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References from Role of sirtuin 7 (SIRT7) in hepatic physiology and pathophysiology: mechanism, prospective and therapeutic potential. Local targets link to admitted publications; unresolved targets remain external evidence.
The sirtuin family in health and disease
10.1038/s41392-022-01257-8 · 2022 · External reference
Sirtuins: NAD(+)-dependent deacetylase mechanism and regulation
10.1016/j.cbpa.2012.10.003 · 2012 · External reference
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
10.1111/j.1474-9726.2007.00304.x · 2007 · External reference
Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism
10.1016/j.tips.2015.08.001 · 2015 · External reference
SIRT2 puts the brakes on human β cell proliferation: therapeutic opportunities and next challenges
10.1172/jci197142 · 2025 · External reference
SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions
10.3390/genes12091361 · 2021 · External reference
Unraveling the multifaceted role of SIRT7 and its therapeutic potential in human diseases
2024 · External reference
A Double-Edged Role for SIRT7 in Cancer: can Anti-Cancer Immunity Tip the Balance?
10.3390/ph18121878 · 2025 · External reference
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
10.1007/s13238-020-00728-4 · 2020 · External reference
Sirtuin 7 Promotes Alcohol-Associated Liver Injury via Modulating Myeloid Cell Chemokine (C-C motif) Ligand 2 Secretion through the NF-κB Signaling Pathway
10.1016/j.ajpath.2024.12.006 · 2025 · External reference
SIRT7 protects against liver fibrosis by suppressing stellate cell activation via TGF-β/SMAD2/3 pathway
10.1016/j.biopha.2024.117477 · 2024 · External reference
SIRT7 promotes Hippo/YAP activation and cancer cell proliferation in hepatocellular carcinoma via suppressing MST1
10.1111/cas.16091 · 2024 · External reference
10.1016/j.isci.2024.110911
10.1016/j.isci.2024.110911 · External reference
Sirtuin 6: linking longevity with genome and epigenome stability
10.1016/j.tcb.2021.06.009 · 2021 · External reference
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis
10.1371/journal.pone.0000784 · 2007 · External reference
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
10.1128/mcb.01636-07 · 2007 · External reference
SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK
10.18632/aging.100616 · 2013 · External reference
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
10.1016/j.cell.2009.02.026 · 2009 · External reference
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
10.1242/jcs.042382 · 2009 · External reference
SIRT7: the seventh key to unlocking the mystery of aging
10.1152/physrev.00044.2022 · 2024 · External reference
SIRT7 is a Lysine Deacylase with a Preference for Depropionylation and Demyristoylation
10.3390/ijms26073153 · 2025 · External reference
SIRT7 is an RNA-Activated Protein Lysine Deacylase
10.1021/acschembio.6b00954 · 2017 · External reference
SIRT7 in the aging process
10.1007/s00018-022-04342-x · 2022 · External reference
Structural basis of SIRT7 nucleosome engagement and substrate specificity
10.1038/s41467-025-56529-y · 2025 · External reference
Discovery of SIRT7 Inhibitor as New Therapeutic Options against Liver Cancer
10.3389/fcell.2021.813233 · 2022 · External reference
Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal
10.1111/febs.12346 · 2013 · External reference
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
10.1091/mbc.e05-01-0033 · 2005 · External reference
Sirtuin catalysis and regulation
10.1074/jbc.r112.378877 · 2012 · External reference
Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7
10.3389/fendo.2018.00652 · 2018 · External reference
SIRT7 is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context
10.1021/acschembio.5b01084 · 2016 · External reference
Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7
10.1016/j.molcel.2013.10.010 · 2013 · External reference
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function
10.1016/j.cmet.2014.08.001 · 2014 · External reference
SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair
10.1126/sciadv.aav1118 · 2019 · External reference
SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription
10.1093/nar/gkx053 · 2017 · External reference
Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging
10.1002/pmic.201400001 · 2014 · External reference
SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury
10.1038/s41419-025-07549-5 · 2025 · External reference
10.1016/j.isci.2024.110014
10.1016/j.isci.2024.110014 · External reference
Identification of a novel SIRT7 inhibitor as anticancer drug candidate
10.1016/j.bbrc.2018.11.120 · 2019 · External reference
Dual Roles of SIRT7 Inhibition by Oroxylin a Reprogram HSCs Fate: PRMT5 Succinylation-Driven Senescence and Ecto-Calreticulin-Dependent NK Cell Immune Clearance in Liver Fibrosis
2025 · External reference
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
