Research graph
References from Chemical proteomics and phenotypic profiling identify αFOD as a podophyllotoxin-derived PGK1 inhibitor that suppresses glycolysis and proliferation in hepatocellular carcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
The latest global burden of liver cancer: a past and present threat
10.3350/cmh.2023.0070 · 2023 · External reference
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018 · External reference
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma
10.1002/ijc.31963 · 2019 · External reference
Advances in the treatment of hepatocellular carcinoma: an overview of the current and evolving therapeutic landscape for clinicians
2025 · External reference
Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: from Molecular Genetics to Targeted Therapies
10.1002/hep.31310 · 2021 · External reference
A new treatment combination for liver cancer
2021 · External reference
Ganoderic acid T, a novel activator of pyruvate carboxylase, exhibits potent anti-liver cancer activity
10.1016/j.metabol.2025.156321 · 2025 · External reference
Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase
10.1038/s41467-023-38753-6 · 2023 · External reference
Identification of a Selective Anticancer Agent from a Collection of Complex-and-Diverse Compounds Synthesized from Stevioside
10.1021/jacs.5c00919 · 2025 · External reference
Hallmarks of cancer: the next generation
10.1016/j.cell.2011.02.013 · 2011 · External reference
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
10.1016/j.cmet.2007.10.002 · 2008 · External reference
In silico analysis of cancer through the Cancer Genome Anatomy Project
10.1016/s0962-8924(01)02104-3 · 2001 · External reference
SAGEmap: a public gene expression resource
10.1101/gr.10.7.1051 · 2000 · External reference
PGK1 is a new member of the protein kinome
10.1080/15384101.2016.1179037 · 2016 · External reference
100 years of the Warburg effect: a cancer metabolism endeavor
10.1016/j.cell.2024.06.026 · 2024 · External reference
On the origin of cancer cells
10.1126/science.123.3191.309 · 1956 · External reference
Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis
10.1002/hep.28887 · 2017 · External reference
Regulation of phosphoglycerate kinase 1 and its critical role in cancer
10.1186/s12964-023-01256-4 · 2023 · External reference
Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication
10.1016/j.molcel.2018.09.007 · 2018 · External reference
Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo
10.1016/j.ejmech.2024.116209 · 2024 · External reference
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6
10.1016/j.apsb.2022.05.012 · 2022 · External reference
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52
10.1038/s41401-020-0465-8 · 2021 · External reference
Highly potent bisphosphonate ligands for phosphoglycerate kinase
10.1021/jm970839y · 1998 · External reference
Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products
10.1016/j.bcp.2020.114343 · 2021 · External reference
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling
10.1038/s41586-018-0622-0 · 2018 · External reference
A novel inhibitor of PGK1 suppresses the aerobic glycolysis and proliferation of hepatocellular carcinoma
10.1016/j.biopha.2022.114115 · 2023 · External reference
Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers
10.1038/s41467-021-25341-9 · 2021 · External reference
Conjugating 4β-NH-(5-Aminoindazole)-podophyllotoxin and Galectin-1-Targeted Aptamer for Synergistic Chemo-Immunotherapy of Hepatocellular Carcinoma
10.1002/adhm.202203144 · 2023 · External reference
Photoaffinity labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE, Cell
2021 · External reference
Protocol for clickable photoaffinity labeling and quantitative chemical proteomics
10.1016/j.xpro.2021.100593 · 2021 · External reference
Terazosin activates Pgk1 and Hsp90 to promote stress resistance
10.1038/nchembio.1657 · 2015 · External reference
Protein Tyrosine Amination: Detection, Imaging, and Chemoproteomic Profiling with Synthetic Probes
10.1021/jacs.4c01028 · 2024 · External reference
Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
10.1038/s41467-025-58107-8 · 2025 · External reference
Gelsedine-type alkaloids: Discovery of natural neurotoxins presented in toxic honey
10.1016/j.jhazmat.2019.120999 · 2020 · External reference
Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025
10.1186/s12943-025-02338-2 · 2025 · External reference
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: an update (2010-2020)
10.1016/j.ejmech.2020.112830 · 2020 · External reference
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis
10.1016/j.molcel.2016.02.009 · 2016 · External reference
A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1
10.1073/pnas.2318956121 · 2024 · External reference
Podophyllum hexandrum and its active constituents: Novel radioprotectants
10.1016/j.biopha.2021.112555 · 2022 · External reference
Insight into the Molecular Mechanism of Podophyllotoxin Derivatives as Anticancer Drugs
10.3389/fcell.2021.709075 · 2021 · External reference
Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1(G93A) astrocytes
10.1080/15548627.2021.1899682 · 2021 · External reference
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms
10.1136/jitc-2021-002722 · 2021 · External reference
Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
2024 · External reference
Topoisomerase II and etoposide - a tangled tale
10.1038/s41589-022-01236-8 · 2023 · External reference
10.1002/advs.202305608
10.1002/advs.202305608 · External reference
Phosphoglycerate kinase 1 (PGK1) in cancer: a promising target for diagnosis and therapy
10.1016/j.lfs.2020.117863 · 2020 · External reference
Bisphosphonate inhibition of phosphoglycerate kinase: quantitative structure-activity relationship and pharmacophore modeling investigation
10.1021/jm0604833 · 2006 · External reference
The FDA Modernization Act 2.0: Drug Testing in animals is Rendered Optional
10.1016/j.amjmed.2023.03.033 · 2023 · External reference
