Research graph
References from Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms. Local targets link to admitted publications; unresolved targets remain external evidence.
Fracture-related infection
10.1038/s41572-022-00396-0 · 2022 · External reference
Fracture-related infection-epidemiology, etiology, diagnosis, prevention, and treatment
2024 · External reference
The global burden of fracture-related infection: can we do better?
10.1016/s1473-3099(23)00503-0 · 2024 · External reference
Prosthetic joint infection
10.1128/cmr.00111-13 · 2014 · External reference
Periprosthetic joint infection: current clinical challenges
10.1093/cid/ciad360 · 2023 · External reference
Mortality during total knee periprosthetic joint infection
10.1016/j.arth.2018.08.021 · 2018 · External reference
Bacterial capture‐killing capsules with remodeling bone immune microenvironment for the effective treatment of osteomyelitis
10.1002/advs.202501505 · 2025 · External reference
Analysis of risk factors for the recurrence of osteomyelitis of the limb after treatment with antibiotic-loaded calcium sulfate and autologous bone graft
10.3389/fbioe.2024.1368818 · 2024 · External reference
The incidence of lower extremity amputation and its associated risk factors in patients with diabetic foot ulcers: a meta‐analysis
10.1111/iwj.14931 · 2024 · External reference
The interaction and implication of stress-induced hyperglycemia and cytokine release following traumatic injury: a structured scoping review
10.3390/diagnostics14232649 · 2024 · External reference
Increased incidence of methicillin-resistant Staphylococcus aureus in knee and hip prosthetic joint infection
10.1016/j.arth.2023.02.025 · 2023 · External reference
Novel antimicrobial agents for combating antibiotic-resistant bacteria
10.1016/j.addr.2022.114378 · 2022 · External reference
Methicillin-resistant staphylococcus aureus: an overview of basic and clinical research
10.1038/s41579-018-0147-4 · 2019 · External reference
Skeletal infections: microbial pathogenesis, immunity and clinical management
10.1038/s41579-022-00686-0 · 2022 · External reference
Staphylococcal osteomyelitis: disease progression, treatment challenges, and future directions
10.1128/cmr.00084-17 · 2018 · External reference
Vancomycin and the kidney
10.1016/s0272-6386(86)80116-0 · 1986 · External reference
Antibiotic perturbations to the gut microbiome
10.1038/s41579-023-00933-y · 2023 · External reference
Vancomycin- and erythromycin-induced hearing loss in humans
10.1128/aac.33.6.791 · 1989 · External reference
Long-term ecological impacts of antibiotic administration on the human intestinal microbiota
10.1038/ismej.2007.3 · 2007 · External reference
Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as ‘gasotransmitters’ in bacteria?
10.1042/bst20170311 · 2018 · External reference
Two's company, three's a crowd: can H2 S be the third endogenous gaseous transmitter?
10.1096/fj.02-0211hyp · 2002 · External reference
Clinical applications for gasotransmitters in the cardiovascular system: are we there yet?
10.3390/ijms241512480 · 2023 · External reference
Gasotransmitter delivery for bone diseases and regeneration
10.59717/j.xinn-life.2023.100015 · 2023 · External reference
Gasotransmitters for the therapeutic prevention of hypertension and kidney disease
10.3390/ijms22157808 · 2021 · External reference
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study
10.1183/09031936.00163206 · 2007 · External reference
Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment
10.1038/s41467-025-61619-y · 2025 · External reference
Trends in the epidemiology of osteomyelitis: a population-based study, 1969 to 2009
10.2106/jbjs.n.01350 · 2015 · External reference
Use of novel strategies to develop guidelines for management of pyogenic osteomyelitis in adults: a WikiGuidelines group consensus statement
10.1001/jamanetworkopen.2022.11321 · 2022 · External reference
Single versus two-stage management of long-bone chronic osteomyelitis in adults: a systematic review and meta-analysis
10.1186/s13018-024-04832-7 · 2024 · External reference
Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the infectious diseases society of America
10.1093/cid/cis803 · 2013 · External reference
Efficacy of debridement, antibiotics, and implant retention for periprosthetic joint infections following hip and knee arthroplasty: a retrospective cohort study
10.7759/cureus.84591 · 2025 · External reference
What factors affect outcome in the treatment of fracture-related infection?
