Research graph
References from Gas-propelled microneedles for precision transdermal therapeutics. Local targets link to admitted publications; unresolved targets remain external evidence.
Transdermal drug delivery
10.1038/nbt.1504 · 2008 · External reference
Insulin delivery systems combined with microneedle technology
10.1016/j.addr.2018.03.011 · 2018 · External reference
Microneedle-mediated vaccination: innovation and translation
10.1016/j.addr.2021.113919 · 2021 · External reference
Lack of pain associated with microfabricated microneedles
10.1213/00000539-200102000-00041 · 2001 · External reference
Artificial intelligence-driven radiological biomarkers: a narrative review of artificial intelligence in meningioma diagnosis
10.1016/j.neumar.2024.100033 · 2025 · External reference
Dissolving polymer microneedle patches for influenza vaccination
10.1038/nm.2182 · 2010 · External reference
Microneedles in the clinic
10.1016/j.jconrel.2017.05.029 · 2017 · External reference
Polymer multilayer tattooing for enhanced DNA vaccination
10.1038/nmat3550 · 2013 · External reference
Transdermal electroosmotic flow generated by a porous microneedle array patch
10.1038/s41467-021-20948-4 · 2021 · External reference
An electrically active microneedle array for electroporation
10.1007/s10544-009-9381-x · 2010 · External reference
Electroporation of a nanoparticle-associated DNA vaccine induces higher inflammation and immunity compared to its delivery with microneedle patches in pigs
10.1016/j.jconrel.2019.06.041 · 2019 · External reference
10.1126/sciadv.adf0854
10.1126/sciadv.adf0854 · External reference
Microneedle system with light trigger for precise and programmable penetration
10.1039/d3mh00352c · 2023 · External reference
An accurate and dual-effective body slimming method through a soluble microneedle patch with variable temperature
10.1039/d0tb01547d · 2021 · External reference
Mechanism-based design of agents that selectively target drug-resistant glioma
10.1126/science.abn7570 · 2022 · External reference
10.1126/sciadv.aba1362
10.1126/sciadv.aba1362 · External reference
Gas-generating nanoplatforms: material chemistry, multifunctionality, and gas therapy
10.1002/adma.201801964 · 2018 · External reference
Microneedle patches with O2 propellant for deeply and fast delivering photosensitizers: towards improved photodynamic therapy
10.1002/advs.202202591 · 2022 · External reference
Microorganism microneedle micro-engine depth drug delivery
10.1038/s41467-024-53280-8 · 2024 · External reference
Nitric oxide nanomotor driving exosomes-loaded microneedles for achilles tendinopathy healing
10.1021/acsnano.1c03177 · 2021 · External reference
Dual engine-driven bionic microneedles for early intervention and prolonged treatment of Alzheimer's disease
10.1016/j.jconrel.2024.01.030 · 2024 · External reference
Role of lipids in the formation and maintenance of the cutaneous permeability barrier
10.1016/j.bbalip.2013.11.007 · 2014 · External reference
Transdermal drug delivery systems in diabetes management: a review
2020 · External reference
Sustained-release hydrogen-powered bilateral microneedles integrating CD-MOFs for in situ treating allergic rhinitis
10.1002/adhm.202400637 · 2024 · External reference
Chapter 3 - skin penetration of nanoparticles
2018 · External reference
Advancements in skin-mediated drug delivery: mechanisms, techniques, and applications
2024 · External reference
Prodrug strategies for enhancing the percutaneous absorption of drugs
10.3390/molecules191220780 · 2014 · External reference
Transcellular route of diffusion through stratum corneum: results from finite element models
10.1002/jps.20695 · 2006 · External reference
Role of transepidermal and transfollicular routes in percutaneous absorption of steroids: in vitro studies on human skin
10.1159/000211300 · 2009 · External reference
Microneedles for enhanced topical treatment of skin disorders: applications, challenges, and prospects
10.1016/j.eng.2023.05.009 · 2023 · External reference
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: the state of the art
10.1016/j.addr.2024.115341 · 2024 · External reference
Microneedles for transdermal drug delivery
10.1016/j.addr.2003.10.023 · 2004 · External reference
Microneedle, bio-microneedle and bio-inspired microneedle: a review
10.1016/j.jconrel.2017.02.011 · 2017 · External reference
A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects
10.1186/s12951-024-02409-4 · 2024 · External reference
