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References from Biochemical, structural, and functional characterization of the Nocardia asteroides dihydrofolate reductase: a primary target of anti-nocardiosis treatment. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogenic nocardia: a diverse genus of emerging pathogens or just poorly recognized?
10.1371/journal.ppat.1008280 · 2020 · External reference
Prognosis and factors associated with disseminated nocardiosis: a ten-year multicenter study
10.1016/j.jinf.2022.05.029 · 2022 · External reference
Management dilemmas in nocardia brain infection
10.1097/qco.0000000000000782 · 2021 · External reference
Trimethoprim-sulfamethoxazole dosing and outcomes of pulmonary nocardiosis
10.1007/s15010-024-02323-9 · 2025 · External reference
How do I manage nocardiosis?
2021 · External reference
Structure, dynamics, and catalytic function of dihydrofolate reductase
10.1146/annurev.biophys.33.110502.133613 · 2004 · External reference
Nocardiosis in Quebec, Canada, 1988–2008
10.1111/j.1469-0691.2010.03306.x · 2011 · External reference
Susceptibility profiles of nocardia spp. to antimicrobial and antituberculotic agents detected by a microplate alamar blue assay
2017 · External reference
Antimicrobial susceptibility profiles and species distribution of medically relevant nocardia species: results from a large tertiary laboratory in Australia
10.1016/j.jgar.2019.06.018 · 2020 · External reference
Pathogenic Nocardia cyriacigeorgica and Nocardia nova evolve to resist trimethoprim-sulfamethoxazole by both expected and unexpected pathways
10.1128/aac.00364-18 · 2018 · External reference
Directed evolution of trimethoprim resistance in Escherichia coli
10.1111/j.1742-4658.2007.05801.x · 2007 · External reference
Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates
10.1039/c6sc05235e · 2017 · External reference
Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens
10.1038/s42003-022-03384-y · 2022 · External reference
Properties of brodimoprim as an inhibitor of dihydrofolate reductases
1984 · External reference
Construction of a pair of practical nocardia-escherichia coli shuttle vectors
10.7883/yoken.jjid.2007.45 · 2007 · External reference
XDS
10.1107/s0907444909047337 · 2010 · External reference
Solving structures of protein complexes by molecular replacement with phaser
10.1107/s0907444906045975 · 2007 · External reference
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in phenix
10.1107/s2059798319011471 · 2019 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Current developments in coot for macromolecular model building of electron Cryo-microscopy and crystallographic data
10.1002/pro.3791 · 2020 · External reference
FoldScript: a web server for the efficient analysis of AI-generated 3D protein models
10.1093/nar/gkaf326 · 2025 · External reference
Massive overproduction of dihydrofolate reductase in bacteria as a response to the use of trimethoprim
10.1111/j.1432-1033.1987.tb10664.x · 1987 · External reference
Opposing effects of target overexpression reveal drug mechanisms
10.1038/ncomms5296 · 2014 · External reference
Cloning, expression, and characterization of Mycobacterium tuberculosis dihydrofolate reductase
10.1016/s0378-1097(04)00038-2 · 2004 · External reference
Kinetic and chemical mechanism of the dihydrofolate reductase from Mycobacterium tuberculosis
10.1021/bi1016843 · 2010 · External reference
Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis
10.1016/j.chembiol.2014.04.009 · 2014 · External reference
10.1128/aac.00717-23
10.1128/aac.00717-23 · External reference
Methotrexate, rheumatoid arthritis and infection risk: what is the evidence?
10.1093/rheumatology/kep101 · 2009 · External reference
Rational exploration of 2,4-Diaminopyrimidines as DHFR inhibitors active against Mycobacterium abscessus and Mycobacterium avium, two emerging human pathogens
10.1021/acs.jmedchem.4c01594 · 2024 · External reference
Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs 1
10.1006/jmbi.1999.3328 · 2000 · External reference
Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence
10.1021/bi962337c · 1997 · External reference
Deciphering key features in protein structures with the new ENDscript server
10.1093/nar/gku316 · 2014 · External reference
10.7554/elife.50509
10.7554/elife.50509 · External reference
Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii
10.1128/aac.01161-13 · 2013 · External reference