10.3390/antibiotics11070946 · 2022 · External reference
IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes-related foot infections (IWGDF/IDSA 2023)
10.1002/dmrr.3687 · 2024 · External reference
Staphylococcus aureus fibronectin binding protein A mediates biofilm development and infection
10.1128/iai.00859-19 · 2020 · External reference
Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall
10.1126/science.285.5428.760 · 1999 · External reference
Staphylococcus aureus fibronectin binding proteins are essential for internalization by osteoblasts but do not account for differences in intracellular levels of bacteria
10.1128/iai.69.5.2872-2877.2001 · 2001 · External reference
Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion
10.1073/pnas.1718104115 · 2018 · External reference
Biofilm formation in staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials
10.1016/j.biomaterials.2012.05.031 · 2012 · External reference
Evolving concepts in bone infection: redefining “biofilm”
2019 · External reference
Staphylococcal manipulation of host immune responses
10.1038/nrmicro3521 · 2015 · External reference
Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection model
10.1371/journal.ppat.1002434 · 2012 · External reference
Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis
10.1038/s41413-022-00227-8 · 2022 · External reference
Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections
10.1038/nrmicro1384 · 2006 · External reference
Staphylococcus aureus infection induces protein A–mediated immune evasion in humans
10.1084/jem.20141404 · 2014 · External reference
MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis
10.1371/journal.ppat.1007744 · 2019 · External reference
RANKL-Mediated osteoclast formation is required for bone loss in a murine model of Staphylococcus aureus osteomyelitis
10.1016/j.bone.2024.117181 · 2024 · External reference
Bacterial hypoxic responses revealed as critical determinants of the host-pathogen outcome by TnSeq analysis of Staphylococcus aureus invasive infection
10.1371/journal.ppat.1005341 · 2015 · External reference
Programmed surface platform orchestrates anti-bacterial ability and time-sequential bone healing for implant-associated infection
10.1016/j.biomaterials.2024.122772 · 2025 · External reference
Synovial pH, lactate, and glucose as adjunct biomarkers to exclude periprosthetic joint infection in hip and knee arthroplasty: a prospective study
10.5194/jbji-10-293-2025 · 2025 · External reference
Biomaterial-mediated macrophage polarization remodeling and sequential regulation: a potential strategy in bone infections treatment
10.1038/s41413-025-00471-8 · 2025 · External reference
The DAIR-procedure in fracture-related infection–when and how
10.1016/j.injury.2024.111977 · 2024 · External reference
Evidence-based recommendations for local antimicrobial strategies and dead space management in fracture-related infection
10.1097/bot.0000000000001615 · 2020 · External reference
Biofilm dispersal, reduced viscoelasticity, and antibiotic sensitization via nitric oxide-releasing biopolymers
10.1021/acsinfecdis.3c00198 · 2023 · External reference
Nitric oxide pretreatment enhances ofloxacin susceptibility of biofilm concomitant with exopolysaccharide depletion
10.1016/j.colcom.2021.100371 · 2021 · External reference
Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase
10.1074/jbc.c100084200 · 2001 · External reference
Nitric oxide synthases: regulation and function
10.1093/eurheartj/ehr304 · 2012 · External reference
Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic Di-GMP levels, and enhanced dispersal
10.1128/jb.00975-09 · 2009 · External reference
Host nitric oxide disrupts microbial cell-to-cell communication to inhibit staphylococcal virulence
10.1016/j.chom.2018.04.001 · 2018 · External reference
DNA deaminating ability and genotoxicity of nitric oxide and its progenitors
10.1126/science.1948068 · 1991 · External reference
Nitric oxide and peroxynitrite in health and disease
10.1152/physrev.00029.2006 · 2007 · External reference
Nitric oxide‐induced bacteriostasis and modification of iron‐sulphur proteins in Escherichia coli
10.1111/j.1365-2958.2008.06464.x · 2008 · External reference
The potential of nitric oxide releasing therapies as antimicrobial agents
10.4161/viru.20328 · 2012 · External reference
Mechanism of [4Fe-4S](Cys)4 cluster nitrosylation is conserved among NO-responsive regulators
10.1074/jbc.m112.439901 · 2013 · External reference
Iron–sulfur proteins are the major source of protein-bound dinitrosyl iron complexes formed in Escherichia coli cells under nitric oxide stress
10.1016/j.freeradbiomed.2011.03.005 · 2011 · External reference
Nitric oxide restricts iron availability and induces quorum sensing in Streptococcus pyogenes
10.1016/j.redox.2025.103699 · 2025 · External reference
Efficacy of nitric oxide donors and EDTA against Pseudomonas aeruginosa biofilms: implications for antimicrobial therapy in chronic wounds
10.1016/j.bioflm.2025.100280 · 2025 · External reference
Nitric oxide promotes rapid development of motility to accelerate biofilm dispersal in Vibrio cholerae
10.1073/pnas.2526864122 · 2025 · External reference
NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1
10.1084/jem.20140654 · 2015 · External reference
Chemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-κB: implications for the health effects of air pollution and oxidative stress
10.1016/j.redox.2020.101581 · 2020 · External reference
Peroxynitrite, a potent macrophage‐derived oxidizing cytotoxin to combat invading pathogens
10.1002/biof.1150 · 2014 · External reference
Peroxynitrite activates the NLRP3 inflammasome Cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis
10.1007/s12035-017-0502-x · 2018 · External reference
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
10.1038/cr.2013.6 · 2013 · External reference
Nitric oxide signaling in health and disease
10.1016/j.cell.2022.06.010 · 2022 · External reference
Nitric oxide represses inhibitory κB kinase through S-nitrosylation
10.1073/pnas.0400588101 · 2004 · External reference
Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes
10.1359/jbmr.1999.14.7.1123 · 1999 · External reference
Nitric oxide synthase expression in bone cells
10.1016/s8756-3282(98)00070-2 · 1998 · External reference
Regulation of bone mass and bone turnover by neuronal nitric oxide synthase
10.1210/en.2004-0205 · 2004 · External reference
Peroxynitrite production by TNF-α and IL-1β: implication for suppression of osteoblastic differentiation
10.1152/ajpendo.2000.278.6.e1031 · 2000 · External reference
Nitric oxide and bone
10.1046/j.1365-2567.2001.01261.x · 2001 · External reference
The NO–cGMP–PKG pathway in skeletal remodeling
10.1111/nyas.14486 · 2021 · External reference
1 Center for natural and human sciences (CCNH), federal university of ABC (UFABC), santo andré, SP, Brazil, 2 nanomedicine research unit (NANOMED), federal university of ABC (UFABC), santo André, SP, Brazil. How can nitric oxide help osteogenesis?
