Research graph
References from Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the global burden of disease study 2021
2023 · External reference
Recent advances in managing spinal intervertebral discs degeneration
2022 · External reference
Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration
10.1186/s13018-024-05280-z · 2024 · External reference
Neuroinflammation and nociception in intervertebral disc degeneration: a review of precision medicine perspective
10.1016/j.spinee.2024.12.033 · 2025 · External reference
Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?
10.1016/j.arr.2023.102094 · 2023 · External reference
Biomaterial-based treatments for structural reconstruction in intervertebral disc degeneration
10.1016/j.biomaterials.2025.123426 · 2026 · External reference
A novel nanotherapeutic strategy: rescuing nucleus pulposus cells from fatty acid metabolic disorder and pyroptosis through ACOT13 by Chinese herbal formula nanoparticles
10.1186/s12951-026-04104-y · 2026 · External reference
From molecular regulation to tissue repair: hydrogels in the fight against intervertebral disc degeneration
10.1080/07853890.2025.2572310 · 2025 · External reference
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
10.1007/s00011-023-01813-0 · 2023 · External reference
ROS/pH dynamically responsive injectable hydrogel ameliorates disc degeneration by re-establishing the oxidative stress microenvironment
2025 · External reference
The role of oxidative stress in intervertebral disc degeneration: mechanisms and therapeutic implications
10.1016/j.arr.2024.102323 · 2024 · External reference
ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration
10.1155/2017/5601593 · 2017 · External reference
Epigenetic modifications of inflammation in intervertebral disc degeneration
10.1016/j.arr.2023.101902 · 2023 · External reference
Epigenetic regulation of ferroptosis-associated genes and its implication in cancer therapy
10.3389/fonc.2022.771870 · 2022 · External reference
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling
10.1038/s41418-021-00883-z · 2022 · External reference
UFMylation of NLRP3 prevents its autophagic degradation and facilitates inflammasome activation
2025 · External reference
Ciliary IFT88 inhibits intervertebral disc degeneration under excessive mechanical stress by regulating endplate cartilage calcification
2025 · External reference
Hypoxic regulation of mitochondrial metabolism and mitophagy in nucleus pulposus cells is dependent on HIF-1α-BNIP3 axis
10.1002/jbmr.4019 · 2020 · External reference
Roles of Hippo-YAP/TAZ signalling in intervertebral disc degeneration
10.1016/j.biopha.2022.114099 · 2023 · External reference
AMOT130 linking F-actin to YAP is involved in intervertebral disc degeneration
10.1111/cpr.12492 · 2018 · External reference
Multiphase mineralized collagen scaffold for infected bone regeneration through oxidative metabolism modulation
10.1002/adfm.202500593 · 2025 · External reference
Bone microenvironment-mimetic scaffolds with hierarchical microstructure for enhanced vascularization and bone regeneration
10.1002/adfm.202200011 · 2022 · External reference
Harnessing anti-inflammatory and regenerative potential: Gelma hydrogel loaded with IL-10 and kartogenin for intervertebral disc degeneration therapy
10.1021/acsbiomaterials.4c01864 · 2025 · External reference
Effects of kartogenin on the attenuated nucleus pulposus cell degeneration of intervertebral discs induced by interleukin-1β and tumor necrosis factor-α
2018 · External reference
Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration
2026 · External reference
Engineering nanomaterials for the treatment of intervertebral disc degeneration: from application to therapeutic mechanisms
10.1002/smll.202509806 · 2025 · External reference
Intervertebral disc degeneration: biomaterials and tissue engineering strategies toward precision medicine
2022 · External reference
Injectable ROS-scavenging trimetallic nanocomposite hydrogel modulates oxidative microenvironment for treatment of intervertebral disc degeneration
2025 · External reference
On-Demand collaborative delivery for remodeling the senescent microenvironment in intervertebral disc degeneration
