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References from Biofilm dispersion: The key to biofilm eradication or opening Pandora’s box?. Local targets link to admitted publications; unresolved targets remain external evidence.
Microbial biofilm formation: a need to act
10.1111/joim.12242 · 2014 · External reference
Role of multicellular aggregates in biofilm formation
10.1128/mbio.00237-16 · 2016 · External reference
Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits in vivo -like characteristics
10.1128/aem.00113-17 · 2017 · External reference
The in vivo biofilm
10.1016/j.tim.2013.06.002 · 2013 · External reference
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria
10.1093/femsre/fux010 · 2017 · External reference
Antimicrobial tolerance in biofilms
10.1128/microbiolspec.mb-0010-2014 · 2015 · External reference
Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials
10.1128/jb.183.23.6746-6751.2001 · 2001 · External reference
The effect of the growth phase of Staphylococcus aureus on resistance to disinfectants in a suspension test
10.4315/0362-028x-65.1.124 · 2002 · External reference
Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms
10.1016/j.tim.2014.02.001 · 2014 · External reference
Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses
10.1177/0022034509359403 · 2010 · External reference
Biofilm dispersion
2011 · External reference
10.1016/j.bioflm.2019.100012 · 2020 · Admitted local publication
Approaches to dispersing medical biofilms
10.3390/microorganisms5020015 · 2017 · External reference
Modulation of pseudomonas aeruginosa biofilm dispersal by a cyclic-di-gmp phosphodiesterase with a putative hypoxia-sensing domain
10.1128/aem.01233-10 · 2010 · External reference
Escaping the biofilm in more than one way: desorption, detachment or dispersion
10.1016/j.mib.2016.01.004 · 2016 · External reference
CdpA is a Burkholderia pseudomallei cyclic di-GMP phosphodiesterase involved in autoaggregation, flagellum synthesis, motility, biofilm formation, cell invasion, and cytotoxicity
10.1128/iai.00446-09 · 2010 · External reference
Cyclic di-GMP inhibits Vibrio cholerae motility by repressing induction of transcription and inducing extracellular polysaccharide production
10.1111/mmi.12432 · 2013 · External reference
Cyclic di-GMP: the first 25 Years of a universal bacterial second messenger
10.1128/mmbr.00043-12 · 2013 · External reference
Discovery of the second messenger cyclic di-GMP
10.1007/978-1-4939-7240-1_1 · 2017 · External reference
Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa
10.1128/jb.00779-06 · 2006 · External reference
Characterization of nutrient-induced dispersion in Pseudomonas aeruginosa PAO1 biofilm
10.1128/jb.186.21.7312-7326.2004 · 2004 · External reference
The phosphodiesterase DipA (PA5017) is essential for Pseudomonas aeruginosa biofilm dispersion
10.1128/jb.05346-11 · 2012 · External reference
Agr-mediated dispersal of Staphylococcus aureus biofilms
10.1371/journal.ppat.1000052 · 2008 · External reference
Diffusion in biofilms
10.1128/jb.185.5.1485-1491.2003 · 2003 · External reference
Physiological heterogeneity in biofilms
10.1038/nrmicro1838 · 2008 · External reference
Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis
10.1136/thx.2009.114512 · 2010 · External reference
Microenvironmental characteristics and physiology of biofilms in chronic infections of CF patients are strongly affected by the host immune response
10.1111/apm.12668 · 2017 · External reference
BdlA, DipA and induced dispersion contribute to acute virulence and chronic persistence of Pseudomonas aeruginosa
10.1371/journal.ppat.1004168 · 2014 · External reference
Insights into biofilm dispersal regulation from the crystal structure of the PAS-GGDEF-EAL region of RbdA from Pseudomonas aeruginosa
2017 · External reference
The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation
10.1099/mic.0.000354 · 2016 · External reference
Susceptibility of Pseudomonas aeruginosa dispersed cells to antimicrobial agents is dependent on the dispersion cue and class of the antimicrobial agent used
10.1128/aac.00846-17 · 2017 · External reference
Nitric oxide and the immune response
10.1038/ni1001-907 · 2001 · External reference
Low-dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis
10.1016/j.ymthe.2017.06.021 · 2017 · External reference
Nitric oxide-mediated dispersal in single- and multi-species biofilms of clinically and industrially relevant microorganisms
10.1111/j.1751-7915.2009.00098.x · 2009 · External reference
Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal
10.1128/jb.00975-09 · 2009 · External reference
