Research graph
References from Are we at risk of increasing sarcopenia? Implications for osteoarthritis and osteoporosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of sarcopenia: prevalence, risk factors, and consequences
2023 · External reference
Sarcopenia
10.1038/s41572-024-00550-w · 2024 · External reference
Sarcopenia: revised European consensus on definition and diagnosis
10.1093/ageing/afy169 · 2019 · External reference
Asian working group for sarcopenia: 2019 consensus update on Sarcopenia diagnosis and treatment
10.1016/j.jamda.2019.12.012 · 2020 · External reference
Toward the recognition and management of sarcopenia in routine clinical care
10.1038/s43587-021-00136-1 · 2021 · External reference
Ten-year incidence of sarcopenia in a population-based cohort: results from the research on Osteoarthritis/Osteoporosis against disability study
10.1016/j.jamda.2024.105263 · 2024 · External reference
Prevalence and risk factors of osteosarcopenia: a systematic review and meta-analysis
10.1186/s12877-023-04085-9 · 2023 · External reference
Global epidemiological features and impact of osteosarcopenia: a comprehensive meta-analysis and systematic review
10.1002/jcsm.13392 · 2024 · External reference
Sarcopenia definition: the position statements of the Sarcopenia definition and outcomes consortium
10.1111/jgs.16372 · 2020 · External reference
Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study
10.1007/s40520-025-03012-9 · 2025 · External reference
Prevalence of osteosarcopenia in patients with end-stage knee OA who underwent total knee arthroplasty
10.1007/s00198-025-07731-7 · 2026 · External reference
Osteosarcopenia as a predictor of postoperative adverse outcomes in older adults undergoing total hip arthroplasty
10.1007/s00774-025-01671-2 · 2026 · External reference
Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort
10.1016/j.joca.2010.02.002 · 2010 · External reference
Addressing the growing burden of musculoskeletal diseases in the ageing US population: challenges and innovations
10.1016/j.lanhl.2025.100707 · 2025 · External reference
Sarcopenia, osteoporosis and frailty
10.1016/j.metabol.2023.155638 · 2023 · External reference
Research progress on sarcopenia in the musculoskeletal system
10.1038/s41413-025-00455-8 · 2025 · External reference
Genetic analysis of comorbidities between osteoarthritis, sarcopenia, and osteoporosis
10.1016/j.exger.2025.112788 · 2025 · External reference
Osteosarcopenia: a narrative review on clinical studies
10.3390/ijms23105591 · 2022 · External reference
Osteosarcopenia: epidemiology, diagnosis, and treatment-facts and numbers
10.1002/jcsm.12567 · 2020 · External reference
Osteosarcopenic obesity: current knowledge, revised identification criteria and treatment principles
10.3390/nu11040747 · 2019 · External reference
Osteosarcopenic obesity: a systematic review and a call for consensus on definitions and diagnostic criteria
10.1016/j.clnu.2025.06.009 · 2025 · External reference
The association between polypharmacy and physical function in older adults: a systematic review
10.1007/s11606-019-05106-3 · 2019 · External reference
Acute Sarcopenia after elective and emergency surgery
10.14336/ad.2022.0404 · 2022 · External reference
The association between malnutrition and physical performance in older adults: a systematic review and meta-analysis of observational studies
10.1093/cdn/nzac007 · 2022 · External reference
Multimorbidity
10.1038/s41572-022-00376-4 · 2022 · External reference
Prevalence of multimorbidity and polypharmacy among adults and older adults: a systematic review
10.1016/s2666-7568(24)00007-2 · 2024 · External reference
Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension
10.1111/dom.14725 · 2022 · External reference
Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies
10.1111/dom.15728 · 2024 · External reference
Daily walking and the risk of incident functional limitation in knee osteoarthritis: an observational study
10.1002/acr.22362 · 2014 · External reference
Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence
10.1136/bmjopen-2017-017042 · 2017 · External reference
Osteoporosis, fear of falling, and restrictions in daily living. Evidence from a nationally representative sample of community-dwelling older adults
10.3389/fendo.2019.00646 · 2019 · External reference
A systematic review of fear of falling and related constructs after hip fracture: prevalence, measurement, associations with physical function, and interventions
10.1186/s12877-023-03855-9 · 2023 · External reference
Acute sarcopenia secondary to hospitalisation - an emerging condition affecting older adults
10.14336/ad.2017.0315 · 2018 · External reference
Loss of skeletal muscle mass can be predicted by sarcopenia and reflects poor functional recovery at one year after surgery for geriatric hip fractures
10.1016/j.injury.2021.08.007 · 2021 · External reference
Unresolved reference
2024 · External reference
Once-weekly semaglutide in adults with overweight or obesity
10.1056/nejmoa2032183 · 2021 · External reference
Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 randomized clinical trial
10.1001/jama.2023.24945 · 2024 · External reference
Is lost lean mass from intentional weight loss recovered during weight regain in postmenopausal women?
