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References from Nontypeable Haemophilus influenzae newly released (NRel) from biofilms by antibody-mediated dispersal versus antibody-mediated disruption are phenotypically distinct. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogenesis of mucosal biofilm infections: challenges and progress
10.1586/14787210.6.2.201 · 2008 · External reference
Bacterial biofilms: a common cause of persistent infections
10.1126/science.284.5418.1318 · 1999 · External reference
The biofilm matrix
10.1038/nrmicro2415 · 2010 · External reference
Insights on persistent airway infection by non-typeable Haemophilus influenzae in chronic obstructive pulmonary disease
10.1093/femspd/ftx042 · 2017 · External reference
Haemophilus influenzae in children with cystic fibrosis: antimicrobial susceptibility, molecular epidemiology, distribution of adhesins and biofilm formation
10.1016/j.ijmm.2011.08.003 · 2012 · External reference
Dps promotes survival of nontypeable Haemophilus influenzae in biofilm communities in vitro and resistance to clearance in vivo
10.3389/fcimb.2012.00058 · 2012 · External reference
Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media
10.1097/inf.0b013e3181950c74 · 2009 · External reference
Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae
2018 · External reference
Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children
10.1186/1471-2334-12-312 · 2012 · External reference
Microbiology of otitis media: a moving target
10.1016/j.vaccine.2008.11.006 · 2008 · External reference
Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule
10.1016/j.vaccine.2011.05.035 · 2011 · External reference
Molecular mechanisms of Moraxella catarrhalis-induced otitis media
10.1007/s11882-013-0374-8 · 2013 · External reference
Microbial otitis media: recent advancements in treatment, current challenges and opportunities
10.1099/jmm.0.000810 · 2018 · External reference
Do orally administered antibiotics reach concentrations in the middle ear sufficient to eradicate planktonic and biofilm bacteria? A review
10.1016/j.ijporl.2015.01.003 · 2015 · External reference
Current understanding of the human microbiome
10.1038/nm.4517 · 2018 · External reference
Reported rates of diarrhea following oral penicillin therapy in pediatric clinical trials
10.5863/1551-6776-20.2.90 · 2015 · External reference
Childhood inflammatory and metabolic disease following exposure to antibiotics in pregnancy
2020 · External reference
Antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and group A beta-haemolytic streptococci in 2002-2003. Results of the multinational GRASP Surveillance Program
10.1016/j.ijantimicag.2004.09.016 · 2005 · External reference
Current management of pediatric acute otitis media
10.1586/eri.09.112 · 2010 · External reference
The relationship between pneumococcal serotypes and antibiotic resistance
10.1016/j.vaccine.2012.01.091 · 2012 · External reference
Vaccination greatly reduces disease, disability, death and inequity worldwide
10.2471/blt.07.040089 · 2008 · External reference
Demonstration of type IV pilus expression and a twitching phenotype by Haemophilus influenzae
10.1128/iai.73.3.1635-1643.2005 · 2005 · External reference
Biological roles of nontypeable Haemophilus influenzae type IV pilus proteins encoded by the pil and com operons
10.1128/jb.06540-11 · 2012 · External reference
Extracellular DNA and type IV pilus expression regulate the structure and kinetics of biofilm formation by nontypeable Haemophilus influenzae
10.1128/mbio.01466-17 · 2017 · External reference
The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract
10.1111/j.1365-2958.2007.05864.x · 2007 · External reference
Expression of the nontypeable Haemophilus influenzae type IV pilus is stimulated by coculture with host respiratory tract epithelial cells
10.1128/iai.00704-19 · 2019 · External reference
Type IV pilus expression is upregulated in nontypeable Haemophilus influenzae biofilms formed at the temperature of the human nasopharynx
10.1128/jb.01022-15 · 2016 · External reference
Nontypeable Haemophilus influenzae Type IV pilus mediates augmented adherence to rhinovirus-infected human airway epithelial cells
10.1128/iai.00248-20 · 2020 · External reference
Antibodies against the majority subunit (PilA) of the type IV pilus of nontypeable Haemophilus influenzae disperse Moraxella catarrhalis from a dual-species biofilm
10.1128/mbio.02423-18 · 2018 · External reference
Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates
10.1016/j.vaccine.2009.08.017 · 2009 · External reference
Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization
10.1016/j.vaccine.2012.10.033 · 2013 · External reference
Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo
10.1016/j.ebiom.2016.06.022 · 2016 · External reference
Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media
10.1111/mmi.12934 · 2015 · External reference
A protein E-PilA fusion protein shows vaccine potential against nontypeable Haemophilus influenzae in mice and chinchillas
10.1128/iai.00345-19 · 2019 · External reference
LuxS promotes biofilm maturation and persistence of nontypeable Haemophilus influenzae in vivo via modulation of lipooligosaccharides on the bacterial surface
10.1128/iai.00320-09 · 2009 · External reference
Haemophilus influenzae luxS mutants form a biofilm and have increased virulence
