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References from Dehydrocostus lactone attenuates sepsis-associated neuroinflammation by directly targeting JAK2 identified through thermal proteome profiling. Local targets link to admitted publications; unresolved targets remain external evidence.
Sepsis-associated encephalopathy
10.1038/nrneurol.2012.183 · 2012 · External reference
Sepsis-associated encephalopathy: Unraveling molecular mechanisms, emerging therapeutics, and translational frontiers
10.1016/j.pharmthera.2025.108971 · 2026 · External reference
Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
10.3389/fcimb.2021.768108 · 2021 · External reference
Microglia Function in the Central nervous System during Health and Neurodegeneration
10.1146/annurev-immunol-051116-052358 · 2017 · External reference
Microglial M1/M2 polarization and metabolic states
10.1111/bph.13139 · 2016 · External reference
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
10.3389/fncel.2020.00198 · 2020 · External reference
Pro-inflammatory activation of microglia in the brain of patients with sepsis
10.1111/nan.12502 · 2019 · External reference
Sepsis-Associated Encephalopathy and Blood-Brain Barrier Dysfunction
10.1007/s10753-021-01501-3 · 2021 · External reference
Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis
10.1038/s41392-022-00872-9 · 2022 · External reference
The JAK-STAT pathway at 30: much learned, much more to do
10.1016/j.cell.2022.09.023 · 2022 · External reference
The IL-6/STAT3 pathway regulates adhesion molecules and cytoskeleton of endothelial cells in thromboangiitis obliterans
10.1016/j.cellsig.2018.01.015 · 2018 · External reference
Microglial Janus kinase/signal transduction and activator of transcription 3 pathway activity directly impacts astrocyte and spinal neuron characteristics
10.1111/jnc.13375 · 2016 · External reference
Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement
10.1136/annrheumdis-2020-218398 · 2021 · External reference
Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a systematic literature research
10.1136/rmdopen-2020-001374 · 2020 · External reference
Dehydrocostus Lactone Induces Apoptosis and Cell Cycle arrest through Regulation of JAK2/STAT3/PLK1 Signaling Pathway in Human Esophageal Squamous Cell Carcinoma Cells
10.2174/1871520621666210805142200 · 2022 · External reference
S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation
10.1021/cb500407d · 2014 · External reference
Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation
10.1371/journal.pone.0020174 · 2011 · External reference
Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes
10.1186/s12953-017-0122-4 · 2016 · External reference
Parthenolide ameliorates inflammation in sepsis via covalently targeting Trim33 and inhibiting NF-kappaB pathway
10.1016/j.phymed.2026.157862 · 2026 · External reference
Analyzing microglial phenotypes across neuropathologies: a practical guide
10.1007/s00401-021-02370-8 · 2021 · External reference
Septic-Associated Encephalopathy: a Comprehensive Review
10.1007/s13311-020-00862-1 · 2020 · External reference
Neurochemical effects of sepsis on the brain
10.1042/cs20220549 · 2023 · External reference
Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo
10.1016/j.intimp.2014.07.012 · 2014 · External reference
Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells
10.1124/jpet.108.148395 · 2009 · External reference
10.18632/aging.103657
10.18632/aging.103657 · External reference
Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-kappaB Signaling Pathway Mediated by p38 MAPK and Akt
10.3390/molecules24081510 · 2019 · External reference
Dehydrocostus lactone inhibits BLM-induced pulmonary fibrosis and inflammation in mice via the JNK and p38 MAPK-mediated NF-kappaB signaling pathways
10.1016/j.intimp.2021.107780 · 2021 · External reference
Protective effects of dehydrocostuslactone on rat hippocampal slice injury induced by oxygen‑glucose deprivation/reoxygenation
2018 · External reference
Dehydrocostus Lactone Inhibits Microglia-Mediated Neuroinflammation by Targeting CYP2A6 to Improve Ischemic Brain Injury
10.1111/cns.70502 · 2025 · External reference
Microglia: Immune and non-immune functions
10.1016/j.immuni.2021.09.014 · 2021 · External reference
Microglia in steady state
10.1172/jci90602 · 2017 · External reference
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
10.1016/j.brainresbull.2011.10.004 · 2012 · External reference
Overexpression of Foxc1 ameliorates sepsis‑associated encephalopathy by inhibiting microglial migration and neuroinflammation through the IkappaBalpha/NF‑kappaB pathway
10.3892/mmr.2022.12623 · 2022 · External reference
Microglial NLRP3 Inflammasome Induces Excitatory Synaptic loss through IL-1beta-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy
10.1007/s12035-022-03067-z · 2023 · External reference
Mechanisms and consequences of Jak-STAT signaling in the immune system
10.1038/ni.3691 · 2017 · External reference
Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry
10.1038/s41467-018-04084-0 · 2018 · External reference
De Moraes, breaking the boundaries of affinity selection-mass spectrometry: from ligand screening to target-ligand interaction insights
10.1016/j.jpha.2025.101379 · 2026 · External reference
