Research graph
References from New developments in the epidemiology and risk factors for osteoarthritis. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of osteoarthritis: literature update
10.1097/bor.0000000000000479 · 2018 · External reference
Epidemiology of osteoarthritis
10.1016/j.joca.2021.04.020 · 2022 · External reference
Osteoarthritis year in review 2024: epidemiology and therapy
10.1016/j.joca.2024.07.014 · 2024 · External reference
Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s2665-9913(23)00163-7 · 2023 · External reference
Burden of knee osteoarthritis in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019
10.1002/acr.25158 · 2023 · External reference
Biopsychosocial, work-related, and environmental factors affecting work participation in people with Osteoarthritis: a systematic review
10.1186/s12891-023-06612-6 · 2023 · External reference
Unresolved reference
2016 · External reference
Cause-specific mortality in osteoarthritis of peripheral joints
10.1016/j.joca.2019.02.793 · 2019 · External reference
Mortality risk in osteoarthritis patients: a meta-analysis of observational studies
10.1186/s12891-025-09321-4 · 2025 · External reference
Evidence on risk factors for knee osteoarthritis in middle-older aged: a systematic review and meta analysis
10.1186/s13018-023-04089-6 · 2023 · External reference
Sex differences in osteoarthritis prevalence, pain perception, physical function and therapeutics
10.1016/j.joca.2024.04.002 · 2024 · External reference
Racial/Ethnic, socioeconomic, and geographic disparities in the epidemiology of knee and hip osteoarthritis
10.1016/j.rdc.2020.09.001 · 2021 · External reference
Race, sex, and risk factors in radiographic worsening of knee osteoarthritis
2017 · External reference
Association between race and radiographic, symptomatic, and clinical hand osteoarthritis: a propensity score-matched study using osteoarthritis initiative data
10.1002/art.41231 · 2022 · External reference
Trends and disparities in osteoarthritis prevalence among US adults, 2005–2018
10.1038/s41598-021-01339-7 · 2021 · External reference
Genetic association studies in osteoarthritis: is it fairytale?
10.1097/bor.0000000000000352 · 2017 · External reference
Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis
10.1186/s13018-018-0939-2 · 2018 · External reference
Correlation investigation between a single nucleotide polymorphism in ADAMTS14 (rs4747096) and osteoarthritis: a meta-analysis
10.1186/s13018-023-04056-1 · 2023 · External reference
MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge
10.1093/bmb/ldz015 · 2019 · External reference
Plasma proteomic profiles predict individual future osteoarthritis risk
10.1002/art.43143 · 2025 · External reference
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
10.1038/s41588-018-0079-y · 2018 · External reference
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion
10.1186/s13075-016-1103-1 · 2016 · External reference
Brief report: association of quantitative and topographic assessment of Heberden's Nodes with knee osteoarthritis: data from the osteoarthritis initiative
10.1002/art.40463 · 2018 · External reference
Finger length pattern as a biomarker for osteoarthritis and chronic joint pain: a population-based study and meta-analysis after systematic review
10.1002/acr.22320 · 2014 · External reference
Are bone mineral density and fractures related to the incidence and progression of radiographic osteoarthritis of the knee, hip, and hand in elderly men and women? The rotterdam study
10.1002/art.40735 · 2019 · External reference
Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study
10.1186/s13075-017-1314-0 · 2017 · External reference
Causal factors for knee, hip, and hand osteoarthritis: a mendelian randomization study in the UK biobank
10.1002/art.40928 · 2019 · External reference
Association of cartilage degeneration with four year weight gain--3T MRI data from the Osteoarthritis Initiative
10.1016/j.joca.2014.10.013 · 2015 · External reference
Association between weight gain and knee osteoarthritis: a systematic review
10.1016/j.joca.2022.10.023 · 2023 · External reference
Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort Study
10.1002/art.39707 · 2016 · External reference
Is weight loss associated with less progression of changes in knee articular cartilage among obese and overweight patients as assessed with MR imaging over 48 months? Data from the Osteoarthritis initiative
10.1148/radiol.2017161005 · 2017 · External reference
Is there a dose-response relationship between weight loss and symptom improvement in persons with knee osteoarthritis?
10.1002/acr.22805 · 2016 · External reference
Once-weekly semaglutide in persons with obesity and knee osteoarthritis
10.1056/nejmoa2403664 · 2024 · External reference
Metformin for knee osteoarthritis in patients with overweight or obesity: a randomized clinical trial
10.1001/jama.2025.3471 · 2025 · External reference
Association of weight loss and weight gain with structural defects and pain in hand osteoarthritis: data from the osteoarthritis initiative
10.1002/acr.25284 · 2024 · External reference
Systolic and pulse pressure associate with incident knee osteoarthritis: data from the Osteoarthritis Initiative
10.1007/s10067-017-3656-z · 2017 · External reference
Is abnormal glucose tolerance or diabetes a risk factor for knee, hip, or hand osteoarthritis? A systematic review
10.1016/j.semarthrit.2018.02.008 · 2018 · External reference
Osteoarthritis and diabetes: where are we and where should we go?