10.1016/j.micpath.2005.06.003 · 2005 · External reference
Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production
10.1073/pnas.96.4.1639 · 1999 · External reference
RbsB (NTHI_0632) mediates quorum signal uptake in nontypeable Haemophilus influenzae strain 86-028NP
10.1111/j.1365-2958.2011.07831.x · 2011 · External reference
Autoinducer 2 (AI-2) production by nontypeable Haemophilus influenzae 86-028NP promotes expression of a predicted glycosyltransferase that is a determinant of biofilm maturation, prevention of dispersal, and persistence in vivo
10.1128/iai.00506-18 · 2018 · External reference
Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling
10.1128/mbio.00102-10 · 2010 · External reference
Comparison of histone-like HU protein DNA-binding properties and HU/IHF protein sequence alignment
10.1371/journal.pone.0188037 · 2017 · External reference
The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure
2018 · External reference
DNABII proteins play a central role in UPEC biofilm structure
10.1111/mmi.12994 · 2015 · External reference
Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein
10.1371/journal.pone.0067629 · 2013 · External reference
Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins
10.1038/mi.2011.27 · 2011 · External reference
Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein
10.1128/jb.01935-06 · 2007 · External reference
Extracellular DNA required for bacterial biofilm formation
10.1126/science.295.5559.1487 · 2002 · External reference
Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms
10.1111/mmi.12735 · 2014 · External reference
Redirecting the immune response towards immunoprotective domains of a DNABII protein resolves experimental otitis media
10.1038/s41541-019-0137-1 · 2019 · External reference
A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein
10.1111/omi.12155 · 2017 · External reference
Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles
10.1038/ncomms5462 · 2014 · External reference
Interkingdom signaling induces Streptococcus pneumoniae biofilm dispersion and transition from asymptomatic colonization to disease
10.1128/mbio.00438-13 · 2013 · External reference
Characterization of nutrient-induced dispersion in Pseudomonas aeruginosa PAO1 biofilm
10.1128/jb.186.21.7312-7326.2004 · 2004 · External reference
Susceptibility of Pseudomonas aeruginosa dispersed cells to antimicrobial agents is dependent on the dispersion cue and class of the antimicrobial agent used
10.1128/aac.00846-17 · 2017 · External reference
Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo
10.1038/s41598-019-40378-z · 2019 · External reference
Escaping the biofilm in more than one way: desorption, detachment or dispersion
10.1016/j.mib.2016.01.004 · 2016 · External reference
Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20
10.1128/jb.187.13.4627-4636.2005 · 2005 · External reference
Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A
10.1128/iai.62.5.2002-2020.1994 · 1994 · External reference
In vitro biofilm formation in an 8-well chamber slide
2011 · External reference
FactoMineR: a package for multivariate analysis
2008 · External reference
Unresolved reference
2016 · External reference
Molecular signatures of non-typeable Haemophilus influenzae lung adaptation in pediatric chronic lung disease
10.3389/fmicb.2019.01622 · 2019 · External reference
The COG database: a tool for genome-scale analysis of protein functions and evolution
10.1093/nar/28.1.33 · 2000 · External reference
Analysis of nontypeable Haemophilus influenzae phase-variable genes during experimental human nasopharyngeal colonization
10.1093/infdis/jit240 · 2013 · External reference
The lipo-oligosaccharides of Haemophilus influenzae: an interesting array of characters
2003 · External reference
Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain
10.1073/pnas.1806822115 · 2018 · External reference
Bacterial lipids: metabolism and membrane homeostasis
10.1016/j.plipres.2013.02.002 · 2013 · External reference
Construction of a mutant and characterization of the role of the vaccine antigen P6 in outer membrane integrity of nontypeable Haemophilus influenzae
10.1128/iai.00692-06 · 2006 · External reference
Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae
10.1128/iai.60.12.5204-5211.1992 · 1992 · External reference
Lag phase is a distinct growth phase that prepares bacteria for exponential growth and involves transient metal accumulation
10.1128/jb.06112-11 · 2012 · External reference
Resistance to antibiotics targeted to the bacterial cell wall
10.1002/pro.2414 · 2014 · External reference
Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics
10.1093/jac/dkn538 · 2009 · External reference
Molecular characterization and antibiotic susceptibility of Haemophilus influenzae clinical isolates
2017 · External reference
Unresolved reference
2020 · External reference
Infection in the pathogenesis and course of chronic obstructive pulmonary disease
10.1056/nejmra0800353 · 2008 · External reference
Antimicrobial resistance in Haemophilus influenzae
10.1128/cmr.00040-06 · 2007 · External reference
Antibiotic recommendations for acute otitis media and acute bacterial sinusitis: conundrum no more
10.1097/inf.0000000000002009 · 2018 · External reference
Acute otitis media in the 21st century: what now?
