Research graph
References from “Structural and Metabolic Reprogramming by Docosahexaenoic Acid in Neuronal Cell Models of Alzheimer’s Disease”. Local targets link to admitted publications; unresolved targets remain external evidence.
Alzheimer’s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs
10.1016/j.bcp.2023.115522 · 2023 · External reference
In vitro Models of Neurodegenerative Diseases
10.3389/fcell.2020.00328 · 2020 · External reference
Computational Lipidomics of the Neuronal Plasma Membrane
10.1016/j.bpj.2017.10.017 · 2017 · External reference
New Forms of Neuroactive Phospholipids for DHA Enrichment in Brain
10.3390/md22030116 · 2024 · External reference
Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms
10.1186/s12944-020-01337-0 · 2020 · External reference
Lipidome atlas of the adult human brain
10.1038/s41467-024-48734-y · 2024 · External reference
Metabotyping of Docosahexaenoic Acid - Treated Alzheimer’s Disease Cell Model
10.1371/journal.pone.0090123 · 2014 · External reference
Emerging Role of Phospholipids and Lysophospholipids for Improving Brain Docosahexaenoic Acid as Potential Preventive and Therapeutic Strategies for Neurological Diseases
10.3390/ijms23073969 · 2022 · External reference
Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids
10.3390/ijms242115693 · 2023 · External reference
Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements
10.1139/h07-034 · 2007 · External reference
Docosahexaenoic Acid (DHA) Bioavailability in Humans after Oral Intake of DHA-Containing Triacylglycerol or the Structured Phospholipid AceDoPC®
10.3390/nu12010251 · 2020 · External reference
Brain docosahexaenoic acid uptake and metabolism
10.1016/j.mam.2017.12.004 · 2018 · External reference
Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain
2021 · External reference
The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer’s disease
10.1016/j.jnutbio.2016.03.002 · 2016 · External reference
Effects of DHA on cognitive dysfunction in aging and Alzheimer’s disease: The mediating roles of ApoE
10.1016/j.plipres.2023.101256 · 2024 · External reference
New Pathways Identify Novel Drug Targets for the Prevention and Treatment of Alzheimer’s Disease
10.3390/ijms24065383 · 2023 · External reference
Dietary Bioactives in Alzheimer’s Disease: A Critical Appraisal of Clinical Trials and Future Nutritional Strategies
10.3390/nu18060907 · 2026 · External reference
Modeling Alzheimer’s disease with iPSC-derived brain cells
10.1038/s41380-019-0468-3 · 2020 · External reference
Development of an accelerated cellular model for early changes in Alzheimer’s disease
10.1038/s41598-023-45826-5 · 2023 · External reference
Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
10.1016/j.stem.2013.01.009 · 2013 · External reference
The Protective Effect of Docosahexaenoic Acid on Mitochondria in SH-SY5Y Model of Rotenone-Induced Toxicity
10.3390/metabo15010029 · 2025 · External reference
Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms
10.1074/jbc.m110.182329 · 2011 · External reference
Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function
10.1111/j.1471-4159.2009.06335.x · 2009 · External reference
A Comparative Study about the Neuroprotective Effects of DHA-Enriched Phosphatidylserine and EPA-Enriched Phosphatidylserine against Oxidative Damage in Primary Hippocampal Neurons
10.3390/md21070410 · 2023 · External reference
Docosahexaenoic acid: membrane properties of a unique fatty acid
10.1016/s0009-3084(03)00101-4 · 2003 · External reference
Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes
10.1016/j.isci.2024.110362 · 2024 · External reference
Docosahexaenoic acid supplementation of primary rat hippocampal neurons attenuates the neurotoxicity induced by aggregated amyloid beta protein42 and up-regulates cytoskeletal protein expression
10.1016/j.jnutbio.2009.01.012 · 2010 · External reference
Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: Implications for Alzheimer’s disease
10.1002/jnr.22603 · 2011 · External reference
The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol
10.1126/science.1219988 · 2012 · External reference
Understanding the cholesterol metabolism-perturbing effects of docosahexaenoic acid by gas chromatography–mass spectrometry targeted metabonomic profiling
