Research graph
References from 3-Methoxychrysazin suppresses RANKL-induced osteoclastogenesis by modulating Notch2 signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Physiology of bone
10.1159/000380991 · 2015 · External reference
Bone remodeling
10.1196/annals.1365.035 · 2006 · External reference
Aging of the bone
10.1007/978-981-13-1117-8_12 · 2018 · External reference
Osteoblast-osteoclast interactions
10.1080/03008207.2017.1290085 · 2018 · External reference
Osteoblast-osteoclast communication and bone homeostasis
10.3390/cells9092073 · 2020 · External reference
Bone quality changes associated with aging and disease: a review
10.1111/nyas.13572 · 2017 · External reference
Functions of RANKL/RANK/OPG in bone modeling and remodeling
10.1016/j.abb.2008.03.018 · 2008 · External reference
Current understanding of RANK signaling in osteoclast differentiation and maturation
10.14348/molcells.2017.0225 · 2017 · External reference
RANKL-RANK signaling in osteoclastogenesis and bone disease
10.1016/j.molmed.2005.11.007 · 2006 · External reference
Bone: oxidative stress and osteoporosis
2014 · External reference
Oxidative stress in bone remodelling and disease
10.1016/j.molmed.2009.08.004 · 2009 · External reference
Regulation of notch signaling activity
10.1016/j.cub.2004.01.023 · 2004 · External reference
Regulation of notch signaling through intracellular transport
10.1016/bs.ircmb.2015.12.002 · 2016 · External reference
Notch signaling: cell fate control and signal integration in development
10.1126/science.284.5415.770 · 1999 · External reference
Jagged: a mammalian ligand that activates Notch1
10.1016/0092-8674(95)90294-5 · 1995 · External reference
The canonical Notch signaling pathway: unfolding the activation mechanism
10.1016/j.cell.2009.03.045 · 2009 · External reference
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
10.1093/intimm/dxf030 · 2002 · External reference
Notch signalling: a simple pathway becomes complex
10.1038/nrm2009 · 2006 · External reference
10.1126/stke.3642006cm7
10.1126/stke.3642006cm7 · External reference
Notch signaling pathway: architecture, disease, and therapeutics
10.1038/s41392-022-00934-y · 2022 · External reference
Notch in skeletal physiology and disease
10.1007/s00198-018-4694-3 · 2018 · External reference
Notch signaling in osteogenesis, osteoclastogenesis, and angiogenesis
10.1016/j.ajpath.2019.05.005 · 2019 · External reference
The role of Notch signaling pathway in metabolic bone diseases
10.1016/j.bcp.2022.115377 · 2023 · External reference
Notch and the regulation of osteoclast differentiation and function
10.1016/j.bone.2020.115474 · 2020 · External reference
Notch2 signaling promotes osteoclast resorption via activation of PYK2
10.1016/j.cellsig.2016.01.016 · 2016 · External reference
NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
10.1074/jbc.m610701200 · 2007 · External reference
Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression
10.1038/aps.2015.85 · 2016 · External reference
Biology of RANK, RANKL, and osteoprotegerin
10.1186/ar2165 · 2007 · External reference
Notch signaling deregulation in multiple myeloma: a rational molecular target
10.18632/oncotarget.5025 · 2015 · External reference
The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis
10.1128/mcb.00299-08 · 2008 · External reference
Insecticidal toxins from the bacterium Photorhabdus luminescens
10.1126/science.280.5372.2129 · 1998 · External reference
Toxins and secretion systems of Photorhabdus luminescens
10.3390/toxins2061250 · 2010 · External reference
Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens
10.1021/cb100117k · 2010 · External reference
Identification of an anthraquinone pigment and a hydroxystilbene antibiotic from Xenorhabdus luminescens
10.1128/aem.54.6.1602-1605.1988 · 1988 · External reference
Selective toxicity of secondary metabolites from the entomopathogenic bacterium Photorhabdus luminescens sonorensis against selected plant parasitic nematodes of the Tylenchina suborder
10.1128/spectrum.02577-21 · 2022 · External reference
Pyrazinone protease inhibitor metabolites from Photorhabdus luminescens
10.1038/ja.2016.79 · 2016 · External reference
Identification, characterization, and regulation of a cluster of genes involved in carbapenem biosynthesis in Photorhabdus luminescens
10.1128/aem.68.8.3780-3789.2002 · 2002 · External reference
Natural products from Photorhabdus and Xenorhabdus: mechanisms and impacts
10.1007/s00253-022-12023-9 · 2022 · External reference
Identification of two pigments and a hydroxystilbene antibiotic from Photorhabdus luminescens
10.1128/aem.61.12.4329-4333.1995 · 1995 · External reference
A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens
10.1002/cbic.200700300 · 2007 · External reference
Neuroprotective and anti-neuroinflammatory activities of anthraquinones isolated from Photorhabdus temperata culture broth
10.4014/jmb.1708.08067 · 2018 · External reference
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
10.1007/s12272-024-01486-1 · 2024 · External reference
Phenolic compounds isolated from Juncus decipiens and their effects on osteoblast differentiation in the mouse mesenchymal stem cell line C3H10T1/2
10.20307/nps.2024.30.2.135 · 2024 · External reference
Activation of cryptic biosynthetic pathways in Saccharopolyspora spinosa through deletion of the spinosyn gene cluster: induction of cryptic and bioactive natural products
10.1007/s12272-025-01553-1 · 2025 · External reference
1, 8-Dihydroxy-3-methoxy-anthraquinone inhibits tumor angiogenesis through HIF-1α downregulation
10.1016/j.bcp.2023.115972 · 2024 · External reference
Chemistry and antifungal activity of Xyris species (Xyridaceae): a new anthraquinone from Xyris Pilosa
10.1016/j.bse.2003.11.006 · 2004 · External reference
Therapeutic antibody targeting of individual Notch receptors
10.1038/nature08878 · 2010 · External reference
Structural basis for autoinhibition of Notch
10.1038/nsmb1227 · 2007 · External reference
Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function
10.1016/j.jbc.2021.101376 · 2021 · External reference
IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways
10.1091/mbc.e02-07-0404 · 2003 · External reference
NOTCH2 promotes osteoclast maturation and metabolism and modulates the transcriptome profile during osteoclastogenesis
10.1016/j.jbc.2023.105613 · 2024 · External reference
presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
10.1038/19083 · 1999 · External reference