10.1542/peds.2017-1966 · 2017 · External reference
Action and resistance mechanisms of antibiotics: a guide for clinicians
10.4103/joacp.joacp_349_15 · 2017 · External reference
Resistance to trimethoprim-sulfamethoxazole
10.1086/320532 · 2001 · External reference
Multidrug efflux pumps: structure, function and regulation
10.1038/s41579-018-0048-6 · 2018 · External reference
Effect of the inhibitors phenylalanine arginyl ss-naphthylamide (PAssN) and 1-(1-naphthylmethyl)-piperazine (NMP) on expression of genes in multidrug efflux systems of Escherichia coli isolates from bovine mastitis
10.1016/j.rvsc.2014.05.013 · 2014 · External reference
The ins and outs of RND efflux pumps in Escherichia coli
10.3389/fmicb.2015.00587 · 2015 · External reference
Changing priorities in vaccinology: antibiotic resistance moving to the top
10.3389/fimmu.2018.01068 · 2018 · External reference
The future of vaccine development
2019 · External reference
Unresolved reference
External reference
Antibiotic discovery: where have we come from, where do we go?
10.3390/antibiotics8020045 · 2019 · External reference
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria
10.1093/femsre/fux010 · 2017 · External reference
Antibiotics versus biofilm: an emerging battleground in microbial communities
10.1186/s13756-019-0533-3 · 2019 · External reference
Otitis media pathogens - a life entrapped in biofilm communities
10.1080/1040841x.2019.1660616 · 2019 · External reference
Mechanisms of antibiotic resistance in bacterial biofilms
10.1078/1438-4221-00196 · 2002 · External reference
Transcriptional profiling of Klebsiella pneumoniae defines signatures for planktonic, sessile and biofilm-dispersed cells
10.1186/s12864-016-2557-x · 2016 · External reference
Dynamic changes in the Streptococcus pneumoniae transcriptome during transition from biofilm formation to invasive disease upon influenza A virus infection
10.1128/iai.02225-14 · 2014 · External reference
Biofilm dispersion
10.1038/s41579-020-0385-0 · 2020 · External reference
Folic acid antagonists: antimicrobial and immunomodulating mechanisms and applications
10.3390/ijms20204996 · 2019 · External reference
Outer membrane permeability and antibiotic resistance
10.1016/j.bbapap.2008.11.005 · 2009 · External reference
Penicillin-binding proteins and beta-lactam resistance
10.1111/j.1574-6976.2007.00095.x · 2008 · External reference
Transcriptional regulation of multidrug efflux pumps in bacteria
10.1006/scdb.2000.0248 · 2001 · External reference
Fis Contributes to resistance of Pseudomonas aeruginosa to ciprofloxacin by regulating pyocin synthesis
10.1128/jb.00064-20 · 2020 · External reference
Fis, an accessorial factor for transcriptional activation of the mar (multiple antibiotic resistance) promoter of Escherichia coli in the presence of the activator MarA, SoxS, or Rob
10.1128/jb.179.23.7410-7419.1997 · 1997 · External reference
Unresolved reference
External reference
How to avoid the inappropriate use of antibiotics in upper respiratory tract infections? A position statement from an expert panel
10.1016/j.bjorl.2018.02.001 · 2018 · External reference
Deploy vaccines to fight superbugs
10.1038/d41586-017-08323-0 · 2017 · External reference
The effect of different antibiotic regimens on bacterial resistance: a systematic review
10.3390/antibiotics9010022 · 2020 · External reference
Immunization with a biofilm-disrupting nontypeable Haemophilus influenzae vaccine antigen did not alter the gut microbiome in chinchillas, unlike oral delivery of a broad-spectrum antibiotic commonly used for otitis media
10.1128/msphere.00296-20 · 2020 · External reference
Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication
10.1503/cmaj.140848 · 2015 · External reference
Gut bacterial microbiota and its resistome rapidly recover to basal state levels after short-term amoxicillin-clavulanic acid treatment in healthy adults
10.1038/s41598-018-29229-5 · 2018 · External reference
Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial
10.4161/gmic.29558 · 2014 · External reference
DNABII targeting antibodies as vaccines against biofilm diseases
10.1016/j.ebiom.2020.102921 · 2020 · External reference
Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections
10.1016/j.ebiom.2020.102867 · 2020 · External reference