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References from Prolactin receptor signaling in liver homeostasis and disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Prolactin (PRL) and its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout mice
10.1210/edrv.19.3.0334 · 1998 · External reference
Minireview: Extrapituitary prolactin: an update on the distribution, regulation, and functions
10.1210/me.2013-1349 · 2014 · External reference
Prolactin - a pleiotropic factor in health and disease
10.1038/s41574-019-0194-6 · 2019 · External reference
Widespread Cell-specific Prolactin Receptor Expression in Multiple Murine Organs
10.1210/en.2019-00234 · 2019 · External reference
A Hormone Cell Atlas maps the human endocrine system at cellular resolution
10.1126/science.aeb2672 · 2026 · External reference
Targeted expression of the dominant-negative prolactin receptor in the mammary gland of transgenic mice results in impaired lactation
10.1210/en.2002-221038 · 2003 · External reference
Prolactin: structure, receptors, and functions
10.1007/s11154-024-09915-8 · 2024 · External reference
Prolactin promotes normal liver growth, survival, and regeneration in rodents: effects on hepatic IL-6, suppressor of cytokine signaling-3, and angiogenesis
10.1152/ajpregu.00282.2013 · 2013 · External reference
Prolactin regulates liver growth during postnatal development in mice
10.1152/ajpregu.00003.2018 · 2018 · External reference
Prolactin Upregulates Female-Predominant P450 Gene Expressions and Downregulates Male-Predominant Gene Expressions in Mouse Liver
10.1124/dmd.116.074658 · 2017 · External reference
Expression and distribution of the prolactin receptor in normal rat liver and in experimental liver cirrhosis
10.1055/s-2001-16229 · 2001 · External reference
Expression and distribution of prolactin receptor in normal, fibrotic, and cirrhotic human liver
10.1055/s-2006-948310 · 2006 · External reference
Prolactin promotes hepatocellular carcinoma through Janus kinase 2
10.1007/s00268-012-1505-4 · 2012 · External reference
Prolactin improves hepatic steatosis via CD36 pathway
10.1016/j.jhep.2018.01.035 · 2018 · External reference
Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice
10.1095/biolreprod.108.070003 · 2008 · External reference
The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5
1990 · External reference
Subdomain 2, not the Transmembrane Domain, Determines the Dimerization Partner of Growth Hormone Receptor and Prolactin Receptor
10.1210/en.2017-00469 · 2017 · External reference
Expression of multiple forms of the prolactin receptor in mouse liver
10.1210/mend-3-4-674 · 1989 · External reference
The prolactin/growth hormone receptor family
10.1210/edrv-12-3-235 · 1991 · External reference
Prolactin: structure, function, and regulation of secretion
10.1152/physrev.2000.80.4.1523 · 2000 · External reference
Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11
10.1074/jbc.m102109200 · 2001 · External reference
Multiple new isoforms of the human prolactin receptor gene
10.1007/978-1-4757-4242-8_71 · 2004 · External reference
Functional characterization of the intermediate isoform of the human prolactin receptor
10.1074/jbc.274.50.35461 · 1999 · External reference
Prolactin receptor signal transduction
10.1191/096120301717164949 · 2001 · External reference
The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer
10.7150/thno.51712 · 2021 · External reference
The human intermediate prolactin receptor is a mammary proto-oncogene
10.1038/s41523-021-00243-7 · 2021 · External reference
Prolactin receptor gene transcriptional control, regulatory modalities relevant to breast cancer resistance and invasiveness
10.3389/fendo.2022.949396 · 2022 · External reference
Mouse prolactin receptor gene: genomic organization reveals alternative promoter usage and generation of isoforms via alternative 3'-exon splicing
10.1089/dna.1998.17.761 · 1998 · External reference
Visualization of gene expression of short and long forms of prolactin receptor in rat reproductive tissues
10.1095/biolreprod49.3.528 · 1993 · External reference
Prolactin Receptor Isoforms as the Basis of Tissue-specific Action of Prolactin in the Norm and Pathology
10.1134/s0006297919040011 · 2019 · External reference
Visualization of gene expression of short and long forms of prolactin receptor in rat digestive tissues
1994 · External reference
Visualization of gene expression of short and long forms of prolactin receptor in the rat
10.1210/endo.133.1.8319561 · 1993 · External reference
Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein
10.1677/jme.0.0300031 · 2003 · External reference
Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice
10.1073/pnas.1404267111 · 2014 · External reference
Prolactin (PRL) receptor gene expression in mouse adipose tissue: increases during lactation and in PRL-transgenic mice
10.1210/endo.141.10.7691 · 2000 · External reference
What can we learn from rodents about prolactin in humans?