PAS domain residues and prosthetic group involved in bdladependent dispersion response by pseudomonas aeruginosa biofilms
10.1128/jb.00780-12 · 2012 · External reference
NO-induced biofilm dispersion in Pseudomonas aeruginosa is mediated by an MHYT domain-coupled phosphodiesterase
10.1128/jb.01156-12 · 2013 · External reference
Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis
2011 · External reference
Cyclic di-GMP-regulated periplasmic proteolysis of a Pseudomonas aeruginosa type vb secretion system substrate
10.1128/jb.00369-15 · 2016 · External reference
The stringent response promotes biofilm dispersal in Pseudomonas putida
10.1038/s41598-017-18518-0 · 2017 · External reference
The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface
10.1002/mbo3.301 · 2015 · External reference
Controlling the connections of cells to the biofilm matrix
10.1128/jb.00865-15 · 2016 · External reference
Pseudomonas aeruginosa requires the DNA-specific endonuclease EndA to degrade eDNA to disperse from the biofilm
10.1128/jb.00059-19 · 2019 · External reference
Two cases of poisoning by contamination of nitrous oxide with higher oxides of nitrogen during anaesthesia
10.1093/bja/39.5.388 · 1967 · External reference
An in vivo safety and efficacy demonstration of a topical liposomal nitric oxide donor treatment for Staphylococcus aureus biofilm-associated rhinosinusitis
10.1016/j.trsl.2015.06.009 · 2015 · External reference
Cephalosporin-3′-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms
10.1002/anie.201202414 · 2012 · External reference
Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase
10.1039/c3cc40869h · 2013 · External reference
Cephalosporin-3’-Diazeniumdiolate NO donor prodrug PYRRO-C3D enhances azithromycin susceptibility of nontypeable Haemophilus influenzae biofilms
10.1128/aac.02086-16 · 2017 · External reference
Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam - mediated activity against Streptococcus pneumoniae biofilms
10.1016/j.niox.2017.02.006 · 2017 · External reference
Interkingdom signaling induces Streptococcus pneumoniae biofilm dispersion and transition from asymptomatic colonization to disease
10.1128/mbio.00438-13 · 2013 · External reference
Candida albicans dispersed cells are developmentally distinct from biofilm and planktonic cells
10.1128/mbio.01338-18 · 2018 · External reference
Dispersion as an important step in the Candida albicans biofilm developmental cycle
10.1371/journal.ppat.1000828 · 2010 · External reference
BdlA, a chemotaxis regulator essential for biofilm dispersion in Pseudomonas aeruginosa
10.1128/jb.00599-06 · 2006 · External reference
Nutrient dispersion enhances conventional antibiotic activity against Pseudomonas aeruginosa biofilms
10.1016/j.ijantimicag.2012.04.015 · 2012 · External reference
Characterization of starvation-induced dispersion in Pseudomonas putida biofilms
10.1111/j.1462-2920.2005.00775.x · 2005 · External reference
Glucose starvation-induced dispersal of Pseudomonas aeruginosa biofilms is cAMP and energy dependent
10.1371/journal.pone.0042874 · 2012 · External reference
Vibrio cholerae combines individual and collective sensing to trigger biofilm dispersal
10.1016/j.cub.2017.09.041 · 2017 · External reference
Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitr o and in vivo
10.1038/s41598-019-40378-z · 2019 · External reference
Heavy metal toxicity, part I: arsenic and mercury
10.1016/s0736-4679(97)00241-2 · 1998 · External reference
Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds
10.1007/s10295-006-0139-7 · 2006 · External reference
Unresolved reference
1988 · External reference
Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous beta-hexosaminidase activity
10.1128/jb.185.16.4693-4698.2003 · 2003 · External reference
Enzymatic detachment of Staphylococcus epidermidis biofilms
10.1128/aac.48.7.2633-2636.2004 · 2004 · External reference
Detachment and killing of Aggregatibacter actinomycetemcomitans biofilms by dispersin B and SDS
10.1177/154405910708600707 · 2007 · External reference
Synergistic activity of dispersin B and cefamandole nafate in inhibition of staphylococcal biofilm growth on polyurethanes
10.1128/aac.01249-06 · 2007 · External reference
Antimicrobial and antibiofilm efficacy of triclosan and DispersinB(R) combination
10.1093/jac/dkp158 · 2009 · External reference
In vitro antimicrobial efficacy of tobramycin against Staphylococcus aureus biofilms in combination with or without DNase I and/or dispersin B: a preliminary investigation
10.1089/mdr.2016.0100 · 2017 · External reference
Antibiofilm and antimicrobial efficacy of DispersinB®-KSL-W peptide-based wound gel against chronic wound infection associated bacteria