10.1038/ncomms12235 · 2016 · External reference
SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing
10.1038/ncomms10734 · 2016 · External reference
Circadian rhythm, glucose metabolism and diabetic complications: the role of glucokinase and the enlightenment on future treatment
2025 · External reference
SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis
10.1038/s42255-019-0136-6 · 2019 · External reference
Systemic oscillator-driven and nutrient-responsive hormonal regulation of daily expression rhythms for gluconeogenic enzyme genes in the mouse liver
10.1080/07420528.2019.1570246 · 2019 · External reference
Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle
2022 · External reference
The role of circadian rhythm disruptions in the diabetes pathogenesis
10.2478/enr-2025-0024 · 2025 · External reference
The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
10.1155/2020/3920196 · 2020 · External reference
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism
10.1016/j.cmet.2025.07.010 · 2025 · External reference
DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver
10.2337/db16-1600 · 2017 · External reference
Dapagliflozin-intermittent fasting combination maximizes weight and metabolic regulation through AMPK/sirtuins/clock genes and gut microbiota signaling in high-fat diet-induced obesity: a novel anti-obesity approach
10.1186/s13578-026-01557-4 · 2026 · External reference
Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis
10.1074/jbc.m117.780130 · 2017 · External reference
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
10.1016/j.celrep.2013.10.007 · 2013 · External reference
Analysis of Myc-induced histone modifications on target chromatin
10.1371/journal.pone.0003650 · 2008 · External reference
Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1
10.1172/jci.insight.147692 · 2021 · External reference
SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging
10.1016/j.molcel.2025.05.025 · 2025 · External reference
SIRT7 regulates T-cell antitumor immunity through modulation BCAA and fatty acid metabolism
10.1038/s41418-025-01490-y · 2025 · External reference
Musclin attenuates lipid deposition in hepatocytes through SIRT7/autophagy-mediated suppression of ER stress
10.1016/j.bbrc.2023.03.065 · 2023 · External reference
The seven faces of SIRT7
10.1080/21541264.2016.1276658 · 2017 · External reference
The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability
10.1074/jbc.ac118.003325 · 2018 · External reference
Epigenetic control of RNA polymerase I transcription in mammalian cells
10.1016/j.bbagrm.2012.10.004 · 2013 · External reference
The epigenetics of rRNA genes: from molecular to chromosome biology
10.1146/annurev.cellbio.24.110707.175259 · 2008 · External reference
SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome
10.1042/cs20210392 · 2021 · External reference
SIRT7 Promotes Hepatitis B Virus Transcription via the Upregulation of DDB1 Expression and Facilitation of DDB1 Recruitment to Covalently Closed Circular DNA
10.31083/fbl46445 · 2025 · External reference
From NAFLD to NASH: Understanding the spectrum of non-alcoholic liver diseases and their consequences
10.1016/j.heliyon.2024.e30387 · 2024 · External reference
10.1159/000539371
10.1159/000539371 · 2024 · External reference
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
10.1016/j.jhep.2023.06.003 · 2023 · External reference
Alcoholic liver disease: pathogenesis and new therapeutic targets
10.1053/j.gastro.2011.09.002 · 2011 · External reference
Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance from the American Association for the Study of Liver Diseases
10.1002/hep.30866 · 2020 · External reference
Pathogenesis of alcoholic liver disease: role of oxidative metabolism
10.3748/wjg.v20.i47.17756 · 2014 · External reference
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease
10.3390/ijms20112712 · 2019 · External reference
Lipid metabolism-MAFLD crosstalk: mechanisms and therapy
2026 · External reference
A Comprehensive Review of Pathophysiological link between Non-alcoholic Fatty Liver Disease, Insulin Resistance, and Metabolic Syndrome
2024 · External reference
Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
10.1016/j.freeradbiomed.2020.02.025 · 2020 · External reference
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway
10.1016/j.cmet.2014.03.006 · 2014 · External reference
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4
10.1016/j.bbrc.2017.06.057 · 2017 · External reference
Crotonylation of IDH1 alleviates MASLD progression by enhancing the TCA cycle
10.1038/s41467-025-62731-9 · 2025 · External reference
Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease
10.3390/biomedicines8030050 · 2020 · External reference
CYP2E1 and oxidative liver injury by alcohol
10.1016/j.freeradbiomed.2007.11.004 · 2008 · External reference
Pathogenesis of Alcoholic Fatty Liver a Narrative Review
