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References from Aripiprazole collapses metabolic plasticity through the GNAQ/RXRα/MCT4 axis in colorectal cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries
2026 · External reference
Energy metabolic plasticity of colorectal cancer cells as a determinant of tumor growth and metastasis
10.3389/fonc.2021.698951 · 2021 · External reference
Mitochondrial, metabolic and bioenergetic adaptations drive plasticity of colorectal cancer cells and shape their chemosensitivity
10.1038/s41419-025-07596-y · 2025 · External reference
Elucidating the metabolic plasticity of cancer: mitochondrial reprogramming and hybrid metabolic states
10.3390/cells7030021 · 2018 · External reference
Autophagic flux-lipid droplet biogenesis cascade sustains mitochondrial fitness in colorectal cancer cells adapted to acidosis
10.1038/s41420-025-02301-6 · 2025 · External reference
Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease
10.1124/pr.119.018762 · 2020 · External reference
Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)
10.1016/j.pharmthera.2021.107862 · 2021 · External reference
Monocarboxylate transporters in cancer
10.1016/j.molmet.2019.07.006 · 2020 · External reference
Loss of lactate/proton monocarboxylate transporter 4 induces ferroptosis via the AMPK/ACC pathway and inhibition of autophagy on human bladder cancer 5637 cell line
10.1155/2023/2830306 · 2023 · External reference
Formosanin C inhibits non-small-cell lung cancer progression by blocking MCT4/CD147-mediated lactate export
10.1016/j.phymed.2022.154618 · 2023 · External reference
MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells
10.1242/jcs.261608 · 2024 · External reference
MCT4 expression is a potential therapeutic target in colorectal cancer with peritoneal carcinomatosis
10.1158/1535-7163.mct-17-0535 · 2018 · External reference
Management of common adverse effects of antipsychotic medications
10.1002/wps.20567 · 2018 · External reference
The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors
10.1186/s13062-023-00375-9 · 2023 · External reference
Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner
10.1016/j.apsb.2021.09.007 · 2022 · External reference
Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis
10.1038/s41419-022-04828-3 · 2022 · External reference
Antipsychotics possess anti-glioblastoma activity by disrupting lysosomal function and inhibiting oncogenic signaling by stabilizing PTEN
10.1038/s41419-024-06779-3 · 2024 · External reference
Dissecting the novel abilities of aripiprazole: the generation of anti-colorectal cancer effects by targeting Gaq via HTR2B
10.1016/j.apsb.2023.05.015 · 2023 · External reference
Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling
10.1096/fj.02-1122fje · 2003 · External reference
5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis
10.1124/jpet.109.159947 · 2010 · External reference
Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets
10.1182/blood-2006-05-022566 · 2007 · External reference
Targeting altered energy metabolism in colorectal cancer: oncogenic reprogramming, the central role of the TCA cycle and therapeutic opportunities
10.3390/cancers12071731 · 2020 · External reference
Targeting cancer and immune cell metabolism with the complex I inhibitors metformin and IACS-010759
10.1002/1878-0261.13583 · 2024 · External reference
Discovery of a potent and oral available complex I OXPHOS inhibitor that abrogates tumor growth and circumvents MEKi resistance
10.1021/acs.jmedchem.2c01844 · 2023 · External reference
Targeting mitochondrial DNA transcription by POLRMT inhibition or depletion as a potential strategy for cancer treatment
10.3390/biomedicines11061598 · 2023 · External reference
Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack
10.1002/hep.32348 · 2023 · External reference
Discovery of clinical candidate AZD0095, a selective inhibitor of monocarboxylate transporter 4 (MCT4) for oncology
10.1021/acs.jmedchem.2c01342 · 2023 · External reference
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
10.1084/jem.20200924 · 2021 · External reference
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism
10.1074/jbc.m511397200 · 2006 · External reference
ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer
10.1016/j.yexcr.2022.113044 · 2022 · External reference
Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells
10.1038/onc.2017.299 · 2018 · External reference