Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Matrix nanoalignment programs macrophage vesicular immunity through TRPV2 mechanogating. Local targets link to admitted publications; unresolved targets remain external evidence.
Engineering nanomaterial physical characteristics for cancer immunotherapy
10.1038/s44222-023-00047-3 · 2023 · External reference
Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
10.1126/sciadv.adg9593 · 2023 · External reference
The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth
10.1016/j.ccell.2023.02.016 · 2023 · External reference
Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2
10.1016/j.matbio.2018.11.001 · 2019 · External reference
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
10.1038/nature25501 · 2018 · External reference
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
10.1038/nature25492 · 2018 · External reference
Sensing the difference: the influence of anisotropic cues on cell behavior
10.3389/fmats.2015.00039 · 2015 · External reference
Extracellular matrix‐bioinspired anisotropic topographical cues of electrospun nanofibers: a strategy of wound healing through macrophage polarization
10.1002/adhm.202304114 · 2024 · External reference
The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics
10.1016/j.ceb.2021.04.002 · 2021 · External reference
Extracellular matrix stiffness and architecture govern intracellular rheology in cancer
10.1016/j.bpj.2009.05.054 · 2009 · External reference
The matrix in cancer
10.1038/s41568-020-00329-7 · 2021 · External reference
Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β
10.1038/s41551-021-00722-z · 2021 · External reference
The integrin adhesome: from genes and proteins to human disease
10.1038/nrm3769 · 2014 · External reference
Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission
10.1038/s41551-023-01080-8 · 2023 · External reference
Collagen reorganization at the tumor-stromal interface facilitates local invasion
10.1186/1741-7015-4-38 · 2006 · External reference
Collagen density promotes mammary tumor initiation and progression
10.1186/1741-7015-6-11 · 2008 · External reference
Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates
10.1073/pnas.2021135118 · 2021 · External reference
Role of extracellular matrix architecture and signaling in melanoma therapeutic resistance
10.3389/fonc.2022.924553 · 2022 · External reference
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · 2016 · External reference
Magnetic manipulation of reversible nanocaging controls in vivo adhesion and polarization of macrophages
10.1021/acsnano.8b02226 · 2018 · External reference
The role of tumor associated macrophages (TAMs) in cancer progression, chemoresistance, angiogenesis and metastasis-current status
10.2174/0929867328666210720143721 · 2021 · External reference
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments
10.1038/s41392-025-02325-5 · 2025 · External reference
Macrophages in melanoma: a double-edged sword and targeted therapy strategies
10.3892/etm.2022.11577 · 2022 · External reference
Tumor-associated macrophages: from mechanisms to therapy
10.1016/j.immuni.2014.06.010 · 2014 · External reference
Extracellular vesicles in cancers: mechanisms, biomarkers, and therapeutic strategies
10.1002/mco2.70009 · 2024 · External reference
Extracellular vesicles and particles impact the systemic landscape of cancer
10.15252/embj.2021109288 · 2022 · External reference
Tumor-associated macrophages derived exosomes; from pathogenesis to therapeutic opportunities
10.1016/j.intimp.2024.112406 · 2024 · External reference
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
10.1038/s41467-018-03224-w · 2018 · External reference
Macrophages and therapeutic resistance in cancer
10.1016/j.ccell.2015.02.015 · 2015 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
The biology, function, and biomedical applications of exosomes
10.1126/science.aau6977 · 2020 · External reference
Tumor-associated macrophages in cancer: from mechanisms to application
10.1186/s43556-025-00396-y · 2025 · External reference
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles
10.1016/j.apsb.2023.03.020 · 2023 · External reference
Rab27a and Rab27b control different steps of the exosome secretion pathway
10.1038/ncb2000 · 2010 · External reference
Exosome secretion and red cell maturation: exploring molecular components involved in the docking and fusion of multivesicular bodies in K562 cells
10.1016/j.bcmd.2005.07.002 · 2005 · External reference
A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4
10.1083/jcb.201710132 · 2018 · External reference
Exocyst controls exosome biogenesis via Rab11a
10.1016/j.omtn.2021.12.023 · 2022 · External reference
Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed?