2023 · External reference
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
10.1101/gad.1399706 · 2006 · External reference
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
10.1038/nature11043 · 2012 · External reference
Innate immunity in alcoholic liver disease
10.1152/ajpgi.00537.2010 · 2011 · External reference
Baveno VII - Renewing consensus in portal hypertension
10.1016/j.jhep.2021.12.022 · 2022 · External reference
AASLD Practice Guidance on risk stratification and management of portal hypertension and varices in cirrhosis
10.1097/hep.0000000000000647 · 2024 · External reference
Molecular and cellular mechanisms of liver fibrosis and its regression
10.1038/s41575-020-00372-7 · 2021 · External reference
Single-Cell Transcriptomic Analysis reveals a Hepatic Stellate Cell-Activation Roadmap and Myofibroblast Origin during Liver Fibrosis in mice
10.1002/hep.31987 · 2021 · External reference
SIRT7 affects autophagy and activation of hepatic stellate cells by regulating the acetylation level of high mobility group protein 1
10.1016/j.imbio.2022.152323 · 2023 · External reference
Rehmannioside D ameliorates hepatocyte apoptosis and liver fibrosis by suppressing Sirt7/p53 axis
10.1016/j.jep.2025.120863 · 2026 · External reference
A novel RELA K119 deacetylation mediated by SIRT7 is a pivotal activator to exacerbate liver inflammation and fibrosis in teleosts
10.1007/s42995-025-00287-9 · 2025 · External reference
AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma
10.1097/hep.0000000000000466 · 2023 · External reference
Management of hepatocellular carcinoma
10.1016/j.jhep.2018.03.019 · 2018 · External reference
10.1016/j.jhep.2024.08.028
10.1016/j.jhep.2024.08.028 · 2025 · External reference
Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma
10.1038/s41575-020-00395-0 · 2021 · External reference
Mechanisms of drug resistance in HCC
10.1097/hep.0000000000000237 · 2024 · External reference
CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma
10.1038/s41417-022-00512-y · 2022 · External reference
Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b
10.1002/hep.26101 · 2013 · External reference
Analysis of the Expression and Prognostic Value of SIRTs in Hepatocellular Carcinoma
10.2147/ijgm.s460549 · 2024 · External reference
Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis
10.1016/j.canlet.2021.10.039 · 2022 · External reference
SIRT7 stabilizes β-catenin and promotes canonical Wnt activation via upregulating FZD7
10.1016/j.lfs.2024.123240 · 2024 · External reference
Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair
10.5483/bmbrep.2023-0187 · 2024 · External reference
SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway
10.1186/s13046-019-1246-4 · 2019 · External reference
Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma
10.1016/j.drup.2024.101054 · 2024 · External reference
Disruption of SIRT7 increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells
10.1053/j.gastro.2019.10.025 · 2020 · External reference
Protein phosphatases regulate the liver microenvironment in the development of hepatocellular carcinoma
10.1038/s12276-022-00883-0 · 2022 · External reference
Emerging roles of SIRT7 in metabolic homeostasis and related disorders
10.1016/j.bbadis.2026.168343 · 2026 · External reference
MiR-148a-3p/SIRT7 Axis Relieves Inflammatory-Induced Endothelial Dysfunction
10.3390/ijms25105087 · 2024 · External reference
Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis
10.1038/s41467-021-25274-3 · 2021 · External reference
Resmetirom therapy for metabolic dysfunction-associated steatotic liver disease: October 2024 updates to AASLD Practice Guidance
10.1097/hep.0000000000001112 · 2025 · External reference
Semaglutide therapy for metabolic dysfunction-associated steatohepatitis: November 2025 updates to AASLD Practice Guidance
10.1097/hep.0000000000001608 · 2026 · External reference
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
10.3390/cells9040875 · 2020 · External reference
Tacrolimus Inhibits Hepatic Ferroptosis through Modulating SIRT7-Dependent NRF2 Activation in Diabetes
10.3390/antiox15050589 · 2026 · External reference
Discovery of SIRT7 Inhibitor as New Therapeutic Options against Liver Cancer
2021 · External reference
A Candidate Drug Screen Strategy: the Discovery of Oroxylin a in Scutellariae Radix against Sepsis via the Correlation Analysis between Plant Metabolomics and Pharmacodynamics
2022 · External reference
Quality evaluation of Xinjiang Rehmannia glutinosa and Rehmannia glutinosa based on fingerprint and multi-component quantification combined with chemical pattern recognition
2025 · External reference
Clinical significance of the Pharmacological Efficacy of Tacrolimus estimated by the Lymphocyte Immunosuppressant Sensitivity Test (LIST) before and after Renal Transplantation
10.3727/215517912x639360 · 2012 · External reference