10.3945/ajcn.110.004895 · 2011 · External reference
Weight change and the conservation of lean mass in old age: the health, aging and body composition study
10.1093/ajcn/82.4.872 · 2005 · External reference
Prevalence of sarcopenia in knee osteoarthritis: a systematic review and meta-analysis
10.3390/jcm12041532 · 2023 · External reference
Neuromuscular joint function in knee osteoarthritis: a systematic review and meta-analysis
10.1016/j.rehab.2022.101662 · 2023 · External reference
The effects of pain on quadriceps strength, joint proprioception and dynamic balance among women aged 65 to 75 years with knee osteoarthritis
10.1186/s12877-018-0932-y · 2018 · External reference
Hip strength deficits in people with symptomatic knee osteoarthritis: a systematic review with meta-analysis
10.2519/jospt.2016.6618 · 2016 · External reference
Gait strategies for individuals with knee osteoarthritis when transitioning between floor and stair walking
10.3389/fphys.2023.1026299 · 2023 · External reference
Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis
10.1002/art.24182 · 2009 · External reference
Exploring the link between osteosarcopenia and osteoarthritis in prediabetic adults using NHANES data
2025 · External reference
Sarcopenia and its association with falls and fractures in older adults: a systematic review and meta-analysis
10.1002/jcsm.12411 · 2019 · External reference
Muscle weakness and falls in older adults: a systematic review and meta-analysis
10.1111/j.1532-5415.2004.52310.x · 2004 · External reference
The association between physical activity and osteoporotic fractures: a review of the evidence and implications for future research
10.1016/j.annepidem.2008.08.007 · 2008 · External reference
Stepping impairment and falls in older adults: a systematic review and meta-analysis of volitional and reactive step tests
10.1016/j.arr.2020.101238 · 2021 · External reference
Skeletal muscle disuse atrophy and the rehabilitative role of protein in recovery from musculoskeletal injury
10.1093/advances/nmaa015 · 2020 · External reference
The time course of disuse muscle atrophy of the lower limb in health and disease
10.1002/jcsm.13067 · 2022 · External reference
Change in muscle mass and muscle strength after a hip fracture: relationship to mobility recovery
10.1093/gerona/55.8.m434 · 2000 · External reference
Comparing the fracture profile of osteosarcopenic older adults with Osteopenia/Osteoporosis alone
10.1007/s00223-022-01044-1 · 2023 · External reference
Associations between Osteosarcopenia and falls, fractures, and frailty in older adults: results from the Canadian longitudinal study on aging (CLSA)
10.1016/j.jamda.2023.09.027 · 2024 · External reference
Osteosarcopenia, sarcopenia, and their associations with validated recent fragility fractures in older women: applying seven definitions in the FRISBEE 2 study
10.1007/s41999-025-01273-1 · 2025 · External reference
Prediction of fragility fractures and mortality in a cohort of geriatric patients
10.1002/jcsm.13631 · 2024 · External reference
Impact of osteosarcopenia on disability and mortality among Japanese older adults
10.1002/jcsm.13209 · 2023 · External reference
Osteosarcopenia predicts greater risk of functional disability than sarcopenia: a longitudinal analysis of FraDySMex cohort study
10.1016/j.jnha.2024.100368 · 2024 · External reference
Association between osteosarcopenia and frailty in older adults: a systematic review and meta-analysis
10.1186/s12877-026-06976-z · 2026 · External reference
Osteosarcopenia, bone-muscle interactions, and frailty risk: a prospective cohort study of community-dwelling older adults
10.1007/s40520-025-03242-x · 2025 · External reference
Osteosarcopenia and frailty risk in community-dwelling older adults: a follow-up of the I-Lan longitudinal aging study
10.1016/j.archger.2025.105888 · 2025 · External reference
Three-year mortality of older hospitalized patients with Osteosarcopenia: data from the OsteoSys study
10.3390/nu16091328 · 2024 · External reference
Osteosarcopenia and mortality in older adults undergoing transcatheter aortic valve replacement
10.1001/jamacardio.2024.0911 · 2024 · External reference
Effect of osteosarcopenia on longitudinal mortality risk and chronic kidney disease progression in older adults
10.1016/j.bone.2023.116975 · 2024 · External reference