10.1210/er.2007-0017 · 2008 · External reference
The prolactin receptor: a cross-species comparison of gene structure, transcriptional regulation, tissue-specificity, and genetic variation
10.1111/jne.13385 · 2024 · External reference
PRLR regulates hepatic insulin sensitivity in mice via STAT5
10.2337/db13-0182 · 2013 · External reference
Janus kinases: components of multiple signaling pathways
10.1038/sj.onc.1203925 · 2000 · External reference
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways
10.1210/me.2007-0173 · 2007 · External reference
Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor
10.1038/79047 · 2000 · External reference
Activation of receptor-associated tyrosine kinase JAK2 by prolactin
10.1016/s0021-9258(17)37695-0 · 1994 · External reference
Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
10.1016/j.cellsig.2011.06.014 · 2011 · External reference
The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
10.7554/elife.84645 · 2023 · External reference
STAT5 acts as a repressor to regulate early embryonic erythropoiesis
10.1182/blood-2006-05-022137 · 2006 · External reference
The JAK/STAT signaling pathway: from bench to clinic
10.1038/s41392-021-00791-1 · 2021 · External reference
JAK-STAT signaling: from interferons to cytokines
10.1074/jbc.r700016200 · 2007 · External reference
DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites
10.1128/mcb.20.1.389-401.2000 · 2000 · External reference
Stoichiometric structure-function analysis of the prolactin receptor signaling domain by receptor chimeras
10.1128/mcb.18.2.896 · 1998 · External reference
Tyrosine docking sites of the rat prolactin receptor required for association and activation of stat5
10.1074/jbc.272.40.25043 · 1997 · External reference
Rapid stimulation of mitogen-activated protein kinase of rat liver by prolactin
10.1042/bj3030429 · 1994 · External reference
Prolactin activates protein kinase C and stimulates growth-related gene expression in rat liver
10.1016/0303-7207(91)90092-7 · 1991 · External reference
A short form of the prolactin (PRL) receptor is able to rescue mammopoiesis in heterozygous PRL receptor mice
10.1210/me.2002-0181 · 2003 · External reference
Inhibition of MAPK by prolactin signaling through the short form of its receptor in the ovary and decidua: involvement of a novel phosphatase
10.1074/jbc.m110.166603 · 2011 · External reference
Rapid activation of protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogen
10.1073/pnas.85.22.8649 · 1988 · External reference
Identification of prolactin receptors in hepatic nuclei
10.1016/0003-9861(92)90563-c · 1992 · External reference
HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription
10.1210/me.2011-0106 · 2011 · External reference
Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development
10.1172/jci119239 · 1997 · External reference
The regulation of IGFs and IGFBPs by prolactin in primary culture of fetal rat hepatocytes is influenced by maternal malnutrition
10.1152/ajpendo.00509.2005 · 2006 · External reference
Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations
10.1210/edrv-10-1-68 · 1989 · External reference
Acute effects of rat growth hormone (GH), human GH and prolactin on proliferating rat liver cells in vitro: a study of mitotic behaviour and ultrastructural alterations
10.1016/0040-8166(94)90029-9 · 1994 · External reference
Prolactin receptor is associated with c-src kinase in rat liver
1995 · External reference
Signal transduction pathway of prolactin in rat liver
10.1016/s0303-7207(97)00204-9 · 1997 · External reference
Prolactin administration stimulates rat hepatic DNA synthesis
10.1016/s0006-291x(86)80401-6 · 1986 · External reference
Hepatic protein kinase C: translocation stimulated by prolactin and partial hepatectomy
10.1016/0024-3205(87)90429-2 · 1987 · External reference
Ablation of prolactin receptor increases hepatic triglyceride accumulation