10.1021/acsnano.5c11287 · 2025 · External reference
An esterase-responsive ibuprofen nano-micelle pre-modified embryo derived nucleus pulposus progenitor cells promote the regeneration of intervertebral disc degeneration
2023 · External reference
Oxidative stress, inflammation and metallomatrix proteinase-regulated hydrogels for intervertebral disc regeneration
10.1016/j.matdes.2024.112716 · 2024 · External reference
Silk-based multilayered angle-ply annulus fibrosus construct to recapitulate form and function of the intervertebral disc
10.1073/pnas.1715912115 · 2018 · External reference
Recent progress in electrospun nanofiber-based degenerated intervertebral disc repair
10.1021/acsbiomaterials.1c00970 · 2022 · External reference
Modelling disc degeneration-induced neurovascular invasion on a chip for chronic low back pain therapeutic testing
10.1016/j.actbio.2026.05.037 · 2026 · External reference
Injectable and degradable hydrogel: in vitro drug release behavior and evaluation in a brain repair context
10.1016/j.ijpharm.2026.127030 · 2026 · External reference
Degradable and injectable hydrogel for drug delivery in soft tissues
10.1021/acs.biomac.8b01242 · 2019 · External reference
Polyphenol and metal ion-reinforced supermolecular hydrogels incorporating nanofiber drug and peptide for annulus fibrosus regeneration
10.7150/thno.106913 · 2025 · External reference
Oxidative stress and intervertebral disc degeneration: pathophysiology, signaling pathway, and therapy
10.1155/2022/1984742 · 2022 · External reference
The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair
2025 · External reference
The application prospect of metal/metal oxide nanoparticles in the treatment of intervertebral disc degeneration
10.1039/d4nr05504g · 2025 · External reference
Photothermal hydrogel with Mn3O4 nanoparticles alleviates intervertebral disc degeneration by scavenging ROS and regulating extracellular matrix metabolism
10.1002/adfm.202422817 · 2025 · External reference
Core–shell structured nanozyme with PDA-mediated enhanced antioxidant efficiency to treat early intervertebral disc degeneration
10.1021/acsami.3c15938 · 2024 · External reference
Inhibition of hypersialylation in human intervertebral disc degeneration modulates inflammation and metabolism
2025 · External reference
Sequential redox control and SDF-1α release by diselenide-bridged mesoporous silica nanoparticles promote intervertebral disc regeneration
10.1016/j.biomaterials.2026.124300 · 2026 · External reference
Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration
2024 · External reference
Smart biomaterials in healthcare: breakthroughs in tissue engineering, immunomodulation, patient-specific therapies, and biosensor applications
10.1063/5.0238817 · 2025 · External reference
Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications
10.1186/s12951-025-03237-w · 2025 · External reference
An overview of mechanical microenvironment and mechanotransduction in intervertebral disc degeneration
10.1038/s12276-025-01546-6 · 2025 · External reference
MicroSphere 3D structures delay tissue senescence through mechanotransduction
10.1021/acsnano.4c14874 · 2025 · External reference
Multiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration
2025 · External reference
Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence
10.1186/s13287-018-0919-9 · 2018 · External reference
Restoring disc matrix homeostasis: dual-mirna and human platelet lysate as a novel therapeutic strategy
2026 · External reference
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications
10.1016/j.jconrel.2022.12.027 · 2023 · External reference
A multifunctional mitochondria-protective gene delivery platform promote intervertebral disc regeneration
10.1016/j.biomaterials.2024.123067 · 2025 · External reference
Targeting MT-tsRNA IDDMT with nanoparticles to annulus fibrosus: a novel therapeutic approach for intervertebral disc degeneration
2025 · External reference
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration
10.1038/s41467-025-63194-8 · 2025 · External reference
Discovery of mannose as an alternative non-nutrient-deficient regulator of lipid accumulation in microalgae