2020 · External reference
Nitric oxide donor increases osteoprotegerin production and osteoclastogenesis inhibitory activity in bone marrow stromal cells from ovariectomized rats
10.1210/en.2003-1074 · 2004 · External reference
Sodium nitroprusside-induced osteoblast apoptosis is mediated by long chain ceramide and is decreased by raloxifene
10.1016/j.bcp.2004.11.030 · 2005 · External reference
Role of nitric oxide in orthodontic tooth movement
10.3892/ijmm.2021.5001 · 2021 · External reference
Carbon monoxide, the silent killer, May have met its match
10.1126/science.354.6317.1215 · 2016 · External reference
Specific requirement of NADPH‐cytochrome c reductase for the microsomal heme oxygenase reaction yielding biliverdin IXα
10.1016/0014-5793(79)80200-8 · 1979 · External reference
Carbon monoxide gas is not inert, but global, in its consequences for bacterial gene expression, iron acquisition, and antibiotic resistance
10.1089/ars.2015.6501 · 2016 · External reference
Reactive oxygen species mediate bactericidal killing elicited by carbon monoxide-releasing molecules
10.1074/jbc.m111.255752 · 2011 · External reference
Carbon monoxide releasing molecule-2 (CORM-2) inhibits growth of multidrug-resistant uropathogenic Escherichia coli in biofilm and following host cell colonization
10.1186/s12866-016-0678-7 · 2016 · External reference
In situ generating CO gas for destroying bacterial biofilms
10.1016/j.nantod.2024.102296 · 2024 · External reference
Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation
10.1172/jci72853 · 2014 · External reference
Heme oxygenase-1–derived carbon monoxide enhances the host defense response to microbial sepsis in mice
10.1172/jci32730 · 2008 · External reference
Intracellular carbon monoxide release unveils selective antibacterial effects
10.1007/s40843-024-2989-0 · 2024 · External reference
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
10.1038/74680 · 2000 · External reference
MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury
10.1016/s0002-9440(10)63610-3 · 2003 · External reference
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
10.1084/jem.20060845 · 2006 · External reference
The heme Oxygenase-1/Carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with Caveolin-1
10.4049/jimmunol.0712437 · 2009 · External reference
Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-β/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophages
10.1097/shk.0b013e3181e46f15 · 2010 · External reference
Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages
10.1152/ajplung.00400.2014 · 2015 · External reference
Activation of mitochondrial biogenesis by heme Oxygenase-1–mediated NF-E2–related Factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis
10.1164/rccm.201106-1152oc · 2012 · External reference
Carbon monoxide-releasing molecule suppresses inflammatory and osteoclastogenic cytokines in nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via the heme oxygenase-1 pathway
10.3892/ijmm.2017.3129 · 2017 · External reference
Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation
10.1007/s00774-009-0134-y · 2010 · External reference
Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation
10.5483/bmbrep.2017.50.2.220 · 2017 · External reference
Carbon monoxide inhibits receptor activator of NF-κB (RANKL)-induced osteoclastogenesis
10.1159/000430294 · 2015 · External reference
Carbon monoxide-releasing Molecule-3 enhances osteogenic differentiation of rat bone marrow mesenchymal stem cells via miR-195-5p/Wnt3a pathway
10.2147/dddt.s367277 · 2022 · External reference
CORM‐3 attenuates oxidative stress‐induced bone loss via the Nrf2/HO‐1 pathway
10.1155/2022/5098358 · 2022 · External reference
International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors
10.1124/pr.117.014050 · 2017 · External reference
Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis
10.1038/s41423-018-0037-8 · 2019 · External reference
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
10.1152/physrev.00028.2021 · 2023 · External reference
Sulfide regulation of cardiovascular function in health and disease
