Research graph
References from CIO-IAA is a dual ETA/ETB receptor antagonist that suppresses endothelin-1-induced macrophage activation and inflammatory signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Long-term activation of the innate immune system in atherosclerosis
10.1016/j.smim.2016.04.004 · 2016 · External reference
The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications
10.1038/s41392-025-02220-z · 2025 · External reference
Reactive oxygen species (ROS) in macrophage activation and function in diabetes
10.1016/j.imbio.2018.11.010 · 2019 · External reference
Integrin CD11b contributes to hypertension and vascular dysfunction through mediating macrophage adhesion and migration
10.1161/hypertensionaha.122.20328 · 2023 · External reference
Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils
10.1371/journal.pone.0014525 · 2011 · External reference
Endothelial response to pathophysiological stress
10.1161/atvbaha.119.312580 · 2019 · External reference
Inflammation, immunity, and hypertensive end-organ damage
10.1161/circresaha.116.303697 · 2015 · External reference
Endothelin system in hypertension and chronic kidney disease
10.1161/hypertensionaha.123.21716 · 2024 · External reference
The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis
10.1007/s00005-014-0310-1 · 2015 · External reference
Endothelin: 30 years from discovery to therapy
10.1161/hypertensionaha.119.12105 · 2019 · External reference
The causal relationship between endothelin-1 and hypertension: focusing on endothelial dysfunction, arterial stiffness, vascular remodeling, and blood pressure regulation
10.3390/life11090986 · 2021 · External reference
PKC-mediated endothelin-1 expression in endothelial cell promotes macrophage activation in atherogenesis
10.1093/ajh/hpz069 · 2019 · External reference
Endothelin receptor antagonists in chronic kidney disease
10.1038/s41581-024-00908-z · 2025 · External reference
Current and future strategies for targeting the endothelin pathway in cardiovascular disease
10.1038/s44161-023-00347-2 · 2023 · External reference
Endothelin-1 signaling in the kidney: recent advances and remaining gaps
10.1152/ajprenal.00304.2024 · 2025 · External reference
Dapagliflozin induces vasodilation in resistance-size mesenteric arteries by stimulating smooth muscle cell KV7 ion channels
10.1016/j.heliyon.2022.e09503 · 2022 · External reference
Mechanism of canagliflozin-induced vasodilation in resistance mesenteric arteries and the regulation of systemic blood pressure
10.1016/j.jphs.2022.09.004 · 2022 · External reference
Neflamapimod inhibits endothelial cell activation, adhesion molecule expression, leukocyte attachment and vascular inflammation by inhibiting p38 MAPKα and NF-κB signaling
10.1016/j.bcp.2023.115683 · 2023 · External reference
Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK–Akt–eNOS pathway in the isoprenaline-induced oxidative stress model
10.1038/s41598-020-71599-2 · 2020 · External reference
Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways
10.1038/s41598-020-71449-1 · 2020 · External reference
SUMO1 modification of PKD2 channels regulates arterial contractility
10.1073/pnas.1917264116 · 2019 · External reference
Measurement of DCF fluorescence as a measure of reactive oxygen species in murine islets of Langerhans
10.1039/c4ay00288a · 2014 · External reference
10.1007/978-1-60761-411-1_4
10.1007/978-1-60761-411-1_4 · External reference
Monocyte adhesion assays for detecting endothelial cell activation in vascular inflammation and atherosclerosis
10.1007/978-1-0716-1924-7_10 · 2022 · External reference
A simple protocol for the subcellular fractionation of skeletal muscle cells and tissue
10.1186/1756-0500-5-513 · 2012 · External reference
Sequential fractionation and isolation of subcellular proteins from tissue or cultured cells
10.1016/j.mex.2015.11.001 · 2015 · External reference
Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway
10.1038/s41598-017-13343-x · 2017 · External reference
Structural basis of antagonist selectivity in endothelin receptors
10.1038/s41421-024-00705-9 · 2024 · External reference
X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
10.1038/nsmb.3450 · 2017 · External reference
OPLS4: improving force field accuracy on challenging regimes of chemical space
10.1021/acs.jctc.1c00302 · 2021 · External reference
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Molecular dynamics simulations of phosphatidylcholine membranes: a comparative force field study
10.1021/ct3003157 · 2012 · External reference
The nose–hoover thermostat
1985 · External reference
Neflamapimod induces vasodilation in resistance mesenteric arteries by inhibiting p38 MAPKα and downstream Hsp27 phosphorylation
10.1038/s41598-022-08877-8 · 2022 · External reference
Reduced macrophage-dependent inflammation improves endothelin-1–induced vascular injury
10.1161/hypertensionaha.113.01298 · 2013 · External reference
Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques
10.1016/j.atherosclerosis.2019.09.020 · 2020 · External reference
Oxidative stress and hypertension
10.1161/circresaha.121.318063 · 2021 · External reference
Leukocyte engagement of platelet glycoprotein Ibα via the integrin Mac-1 is critical for the biological response to vascular injury
10.1161/circulationaha.105.571315 · 2005 · External reference
Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure
10.1371/journal.pone.0036815 · 2012 · External reference
Analysis and quantitation of NF-κB nuclear translocation in tumor necrosis factor alpha (TNF-α) activated vascular endothelial cells
10.1017/s1431927606060260 · 2006 · External reference
Signaling pathways in inflammation and cardiovascular diseases: an update of therapeutic strategies
10.3390/immuno2040039 · 2022 · External reference
A p38–p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells, Biochimica et Biophysica Acta (BBA)-Molecular
2008 · External reference
Understanding the molecular mechanism of endothelin ETA receptor selecting isopeptides endothelin-1 and-3
10.1016/j.bpj.2022.06.006 · 2022 · External reference
Activation mechanism of endothelin ETB receptor by endothelin-1
10.1038/nature19319 · 2016 · External reference
Endothelin-1 stimulates the biosynthesis of tumour necrosis factor in macrophages; et-receptors, signal transduction and inhibition by dexamethasone
1997 · External reference
Rat peritoneal macrophages express endothelin ETB but not endothelin ETA receptors
10.1016/s0014-2999(97)81949-8 · 1997 · External reference
Stimuli of sensory-motor nerves terminate arterial contractile effects of endothelin-1 by CGRP and dissociation of ET-1/ETA-receptor complexes
10.1371/journal.pone.0010917 · 2010 · External reference
10.1371/journal.pone.0047662
10.1371/journal.pone.0047662 · External reference
Endothelin receptor heteromerization inhibits β-arrestin function in HEK293 cells
10.1139/cjpp-2019-0620 · 2020 · External reference
Endothelin-1 induces CD40 but not IL-6 in human monocytes via the proinflammatory transcription factor NF-kappaB
2005 · External reference
BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist
10.1016/s0022-3565(25)24538-4 · 1995 · External reference
GPCR signaling via β-arrestin-dependent mechanisms
10.1097/fjc.0000000000000482 · 2017 · External reference
Endothelin‐1 stimulates human monocytes in vitro to release TNF‐α, IL‐1β and IL‐6
10.1155/s0962935193000596 · 1993 · External reference
Endothelin-1 impairs coronary arteriolar dilation: role of p38 kinase-mediated superoxide production from NADPH oxidase
10.1016/j.yjmcc.2015.07.014 · 2015 · External reference
Dissociation characteristics of endothelin ETA receptor agonists and antagonists
10.1097/00005344-199506263-00113 · 1995 · External reference