10.1016/j.jare.2025.03.019 · 2026 · External reference
Hyaluronan composite bioink preserves nucleus pulposus cell phenotype in a stiffness-dependent manner
10.1016/j.carbpol.2025.123277 · 2025 · External reference
Gradient hydrogels: from fabrication strategies, reinforcement mechanisms, to biomedical applications
10.1016/j.cej.2025.167390 · 2025 · External reference
Construction of hydroxyapatite bioceramics with biomimetic structures by weak magnetic field-assisted 3D printing
10.26599/jac.2025.9221144 · 2025 · External reference
3D bioprinting of an intervertebral disc tissue analogue with a highly aligned annulus fibrosus via suspended layer additive manufacture
10.1088/1758-5090/ad8379 · 2024 · External reference
Three-dimensional-printed flexible scaffolds have tunable biomimetic mechanical properties for intervertebral disc tissue engineering
10.1021/acsbiomaterials.1c01326 · 2021 · External reference
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration
2022 · External reference
3D-Printing of ultratough and healable elastomers
10.1002/adma.202507908 · 2025 · External reference
Integrating engineered living materials with 3D bioprinting
10.1002/adfm.202500934 · 2025 · External reference
The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation
10.3389/fcell.2024.1492870 · 2024 · External reference
Anisotropic mechanical and mass-transport performance of Ti6Al4V plate-lattice scaffolds prepared by laser powder bed fusion
10.1016/j.actbio.2022.06.016 · 2022 · External reference
Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration
2021 · External reference
Biomimetic microstructural materials for intervertebral disk degeneration repair
10.1002/sstr.202400330 · 2025 · External reference
Local delivery of senolytic drug inhibits intervertebral disc degeneration and restores intervertebral disc structure
10.1002/adhm.202101483 · 2022 · External reference
Collagens and associated glycoproteins in the human intervertebral disc. Variations in sugar and amino acid composition in relation to location and age
10.1136/ard.31.1.45 · 1972 · External reference
Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc
10.1126/scitranslmed.aau0670 · 2018 · External reference
Metabolomic signature and molecular profile of normal and degenerated human intervertebral disc cells
10.1016/j.spinee.2023.06.005 · 2023 · External reference
YAP condensates are highly organized hubs
10.1016/j.isci.2024.109927 · 2024 · External reference
IL-6/YAP1/β-catenin signaling is involved in intervertebral disc degeneration
10.1002/jcp.27065 · 2019 · External reference
In situ cell signalling of the Hippo-YAP/TAZ pathway in reaction to complex dynamic loading in an intervertebral disc organ culture
10.3390/ijms222413641 · 2021 · External reference
3D virtual reconstruction and quantitative assessment of the human intervertebral disc's annulus fibrosus: a DTI tractography study
10.1038/s41598-021-86334-8 · 2021 · External reference
Intraflagellar transport protein 88 interacts with polycystin 2 to regulate mechanosensitive hedgehog signaling in mandibular condylar chondrocytes
10.1016/j.archoralbio.2022.105548 · 2022 · External reference
Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice
10.1038/s41467-024-47317-1 · 2024 · External reference
Exosome-loaded methacrylated silk fibroin hydrogel delays intervertebral disc degeneration by DKK2-mediated mitochondrial unfolded protein response
10.1016/j.cej.2025.162191 · 2025 · External reference
Numerical exploration of the combined effect of nutrient supply, tissue condition and deformation in the intervertebral disc
10.1016/j.jbiomech.2014.02.004 · 2014 · External reference
Depletion of aquaporin 1 decreased ADAMTS-4 expression in human chondrocytes
2018 · External reference
Senolytics: eliminating senescent cells and alleviating intervertebral disc degeneration
2022 · External reference
p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
10.7554/elife.52570 · 2020 · External reference
Dysfunction of STING autophagy degradation in senescent nucleus pulposus cells accelerates intervertebral disc degeneration
10.7150/ijbs.88534 · 2024 · External reference