10.1007/s00284-014-0519-6 · 2014 · External reference
Antibiofilm efficacy of DispersinB ® wound spray used in combination with a silver wound dressing
10.4137/mbi.s13914 · 2014 · External reference
Untethering and degradation of the polysaccharide matrix are essential steps in the dispersion response of Pseudomonas aeruginosa biofilms
2019 · External reference
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
10.1126/sciadv.1501632 · 2016 · External reference
PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix
10.1038/cr.2015.129 · 2015 · External reference
The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix
10.1111/j.1462-2920.2011.02657.x · 2012 · External reference
Extracellular DNA required for bacterial biofilm formation
10.1126/science.295.5559.1487 · 2002 · External reference
Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci
10.1038/ja.2011.113 · 2012 · External reference
Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates
10.1186/1471-2180-8-173 · 2008 · External reference
Effect of DNase and antibiotics on biofilm characteristics
10.1128/aac.00471-08 · 2009 · External reference
Extracellular DNA is essential for maintaining Bordetella biofilm integrity on abiotic surfaces and in the upper respiratory tract of mice
10.1371/journal.pone.0016861 · 2011 · External reference
DNase inhibits Gardnerella vaginalis biofilms in vitro and in vivo
10.1093/infdis/jit047 · 2013 · External reference
Achromobacter species isolated from cystic fibrosis patients reveal distinctly different biofilm morphotypes
10.3390/microorganisms4030033 · 2016 · External reference
Effect of aerosolized rhDNase (Pulmozyme®) on pulmonary colonization in patients with cystic fibrosis
10.1080/08035250600752466 · 2006 · External reference
Dispersal of biofilms by secreted, matrix degrading, bacterial DNase
10.1371/journal.pone.0015668 · 2010 · External reference
Dispersal of Bap-mediated Staphylococcus aureus biofilm by proteinase K
10.1038/ja.2012.98 · 2013 · External reference
DNase I and proteinase K impair Listeria monocytogenes biofilm formation and induce dispersal of pre-existing biofilms
10.1016/j.ijfoodmicro.2014.06.025 · 2014 · External reference
Enzymatic degradation of in vitro Staphylococcus aureus biofilms supplemented with human plasma
2016 · External reference
Unresolved reference
2003 · External reference
Analysis of the mechanical stability and surface detachment of mature Streptococcus mutans biofilms by applying a range of external shear forces
10.1080/08927014.2014.969249 · 2014 · External reference
Quantitative analyses of Streptococcus mutans biofilms with quartz crystal microbalance, microjet impingement and confocal microscopy
10.1017/s1479050504001516 · 2004 · External reference
Regular debridement is the main tool for maintaining a healthy wound bed in most chronic wounds
10.12968/jowc.2009.18.2.38743 · 2009 · External reference
Biofilm maturity studies indicate sharp debridement opens a timedependent therapeutic window
10.12968/jowc.2010.19.8.77709 · 2010 · External reference
Effect of a dental water jet with orthodontic tip on plaque and bleeding in adolescent patients with fixed orthodontic appliances
10.1016/j.ajodo.2007.12.008 · 2008 · External reference
Biofilm removal with a dental water jet
2009 · External reference
“Escherichia coli -milk” biofilm removal from stainless steel surfaces: synergism between ultrasonic waves and enzymes
2003 · External reference
Combined effect of chelating agents and ultrasound on biofilm removal from stainless steel surfaces. Application to “ Escherichia coli milk” and “ Staphylococcus aureus milk” biofilms
10.1017/s1479050504001140 · 2004 · External reference
The effect of ultrasonic frequency upon enhanced killing ofP. aeruginosa biofilms
10.1007/bf02738539 · 1997 · External reference
The role of insonation intensity in acoustic-enhanced antibiotic treatment of bacterial biofilms
10.1016/s0927-7765(97)00029-5 · 1997 · External reference
Effect of low-intensity ultrasound upon biofilm structure from confocal scanning laser microscopy observation
10.1016/0142-9612(96)00022-1 · 1996 · External reference
Ultrasonic enhancement of antibiotic action on Escherichia coli biofilms: an in vivo model
10.1128/aac.43.5.1211 · 1999 · External reference
Effect of pulsed ultrasound in combination with gentamicin on bacterial viability in biofilms on bone cements in vivo
10.1111/j.1365-2672.2005.02643.x · 2005 · External reference
Ultrasonically enhanced vancomycin activity against Staphylococcus epidermidis biofilms in vivo
10.1177/0885328204040540 · 2004 · External reference
Passive ultrasonic irrigation of the root canal: a review of the literature
