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References from Forming and waking dormant cells: The ppGpp ribosome dimerization persister model. Local targets link to admitted publications; unresolved targets remain external evidence.
Observations on the mechanism of action of penicillin
10.3181/00379727-50-13773 · 1942 · External reference
Treatment of staphylococcal infections with penicillin by intermittent sterilisation
10.1016/s0140-6736(00)74210-3 · 1944 · External reference
Persisters: a distinct physiological state of E. coli
10.1186/1471-2180-6-53 · 2006 · External reference
Dormancy is not necessary or sufficient for bacterial persistence
10.1128/aac.00243-13 · 2013 · External reference
Bacterial persister cell formation and dormancy
10.1128/aem.02636-13 · 2013 · External reference
Development of Persister-FACSeq: a method to massively parallelize quantification of persister physiology and its heterogeneity
10.1038/srep25100 · 2016 · External reference
Slow growth determines nonheritable antibiotic resistance in Salmonella enterica
10.1126/scisignal.aax3938 · 2019 · External reference
Persister cells, dormancy, and infectious disease
10.1038/nrmicro1557 · 2007 · External reference
Multidrug tolerance of biofilms and persister cells
2008 · External reference
Formation, physiology, ecology, evolution and clinical importance of bacterial persisters
10.1093/femsre/fux001 · 2017 · External reference
Fighting bacterial persistence: current and emerging anti-persister strategies and therapeutics
10.1016/j.drup.2018.03.002 · 2018 · External reference
Bacteria battling for survival
2012 · External reference
Viable but non-culturable and persistence describe the same bacterial stress state
10.1111/1462-2920.14075 · 2018 · External reference
Survival and viability of nonculturable Escherichia coli and Vibrio cholerae in the estuarine and marine environment
10.1007/bf02010671 · 1982 · External reference
Persistence in phytopathogenic bacteria: do we know enough?
10.3389/fmicb.2018.01099 · 2018 · External reference
Metabolic control of PersisteMol cellr formation in Escherichia coli
10.1016/j.molcel.2013.04.002 · 2013 · External reference
Nutrient transitions are a source of persisters in Escherichia coli biofilms
10.1371/journal.pone.0093110 · 2014 · External reference
Persister heterogeneity arising from a single metabolic stress
10.1016/j.cub.2015.06.034 · 2015 · External reference
Bacterial persistence is an active σS stress response to metabolic flux limitation
10.15252/msb.20166998 · 2016 · External reference
Inhibition of stationary phase respiration impairs persister formation in E. coli
10.1038/ncomms8983 · 2015 · External reference
Single cell observations show persister cells wake based on ribosome content
10.1111/1462-2920.14093 · 2018 · External reference
Arrested protein synthesis increases persister-like cell formation
10.1128/aac.02135-12 · 2013 · External reference
Generation of persister cells of Pseudomonas aeruginosa and Staphylococcus aureus by chemical treatment and evaluation of their susceptibility to membrane-targeting agents
10.3389/fmicb.2017.01917 · 2017 · External reference
Identification of genes involved in bacteriostatic antibiotic-induced persister formation
10.3389/fmicb.2018.00413 · 2018 · External reference
Novel glycopolymer eradicates antibiotic- and CCCP-induced persister cells in Pseudomonas aeruginosa
10.3389/fmicb.2018.01724 · 2018 · External reference
Specific enrichment and proteomics analysis of Escherichia coli persisters from rifampin pretreatment
10.1021/acs.jproteome.8b00625 · 2018 · External reference
Bacteriophage Sb-1 enhances antibiotic activity against biofilm, degrades exopolysaccharide matrix and targets persisters of Staphylococcus aureus
10.1016/j.ijantimicag.2018.09.006 · 2018 · External reference
ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance
10.1016/j.molcel.2018.10.022 · 2019 · External reference
SOS response induces persistence to fluoroquinolones in Escherichia coli
10.1371/journal.pgen.1000760 · 2009 · External reference
Bacterial persistence increases as environmental fitness decreases
10.1111/j.1751-7915.2011.00327.x · 2012 · External reference
Toxin YafQ increases persister cell formation by reducing indole signalling
10.1111/1462-2920.12567 · 2015 · External reference
Phosphodiesterase DosP increases persistence by reducing cAMP which reduces the signal indole
10.1002/bit.25456 · 2015 · External reference
Halogenated indoles eradicate bacterial persister cells and biofilms
10.1186/s13568-016-0297-6 · 2016 · External reference
hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis
10.1128/jb.155.2.768-775.1983 · 1983 · External reference
HipBA-promoter structures reveal the basis of heritable multidrug tolerance
10.1038/nature14662 · 2015 · External reference
Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis
10.1046/j.1365-2958.2003.03779.x · 2003 · External reference
An Escherichia coli chromosomal "addiction module" regulated by guanosine 3’,5’-bispyrophosphate: a model for programmed bacterial cell death
10.1073/pnas.93.12.6059 · 1996 · External reference
Retraction notice to: ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity
10.1016/j.cell.2018.02.023 · 2018 · External reference
Bacterial persistence by RNA endonucleases
2018 · External reference
Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases
2019 · External reference
Commentary: what is the link between stringent response, endoribonuclease encoding type II toxin-antitoxin systems and persistence?