The role of endoplasmic reticulum stress, mitochondrial dysfunction and their crosstalk in intervertebral disc degeneration
10.1016/j.cellsig.2023.110986 · 2024 · External reference
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration
10.1080/15548627.2024.2440844 · 2025 · External reference
A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics
10.1007/s00011-022-01570-6 · 2022 · External reference
Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway
10.1038/s42003-024-06248-9 · 2024 · External reference
Rebalance of the polyamine metabolism suppresses oxidative stress and delays senescence in nucleus pulposus cells
10.1155/2022/8033353 · 2022 · External reference
Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration
10.1186/s13075-025-03489-9 · 2025 · External reference
Expression of polyamine oxidase in fibroblasts induces MMP-1 and decreases the integrity of extracellular
2022 · External reference
Mechanically conditioned multilayered angle-ply collagen scaffolds promote annulus fibrosus regeneration
2023 · External reference
Collagen glycation-mediated mechanical stress aggravates ischemia-reperfusion injury
10.1016/j.actbio.2025.06.012 · 2025 · External reference
NF-κB signaling pathway in controlling intervertebral disk cell response to inflammatory and mechanical stressors
10.2522/ptj.20150045 · 2016 · External reference
A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain
10.1038/s41598-017-17289-y · 2017 · External reference
Raphanus sativus Linne protects human nucleus pulposus cells against H2O2-Induced damage by inhibiting TREM2
2024 · External reference
A redox homeostasis modulatory hydrogel with GLRX3+ extracellular vesicles attenuates disc degeneration by suppressing nucleus pulposus cell senescence
10.1021/acsnano.3c01713 · 2023 · External reference
Breaking the vicious cycle of cellular senescence and ROS via a mitochondrial-targeted hydrogel for aged bone regeneration
10.1016/j.cej.2024.158540 · 2025 · External reference
Expressions of IL-1α and MMP-9 in degenerated lumbar disc tissues and their clinical significance
2017 · External reference
Role of cytokines in intervertebral disc degeneration: pain and disc content
10.1038/nrrheum.2013.160 · 2014 · External reference
The mechanisms and functions of IL-1β in intervertebral disc degeneration
10.1016/j.exger.2023.112181 · 2023 · External reference
Baicalein inhibits the IL-1β-Induced inflammatory response in nucleus pulposus cells and attenuates disc degeneration in vivo
10.1007/s10753-019-00965-8 · 2019 · External reference
Obesity-induced NLRP3 inflammasome activation in nucleus pulposus cells accelerates intervertebral disk degeneration
10.1186/s13018-025-06382-y · 2025 · External reference
Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration
10.1186/s12974-025-03335-4 · 2025 · External reference
SOX4 accelerates intervertebral disc degeneration via EZH2/NRF2 pathway in response to mitochondrial ROS-dependent NLRP3 inflammasome activation in nucleus pulposus cells
10.1186/s12967-024-05913-1 · 2025 · External reference
Persistent expression of NLRP3 in spinal microglia promotes development of lumbar disc degeneration
2022 · External reference
IL-1β/HMGB1 signalling promotes the inflammatory cytokines release via TLR signalling in human intervertebral disc cells
10.1042/bsr20160118 · 2016 · External reference
Short link N modulates inflammasome activity in intervertebral discs through interaction with CD14
2024 · External reference
High amplitude and low frequency cyclic mechanical strain promotes degeneration of human nucleus pulposus cells via the NF-κB p65 pathway
10.1002/jcp.26551 · 2018 · External reference
YTHDF2-dependent m6A modification of FOXO3 mRNA mediates TIMP1 expression and contributes to intervertebral disc degeneration following ROS stimulation
10.1007/s00018-024-05503-w · 2024 · External reference
Inhibiting heat shock protein 90 attenuates nucleus pulposus fibrosis and pathologic angiogenesis induced by macrophages via down-regulating cell migration–inducing protein
10.1016/j.ajpath.2023.03.014 · 2023 · External reference
Cytokine imbalance as a biomarker of treatment-resistant schizophrenia