A clinical guide to the pathophysiology, diagnosis and treatment of osteosarcopenia
10.1016/j.maturitas.2020.05.012 · 2020 · External reference
Osteosarcopenic obesity and the progression of physical frailty, cognition function, and mental health: first longitudinal evidence from ELSA
10.1016/j.jnha.2025.100744 · 2026 · External reference
Advances in body composition and gender differences in susceptibility to frailty syndrome: role of osteosarcopenic obesity
10.1016/j.metabol.2024.156052 · 2024 · External reference
A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities
10.1007/s00198-023-07007-y · 2024 · External reference
Sarcopenic obesity in older adults: a clinical overview
10.1038/s41574-023-00943-z · 2024 · External reference
Osteosarcopenic obesity: the role of bone, muscle, and fat on health
10.1007/s13539-014-0146-x · 2014 · External reference
Comparative efficacy of different weight loss treatments on knee osteoarthritis: a network meta-analysis
10.1111/obr.13230 · 2021 · External reference
Quadriceps arthrogenic muscle inhibition: neural mechanisms and treatment perspectives
10.1016/j.semarthrit.2009.10.001 · 2010 · External reference
Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects
10.1186/ar3467 · 2011 · External reference
Quadriceps arthrogenic muscle inhibition: the effects of experimental knee joint effusion on motor cortex excitability
10.1186/s13075-014-0502-4 · 2014 · External reference
Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines
10.1007/s11914-020-00599-y · 2020 · External reference
Muscle-bone crosstalk and potential therapies for sarco-osteoporosis
10.1002/jcb.28946 · 2019 · External reference
Estimation of skeletal muscle mass relative to adiposity improves prediction of physical performance and incident disability
10.1093/gerona/glx064 · 2018 · External reference
Tale of quadriceps and hamstring muscle strength after ACL reconstruction: a systematic review with longitudinal and multivariate meta-analysis
10.1136/bjsports-2023-107977 · 2025 · External reference
International clinical practice guidelines for Sarcopenia (ICFSR): screening, diagnosis and management
10.1007/s12603-018-1139-9 · 2018 · External reference
Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN expert group
10.1016/j.clnu.2014.04.007 · 2014 · External reference
Mitigating skeletal muscle wasting in unloading and augmenting subsequent recovery
10.1113/jp284301 · 2025 · External reference
Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults
10.1249/mss.0b013e31816a85ce · 2008 · External reference
The impact of ageing mechanisms on musculoskeletal system diseases in the elderly
10.3389/fimmu.2024.1405621 · 2024 · External reference
The role of the kynurenine pathway in the pathophysiology of frailty, Sarcopenia, and osteoporosis
10.3390/nu15143132 · 2023 · External reference
Muscle-bone biochemical crosstalk in osteosarcopenia: focusing on mechanisms and potential therapeutic strategies
10.1530/joe-25-0234 · 2025 · External reference
Insights into the notch signaling pathway in degenerative musculoskeletal disorders: mechanisms and perspectives
10.1016/j.biopha.2023.115884 · 2023 · External reference
Osteosarcopenia: epidemiology, molecular mechanisms, and management
10.3389/fendo.2025.1577758 · 2025 · External reference
Irisin in degenerative musculoskeletal diseases: functions in system and potential in therapy
10.1016/j.phrs.2024.107480 · 2024 · External reference
Exosomal miRNAs in muscle-bone crosstalk: mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia
10.1016/j.metabol.2025.156333 · 2025 · External reference
Microbiome's role in musculoskeletal health through the gut-bone axis insights
10.1080/19490976.2024.2410478 · 2024 · External reference
Effects and mechanisms of polyunsaturated fatty acids on age-related musculoskeletal diseases: sarcopenia, osteoporosis, and Osteoarthritis-A narrative review
10.3390/nu16183130 · 2024 · External reference
Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis
10.1038/s41584-023-00921-9 · 2023 · External reference
Hand grip strength as a proposed new vital sign of health: a narrative review of evidences
10.1186/s41043-024-00500-y · 2024 · External reference
Performance on sit-to-stand tests in relation to measures of functional fitness and sarcopenia diagnosis in community-dwelling older adults
