Research graph
References from Aptamer-functionalized EGCG nanocarrier for neutrophil-targeted AKBA delivery promotes anxiety-related fracture healing. Local targets link to admitted publications; unresolved targets remain external evidence.
Non-union bone fractures
10.1038/s41572-021-00289-8 · 2021 · External reference
Fracture healing in the setting of endocrine diseases, aging, and cellular senescence
10.1210/endrev/bnac008 · 2022 · External reference
Electric field stimulation-responsive hydrogels for bone regeneration: from mechanisms to applications
10.1038/s41413-025-00482-5 · 2026 · External reference
Depression, antidepressants, and bone health in older adults: a systematic review
10.1111/jgs.12945 · 2014 · External reference
Depression and risk of fracture and bone loss: an updated meta-analysis of prospective studies
10.1007/s00198-018-4420-1 · 2018 · External reference
Pathophysiological mechanism of acute bone loss after fracture
10.1016/j.jare.2022.08.019 · 2023 · External reference
Hip fracture
10.1056/nejm199606063342307 · 1996 · External reference
Adverse effects of depression and cognitive impairment on rehabilitation participation and recovery from hip fracture
10.1002/gps.1116 · 2004 · External reference
Depressive symptom heterogeneity among older adults after hip fracture
10.1093/ageing/afab168 · 2021 · External reference
Depression and hip fracture risk: the NHANES I epidemiologic follow-up study
10.1177/003335490512000112 · 2005 · External reference
Impact of depression and its treatment on the bones of growing children
10.1007/s11920-007-0077-8 · 2007 · External reference
Bone mineral density in women with depression
10.1056/nejm199610173351602 · 1996 · External reference
The devastating effects of tibial nonunion on health-related quality of life
10.2106/jbjs.l.00803 · 2013 · External reference
The effect of depression, generalized anxiety, and selective serotonin reuptake inhibitors on change in bone metabolism in adolescents and emerging adults
10.1002/jbmr.3238 · 2017 · External reference
Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing
10.1038/s41392-023-01457-w · 2023 · External reference
Fracture repair requires TrkA signaling by skeletal sensory nerves
10.1172/jci128428 · 2019 · External reference
Skeletal interoception in bone homeostasis and pain
10.1016/j.cmet.2022.09.025 · 2022 · External reference
Effects of massage on pain, mood status, relaxation, and sleep in Taiwanese patients with metastatic bone pain: a randomized clinical trial
10.1016/j.pain.2011.06.021 · 2011 · External reference
Fracture hematoma is a potent proinflammatory mediator of neutrophil function
10.1097/01.ta.0000169866.88781.f1 · 2005 · External reference
Functional roles of immune cells in osteoporosis
10.3389/fimmu.2025.1698283 · 2025 · External reference
Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model
10.1038/cmi.2012.56 · 2013 · External reference
Conductive hydrogel inspires neutrophil extracellular traps to combat bacterial infections in wounds
10.1021/acsnano.4c14487 · 2025 · External reference
TGFbeta1(+)CCR5(+) neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice
10.1038/s41467-023-35801-z · 2023 · External reference
Boswellia serrata preserves intestinal epithelial barrier from oxidative and inflammatory damage
10.1371/journal.pone.0125375 · 2015 · External reference
Acetyl-keto-beta-boswellic acid induces lipolysis in mature adipocytes
10.1016/j.bbrc.2012.12.136 · 2013 · External reference
Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis
10.1158/0008-5472.can-09-0755 · 2009 · External reference
Acetyl-11-keto-beta-boswellia acid attenuates Ti particle-induced osteoblastic oxidative stress and osteolysis through the Foxo3 signaling pathway
2024 · External reference
Acetyl-11-keto-beta-boswellic acid attenuates titanium particle-induced osteogenic inhibition via activation of the GSK-3beta/beta-catenin signaling pathway
10.7150/thno.35988 · 2019 · External reference
The beneficial effect of boswellic acid on bone metabolism and possible mechanisms of action in experimental osteoporosis
10.3390/nu12103186 · 2020 · External reference
Acetyl-11-keto-beta-boswellic acid ameliorates cognitive deficits and reduces amyloid-beta levels in APPswe/PS1dE9 mice through antioxidant and anti-inflammatory pathways
10.1016/j.freeradbiomed.2020.02.022 · 2020 · External reference
Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: molecular mechanism
10.4103/1673-5374.339494 · 2022 · External reference
Neuro-protective effect of Acetyl-11-keto-beta-boswellic acid in a rat model of scopolamine-induced cholinergic dysfunction
10.2174/0113816128269289231226115446 · 2024 · External reference
Locally delivered lovastatin nanoparticles enhance fracture healing in rats
10.1002/jor.20391 · 2007 · External reference
Development and optimisation of 3-Acetyl-11-keto-beta-boswellic acid loaded poly-lactic-co-glycolic acid-nanoparticles with enhanced oral bioavailability and in-vivo anti-inflammatory activity in rats