10.3390/ijms231911324 · 2022 · External reference
Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/Gαi2/YAP signaling
10.7150/ijbs.65973 · 2022 · External reference
Caveolin-1 regulates oxidative stress-induced senescence in nucleus pulposus cells primarily via the p53/p21 signaling pathway in vitro
10.3892/mmr.2017.7789 · 2017 · External reference
Mechanical stretch-mediated fibroblast activation: the pivotal role of Piezo1 channels
10.1016/j.bbamcr.2025.120008 · 2025 · External reference
Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1
10.1186/s13075-023-03093-9 · 2023 · External reference
PACS-2 mitigates NPSC apoptosis and intervertebral disc degeneration by preserving MAM integrity via the SP1/LRRK2/Mfn2 axis
2025 · External reference
Macrophage migration inhibitory factor (MIF) promotes intervertebral disc degeneration through the NF-κB pathway, and the MIF inhibitor CPSI-1306 alleviates intervertebral disc degeneration in a mouse model
10.1096/fj.202301441r · 2023 · External reference
DUSP-1 induced by PGE2 and PGE1 attenuates IL-1β-Activated MAPK signaling
2022 · External reference
Astragaloside IV attenuates IL-1β-induced intervertebral disc degeneration through inhibition of the NF-κB pathway
10.1186/s13018-022-03438-1 · 2022 · External reference
Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy
10.1080/21655979.2022.2031396 · 2022 · External reference
Palladium nanoparticles degrade advanced glycation end products via valosin-containing protein mediated autophagy to attenuate high-glucose/high-fat-induced intervertebral disc degeneration
2025 · External reference
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis
10.1016/j.freeradbiomed.2023.04.018 · 2023 · External reference
Advanced oxidation protein products induce annulus fibrosus cell senescence through a NOX4-dependent, MAPK-mediated pathway and accelerate intervertebral disc degeneration
10.7717/peerj.13826 · 2022 · External reference
SIRT3 retards intervertebral disc degeneration by anti-oxidative stress by activating the SIRT3/FOXO3/SOD2 signaling pathway
2019 · External reference
CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro
10.1186/s10020-021-00351-x · 2021 · External reference
Highly adhesive self-reinforce hydrogel for the amelioration of intervertebral disc degeneration: eliminating reactive oxygen species and regulating extracellular matrix
10.1016/j.compositesb.2024.111280 · 2024 · External reference
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy
10.1038/s12276-019-0331-2 · 2019 · External reference
Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells
10.1186/s12951-023-01856-9 · 2023 · External reference
Role of macrophage in intervertebral disc degeneration
10.1038/s41413-024-00397-7 · 2025 · External reference
CCR2 monocytes as therapeutic targets for acute disc herniation and radiculopathy in mouse models
10.1016/j.joca.2023.08.014 · 2024 · External reference
An engineered bionic nanoparticle sponge as a cytokine trap and reactive oxygen species scavenger to relieve disc degeneration and discogenic pain
10.1021/acsnano.3c08097 · 2024 · External reference
An intelligent nanoliposome alleviates disc degeneration and discogenic pain by inhibiting neurovascular ingrowth via a “Soil-conditioning, seed-modulating, and weeds-suppressing” strategy
2026 · External reference
The mechanosensitive ion channel Piezo1 regulates chondrocyte homeostasis through the PI3K/AKT/mTORC1 pathway in osteoarthritis
10.1111/jcmm.70734 · 2025 · External reference
Hypofunctional TrkA accounts for the absence of pain sensitization in the African naked mole-rat
10.1016/j.celrep.2016.09.035 · 2016 · External reference
Syndecan-4 is a novel therapeutic target for intervertebral disc degeneration via suppressing JNK/p53 pathway
10.7150/ijbs.40189 · 2020 · External reference
Targeting STING attenuates ROS induced intervertebral disc degeneration
10.1016/j.joca.2021.04.017 · 2021 · External reference
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair
2025 · External reference
Stimuli-responsive gyroid scaffolds: hierarchical architecture and electric stimulation promote bone regeneration