10.1038/pcan.2017.7 · 2017 · External reference
Tumor gene signatures that correlate with release of extracellular vesicles shape the immune landscape in head and neck squamous cell carcinoma
10.1093/cei/uxad019 · 2023 · External reference
Stiff matrix induces exosome secretion to promote tumour growth
10.1038/s41556-023-01092-1 · 2023 · External reference
Mechanical stress-dependent autophagy component release via extracellular nanovesicles in tumor cells
10.1021/acsnano.9b00587 · 2019 · External reference
Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets
10.1186/s40364-025-00745-7 · 2025 · External reference
Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread
2018 · External reference
Anisotropic ligand nanogeometry modulates the adhesion and polarization state of macrophages
10.1021/acs.nanolett.8b05150 · 2019 · External reference
Modelling the tumor microenvironment: recapitulating Nano- and micro-scale properties that regulate tumor progression
10.3389/fcell.2022.908799 · 2022 · External reference
Integrin clustering matters: a review of biomaterials functionalized with multivalent integrin-binding ligands to improve cell adhesion, migration, differentiation, angiogenesis, and biomedical device integration
2018 · External reference
Carrier-free immunotherapeutic nano-booster with dual synergistic effects based on glutaminase inhibition combined with photodynamic therapy
10.1021/acsnano.2c11037 · 2023 · External reference
Reconstruction of postinfarcted cardiac functions through injection of tanshinone IIA@ reactive oxygen species‐sensitive microspheres encapsulated in a thermoreversible hydrogel
10.1002/eem2.12555 · 2024 · External reference
Luminescence-activated Pt (IV) prodrug for in situ triggerable cancer therapy
10.1016/j.cclet.2023.109134 · 2024 · External reference
Injectable nitric oxide-generated hydrogel delivering tanshinone IIA for cardiac remodeling in zebrafish and porcine models
10.1016/j.cej.2025.165249 · 2025 · External reference
Inverse poroelasticity as a fundamental mechanism in biomechanics and mechanobiology
10.1038/s41467-017-00801-3 · 2017 · External reference
Immunoregulation of macrophages by controlling winding and unwinding of nanohelical ligands
2021 · External reference
TRP channels and cancer modulation: a voyage beyond metabolic reprogramming, oxidative stress and the advent of nanotechnologies in targeted therapy
10.1186/s13046-025-03495-4 · 2025 · External reference
Elevated TRPP2 promotes malignant behavior of head and neck cancer via enhancing exosome biogenesis
10.1016/j.vesic.2026.100105 · 2026 · External reference
The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies
10.1016/j.apsb.2021.11.001 · 2022 · External reference
Microenvironmental cue-regulated exosomes as therapeutic strategies for improving chronic wound healing
10.1038/s41427-022-00419-y · 2022 · External reference
STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
10.1016/j.molcel.2010.07.023 · 2010 · External reference
miR-181a is a novel player in the STAT3-mediated survival network of TCRalphabeta+ CD8+ T large granular lymphocyte leukemia
10.1038/s41375-021-01480-2 · 2022 · External reference
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
10.1038/emboj.2010.268 · 2010 · External reference
Programmatic regulation of macrophage polarization by HAp@ MXene nanocomposites to promote bone repair
10.1002/bmm2.70034 · 2026 · External reference
Systemic T‐cell and local macrophage interactions mediate granule size‐dependent biological hydroxyapatite foreign body reaction
10.1002/bmm2.12133 · 2025 · External reference
M1/M2 macrophage skewing is related to reduction in types I, V, and VI collagens with aging in sun-exposed human skin
10.1016/j.xjidi.2023.100222 · 2023 · External reference
Integrating PROTAC-based targeted protein degradation with nanodelivery systems to overcome cancer therapeutic resistance
2025 · External reference
Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment
10.1016/j.cclet.2024.109779 · 2024 · External reference
Synthetic polymers for drug, gene, and vaccine delivery
10.1021/polymscitech.5c00010 · 2025 · External reference
Multifunctional poly (amino acid) nanomedicine modulates macrophage polarization for osteosarcoma immunotherapy
2025 · External reference
Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy
2021 · External reference
The interplay between epigenetic regulation and CD8+ T cell differentiation/exhaustion for T cell immunotherapy
10.3389/fcell.2021.783227 · 2022 · External reference
The extracellular matrix and the immune system: a mutually dependent relationship
10.1126/science.abp8964 · 2023 · External reference
Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis
10.1038/s41467-023-38093-5 · 2023 · External reference