An intelligent and soluble microneedle composed of Bi/BiVO4 schottky heterojunction for tumor Ct imaging and Starvation/Gas therapy-promoted synergistic cancer treatment
10.1002/adhm.202303147 · 2024 · External reference
Oxygen-boosted dual-section microneedle patch for enhanced drug penetration and improved photodynamic and anti-inflammatory therapy in psoriasis
10.1016/j.apsb.2025.09.037 · 2026 · External reference
Multimodal antibacterial microneedles with nanozymes mediated ROS-scavenging and oxygen-generation synergistic photothermal/photodynamic therapy to promote diabetic ulcer healing
2025 · External reference
Nanostrategies for potentiating gas-immunotherapy: from advanced delivery platforms to anti-tumor applications
10.1016/j.jconrel.2026.114604 · 2026 · External reference
Piezo-STING agonists enhance tumor penetration and catalytic-immunotherapy
10.1002/adfm.202419032 · 2025 · External reference
Nitric oxide modulating calcium Store for Ca2+-Initiated cancer therapy
10.1002/adfm.202008507 · 2021 · External reference
Nitric oxide-driven nanotherapeutics for cancer treatment
10.1016/j.jconrel.2023.08.038 · 2023 · External reference
Polyphenol-integrated carboxymethyl chitosan hydrogels with immunoregulatory properties remodeling of inflammatory microenvironment for spinal cord injury repair
10.1016/j.cej.2024.149522 · 2024 · External reference
A photocatalytic carbon monoxide-generating effervescent microneedle patch for improved transdermal chemotherapy
10.1039/d2tb02613a · 2023 · External reference
State of the art in constructing gas-propelled dissolving microneedles for significantly enhanced drug-loading and delivery efficiency
10.3390/pharmaceutics15041059 · 2023 · External reference
H2S-Reactivating antitumor immune response after microwave thermal therapy for long-term tumor suppression
10.1021/acsnano.3c05936 · 2023 · External reference
Photothermo-promoted nanocatalysis combined with H2S-Mediated respiration inhibition for efficient cancer therapy
2021 · External reference
Metal–organic framework nanocomposites in conquering hypoxia for tumor therapy
10.1002/adfm.202314012 · 2024 · External reference
Strategic design of conquering hypoxia in tumor for advanced photodynamic therapy
10.1002/adhm.202300530 · 2023 · External reference
Diagnostic and drug release systems based on microneedle arrays in breast cancer therapy
10.1016/j.jconrel.2021.08.036 · 2021 · External reference
Achieving deep intratumoral penetration and multimodal combined therapy for tumor through algal photosynthesis
10.1186/s12951-024-02476-7 · 2024 · External reference
Modular prodrug-engineered oxygen nano-tank with outstanding nanoassembly performance, high oxygen loading, and closed-loop tumor hypoxia relief
10.1002/advs.202405583 · 2024 · External reference
Supramolecular approaches for the treatment of hypoxic regions in tumours
10.1038/s41570-025-00705-7 · 2025 · External reference
Breaking the hypoxia barrier: supramolecular nanoassemblies empower photodynamic therapy of tumors
10.1002/anie.202525238 · 2026 · External reference
Multifunctional hydrogel containing oxygen vacancy-rich WOx for synergistic photocatalytic O2 production and photothermal therapy promoting bacteria-infected diabetic wound healing
10.1002/adfm.202411117 · 2024 · External reference
Cascade-driven nanomotors promote diabetic wound healing by eradicating MRSA biofilm infection
10.1016/j.cej.2024.148790 · 2024 · External reference
Chronological adaptive polyoxometalate-based hydrogel for diabetic chronic wounds through synchronous bacterial ferroptosis death and immunomodulation
10.1016/j.nantod.2024.102415 · 2024 · External reference
Chlorella-loaded antibacterial microneedles for microacupuncture oxygen therapy of diabetic bacterial infected
2024 · External reference
Bioprinted dressing with symbiotic microbes for oxygen supply and antibacterial therapy for enhanced diabetic wound healing
10.1016/j.jconrel.2026.114653 · 2026 · External reference
An intelligent core–shell microneedle patch loaded with oxygen-vacancy-engineered ROS nanogenerators for a programmed ICB therapy against “cold” tumors
2025 · External reference
Filling core–shell microneedles with pressurized oxygen-embedded particles (POPs) to improve photodynamic therapy
10.1039/d5mh00253b · 2025 · External reference
Activatable enzymatic nanoplatform incorporated into microneedle patch for relieving tumor Hypoxia augmented photodynamic therapy
2025 · External reference