10.3389/fmicb.2017.00191 · 2017 · External reference
Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity
10.4161/bioe.29261 · 2014 · External reference
Genetic basis of persister tolerance to aminoglycosides in Escherichia coli
10.1128/mbio.00078-15 · 2015 · External reference
Persistence increases in the absence of the alarmone guanosine tetraphosphate by reducing cell growth
10.1038/srep20519 · 2016 · External reference
What is the link between stringent response, endoribonuclease encoding type II toxin–antitoxin systems and persistence?
10.3389/fmicb.2016.01882 · 2016 · External reference
ATP-dependent persister formation in Escherichia coli
10.1128/mbio.02267-16 · 2017 · External reference
Prophages and growth dynamics confound experimental results with antibiotic-tolerant persister cells
10.1128/mbio.01964-17 · 2017 · External reference
Contact-dependent growth inhibition induces high levels of antibiotic-tolerant persister cells in clonal bacterial populations
10.15252/embj.201798026 · 2018 · External reference
Reassessing the role of type II toxin-antitoxin systems in formation of Escherichia coli type II persister cells
2018 · External reference
Birth and resuscitation of (p)ppGpp induced antibiotic tolerant persister cells
10.1038/s41598-019-42403-7 · 2019 · External reference
Toxin MqsR cleaves single-stranded mRNA with various 5’ ends
10.1002/mbo3.335 · 2016 · External reference
Gene expression in Escherichia coli biofilms
10.1007/s00253-003-1517-y · 2004 · External reference
Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation
10.1074/jbc.m110.172643 · 2011 · External reference
Antitoxin MqsA helps mediate the bacterial general stress response
10.1038/nchembio.560 · 2011 · External reference
Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS
10.1111/1462-2920.12063 · 2013 · External reference
Post-segregational killing and phage inhibition are not mediated by cell death through toxin/antitoxin systems
10.3389/fmicb.2018.00814 · 2018 · External reference
Exclusion of T4 phage by the hok/sok killer locus from plasmid R1
10.1128/jb.178.7.2044-2050.1996 · 1996 · External reference
Mini-F plasmid genes that couple host cell division to plasmid proliferation
10.1073/pnas.80.15.4784 · 1983 · External reference
Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress
10.1128/jb.182.3.561-572.2000 · 2000 · External reference
Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)
10.1128/jb.188.1.305-316.2006 · 2006 · External reference
Toxin-antitoxin systems in Escherichia coli influence biofilm formation through YjgK (TabA) and fimbriae
10.1128/jb.01465-08 · 2009 · External reference
Many means to a common end: the intricacies of (p)ppGpp metabolism and its control of bacterial homeostasis
10.1128/jb.02577-14 · 2015 · External reference
Involvement of cyclic AMP receptor protein in regulation of the rmf gene encoding the ribosome modulation factor in Escherichia coli
10.1128/jb.02279-12 · 2013 · External reference
ppGpp: magic beyond RNA polymerase
10.1038/nrmicro2720 · 2012 · External reference
Affinity-based capture and identification of protein effectors of the growth regulator ppGpp
10.1038/s41589-018-0183-4 · 2019 · External reference
ppGpp regulates a bacterial nucleosidase by an allosteric two-domain switch
10.1016/j.molcel.2019.03.035 · 2019 · External reference
The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus
10.1371/journal.pgen.1008346 · 2019 · External reference
Novel (p)ppGpp binding and metabolizing proteins of Escherichia coli
10.1128/mbio.02188-17 · 2018 · External reference
Expression of ribosome modulation factor (RMF) in Escherichia coli requires ppGpp
10.1046/j.1365-2443.2001.00457.x · 2001 · External reference
Ribosome modulation factor: stationary growth phase-specific inhibitor of ribosome functions from Escherichia coli
10.1006/bbrc.1995.2302 · 1995 · External reference
Ribosome binding proteins YhbH and YfiA have opposite functions during 100S formation in the stationary phase of Escherichia coli
10.1111/j.1365-2443.2005.00903.x · 2005 · External reference
Ribosome hibernation
10.1146/annurev-genet-120215-035130 · 2018 · External reference
Coordinated hibernation of transcriptional and translational apparatus during growth transition of Escherichia coli to stationary phase
10.1128/msystems.00057-18 · 2018 · External reference