2023 · External reference
Metabolic syndrome and trajectory of knee pain in older adults
10.1016/j.joca.2019.05.030 · 2020 · External reference
Metabolic syndrome increases osteoarthritis risk: findings from the UK Biobank prospective cohort study
10.1186/s12889-024-17682-z · 2024 · External reference
Risk factors for development of lower limb osteoarthritis in physically demanding occupations: a systematic review and meta-analysis
10.1016/j.apergo.2020.103097 · 2020 · External reference
Occupational risk in knee osteoarthritis: a systematic review and meta-analysis of observational studies
10.1002/acr.24333 · 2020 · External reference
Is participation in certain sports associated with knee osteoarthritis? A systematic review
10.4085/1062-6050-50.2.08 · 2017 · External reference
Is physical activity, practiced as recommended for health benefit, a risk factor for osteoarthritis?
10.1016/j.rehab.2016.02.007 · 2016 · External reference
Is long-term physical activity safe for older adults with knee pain?: a systematic review
10.1016/j.joca.2015.05.002 · 2015 · External reference
Bicycling over a lifetime is associated with less symptomatic knee osteoarthritis: data from the osteoarthritis initiative
10.1249/mss.0000000000003449 · 2024 · External reference
Association of walking with incident knee osteoarthritis: a prospective cohort study using data from the UK Biobank
10.1016/j.ard.2025.01.019 · 2025 · External reference
Strength training is associated with less knee osteoarthritis: data from the osteoarthritis initiative
10.1002/art.42732 · 2024 · External reference
Maintaining vitamin D sufficiency is associated with improved structural and symptomatic outcomes in knee osteoarthritis
10.1016/j.amjmed.2017.04.038 · 2017 · External reference
Association between vitamin D and knee osteoarthritis: a PRISMA-Compliant meta-analysis
10.1055/a-1098-8815 · 2021 · External reference
The relationship between vitamin K and osteoarthritis: a review of current evidence
10.3390/nu12051208 · 2020 · External reference
Warfarin use and risk of knee and hip replacements
10.1136/annrheumdis-2020-219646 · 2021 · External reference
Exploratory analysis of osteoarthritis progression among medication users: data from the Osteoarthritis Initiative
10.1177/1759720x16664323 · 2016 · External reference
Association between statin use and consultation or surgery for osteoarthritis of the hip or knee: a pooled analysis of four cohort studies
10.1016/j.joca.2017.07.013 · 2017 · External reference
Association between smoking and risk of knee osteoarthritis: a systematic review and meta-analysis
10.1016/j.joca.2016.12.020 · 2017 · External reference
Association of smoking with knee osteoarthritis structural defects and symptoms: an individual participant data meta-analysis
10.1038/s41598-024-80345-x · 2024 · External reference
Environmental pollutants as emerging risk factors in osteoarthritis: mechanistic and epidemiological evidence
10.1016/j.ecoenv.2025.119453 · 2026 · External reference
Analyzing the impact of heavy metal exposure on osteoarthritis and rheumatoid arthritis: an approach based on interpretable machine learning
10.3389/fnut.2024.1422617 · 2024 · External reference
Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: insights from a prospective cohort study
10.1016/j.ecoenv.2025.117770 · 2025 · External reference
Pollutants make rheumatic diseases worse: facts on polychlorinated biphenyls (PCBs) exposure and rheumatic diseases
10.1016/j.lfs.2016.06.010 · 2016 · External reference
Omeprazole and risk of osteoarthritis: insights from a mendelian randomization study in the UK Biobank
10.1186/s12967-024-05255-y · 2024 · External reference
Association between statin use and incidence or progression of osteoarthritis: meta-analysis of observational studies
10.1016/j.joca.2020.04.007 · 2020 · External reference
Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study
10.1186/s13075-021-02540-9 · 2021 · External reference
Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: data from the OAI and CHECK studies
10.1016/j.ocarto.2023.100427 · 2024 · External reference
Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial
10.1001/jama.2017.5283 · 2017 · External reference
Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative
10.1016/j.joca.2019.01.007 · 2019 · External reference
Bone shape mediates the relationship between sex and incident knee osteoarthritis
10.1186/s12891-018-2251-z · 2018 · External reference
The morphology of proximal tibiofibular joint (PTFJ) predicts incident radiographic osteoarthritis: data from Osteoarthritis Initiative
10.1016/j.joca.2019.11.001 · 2020 · External reference
Hazard of incident and progressive knee and hip radiographic osteoarthritis and chronic joint symptoms in individuals with and without limb length inequality
10.3899/jrheum.091410 · 2010 · External reference
Weight, height, waist circumference: association with knee osteoarthritis findings from the osteoarthritis initiative
10.1097/pr9.0000000000001187 · 2024 · External reference