10.1007/s00394-015-1053-4 · 2017 · External reference
Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels
10.1074/jbc.m801520200 · 2008 · External reference
Docosahexaenoic acid stimulates non‐amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer’s disease
10.1111/j.1460-9568.2007.05719.x · 2007 · External reference
Neuroprotective Role of Omega-3 Fatty Acids: Fighting Alzheimer’s Disease
10.3390/molecules30153057 · 2025 · External reference
A comparative study of the effects of phosphatidylserine rich in DHA and EPA on Aβ-induced Alzheimer’s disease using cell models
10.1039/d1fo00286d · 2021 · External reference
Molecular and Signaling Mechanisms for Docosahexaenoic Acid-Derived Neurodevelopment and Neuroprotection
10.3390/ijms23094635 · 2022 · External reference
Effects of docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and 16O/18O labeling
10.1021/pr2007285 · 2011 · External reference
Docosahexaenoic Acid Promotes Axon Outgrowth by Translational Regulation of Tau and Collapsin Response Mediator Protein 2 Expression
10.1074/jbc.m115.693499 · 2016 · External reference
Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid-β oligomers
10.1111/j.1471-4159.2005.03541.x · 2006 · External reference
Polyunsaturated fatty acids in lipid membranes regulate human neuronal function and amyloid-β production
10.1016/j.isci.2025.112557 · 2025 · External reference
A comparative study of the effects of phosphatidylserine rich in DHA and EPA on Aβ-induced Alzheimer’s disease using cell models
10.1039/d1fo00286d · 2021 · External reference
Mechanism of docosahexaenoic acid‐induced inhibition of in vitro Aβ1–42 fibrillation and Aβ1–42‐induced toxicity in SH‐S5Y5 cells
10.1111/j.1471-4159.2009.06336.x · 2009 · External reference
Increasing the Survival of a Neuronal Model of Alzheimer’s Disease Using Docosahexaenoic Acid, Restoring Endolysosomal Functioning by Modifying the Interactions between the Membrane Proteins C99 and Rab5
10.3390/ijms25136816 · 2024 · External reference
Chronic exposure to sub-lethal beta-amyloid (Aβ) inhibits the import of nuclear-encoded proteins to mitochondria in differentiated PC12 cells
10.1111/j.1471-4159.2007.04907.x · 2007 · External reference
Maternal omega-3 polyunsaturated fatty acids improved levels of DHA-enriched phosphatidylethanolamines and enriched lipid clustering in the neuronal membranes of C57BL/6 mice fetal brains during gestation
10.1016/j.jnutbio.2025.109891 · 2025 · External reference
Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer’s Disease-Related Animal Model
10.3390/ijms21113879 · 2020 · External reference
Effect of DHA and CoenzymeQ10 Against Aβ- and Zinc-Induced Mitochondrial Dysfunction in Human Neuronal Cells
10.1159/000354433 · 2013 · External reference
Dual Mechanism of Docosahexaenoic acid (DHA) in Alzheimer’s Disease: PAD4 Inhibition and Autophagy Stimulation
10.1007/s12035-025-05008-y · 2025 · External reference
Anti-Oxidative Effects of Melatonin Receptor Agonist and Omega-3 Polyunsaturated Fatty Acids in Neuronal SH-SY5Y Cells: Deciphering Synergic Effects on Anti-Depressant Mechanisms
10.1007/s12035-018-0899-x · 2018 · External reference
DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells
10.3390/ijms22063213 · 2021 · External reference
Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer’s disease
10.1016/j.ijpharm.2024.125125 · 2025 · External reference
Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer’s disease model rats
10.1111/j.1471-4159.2008.05731.x · 2008 · External reference
Differential impact of eicosapentaenoic acid and docosahexaenoic acid in an animal model of Alzheimer’s disease
10.1016/j.jlr.2024.100682 · 2024 · External reference
Docosahexaenoic Acid Ameliorates Contextual Fear Memory Deficits in the Tg2576 Alzheimer’s Disease Mouse Model: Cellular and Molecular Correlates
10.3390/pharmaceutics15010082 · 2022 · External reference
Editorial: Genetic disorders and rare diseases: in vitro models for preclinical pharmacological studies and translation
10.3389/fphar.2023.1346648 · 2023 · External reference
Human disease models in drug development
10.1038/s44222-023-00063-3 · 2023 · External reference