Microneedle patch loaded with calcium peroxide nanoparticles for oxygen healing and biofilm inhibition in diabetic wound healing
10.1021/acsanm.4c01973 · 2024 · External reference
A self-oxygenating nanozyme Cascade system for drug-resistant bacterial infected diabetic wound healing
10.1021/acsami.5c20613 · 2025 · External reference
Nanozyme-incorporated microneedles for the treatment of chronic wounds
10.1002/adhm.202400101 · 2024 · External reference
Chlorella-loaded antibacterial microneedles for microacupuncture oxygen therapy of diabetic bacterial infected wounds
10.1002/adma.202307585 · 2024 · External reference
Self-adaptive hydrogen nano-delivery system in glaucoma management: synergistic antioxidation and anti-inflammation therapeutic strategy
10.1021/acsnano.6c01611 · 2026 · External reference
Advances in hydrogen delivery strategies for therapeutic applications
10.1016/j.addr.2025.115734 · 2026 · External reference
Sustained-release photothermal microneedles for postoperative incisional analgesia and wound healing via hydrogen therapy
2025 · External reference
Built-In active microneedle patch with enhanced autonomous drug delivery
10.1002/adma.201905740 · 2020 · External reference
Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species
10.1016/j.neures.2014.08.009 · 2014 · External reference
Wireless, self-powered phototrophic algaerobot-infused nanotherapeutic hydrogels for enhanced diabetic wound healing
10.1016/j.cej.2025.163469 · 2025 · External reference
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
10.1038/nm1577 · 2007 · External reference
NIR-Driven electron transfer for in situ gelation and enhanced hydrogen therapy
10.1016/j.biomaterials.2025.123822 · 2026 · External reference
An iron-scavenging and hydrogen-releasing microneedle patch suppresses ferroptosis and promotes spinal cord repair
10.1021/acsnano.5c19206 · 2026 · External reference
Sustained-release photothermal microneedles for postoperative incisional analgesia and wound healing via hydrogen therapy
10.1002/advs.202503698 · 2025 · External reference
Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing
2023 · External reference
Synergistic calcium overload and hydrogen release potentiate robust antitumor immunity
10.1002/adhm.202505332 · 2026 · External reference
Spatiotemporal Co-Delivery of hydrogen and magnesium via microneedle patches for neuroinflammation modulation after spinal cord injury: a multi-modal in vivo study
10.1002/smll.202514854 · 2026 · External reference
Hydrogen gas from inflammation treatment to cancer therapy
10.1021/acsnano.9b05124 · 2019 · External reference
Progress and promise of nitric oxide-releasing platforms
10.1002/advs.201701043 · 2018 · External reference
Nitric oxide in cellular adaptation and disease
10.1016/j.redox.2020.101550 · 2020 · External reference
Prepared MW-Immunosensitizers precisely release NO to downregulate HIF-1α expression and enhance immunogenic cell death
10.1002/smll.202308055 · 2024 · External reference
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
10.1161/circresaha.116.309326 · 2017 · External reference
A self-adaptive biomimetic periosteum employing nitric oxide release for augmenting angiogenesis in bone defect regeneration
10.1002/adhm.202302153 · 2024 · External reference
Nitric oxide-releasing bioinspired scaffold for exquisite regeneration of osteoporotic bone via regulation of homeostasis
10.1002/advs.202205336 · 2023 · External reference
Nitric oxide stimulated programmable drug release of nanosystem for multidrug resistance cancer therapy
10.1021/acs.nanolett.9b01869 · 2019 · External reference
Nitric oxide release: part II. Therapeutic applications
10.1039/c2cs15273h · 2012 · External reference
Spatiotemporally responsive Cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing
10.1016/j.apsb.2024.06.014 · 2024 · External reference
Nitric oxide-releasing nanocarriers integrated with ginsenoside compound K in dissolvable microneedles for androgenetic alopecia
10.1186/s12951-025-03944-4 · 2025 · External reference
MXene hydrogel microneedles with nitric oxide and HIF-1α plasmid controllable releasing for wound healing
10.1016/j.eng.2025.06.034 · 2025 · External reference
Microneedles loaded with nitric-oxide driven nanomotors improve force-induced efferocytosis impairment and sterile inflammation by revitalizing macrophage energy metabolism
10.1021/acsnano.5c01877 · 2025 · External reference