Risk factors for knee osteoarthritis after traumatic knee injury: a systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus
10.1136/bjsports-2022-105496 · 2022 · External reference
Unresolved reference
2019 · External reference
Risk of knee osteoarthritis after different types of knee injuries in young adults: a population-based cohort study
10.1136/bjsports-2019-100959 · 2020 · External reference
What's the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review
10.1136/bjsports-2018-099751 · 2019 · External reference
Risk factors and burden of osteoarthritis
10.1016/j.rehab.2016.01.006 · 2016 · External reference
Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis
10.1136/bjsports-2018-100022 · 2019 · External reference
What comes first? Multitissue involvement leading to radiographic osteoarthritis: magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative
10.1002/art.39176 · 2015 · External reference
Association between quantitatively measured infrapatellar fat pad high signal-intensity alteration and magnetic resonance imaging-assessed progression of knee osteoarthritis
10.1002/acr.23713 · 2019 · External reference
Stage-specific meniscal features predict progression of osteoarthritis of the knee: a retrospective cohort study using data from the osteoarthritis initiative
10.1186/s12891-019-2413-7 · 2019 · External reference
Periarticular bone predicts knee osteoarthritis progression: data from the Osteoarthritis Initiative
10.1016/j.semarthrit.2018.01.008 · 2018 · External reference
Longitudinal change in thigh muscle strength prior to and concurrent with symptomatic and radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative
10.1016/j.joca.2017.07.003 · 2017 · External reference
Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies
10.1007/s00256-022-04266-4 · 2023 · External reference
Knee Extensor strength and risk of structural, symptomatic, and functional decline in knee osteoarthritis: a systematic review and meta-analysis
10.1002/acr.23005 · 2017 · External reference
Thigh muscle specific-strength and the risk of incident knee osteoarthritis: the influence of sex and greater body mass index
10.1002/acr.23182 · 2017 · External reference
Longitudinal associations between Baseline Sarcopenia and knee osteoarthritis progression and risk of knee replacement
10.1002/art.43213 · 2025 · External reference
Association of thigh intramuscular fat infiltration with incident knee and hip osteoarthritis: a longitudinal cohort Study
10.1002/art.43159 · 2025 · External reference
Varus thrust and incident and progressive knee osteoarthritis
10.1002/art.40224 · 2017 · External reference
Which knee phenotypes exhibit the strongest correlation with cartilage degeneration?
10.1097/corr.0000000000002831 · 2024 · External reference
Lateral displacement, sulcus angle and trochlear angle are associated with early patellofemoral osteoarthritis following anterior cruciate ligament reconstruction
10.1007/s00167-017-4571-1 · 2018 · External reference
Association of malalignment, muscular dysfunction, proprioception, laxity and abnormal joint loading with tibiofemoral knee osteoarthritis - a systematic review and meta-analysis
10.1186/s12891-018-2202-8 · 2018 · External reference
Pediatric hip disorders: slipped capital femoral epiphysis and legg-calvé-perthes disease
10.1542/pir.2017-0197 · 2018 · External reference
A prospective multicenter study of legg-calve-perthes disease: functional and radiographic outcomes of nonoperative treatment at a mean follow-up of twenty years
10.2106/jbjs.j.01073 · 2012 · External reference
Is hip morphology a risk factor for developing hip osteoarthritis? A systematic review with meta-analysis
10.1016/j.joca.2021.06.007 · 2021 · External reference
Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review
10.1016/j.joca.2020.12.003 · 2021 · External reference
Association between hip morphology and prevalence, clinical severity and progression of hip osteoarthritis over 3 years: the knee and hip osteoarthritis long-term assessment cohort results
10.1016/j.jbspin.2015.09.005 · 2016 · External reference
Acetabular dysplasia and the risk of developing hip osteoarthritis at 2,5,8, and 10 years follow-up in a prospective nationwide cohort study (CHECK)
10.1016/j.semarthrit.2023.152194 · 2023 · External reference
The natural history of acetabular dysplasia and later total hip arthroplasty in late-detected DDH: 48 patients with closed reduction followed to a mean age of 62 years
10.2340/17453674.2023.11664 · 2023 · External reference
Measures of hip morphology are related to development of worsening radiographic hip osteoarthritis over 6 to 13 year follow-up: the Johnston County Osteoarthritis Project
10.1016/j.joca.2015.10.007 · 2016 · External reference
Cam deformity and acetabular dysplasia as risk factors for hip osteoarthritis
10.1002/art.39929 · 2017 · External reference
Brief report: leg length inequality and hip osteoarthritis in the multicenter osteoarthritis Study and the osteoarthritis initiative
10.1002/art.40537 · 2018 · External reference