10.1038/s41569-022-00741-6 · 2023 · External reference
Hydrogen sulfide and carbon monoxide tolerance in bacteria
10.3390/antiox10050729 · 2021 · External reference
Impact of hydrogen sulfide on mitochondrial and bacterial bioenergetics
10.3390/ijms222312688 · 2021 · External reference
H2 S: a universal defense against antibiotics in bacteria
10.1126/science.1209855 · 2011 · External reference
Inhibitors of bacterial H2 S biogenesis targeting antibiotic resistance and tolerance
10.1126/science.abd8377 · 2021 · External reference
H2 S, a bacterial defense mechanism against the host immune response. Freitag NE
10.1128/iai.00272-18 · 2019 · External reference
H2S scavenger as a broad-spectrum strategy to deplete bacteria-derived H2S for antibacterial sensitization
10.1038/s41467-024-53764-7 · 2024 · External reference
Hydrogen sulfide inhibits the growth of Escherichia coli through oxidative damage
10.1007/s12275-018-7537-1 · 2018 · External reference
Hydrogen sulfide sensitizes Acinetobacter baumannii to killing by antibiotics
10.3389/fmicb.2020.01875 · 2020 · External reference
Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation
10.1164/rccm.200907-1145oc · 2010 · External reference
Hydrogen sulfide exposure induces NLRP3 inflammasome‐dependent IL‐1β and IL‐18 secretion in human mononuclear leukocytes in vitro
10.1002/cre2.69 · 2017 · External reference
Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation
10.1074/jbc.m117.806869 · 2018 · External reference
Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation
10.2337/db16-0020 · 2016 · External reference
Endogenous hydrogen sulfide is involved in osteogenic differentiation in human periodontal ligament cells
10.1016/j.archoralbio.2016.03.009 · 2016 · External reference
H2S donor and bone metabolism
10.3389/fphar.2021.661601 · 2021 · External reference
Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism
10.1016/j.phrs.2014.06.014 · 2014 · External reference
Peroxynitrite/PKR axis modulates the NLRP3 inflammasome of cardiac fibroblasts
10.3389/fimmu.2020.558712 · 2020 · External reference
NO• binds human cystathionine β-Synthase quickly and tightly
10.1074/jbc.m113.507533 · 2014 · External reference
Heme regulation of human cystathionine β-Synthase activity: insights from fluorescence and raman spectroscopy
10.1021/ja904468w · 2009 · External reference
Human cystathionine γ-Lyase is inhibited by s-Nitrosation: a new crosstalk mechanism between NO and H2S
10.3390/antiox10091391 · 2021 · External reference
Nitrosopersulfide (SSNO − ) targets the Keap-1/Nrf2 redox system
10.1016/j.phrs.2016.09.022 · 2016 · External reference
Cytochrome bd oxidase and bacterial tolerance to oxidative and nitrosative stress
10.1016/j.bbabio.2014.01.016 · 2014 · External reference
Nitric-oxide dioxygenase activity and function of flavohemoglobins
10.1074/jbc.m004141200 · 2000 · External reference
Cystathionine γ-Lyase–Hydrogen sulfide induces runt-related transcription factor 2 sulfhydration, thereby increasing osteoblast activity to promote bone fracture healing
10.1089/ars.2016.6826 · 2017 · External reference
Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation
10.1073/pnas.1202916109 · 2012 · External reference
Orchestrating nitric oxide and carbon monoxide signaling molecules for synergistic treatment of MRSA infections
10.1002/anie.202112782 · 2022 · External reference
In situ nitric oxide generating nano‐bioactive glass‐based coatings and its therapeutic ion release toward attenuating implant‐associated fibrosis and infection
10.1002/smll.202411984 · 2025 · External reference
Regulation of HIF-1α stability through S-Nitrosylation
10.1016/j.molcel.2007.02.024 · 2007 · External reference
MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice
10.1038/s41467-024-53006-w · 2024 · External reference
Inducible nitric oxide synthase regulates macrophage polarization via the MAPK signals in concanavalin A‐induced hepatitis
10.1002/iid3.643 · 2022 · External reference
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
10.1038/s41467-020-14433-7 · 2020 · External reference