Nanomotors-loaded microneedle patches for the treatment of bacterial biofilm-related infections of wound
10.1016/j.jcis.2023.05.080 · 2023 · External reference
Porous MOF microneedle array patch with photothermal responsive nitric oxide delivery for wound healing
10.1002/advs.202103449 · 2022 · External reference
Microneedles with therapeutic gas: integrating drug propulsion and intrinsic bioactivity
10.1007/s40843-025-4027-0 · 2026 · External reference
Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus
10.1016/j.freeradbiomed.2017.01.022 · 2017 · External reference
Modulatory role of carbon monoxide on the inflammatory response and oxidative stress linked to gastrointestinal disorders
2021 · External reference
Carbon monoxide-induced arterial wall hypoxia and atherosclerosis
10.1016/0021-9150(78)90148-x · 1978 · External reference
Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption
10.1186/s12974-018-1226-1 · 2018 · External reference
Harnessing carbon monoxide-releasing platforms for cancer therapy
10.1016/j.biomaterials.2020.120193 · 2020 · External reference
Synthesis of bifunctional lipoxin-derived enzyme-triggered CO-Releasing molecules (LipET-CORMs)
10.1002/ejoc.202201424 · 2023 · External reference
Green-light-triggered and self-calibrated Cascade release of nitric oxide and carbon monoxide for synergistic glaucoma therapy
2024 · External reference
DNA-based Bi-layered effervescent ejecting microneedle (BEE MN) for glucose-responsive insulin delivery
10.1039/d5mh01816a · 2026 · External reference
Inflammatory responses to acute elevations of carbon dioxide in mice
2017 · External reference
Smart H2S-Triggered/Therapeutic System (SHTS)-Based nanomedicine
10.1002/advs.201901724 · 2019 · External reference
Trends in H2S-Donors chemistry and their effects in cardiovascular diseases
10.3390/antiox10030429 · 2021 · External reference
Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages
10.1016/j.biomaterials.2019.119398 · 2019 · External reference
Advances of H2S in regulating neurodegenerative diseases by preserving mitochondria function
10.3390/antiox12030652 · 2023 · External reference
The Triple Crown: NO, CO, and H2S in cancer cell biology
10.1016/j.pharmthera.2023.108502 · 2023 · External reference
Nitrous oxide for the treatment of complex regional pain syndrome: a randomized blinded trial
10.1136/rapm-2023-104537 · 2024 · External reference
Biomimetic single-atom nanozyme system for efficient inhibition of gastric cancer ascites via SO2 gas-enhanced nanocatalytic cancer therapy
10.1016/j.cej.2023.143386 · 2023 · External reference
Structural characterization and in-vivo reliability evaluation of silicon microneedles
10.1007/s10544-014-9836-6 · 2014 · External reference
Unresolved reference
2011 · External reference
Long-acting microneedle formulations
10.1016/j.addr.2023.115055 · 2023 · External reference
Transdermal drug delivery via microneedles to mediate wound microenvironment
10.1016/j.addr.2023.114753 · 2023 · External reference
Antibacterial hydrogels
10.1002/advs.201700527 · 2018 · External reference
Biocompatibility of hydrogel-based scaffolds for tissue engineering applications
10.1016/j.biotechadv.2017.05.006 · 2017 · External reference
State-of-the-art strategies to enhance the mechanical properties of microneedles
10.1016/j.ijpharm.2024.124547 · 2024 · External reference
Dissolving microneedles for transdermal drug delivery
10.1016/j.biomaterials.2007.12.048 · 2008 · External reference
Programmed upregulation of HSP70 by metal-organic frameworks nanoamplifier for enhanced microwave thermal-immunotherapy
10.1002/adhm.202201441 · 2022 · External reference
Photoresponsive polymeric microneedles: an innovative way to monitor and treat diseases
10.1016/j.jconrel.2022.12.036 · 2023 · External reference
Thermosensitive hydrogel microneedles for controlled transdermal drug delivery
10.1016/j.actbio.2022.08.061 · 2022 · External reference
A pH-Responsive core-shell microneedle patch with self-monitoring capability for local long-lasting analgesia
10.1002/adfm.202314048 · 2024 · External reference
Conductive polymer-coated 3D printed microneedles: biocompatible platforms for minimally invasive biosensing interfaces
10.1002/smll.202206301 · 2023 · External reference
Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis
10.1016/j.ejpb.2016.06.023 · 2016 · External reference
Transdermal drug delivery by coated microneedles: geometry effects on effective skin thickness and drug permeability
