Research graph
References from Injectable ECM-mimetic dynamic Schiff-base hydrogels deliver 5-aminosalicylic acid for immunomodulatory and alleviation of ferroptosis-associated injury of intervertebral disc degeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of low back pain, 1990-2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
10.1016/s2665-9913(23)00098-x · 2023 · External reference
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
10.1038/ncomms2226 · 2012 · External reference
Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration
10.1016/j.celrep.2024.114342 · 2024 · External reference
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair
10.1038/s41467-025-66116-w · 2025 · External reference
Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration
10.1016/j.joca.2021.06.010 · 2021 · External reference
An SSK1-loaded decellularized annulus fibrosus matrix-based PD hydrogel alleviates intervertebral disc degeneration through modulation of NF-κB signaling and ferroptosis
10.1016/j.jot.2026.101168 · 2026 · External reference
UCHL3 drives ferroptosis in nucleus pulposus cells by deubiquitinating HMGB1 to activate NCOA4-mediated ferritinophagy
10.1080/15548627.2026.2684463 · 2026 · External reference
PPARgamma-Axl axis ameliorates intervertebral disc degeneration by activating PI3K/AKT-mediated autophagy to suppress ferroptosis
10.1186/s11658-025-00802-x · 2025 · External reference
Mitochondrial quality control in intervertebral disc degeneration
10.1038/s12276-021-00650-7 · 2021 · External reference
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance
10.1111/cpr.12779 · 2020 · External reference
Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis
10.1002/jcp.30039 · 2021 · External reference
Role of cytokines in intervertebral disc degeneration: pain and disc content
10.1038/nrrheum.2013.160 · 2014 · External reference
Tumor necrosis factor α– and interleukin-1β–dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1
10.1002/art.37819 · 2013 · External reference
Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration
10.1016/j.spinee.2017.09.018 · 2018 · External reference
Polarization of infiltrating macrophages in the outer annulus fibrosus layer associated with the process of intervertebral disc degeneration and neural ingrowth in the human cervical spine
10.1016/j.spinee.2021.12.005 · 2022 · External reference
Macrophage-derived inflammatory cytokines regulate growth factors and pain-related molecules in mice with intervertebral disc injury
10.1002/jor.23888 · 2018 · External reference
AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis
10.1053/j.gastro.2018.12.009 · 2019 · External reference
Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity
10.1074/jbc.274.37.26448 · 1999 · External reference
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ
10.1084/jem.20041948 · 2005 · External reference
Solute Transport in Intervertebral Disc
10.1111/j.1749-6632.2008.04075.x · 2009 · External reference
The Leakage Pathway and Effect of Needle Gauge on Degree of Disc Injury Post Anular Puncture: A Comparative Study Using Aged Human and Adolescent Porcine Discs
10.1097/brs.0b013e31811ec282 · 2007 · External reference
Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture: Laboratory investigation
10.3171/2009.2.spine08925 · 2009 · External reference
Designing hydrogels for controlled drug delivery
10.1038/natrevmats.2016.71 · 2016 · External reference
Biology of Intervertebral Disc Aging and Degeneration: Involvement of the Extracellular Matrix
10.1097/01.brs.0000146101.53784.b1 · 2004 · External reference
Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target
10.1038/srep37360 · 2016 · External reference
Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues
10.1016/j.pmatsci.2020.100738 · 2021 · External reference
Injectable oxidized hyaluronic acid/adipic acid dihydrazide hydrogel for nucleus pulposus regeneration
10.1016/j.actbio.2010.02.037 · 2010 · External reference
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Regulation of Ferroptotic Cancer Cell Death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
Ferroptosis: mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-κB/MAPK signaling
10.1016/j.jot.2023.02.005 · 2023 · External reference
Glutaminolysis and Transferrin Regulate Ferroptosis
10.1016/j.molcel.2015.06.011 · 2015 · External reference
Secreted Factors From Intervertebral Disc Cells and Infiltrating Macrophages Promote Degenerated Intervertebral Disc Catabolism
10.1097/brs.0000000000002953 · 2019 · External reference
Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway
10.1038/s12276-024-01168-4 · 2024 · External reference
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
10.1016/j.immuni.2014.06.008 · 2014 · External reference
5-Aminosalicylic acid inhibits inflammatory responses by suppressing JNK and p38 activity in murine macrophages
10.1080/08923973.2016.1274997 · 2017 · External reference
RSL3 Drives Ferroptosis through NF-κB Pathway Activation and GPX4 Depletion in Glioblastoma
10.1155/2021/2915019 · 2021 · External reference
Slow depressurization following intradiscal injection leads to injectate leakage in a large animal model
10.1002/jsp2.1061 · 2019 · External reference
Hydrolytic Stability of Hydrazones and Oximes
10.1002/anie.200802651 · 2008 · External reference
Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently
10.1007/s00586-010-1473-z · 2010 · External reference
ISSLS PRIZE IN BASIC SCIENCE 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model
10.1007/s00586-018-5488-1 · 2018 · External reference
A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail
10.1097/brs.0b013e31817c64a9 · 2008 · External reference
Hydrolytic Stability of Hydrazones and Oximes
10.1002/anie.200802651 · ExternalCitation · doi-reference