Role of NO/VASP signaling pathway against obesity-related inflammation and insulin resistance
10.4093/dmj.2017.41.2.89 · 2017 · External reference
Nitric oxide in macrophage immunometabolism: hiding in plain sight
10.3390/metabo10110429 · 2020 · External reference
Opportunities and challenges of arginase inhibitors in cancer: a medicinal chemistry perspective
10.1021/acs.jmedchem.4c01429 · 2024 · External reference
Low‐dose decitabine promotes M2 macrophage polarization in patients with primary immune thrombocytopenia via enhancing KLF4 binding to PPARγ promoter
10.1002/ctm2.1344 · 2023 · External reference
Carbon monoxide regulates macrophage differentiation and polarization toward the M2 phenotype through upregulation of heme oxygenase 1
10.3390/cells10123444 · 2021 · External reference
Carbon monoxide orchestrates a protective response through PPARγ
10.1016/j.immuni.2006.03.012 · 2006 · External reference
An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut immune homeostasis
10.1021/acsnano.3c04819 · 2023 · External reference
“thermal bubbles”: photothermally triggered by a carbon monoxide nanocontainer for antibiosis and immune modulation therapy
10.1016/j.nantod.2025.102758 · 2025 · External reference
A smart CO-releasing MnSiO3-based hydrogel enhances diabetic wound healing through NIR-Triggered antibacterial, anti-inflammatory, and pro-regenerative mechanisms
2025 · External reference
Multifunctional injectable hydrogel with self-supplied H2S release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K/Akt pathway
10.1016/j.biomaterials.2025.123144 · 2025 · External reference
H2S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling
10.1016/j.yexcr.2019.111779 · 2020 · External reference
Cardiotrophin‐1 is an anti‐inflammatory cytokine and promotes IL‐4–induced M2 macrophage polarization
10.1096/fj.201801563r · 2019 · External reference
Macrophages in immunoregulation and therapeutics
10.1038/s41392-023-01452-1 · 2023 · External reference
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages
10.1089/ars.2009.2899 · 2010 · External reference
Hydrogen sulfide plays an important role by influencing NLRP3 inflammasome
10.7150/ijbs.47595 · 2020 · External reference
Stimuli-responsive hydrogel with spatiotemporal co-delivery of FGF21 and H2S for synergistic diabetic wound repair
10.1016/j.jconrel.2025.113749 · 2025 · External reference
An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment
10.1126/sciadv.adi1078 · 2023 · External reference
Glucose oxidase driven hydrogen sulfide-releasing nanocascade for diabetic infection treatment
10.1021/acs.nanolett.3c01771 · 2023 · External reference
Role and therapeutic targeting strategies of neutrophil extracellular traps in inflammation
10.2147/ijn.s418259 · 2023 · External reference
Acod1 promotes PAD4 ubiquitination via UBR5 alkylation to modulate NETosis and exert protective effects in sepsis
10.1002/advs.202411652 · 2025 · External reference
Functional role of iNOS-Rac2 interaction in neutrophil extracellular traps (NETs) induced cytotoxicity in sepsis
10.1016/j.cca.2020.12.004 · 2021 · External reference
Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps
10.1007/s00018-019-03331-x · 2020 · External reference
Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation
10.1016/j.niox.2010.01.001 · 2010 · External reference
Heme Oxygenase-1 as a pharmacological target for host-directed therapy to limit tuberculosis associated immunopathology
10.3390/antiox10020177 · 2021 · External reference
Carbon monoxide alleviates endotoxin-induced acute lung injury via NADPH oxidase inhibition in macrophages and neutrophils
10.1016/j.bcp.2025.116782 · 2025 · External reference
Exogenous carbon monoxide inhibits neutrophil infiltration in LPS-induced sepsis by interfering with FPR1 via p38 MAPK but not GRK2
10.18632/oncotarget.9084 · 2016 · External reference
FeMOFs/CO loading reduces NETosis and macrophage inflammatory response in PLA based cardiovascular stent materials
10.1093/rb/rbae140 · 2025 · External reference
Intravascular neutrophil activation due to carbon monoxide poisoning
10.1164/rccm.200604-557oc · 2006 · External reference