10.1016/j.mattod.2025.06.013 · 2025 · External reference
Engineered high-strength biohydrogel as a multifunctional platform to deliver nucleic acid for ameliorating intervertebral disc degeneration
2023 · External reference
Microenvironment-targeted strontium delivery system reshapes redox homeostasis to halt degenerative cascades in intervertebral discs
10.1016/j.jconrel.2025.114449 · 2026 · External reference
Antioxidant carbon dot of selenomethionine alleviates oxidative stress in intervertebral disc degeneration
10.1002/advs.202514217 · 2025 · External reference
Synergistic reversal of inflammation-mediated degeneration in intervertebral discs: phenylboric acid-grafted hyaluronic acid hydrogel as an anti-oxidative vehicle for Timp-3 delivery and promotion of extracellular matrix synthesis
10.1016/j.actbio.2025.06.011 · 2025 · External reference
ROS-responsive wedelolactone hydrogel promotes intervertebral disc repair by disrupting the NF-κB–LCN2 inflammatory feedback loop
2026 · External reference
ROS-scavenging hydrogel microneedles reverse intervertebral disc degeneration via combined mild photothermal and NO gas therapy
2025 · External reference
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes
10.1038/s41467-025-58447-5 · 2025 · External reference
Nano-assisted dynamically assembled hydrogels with strong tissue adhesion and proactive immunomodulation for bone defect repair
2025 · External reference
Spatiotemporal hydrogel delivery platform with offense and defense functions for intervertebral disc degeneration: immune and autophagy modulation
10.1016/j.cej.2025.164351 · 2025 · External reference
Strontium alginate hydrogel containing psoralen has superior mechanical properties and immunomodulatory functions to alleviate intervertebral disc degeneration
10.1016/j.ijbiomac.2025.142706 · 2025 · External reference
Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration
2022 · External reference
Polyphenol-mediated adhesive and anti-inflammatory double-network hydrogels for repairing postoperative intervertebral disc defects
10.1021/acsami.4c11901 · 2024 · External reference
A bioactive hydrogel harnessing the regenerative potential of notochordal cells serves as instructive cell carrier for nucleus pulposus repair
10.1016/j.biomaterials.2025.123895 · 2026 · External reference
Regulating inflammation and apoptosis: a smart microgel gene delivery system for repairing degenerative nucleus pulposus
10.1016/j.jconrel.2023.12.029 · 2024 · External reference
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration
10.1016/j.jconrel.2025.02.052 · 2025 · External reference
Mechanical signal-tailored hydrogel microspheres recruit and train stem cells for precise differentiation
2023 · External reference
Injectable radiopaque hyaluronic acid granular hydrogels for intervertebral disc repair
10.1002/adhm.202303326 · 2024 · External reference
A pH/ROS dual responsive smart microgel miRNA delivery system for repair of intervertebral disc degeneration
10.1039/d5tb01505g · 2025 · External reference
Dynamic dual-network hydrogel microspheres for enhanced nucleus pulposus regeneration via extracellular matrix mimicry
10.1016/j.compositesb.2025.112715 · 2025 · External reference
Water transport-modulated highly compressive hydrogel for total biomimetic sensing intervertebral disc
10.1002/smtd.202500292 · 2025 · External reference
A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction
2021 · External reference
Innovative 3D-printed porous piezoelectric poly(vinylidene fluoride) cages with accelerated spinal fusion
2025 · External reference
Stiffness of photocrosslinkable gelatin hydrogel influences nucleus pulposus cell propertiesin vitro
10.1111/jcmm.16141 · 2021 · External reference
3D-printed composite scaffold with gradient structure and programmed biomolecule delivery to guide stem cell behavior for osteochondral regeneration
10.1016/j.bioadv.2022.213067 · 2022 · External reference
Peptide-functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration
10.1002/btm2.10447 · 2022 · External reference
Biomimetic hydrogel micro-/nanofibers for in situ soft tissue repair and regeneration
2026 · External reference
