human disease and therapeutic intervention
10.1146/annurev-med-051113-024537 · 2015 · External reference
A new protein containing an SH2 domain that inhibits JAK kinases
10.1038/43213 · 1997 · External reference
Targeting SOCS Proteins to Control JAK-STAT Signalling in Disease
10.1016/j.tips.2019.03.001 · 2019 · External reference
The tumor suppressor activity of SOCS-1
10.1038/sj.onc.1205537 · 2002 · External reference
The molecular basis of JAK/STAT inhibition by SOCS1
10.1038/s41467-018-04013-1 · 2018 · External reference
GRK2: multiple roles beyond G protein-coupled receptor desensitization
10.1016/j.tips.2011.12.003 · 2012 · External reference
The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets
10.1111/j.1476-5381.2010.00727.x · 2010 · External reference
Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats
10.1016/j.apsb.2021.01.015 · 2021 · External reference
Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis
10.1097/cm9.0000000000003165 · 2025 · External reference
GRK2 inhibits Flt-1(+) macrophage infiltration and its proangiogenic properties in rheumatoid arthritis
10.1016/j.apsb.2023.09.013 · 2024 · External reference
GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis
10.1016/j.apsb.2023.12.007 · 2024 · External reference
TNF-α impairs EP4 signaling through the association of TRAF2-GRK2 in primary fibroblast-like synoviocytes
10.1038/s41401-021-00654-z · 2022 · External reference
GRK2 activates TRAF2-NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis
10.1016/j.apsb.2025.02.031 · 2025 · External reference
Paeoniflorin-6'-O-benzene sulfonate inhibits keratinocyte proliferation by restoring GRK2-JAK1 colocalization in mouse model of psoriasis
10.1016/j.cellsig.2025.111706 · 2025 · External reference
Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League against Rheumatism collaborative initiative
10.1002/art.27584 · 2010 · External reference
Paeoniflorin-6'-o-benzene sulfonate (CP-25) improves vasculitis through inhibiting IL-17A/JAK/STAT3 signaling pathway in endothelial cells of HFD CIA rats
10.1002/ptr.6870 · 2021 · External reference
Combined use of etanercept and MTX restores CD4+/CD8+ ratio and Tregs in spleen and thymus in collagen-induced arthritis
10.1007/s00011-012-0520-0 · 2012 · External reference
Synovitis score: discrimination between chronic low-grade and high-grade synovitis
10.1111/j.1365-2559.2006.02508.x · 2006 · External reference
Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6/JAK2/STAT3 signaling in vivo and in vitro
10.1016/j.molimm.2023.04.001 · 2023 · External reference
Juglone suppresses vasculogenic mimicry in glioma through inhibition of HuR-mediated VEGF-A expression
10.1016/j.bcp.2024.116458 · 2024 · External reference
Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq
10.1016/s0026-895x(24)26486-5 · 2000 · External reference
Interaction between the conserved region in the C-terminal domain of GRK2 and rhodopsin is necessary for GRK2 to catalyze receptor phosphorylation
10.1074/jbc.275.12.8469 · 2000 · External reference
Crystal Structure of a complex of the Intracellular Domain of Interferon λ Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1
10.1016/j.jmb.2016.10.005 · 2016 · External reference
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
10.1074/jbc.m500822200 · 2005 · External reference
Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors
10.1038/nrrheum.2012.190 · 2013 · External reference
Ectopic RASGRP2 (CalDAG-GEFI) expression in rheumatoid synovium contributes to the development of destructive arthritis
10.1136/annrheumdis-2018-213588 · 2018 · External reference
Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast production of Inflammatory Mediators
10.1016/j.immuni.2017.01.004 · 2017 · External reference
The Structural Basis for Class II Cytokine Receptor Recognition by JAK1
10.1016/j.str.2016.03.023 · 2016 · External reference
G protein-coupled receptor Kinase 2/G alpha q/11 interaction. a novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits
10.1074/jbc.m208787200 · 2003 · External reference
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
10.1074/jbc.274.49.34531 · 1999 · External reference
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase a and its anchoring protein AKAP79
10.1074/jbc.m009130200 · 2001 · External reference
Start RA treatment - Biologics or JAK-inhibitors?
10.1016/j.autrev.2023.103429 · 2024 · External reference