10.1111/j.1365-2591.2007.01243.x · 2007 · External reference
Efficacy of sonically, ultrasonically and laser-activated irrigation in removing a biofilm-mimicking hydrogel from an isthmus model
10.1111/iej.13024 · 2019 · External reference
Laser disruption of biofilm
10.1097/mlg.0b013e31816ed59d · 2008 · External reference
Laser-generated shockwave for clearing medical device biofilms
10.1089/pho.2010.2788 · 2011 · External reference
Laser disruption and killing of methicillin-resistant Staphylococcus aureus biofilms
10.1016/j.amjoto.2010.01.010 · 2011 · External reference
Laser-induced shock waves enhance sterilization of infected vascular prosthetic grafts
10.1002/lsm.1138 · 2001 · External reference
Analysis of flexible substrates for clinical translation of laser-generated shockwave therapy
10.1364/boe.6.000827 · 2015 · External reference
Laser-generated shockwaves as a treatment to reduce bacterial load and disrupt biofilm
10.1109/tbme.2016.2581778 · 2017 · External reference
Laser-generated shockwaves enhance antibacterial activity against biofilms in vitro
10.1002/lsm.22627 · 2017 · External reference
In-depth analysis of antibacterial mechanisms of laser generated shockwave treatment
10.1002/lsm.23018 · 2019 · External reference
Cavitation as a working mechanism of the Er, Cr: YSGG laser in endodontics: a visualization study
2007 · External reference
Efficacy of ultrasonic versus laser-activated irrigation to remove artificially placed dentin debris plugs
2010 · External reference
Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms
10.1038/s41467-018-06884-w · 2018 · External reference
10.1016/j.bioflm.2019.100004 · 2019 · Admitted local publication
Electrical enhancement of biocide efficacy against Pseudomonas aeruginosa biofilms
10.1128/aem.58.11.3770-3773.1992 · 1992 · External reference
Electric current-induced detachment of Staphylococcus epidermidis biofilms from surgical stainless steel
10.1128/aem.70.11.6871-6874.2004 · 2004 · External reference
Removal and inactivation of Staphylococcus epidermidis biofilms by electrolysis
10.1128/aem.00442-06 · 2006 · External reference
Bioelectric effect and bacterial biofilms. A systematic review
10.1177/039139880803100906 · 2008 · External reference
Electrical enhancement of Streptococcus gordonii biofilm killing by gentamicin
10.1016/s0003-9969(99)00132-6 · 2000 · External reference
The electricidal effect: reduction of Staphylococcus and Pseudomonas biofilms by prolonged exposure to low-intensity electrical current
10.1128/aac.00680-08 · 2009 · External reference
Electrolytic generation of oxygen partially explains electrical enhancement of tobramycin efficacy againstPseudomonas aeruginosa biofilm
10.1128/aac.43.2.292 · 1999 · External reference
Exposure of bacterial biofilms to electrical current leads to cell death mediated in part by reactive oxygen species
10.1371/journal.pone.0168595 · 2016 · External reference
Capacitive coupling reduces instrumentation-related infection in rabbit spines: a pilot study
10.1007/s11999-011-2231-1 · 2012 · External reference
Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles
10.1038/ncomms5462 · 2014 · External reference
Bis-(3’-5’)-cyclic dimeric GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa
10.1128/aac.02499-12 · 2013 · External reference
The consequences of biofilm dispersal on the host
10.1038/s41598-018-29121-2 · 2018 · External reference
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
10.1038/nrmicro1871 · 2008 · External reference
Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children
10.1016/s0140-6736(04)16357-5 · 2004 · External reference
Host physiologic changes induced by influenza A virus lead to Staphylococcus aureus biofilm dispersion and transition from asymptomatic colonization to invasive disease
10.1128/mbio.01235-16 · 2016 · External reference
Streptococcus pneumoniae modulates Staphylococcus aureus biofilm dispersion and the transition from colonization to invasive disease
10.1128/mbio.02089-17 · 2018 · External reference
Nitric oxide-mediated induction of dispersal in Pseudomonas aeruginosa biofilms is inhibited by flavohemoglobin production and is enhanced by imidazole
10.1128/aac.01832-17 · 2018 · External reference
Debridement and wound bed preparation
10.1111/j.1529-8019.2006.00090.x · 2006 · External reference
Hydrodebridement of wounds: effectiveness in reducing wound bacterial contamination and potential for air bacterial contamination
2009 · External reference
Effect of laser generated shockwaves 1 on ex-vivo pigskin
10.1002/lsm.22278 · 2014 · External reference
Unresolved reference
2017 · External reference