Research graph
References from Cebpb/JAK2/STAT3 signaling pathway mediated M1 macrophage polarization and metabolic rewiring drive COPD pathogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Advances in chronic obstructive pulmonary disease
10.1146/annurev-med-080919-112707 · 2021 · External reference
Contemporary concise review 2022: chronic obstructive pulmonary disease
10.1111/resp.14489 · 2023 · External reference
Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations
10.1016/j.ccm.2020.06.007 · 2020 · External reference
Evaluation and management of asthma and chronic obstructive pulmonary disease exacerbation in the emergency department
10.1016/j.emc.2022.05.007 · 2022 · External reference
Early origins of chronic obstructive pulmonary disease: prenatal and early life risk factors
10.3390/ijerph20032294 · 2023 · External reference
Chronic obstructive pulmonary disease in non-smokers
10.1016/s0140-6736(09)61303-9 · 2009 · External reference
The role of lung macrophages in chronic obstructive pulmonary disease
10.1016/j.rmed.2022.107035 · 2022 · External reference
The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis
10.1183/16000617.0263-2023 · 2024 · External reference
Macrophage polarization and functions in pathogenesis of chronic obstructive pulmonary disease
10.3390/ijms25115631 · 2024 · External reference
Epigenetic regulation of macrophage activation in chronic obstructive pulmonary disease
2024 · External reference
Macrophage polarization involved the inflammation of chronic obstructive pulmonary disease by S1P/HDAC1 signaling
2023 · External reference
Exosome microRNA-125a-5p derived from epithelium promotes M1 macrophage polarization by targeting IL1RN in chronic obstructive pulmonary disease
10.1016/j.intimp.2024.112466 · 2024 · External reference
Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease
10.1016/j.intimp.2021.107700 · 2021 · External reference
Metabolic regulation of the immune system in health and diseases: mechanisms and interventions
10.1038/s41392-024-01954-6 · 2024 · External reference
Role of cellular metabolism in the formation of neutrophil extracellular traps in airway diseases
10.3389/fimmu.2022.850416 · 2022 · External reference
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
10.1038/cr.2015.68 · 2015 · External reference
Physiologic disruption and metabolic reprogramming in infection and sepsis
10.1016/j.cmet.2024.02.013 · 2024 · External reference
Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts
10.3389/fimmu.2024.1394108 · 2024 · External reference
Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages
10.1016/j.cmet.2024.08.010 · 2024 · External reference
NRF2 activation reprograms defects in oxidative metabolism to restore macrophage function in chronic obstructive pulmonary disease
10.1164/rccm.202203-0482oc · 2023 · External reference
A review of single-cell RNA-Seq annotation, integration, and cell-cell communication
10.3390/cells12151970 · 2023 · External reference
scRNA-seq data analysis method to improve analysis performance
10.1049/nbt2.12115 · 2023 · External reference
A single-cell RNA sequencing atlas of the chronic obstructive pulmonary disease distal lung to predict cell-cell communication
10.1165/rcmb.2024-0232le · 2025 · External reference
Single-cell hdWGCNA reveals a novel diagnostic model and signature genes of macrophages associated with chronic obstructive pulmonary disease
10.1007/s00011-025-02025-4 · 2025 · External reference
Impaired immune metabolism in COPD driven by dysfunction of CXCL16 + alveolar macrophages: multivariate causal evidence
10.1007/s00335-025-10163-7 · 2025 · External reference
Development, characterization and comparisons of targeted and non-targeted metabolomics methods
10.1371/journal.pone.0207082 · 2018 · External reference
Serum metabolomics analysis of patients with chronic obstructive pulmonary disease and 'frequent exacerbator' phenotype
10.3892/mmr.2024.13261 · 2024 · External reference
Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD)
10.1080/10937404.2023.2208886 · 2023 · External reference
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction
2022 · External reference
Differentiation of THP1 cells into macrophages for transwell co-culture assay with melanoma cells
10.21769/bioprotoc.1638 · 2015 · External reference
Expression characteristics of lipid metabolism-related genes and correlative immune infiltration landscape in acute myocardial infarction
10.1038/s41598-024-65022-3 · 2024 · External reference
TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions
10.1530/jme-13-0243 · 2014 · External reference
S100A4 mediates the accumulation and functions of myeloid-derived suppressor cells via GP130/JAK2/STAT3 signaling in acute myeloid leukemia
10.1016/j.bbadis.2024.167498 · 2025 · External reference
The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease
10.1016/j.ebiom.2019.03.054 · 2019 · External reference
Circular RNA FCHO2 promotes airway remodeling in COPD via regulating nuclear translocation of PTBP1 to repress the splicing of GRN pre-mRNA
10.1038/s41419-025-08107-9 · 2025 · External reference
Metabolomics in COPD
10.1016/j.arbres.2022.12.018 · 2023 · External reference
HMGB1 promotes M1 polarization of macrophages and induces COPD inflammation
10.1002/cbin.12252 · 2025 · External reference
Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1
10.1186/s12931-024-03064-x · 2024 · External reference
The role of macrophages in the development of acute and chronic inflammatory lung diseases
10.3390/cells10040897 · 2021 · External reference
Metabolism, metabolites, and macrophages in cancer
10.1186/s13045-023-01478-6 · 2023 · External reference
Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis
10.1016/j.cmet.2020.11.016 · 2021 · External reference
Neutrophil membrane-camouflaged polyprodrug nanomedicine for inflammation suppression in ischemic stroke therapy
10.1002/adma.202311803 · 2024 · External reference
Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
10.1186/s11658-023-00494-1 · 2023 · External reference
β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury
10.7554/elife.102068.3 · 2025 · External reference
AIM2 inflammasome regulated by the IFN-γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease
10.1002/iid3.1317 · 2024 · External reference
TREM2 impairs glycolysis to interrupt microglial M1 polarization and inflammation via JAK2/STAT3 axis
10.1007/s12013-024-01520-5 · 2025 · External reference
Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling pathways
10.1016/j.ecoenv.2022.114066 · 2022 · External reference
Scutellarin attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting M1 macrophage polarization via the GBP2/JAK2/STAT3 signaling pathway
10.1002/ptr.70099 · 2025 · External reference