Hydrogen sulfide primes diabetic wound to close through inhibition of NETosis
10.1016/j.mce.2018.10.013 · 2019 · External reference
Activation of PAD4 in NET formation
10.3389/fimmu.2012.00360 · 2012 · External reference
Neutrophil extracellular traps in homeostasis and disease
10.1038/s41392-024-01933-x · 2024 · External reference
The triple crown: NO, CO, and H2S in cancer cell biology
10.1016/j.pharmthera.2023.108502 · 2023 · External reference
Cellular metabolism regulates the differentiation and function of T-cell subsets
10.1038/s41423-024-01148-8 · 2024 · External reference
T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation
10.1084/jem.20122494 · 2013 · External reference
Heme oxygenase–1 and carbon monoxide suppress autoimmune neuroinflammation
10.1172/jci28844 · 2007 · External reference
Hydrogen sulfide promotes Tet1- and Tet2-Mediated Foxp3 demethylation to drive regulatory T cell differentiation and maintain immune homeostasis
10.1016/j.immuni.2015.07.017 · 2015 · External reference
Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation
10.1016/j.cmet.2023.11.012 · 2024 · External reference
A H2-bioreactor for mitochondrial rehabilitation in infected bone defects regeneration
2025 · External reference
Local H2 release remodels senescence microenvironment for improved repair of injured bone
10.1038/s41467-023-43618-z · 2023 · External reference
Delivery of molecular hydrogen for precision immunomodulation: mechanisms, detection methods, and applications
10.1002/advs.202500283 · 2025 · External reference
Local sustained H2 release assisted stem cell transplantation for enhanced osteoarthritic cartilage regeneration
2025 · External reference
Ozone-delivering nanocomposite hydrogel for acute Staphylococcus aureus osteomyelitis treatment via neutrophil regulation
10.1016/j.cej.2024.151209 · 2024 · External reference
The role of Nrf2 in the antioxidant cellular response to medical ozone exposure
10.3390/ijms20164009 · 2019 · External reference
Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair
2023 · External reference
A “Mesoporous Oxygen Chamber” scaffold with antibacterial and early immunomodulatory effect for promoting bone regeneration
10.1002/advs.202506737 · 2025 · External reference
Assessing the physiological concentration and targets of nitric oxide in brain tissue
10.1113/jphysiol.2008.154724 · 2008 · External reference
Nitrite: a physiological store of nitric oxide and modulator of mitochondrial function
10.1016/j.redox.2012.11.005 · 2013 · External reference
Thresholds of nitric oxide-mediated toxicity in human lymphoblastoid cells
10.1021/tx0340448 · 2003 · External reference
Familial psychomotor delay of an uncommon cause: type II congenital methemoglobinemia
10.1177/11795565241229007 · 2024 · External reference
Elevated carboxyhemoglobin: sources of carbon monoxide exposure
10.1016/j.arbres.2014.03.005 · 2014 · External reference
Carbon monoxide as a potential therapeutic agent: a molecular analysis of its safety profiles
10.1021/acs.jmedchem.4c00823 · 2024 · External reference
Toward carbon monoxide–based therapeutics: critical drug delivery and developability issues
10.1016/j.xphs.2015.10.018 · 2016 · External reference
Influence of blood thiosulfate produced by postmortem changes for the diagnosis of hydrogen sulfide poisoning in forensic autopsy
10.2478/abm-2024-0035 · 2024 · External reference
The carbon monoxide releasing molecule CORM-2 attenuates Pseudomonas aeruginosa biofilm formation
10.1371/journal.pone.0035499 · 2012 · External reference
Carbon monoxide releasing molecule-3 promotes the osteogenic differentiation of rat bone marrow mesenchymal stem cells by releasing carbon monoxide
2018 · External reference
GYY4137 stimulates osteoblastic cell proliferation and differentiation via an ERK1/2-dependent anti-oxidant mechanism
2017 · External reference
Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage—implications for the treatment of osteoporosis
10.1016/j.freeradbiomed.2011.02.016 · 2011 · External reference
Unresolved reference
2021 · External reference
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