10.1186/s11556-020-00255-5 · 2021 · External reference
A systematic review of the psychometric properties of physical performance tests for sarcopenia in community-dwelling older adults
10.1093/ageing/afae113 · 2024 · External reference
A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission
10.1093/geronj/49.2.m85 · 1994 · External reference
Screening accuracy of SARC-F for sarcopenia in the elderly: a diagnostic meta-analysis
10.1007/s12603-020-1471-8 · 2021 · External reference
The efficacy of nutritional screening indexes in predicting the incidence of osteosarcopenia and major osteoporotic fracture in the elderly
10.1007/s00774-024-01514-6 · 2024 · External reference
Calf circumference as a simple tool versus chest-CT derived skeletal muscle index in assessing osteosarcopenia and one-year outcomes in osteoporotic vertebral fractures
10.1007/s40520-025-03281-4 · 2026 · External reference
The value of ultrasound-measured rectus femoris thickness, cross-sectional area, and shear wave velocity in assessment of muscle in postmenopausal women with osteosarcopenia
10.1093/bjr/tqaf012 · 2025 · External reference
Fourier-transform infrared spectroscopy as a screening tool for Osteosarcopenia in community-dwelling older women
10.1093/gerona/glad081 · 2023 · External reference
Exploring biomarkers of osteosarcopenia in older adults attending a frailty clinic
10.1016/j.exger.2022.112047 · 2023 · External reference
Why Osteosarcopenia matters: clinical and investigative implications
10.1111/eci.70221 · 2026 · External reference
Musculoskeletal exercise: its role in promoting health and longevity
10.1016/j.pcad.2023.02.006 · 2023 · External reference
Which approach to choose to counteract musculoskeletal aging? A comprehensive review on the multiple effects of exercise
10.3390/ijms26157573 · 2025 · External reference
Exercise adherence improving long-term patient outcome in patients with osteoarthritis of the hip and/or knee
10.1002/acr.20182 · 2010 · External reference
Effects of resistance training on osteosarcopenia in community-dwelling postmenopausal Korean women: randomised controlled ERTO-K trial
10.1016/j.exger.2025.112869 · 2025 · External reference
Effects of 12 weeks of whole-body vibration training and vitamin D supplementation on bone density and muscle quality in the aged with Osteosarcopenia: a randomized controlled trial
10.1159/000547822 · 2025 · External reference
Beyond calcium and vitamin D: exploring creatine, beta-Hydroxy-beta-methylbutyrate, prebiotics and probiotics in Osteosarcopenia
10.3390/nu17142332 · 2025 · External reference
An integrated nutritional and physical activity approach for Osteosarcopenia
10.3390/nu17172842 · 2025 · External reference
Healthy weight loss maintenance with exercise, liraglutide, or both combined
10.1056/nejmoa2028198 · 2021 · External reference
Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: a post-treatment analysis of a randomised placebo-controlled trial
10.1016/j.eclinm.2024.102475 · 2024 · External reference
Impact of denosumab on muscle health in older adults in long-term care
10.1016/j.bone.2025.117552 · 2025 · External reference
Beyond bone effects: the role of denosumab in muscle health - a systematic review
10.1007/s40520-025-03285-0 · 2026 · External reference
Outcomes in clinical trials on sarcopenia: a systematic review and meta-analysis
10.1016/j.jnha.2026.100821 · 2026 · External reference
Taking care of inpatients with fragility hip fractures: the hip-padua osteosarcopenia (Hip-POS) fracture liaison service model
10.1007/s40618-024-02425-z · 2025 · External reference
Grip strength: an indispensable biomarker for older adults
10.2147/cia.s194543 · 2019 · External reference
Fracture liaison service-a multidisciplinary approach to osteoporosis management
10.1007/s00198-024-07181-7 · 2024 · External reference
The clinician's guide to prevention and treatment of osteoporosis
10.1007/s00198-021-05900-y · 2022 · External reference
Preoperative Sarcopenia severity and clinical outcomes after total hip arthroplasty
10.3390/nu16132085 · 2024 · External reference
Factors associated with persistent postsurgical pain after total knee or hip joint replacement: a systematic review and meta-analysis
2023 · External reference