10.1016/j.bbrc.2018.03.048 · 2018 · External reference
Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms
10.1186/1472-6793-7-6 · 2007 · External reference
Upregulation of hepatic prolactin receptor gene expression by 17beta-estradiol following trauma-hemorrhage
10.1152/japplphysiol.00681.2003 · 2003 · External reference
Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-kappaB/NLRP3 inflammasome circuit
10.1073/pnas.2000466117 · 2020 · External reference
Isolation, purification, and characterization of mouse placental lactogen
10.1073/pnas.79.3.771 · 1982 · External reference
Zinc mediation of the binding of human growth hormone to the human prolactin receptor
10.1126/science.2270485 · 1990 · External reference
Molecular mechanisms of prolactin and its receptor
10.1210/er.2011-1040 · 2012 · External reference
Growth hormone pretranslationally regulates the sexually dimorphic expression of the prolactin receptor gene in rat liver
10.1210/mend-4-8-1235 · 1990 · External reference
Functional heterodimerization of prolactin and growth hormone receptors by ovine placental lactogen
10.1074/jbc.275.9.6295 · 2000 · External reference
Development of a novel ligand that activates JAK2/STAT5 signaling through a heterodimer of prolactin receptor and growth hormone receptor
10.1080/10799890902845252 · 2009 · External reference
GHR/PRLR Heteromultimer is Composed of GHR Homodimers and PRLR Homodimers
10.1210/me.2015-1319 · 2016 · External reference
Contrasting acute in vivo nuclear actions of growth hormone and prolactin
10.1016/0303-7207(96)03838-5 · 1996 · External reference
Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism
10.1111/j.1749-6632.2011.06100.x · 2011 · External reference
Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
10.1101/gad.1643908 · 2008 · External reference
The prolactin/growth hormone receptor family: structure/function relationships
10.1023/a:1026313211704 · 1997 · External reference
Liver sex Dimorphism and Zonation shaped by Growth Hormone
10.1210/endocr/bqac087 · 2022 · External reference
Sex-specific early growth hormone response genes in rat liver
10.1210/me.2007-0549 · 2008 · External reference
Epigenetic modifications in the GH-dependent Prlr, Hnf6, Cyp7b1, Adh1 and Cyp2a4 genes
10.1530/jme-19-0205 · 2020 · External reference
Pituitary and brain dopamine D2 receptors regulate liver gene sexual dimorphism
10.1210/en.2014-1714 · 2015 · External reference
Growth hormone regulation of sex-dependent liver gene expression
10.1210/me.2006-0007 · 2006 · External reference
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
10.1073/pnas.94.14.7239 · 1997 · External reference
Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis
10.1210/me.2005-0489 · 2006 · External reference
Recent advances in anterior pituitary hormones and metabolic-associated fatty liver disease
2025 · External reference
Prolactin-provoked alterations of cytosolic, membrane, and nuclear protein kinase C following partial hepatectomy
10.1007/bf01307529 · 1991 · External reference
Changes in prolactin cells caused by partial hepatectomy in the rat
10.1159/000147118 · 1991 · External reference
Lipid metabolism orchestrates liver regeneration: an integrated metabolic network
10.1186/s12967-025-07232-5 · 2025 · External reference
Metabolic changes after hepatectomy: Implications for perioperative management and long-term outcomes
10.4291/wjgp.v16.i4.109860 · 2025 · External reference
Prolactin's role in the early stages of liver regeneration in rats
10.1002/jcp.21707 · 2009 · External reference
Pregnancy facilitates maternal liver regeneration after partial hepatectomy
10.1152/ajpgi.00125.2019 · 2020 · External reference
Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch
10.1101/gad.563110 · 2010 · External reference
Maternal hepatic growth response to pregnancy in the mouse
10.1258/ebm.2011.011076 · 2011 · External reference