10.1111/jphp.12420 · 2015 · External reference
VCAM-1-targeted core/shell nanoparticles for selective adhesion and delivery to endothelial cells with lipopolysaccharide-induced inflammation under shear flow and cellular magnetic resonance imaging in vitro
2013 · External reference
Conjugation of EGCG and chitosan NPs as A novel nano-drug delivery system
10.2147/ijn.s217898 · 2019 · External reference
Synthesis and hypoglycemic efficacy assessment of epigallocatechin gallate-selenium nanoparticles (EGCG-Se NPs) nanocomposites
10.7717/peerj.20939 · 2026 · External reference
Vibrational (FT-IR, Raman) analysis of tea catechins based on both theoretical calculations and experiments
10.1016/j.bpc.2019.106282 · 2020 · External reference
Orally fed EGCG coronate food released TiO(2) and enhanced penetrability into body organs via gut
10.1016/j.bioadv.2022.213205 · 2023 · External reference
Paliperidone prevents brain toll-like receptor 4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress
10.1093/ijnp/pyu070 · 2014 · External reference
Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery
10.1016/j.neuroscience.2009.08.053 · 2009 · External reference
Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure
10.1038/mp.2012.90 · 2013 · External reference
Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats
10.1038/s41398-018-0351-z · 2019 · External reference
Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via beta-AR signaling
10.1073/pnas.1819218116 · 2019 · External reference
Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
10.1038/s41398-023-02326-4 · 2023 · External reference
The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system
10.1016/s0031-6997(24)01470-4 · 2000 · External reference
Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB
10.1016/j.cellsig.2005.03.017 · 2006 · External reference
YAP1-Mediated suppression of USP31 enhances NFkappaB activity to promote sarcomagenesis
10.1158/0008-5472.can-17-4052 · 2018 · External reference
In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils
10.1096/fj.10-178517 · 2011 · External reference
Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
10.1038/nmeth865 · 2006 · External reference
Dexamethasone facilitates NF-kappaB signal pathway in TNF-alpha stimulated rotator cuff tenocytes
10.4014/jmb.1810.10051 · 2019 · External reference
Molecular mechanisms of action of epigallocatechin gallate in cancer: recent trends and advancement
10.1016/j.semcancer.2020.05.011 · 2022 · External reference
A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy
10.1016/j.apsb.2020.07.026 · 2021 · External reference
Colorless multifunctional coatings inspired by polyphenols found in tea, chocolate, and wine
10.1002/anie.201304922 · 2013 · External reference
Versatile surface engineering of porous nanomaterials with bioinspired polyphenol coatings for targeted and controlled drug delivery
10.1039/c6nr00600k · 2016 · External reference
Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via the Ly6 antigen for psoriasiform dermatitis alleviation
10.1039/d2bm01521h · 2023 · External reference
Unravelling the therapeutic properties of aptamer-modified exosome nanocomposite
10.1016/j.cis.2025.103517 · 2025 · External reference
Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy
10.1038/s41392-024-01973-3 · 2024 · External reference
Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions
10.1038/ncomms10363 · 2016 · External reference
Oxygen tension of healing fractures in the rabbit
10.2106/00004623-197254020-00010 · 1972 · External reference
Alkaline biodegradable implants for osteoporotic bone defects--importance of microenvironment pH
10.1007/s00198-015-3217-8 · 2016 · External reference
Early pH changes in musculoskeletal tissues upon injury-aerobic catabolic pathway activity linked to inter-individual differences in local pH
10.3390/ijms21072513 · 2020 · External reference
Dual-action bisphosphonate hydrogel preserves cortical bone integrity and restores healing cascade in osteoporotic fracture-related infection
10.1038/s41467-025-68036-1 · 2026 · External reference
Neutrophil-derived catecholamines mediate negative stress effects on bone
10.1038/s41467-023-38616-0 · 2023 · External reference
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
10.1038/s41589-020-0544-7 · 2020 · External reference
Mechanistic role of boswellic acids in Alzheimer's disease: emphasis on anti-inflammatory properties
10.1016/j.biopha.2021.112250 · 2021 · External reference
Tead1a initiates transcriptional priming through the TEAD1a/YAP-Notch1-Spi1/Cebpα axis to promote neutrophil fate
2025 · External reference
YAP controls endothelial activation and vascular inflammation through TRAF6
10.1161/circresaha.118.313143 · 2018 · External reference
Tea plant-inspired nanoassembled supraparticles alleviate colitis and associated mental disorders via microbiota-gut-brain interactions
10.7150/thno.113573 · 2025 · External reference
The science of tea's mood-altering magic
10.1038/d41586-019-00398-1 · 2019 · External reference