Anti-swelling hydrogel combined with nucleus pulposus cell exosomes and senolytic drugs efficiently repair intervertebral disc degeneration
10.1002/advs.202513645 · 2025 · External reference
Human iPSCs derived MSCs-Secreted exosomes modulate senescent nucleus pulposus cells induced macrophage polarization via metabolic reprogramming to mitigate intervertebral disc degeneration
10.1002/advs.202504347 · 2025 · External reference
Spheroid-derived BMSC exosomes enhance proliferation and matrix remodeling of nucleus pulposus cell clusters in degenerative disc repair
10.1002/smll.202507073 · 2025 · External reference
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
10.1038/s41413-025-00441-0 · 2025 · External reference
Nanocomposite hydrogel orchestrating multiple modulation of degenerative microenvironment for potential application in intervertebral disc regeneration
10.1016/j.jmst.2024.12.042 · 2025 · External reference
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
10.1038/s41573-021-00233-1 · 2021 · External reference
Antioxidant proline carbon dot-composited Poly(L-methionine) hydrogel restores mitophagy to alleviate cellular senescence in intervertebral disc degeneration
10.1002/adma.74557 · 2026 · External reference
Advances in the study of macrophage polarization in intervertebral disc degeneration
10.1007/s00586-026-10010-6 · 2026 · External reference
Repair strategies and bioactive functional materials for intervertebral disc
10.1002/adfm.202209471 · 2022 · External reference
FasL expression on human nucleus pulposus cells contributes to the immune privilege of intervertebral disc by interacting with immunocytes
10.7150/ijms.6223 · 2013 · External reference
Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance
10.1038/s41563-018-0099-0 · 2018 · External reference
MiR-146a promotes tolerogenic properties of dendritic cells through targeting Notch1 signaling
2020 · External reference
Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine
10.1186/s40824-023-00348-z · 2023 · External reference
Amino acid-based biomaterials for modulation of cell behaviors: from mechanisms to biomedical applications
10.1039/d5cs01504a · 2026 · External reference
Bioprinting tissue analogues with decellularized extracellular matrix bioink for regeneration and tissue models of cartilage and intervertebral discs
10.1002/adfm.201909044 · 2020 · External reference
Tissue-mimetic hybrid bioadhesives for intervertebral disc repair
10.1039/d2mh01242a · 2023 · External reference
Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities
10.1038/s41467-022-29874-5 · 2022 · External reference
Biodegradable polymers with tertiary amines enhance mRNA delivery of lipid nanoparticles via improved endosomal escape
10.1016/j.biomaterials.2025.123541 · 2026 · External reference
Polymeric nanoparticles enable mRNA transfection and its translation in intervertebral disc and human joint cells, except for M1 macrophages
10.3390/pharmaceutics16040438 · 2024 · External reference
Optimizing nonviral-mediated transfection of human intervertebral disc chondrocytes
10.1016/j.spinee.2007.05.010 · 2008 · External reference
Harnessing CRISPR potential for intervertebral disc regeneration strategies
10.3389/fbioe.2025.1562412 · 2025 · External reference
Injectable hydrogel loaded with exosomes from hypoxic umbilical cord-derived mesenchymal stem cells alleviates intervertebral disc degeneration by reversing nucleus pulposus cell senescence
10.1093/rb/rbaf039 · 2025 · External reference
Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration
2023 · External reference
Bioinspired hydrogel microspheres enhance nucleus pulposus regeneration through N-cadherin interaction with extracellular matrix mimicry
10.1016/j.jconrel.2025.113771 · 2025 · External reference
Energy metabolism of intervertebral disc under mechanical loading
10.1002/jor.22436 · 2013 · External reference
Dynamic hydrostatic pressure regulates nucleus pulposus phenotypic expression and metabolism in a cell density-dependent manner
10.1115/1.4038758 · 2018 · External reference
The role of YAP/TAZ activity in metabolic reprogramming
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