ppGpp ribosome dimerization model for bacterial persister formation and resuscitation
2019 · External reference
Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli
10.1371/journal.pbio.1000317 · 2010 · External reference
Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress
10.1111/1462-2920.12373 · 2014 · External reference
Persister formation in Staphylococcus aureus is associated with ATP depletion
10.1038/nmicrobiol.2016.51 · 2016 · External reference
A genetic determinant of persister cell formation in bacterial pathogens
10.1128/jb.00303-18 · 2018 · External reference
Persister cells resuscitate using membrane sensors that activate chemotaxis, lower cAMP levels, and revive ribosomes
10.1016/j.isci.2019.100792 · 2020 · External reference
Microbial awakenings
10.1038/4571083a · 2009 · External reference
Power-law tail in lag time distribution underlies bacterial persistence
10.1073/pnas.1903836116 · 2019 · External reference
Ribosome dependence of persister cell formation and resuscitation
2019 · External reference
Single-cell imaging and characterization of Escherichia coli persister cells to ofloxacin in exponential cultures
10.1126/sciadv.aav9462 · 2019 · External reference
A Salmonella toxin promotes persister formation through acetylation of tRNA
10.1016/j.molcel.2016.05.002 · 2016 · External reference
HokB monomerization and membrane repolarization control persister awakening
10.1016/j.molcel.2019.06.015 · 2019 · External reference
The persistence-inducing toxin HokB forms dynamic pores that cause ATP leakage
10.1128/mbio.00744-18 · 2018 · External reference
Obg and membrane depolarization are part of a microbial bet-hedging strategy that leads to antibiotic tolerance
10.1016/j.molcel.2015.05.011 · 2015 · External reference
Survival of the drowsiest: the hibernating 100S ribosome in bacterial stress management
10.1007/s00294-017-0796-2 · 2018 · External reference
Negative effect of glucose on ompA mRNA stability: a potential role of cyclic AMP in the repression of hfq in Escherichia coli
10.1128/jb.05359-11 · 2011 · External reference
HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions
10.1038/nsmb.3103 · 2015 · External reference
Persister cells resuscitate via ribosome modification by 23S rRNA pseudouridine synthase RluD
10.1111/1462-2920.14828 · 2020 · External reference
Bacterial persistence as a phenotypic switch
10.1126/science.1099390 · 2004 · External reference
Stationary-phase genes upregulated by polyamines are responsible for the formation of Escherichia coli persister cells tolerant to netilmicin
10.1093/femsle/fnx084 · 2017 · External reference
Ribosome hibernation facilitates tolerance of stationary-phase bacteria to aminoglycosides
10.1128/aac.01532-15 · 2015 · External reference
The influence of ribosome modulation factor on the survival of stationary-phase Escherichia coli during acid stress
10.1099/mic.0.2006/001552-0 · 2007 · External reference
Role of 100S ribosomes in bacterial decay period
10.1111/gtc.12273 · 2015 · External reference
Regulation of the Escherichia coli rmf gene encoding the ribosome modulation factor: growth phase-and growth rate dependent control
10.1002/j.1460-2075.1993.tb05695.x · 1993 · External reference
Essentiality of ribosomal and transcription antitermination proteins analyzed by systematic gene replacement in Escherichia coli
10.1128/jb.01713-06 · 2007 · External reference
Expression and regulation of the Pseudomonas aeruginosa hibernation promoting factor
10.1111/mmi.14001 · 2018 · External reference
Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria
10.1126/science.1211037 · 2011 · External reference
Resuscitation of Pseudomonas aeruginosa from dormancy requires hibernation promoting factor (PA4463) for ribosome preservation
10.1073/pnas.1700695114 · 2017 · External reference
Unresolved reference
External reference
Identification of a potent indigoid persister antimicrobial by screening dormant cells
10.1002/bit.27078 · 2019 · External reference
DNA-crosslinker cisplatin eradicates bacterial persister cells
10.1002/bit.25963 · 2016 · External reference
Repurposing the anticancer drug mitomycin C for the treatment of persistent Acinetobacter baumannii infections
10.1016/j.ijantimicag.2016.08.022 · 2016 · External reference
Dormant, quiescent, tolerant and persister cells: four synonyms for the same target in cancer
10.1016/j.bcp.2018.11.004 · 2019 · External reference