Long isoform of prolactin receptor predominates in rat intrahepatic bile ducts and further increases under obstructive cholestasis
10.1677/joe.1.06468 · 2006 · External reference
Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma
10.18632/oncotarget.8781 · 2016 · External reference
Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas
10.1385/endo:12:3:265 · 2000 · External reference
Prolactin receptor signaling: a novel target for cancer treatment - Exploring anti-PRLR signaling strategies
2022 · External reference
Lower prolactin levels are associated with histological severity of metabolic dysfunction-associated steatotic liver disease
10.1186/s12902-026-02344-5 · 2026 · External reference
Excessive free fatty acid sensing in pituitary lactotrophs elicits steatotic liver disease by decreasing prolactin levels
10.1016/j.celrep.2024.114465 · 2024 · External reference
Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism
2025 · External reference
Establishment of reference values for endocrine tests. II: Hyperprolactinemia
10.1016/s0300-2977(99)00040-6 · 1999 · External reference
Clinical Impact of New Reference Intervals for the Roche Prolactin II Immunoassay
10.1210/jendso/bvae069 · 2024 · External reference
The beneficial metabolic actions of prolactin
10.3389/fendo.2022.1001703 · 2022 · External reference
A Century of Prolactin: Emerging Perspectives as a Metabolic Regulator
10.1002/dmrr.3836 · 2024 · External reference
The beneficial and detrimental effects of prolactin hormone on metabolic syndrome: a double-edge sword
10.1111/jcmm.70067 · 2024 · External reference
Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance
10.1152/ajpendo.00200.2016 · 2016 · External reference
Metabolic functions of prolactin: Physiological and pathological aspects
10.1111/jne.12888 · 2020 · External reference
Metabolic effects of prolactin and the role of dopamine agonists: a review
10.3389/fendo.2022.1002320 · 2022 · External reference
Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: a systematic review of randomized controlled trials and meta-analysis
10.1007/s11102-010-0290-z · 2011 · External reference
Unresolved reference
2022 · External reference
A pilot study of cabergoline for the treatment of metastatic breast cancer
10.1007/s10549-017-4370-x · 2017 · External reference
Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary
10.1586/17446651.2016.1131119 · 2016 · External reference
Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor
10.1152/ajpendo.00325.2019 · 2020 · External reference
Phase I Study of the Prolactin Receptor Antagonist LFA102 in Metastatic Breast and Castration-Resistant Prostate Cancer
10.1634/theoncologist.2015-0502 · 2016 · External reference
Phase I Study of LFA102 in patients with Advanced Breast Cancer or Castration-resistant Prostate Cancer
10.21873/anticanres.14526 · 2020 · External reference
Targeting Prolactin Receptor (PRLR) Signaling in PRLR-Positive Breast and Prostate Cancer
10.1634/theoncologist.2016-0108 · 2016 · External reference
AZD1480: a phase I study of a novel JAK2 inhibitor in solid tumors
10.1634/theoncologist.2013-0198 · 2013 · External reference
Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates with Treatment Response
10.3389/fimmu.2021.738481 · 2021 · External reference
Ruxolitinib targets JAK-STAT signaling to modulate neutrophil activation in refractory macrophage activation syndrome
10.1182/blood.2024024362 · 2025 · External reference
Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro
10.1016/j.canlet.2013.08.009 · 2013 · External reference
Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma
10.18632/oncotarget.6684 · 2016 · External reference
Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2
10.1186/s12967-022-03366-y · 2022 · External reference
Itacitinib in advanced hepatocellular cancer following first line therapy
10.1038/s41698-026-01273-9 · 2026 · External reference