Tumor necrosis factor α– and interleukin-1β–dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1
10.1002/art.37819 · ExternalCitation · doi-reference
Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis
10.1002/jcp.30039 · ExternalCitation · doi-reference
Macrophage-derived inflammatory cytokines regulate growth factors and pain-related molecules in mice with intervertebral disc injury
10.1002/jor.23888 · ExternalCitation · doi-reference
Slow depressurization following intradiscal injection leads to injectate leakage in a large animal model
10.1002/jsp2.1061 · ExternalCitation · doi-reference
Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently
10.1007/s00586-010-1473-z · ExternalCitation · doi-reference
ISSLS PRIZE IN BASIC SCIENCE 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model
10.1007/s00586-018-5488-1 · ExternalCitation · doi-reference
Injectable oxidized hyaluronic acid/adipic acid dihydrazide hydrogel for nucleus pulposus regeneration
10.1016/j.actbio.2010.02.037 · ExternalCitation · doi-reference
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
10.1016/j.cell.2012.03.042 · ExternalCitation · doi-reference
Regulation of Ferroptotic Cancer Cell Death by GPX4
10.1016/j.cell.2013.12.010 · ExternalCitation · doi-reference
Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration
10.1016/j.celrep.2024.114342 · ExternalCitation · doi-reference
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
10.1016/j.immuni.2014.06.008 · ExternalCitation · doi-reference
Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration
10.1016/j.joca.2021.06.010 · ExternalCitation · doi-reference
Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-κB/MAPK signaling
10.1016/j.jot.2023.02.005 · ExternalCitation · doi-reference
An SSK1-loaded decellularized annulus fibrosus matrix-based PD hydrogel alleviates intervertebral disc degeneration through modulation of NF-κB signaling and ferroptosis
10.1016/j.jot.2026.101168 · ExternalCitation · doi-reference
Glutaminolysis and Transferrin Regulate Ferroptosis
10.1016/j.molcel.2015.06.011 · ExternalCitation · doi-reference
Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues
10.1016/j.pmatsci.2020.100738 · ExternalCitation · doi-reference
Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration
10.1016/j.spinee.2017.09.018 · ExternalCitation · doi-reference
Polarization of infiltrating macrophages in the outer annulus fibrosus layer associated with the process of intervertebral disc degeneration and neural ingrowth in the human cervical spine
10.1016/j.spinee.2021.12.005 · ExternalCitation · doi-reference
Global, regional, and national burden of low back pain, 1990-2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
10.1016/s2665-9913(23)00098-x · ExternalCitation · doi-reference
Designing hydrogels for controlled drug delivery
10.1038/natrevmats.2016.71 · ExternalCitation · doi-reference
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
10.1038/ncomms2226 · ExternalCitation · doi-reference
Role of cytokines in intervertebral disc degeneration: pain and disc content
10.1038/nrrheum.2013.160 · ExternalCitation · doi-reference
Mitochondrial quality control in intervertebral disc degeneration
10.1038/s12276-021-00650-7 · ExternalCitation · doi-reference
Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway
10.1038/s12276-024-01168-4 · ExternalCitation · doi-reference
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair
10.1038/s41467-025-66116-w · ExternalCitation · doi-reference
Ferroptosis: mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · ExternalCitation · doi-reference
Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target
10.1038/srep37360 · ExternalCitation · doi-reference
AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis
10.1053/j.gastro.2018.12.009 · ExternalCitation · doi-reference
Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity
10.1074/jbc.274.37.26448 · ExternalCitation · doi-reference
5-Aminosalicylic acid inhibits inflammatory responses by suppressing JNK and p38 activity in murine macrophages
10.1080/08923973.2016.1274997 · ExternalCitation · doi-reference
UCHL3 drives ferroptosis in nucleus pulposus cells by deubiquitinating HMGB1 to activate NCOA4-mediated ferritinophagy
10.1080/15548627.2026.2684463 · ExternalCitation · doi-reference
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ
10.1084/jem.20041948 · ExternalCitation · doi-reference
Biology of Intervertebral Disc Aging and Degeneration: Involvement of the Extracellular Matrix
10.1097/01.brs.0000146101.53784.b1 · ExternalCitation · doi-reference
Secreted Factors From Intervertebral Disc Cells and Infiltrating Macrophages Promote Degenerated Intervertebral Disc Catabolism
10.1097/brs.0000000000002953 · ExternalCitation · doi-reference
The Leakage Pathway and Effect of Needle Gauge on Degree of Disc Injury Post Anular Puncture: A Comparative Study Using Aged Human and Adolescent Porcine Discs
10.1097/brs.0b013e31811ec282 · ExternalCitation · doi-reference
A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail
10.1097/brs.0b013e31817c64a9 · ExternalCitation · doi-reference
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance
10.1111/cpr.12779 · ExternalCitation · doi-reference
Solute Transport in Intervertebral Disc
10.1111/j.1749-6632.2008.04075.x · ExternalCitation · doi-reference
RSL3 Drives Ferroptosis through NF-κB Pathway Activation and GPX4 Depletion in Glioblastoma
10.1155/2021/2915019 · ExternalCitation · doi-reference
PPARgamma-Axl axis ameliorates intervertebral disc degeneration by activating PI3K/AKT-mediated autophagy to suppress ferroptosis
10.1186/s11658-025-00802-x · ExternalCitation · doi-reference
Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture: Laboratory investigation
10.3171/2009.2.spine08925 · ExternalCitation · doi-reference