10.1016/j.cherd.2008.06.002 · 2008 · External reference
Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force
10.1016/j.jbiomech.2003.12.010 · 2004 · External reference
Transdermal microneedles for drug delivery applications
10.1016/j.mseb.2006.02.008 · 2006 · External reference
Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery
10.1038/nm0402-415 · 2002 · External reference
Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion
10.1007/s40820-021-00611-9 · 2021 · External reference
Oxygen self-sufficient photodynamic therapy
10.1016/j.ccr.2020.213714 · 2021 · External reference
Ultrasound-activated oxygen and ROS generation nanosystem systematically modulates tumor microenvironment and sensitizes sonodynamic therapy for hypoxic solid tumors
10.1002/adfm.201906195 · 2019 · External reference
Gas-mediated cancer therapy combined with starvation therapy, ultrasound therapy, chemotherapy, radiotherapy, and photodynamic therapy: a review
10.1007/s10311-021-01218-7 · 2021 · External reference
Micro/Nanomaterials-Augmented hydrogen therapy
10.1002/adhm.201900463 · 2019 · External reference
Nitric oxide-releasing platforms for treating cardiovascular disease
10.3390/pharmaceutics14071345 · 2022 · External reference
Local generation of hydrogen for enhanced photothermal therapy
10.1038/s41467-018-06630-2 · 2018 · External reference
Emerging delivery strategies of carbon monoxide for therapeutic applications: from CO gas to CO releasing nanomaterials
10.1002/smll.201904382 · 2019 · External reference
Lithographic microneedle-motors from multimodal microfluidics for cargo delivery
10.1002/smll.202206108 · 2023 · External reference
Metal-based nanomaterials in biomedical applications: antimicrobial activity and cytotoxicity aspects
10.1002/adfm.201910021 · 2020 · External reference
Nanozymes for nanohealthcare
10.1038/s43586-024-00315-5 · 2024 · External reference
Biological fate tracking of nitric oxide-propelled microneedle delivery system using an aggregation-caused quenching probe
10.1021/acs.molpharmaceut.4c00435 · 2024 · External reference
Microneedle-mediated cell therapy
10.1002/advs.202304124 · 2024 · External reference
Cryomicroneedle delivery of nanogold-engineered Rhodospirillum rubrum for photochemical transformation and tumor optical biotherapy
2024 · External reference
Polydopamine-armed microalgal oxygenerator targeting the hypoxia-adenosine axis to boost cancer photothermal immunotherapy
10.1016/j.mattod.2024.04.001 · 2024 · External reference
Going below and beyond the surface: microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
2023 · External reference
Microstructure reconstruction of the gas diffusion layer and analyses of the anisotropic transport properties
10.1016/j.enconman.2021.114293 · 2021 · External reference
Mathematical modelling, simulation and optimisation of microneedles for transdermal drug delivery: trends and progress
10.3390/pharmaceutics12080693 · 2020 · External reference
Natural biomaterials from biodiversity for healthcare applications
10.1002/adhm.202101389 · 2022 · External reference
Battery-free and self-propelled bionic microneedle system for chemically controlled on‐demand drug delivery
10.1038/s41378-025-00970-y · 2025 · External reference
Disease-tailored drug delivery microneedle systems: precision engineering for unmet clinical needs
10.1016/j.jconrel.2026.114743 · 2026 · External reference
Transdermal drug delivery system: current status and clinical application of microneedles
10.1021/acsmaterialslett.3c01317 · 2024 · External reference
Panoramic review on polymeric microneedle arrays for clinical applications
10.1007/s10544-024-00724-z · 2024 · External reference
Harnessing the immune system and developing targeted vaccines: overall strategies of leveraging the body's natural defense mechanisms to enhance cancer treatment
2025 · External reference
Rapidly separating microneedles for transdermal drug delivery
10.1016/j.actbio.2016.06.005 · 2016 · External reference
Materials marvels: pioneering paths in microneedle innovation
10.1016/j.matt.2024.05.013 · 2024 · External reference
A bubble-propelled microneedle patch with photothermal-controlled NO release for eradicating biofilms in diabetic wounds
10.1016/j.cej.2026.179725 · 2026 · External reference
A visible light crosslinked angiogenic and anti-inflammatory GelMA microneedle array patch co-releasing nitric oxide and oxygen for diabetic wound healing
10.1016/j.ijbiomac.2025.145450 · 2025 · External reference
