References

Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface

10.1128/cmr.00138-18 · 2019 · External reference

Pseudomonas prosthetic joint infections: a review of 102 episodes

10.7150/jbji.15722 · 2016 · External reference

Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus

10.1586/14787210.2015.1023291 · 2015 · External reference

Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents-how P. aeruginosa can escape antibiotics

10.3389/fmicb.2019.00913 · 2019 · External reference

Multidrug tolerance of biofilms and persister cells

2008 · External reference

Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy

10.1586/eri.09.108 · 2010 · External reference

Biofilm formation and dispersal and the transmission of human pathogens

10.1016/j.tim.2004.11.004 · 2005 · External reference

Persister cells

10.1146/annurev.micro.112408.134306 · 2010 · External reference

Progressive increase in antibiotic resistance of gram-negative bacterial isolates. Walter Reed Hospital, 1976 to 1980: specific analysis of gentamicin, tobramycin, and amikacin resistance

10.1001/archinte.1983.00350110053015 · 1983 · External reference

Sudden increase in Pseudomonas aeruginosa nosocomial strains with broad host range transfer of antibiotic resistance

10.1179/joc.2001.13.6.607 · 2001 · External reference

Global incidence of multidrug-resistant tuberculosis

10.1086/505877 · 2006 · External reference

Prevalence of multidrug-resistant organisms recovered at a military burn center

10.1016/j.burns.2009.10.013 · 2010 · External reference

Prevalence, resistance mechanisms, and susceptibility of multidrug-resistant bloodstream isolates of Pseudomonas aeruginosa

10.1128/aac.01446-09 · 2010 · External reference

High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection

10.1126/science.288.5469.1251 · 2000 · External reference

Adaptive resistance to aminoglycoside antibiotics in Pseudomonas aeruginosa

10.1099/00222615-29-1-41 · 1989 · External reference

Aminoglycoside resistance in Pseudomonas aeruginosa

10.1128/aac.49.2.479-487.2005 · 2005 · External reference

Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene

10.1136/thoraxjnl-2015-208027 · 2017 · External reference

Antibiotic tolerance facilitates the evolution of resistance

10.1126/science.aaj2191 · 2017 · External reference

Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients

10.1128/aac.44.3.710-712.2000 · 2000 · External reference

Gentamicin resistance in clinical-isolates of Pseudomonas aeruginosa associated with diminished gentamicin accumulation and no detectable enzymatic modification

10.7164/antibiotics.29.743 · 1976 · External reference

Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa

10.1128/am.16.9.1276-1281.1968 · 1968 · External reference

Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymatic N-acetylation of the deoxystreptamine moiety

10.1021/bi00755a013 · 1972 · External reference

Inactivation of dihydrostreptomycin by Pseudomonas aeruginosa

10.1111/j.1348-0421.1971.tb00596.x · 1971 · External reference

Expression of the MexXY aminoglycoside efflux pump and presence of an aminoglycoside-modifying enzyme in clinical Pseudomonas aeruginosa isolates are highly correlated

10.1128/aac.01166-20 · 2020 · External reference

The prevalence of aminoglycoside-modifying enzyme genes among Pseudomonas aeruginosa strains isolated from burn patients

2017 · External reference

Aminoglycoside resistance mechanisms in clinical isolates of Pseudomonas aeruginosa from the Canary Islands

10.1016/s0934-8840(00)80008-0 · 2000 · External reference

Mechanisms of fluoroquinolone and aminoglycoside resistance in keratitis-associated Pseudomonas aeruginosa

10.1089/mdr.2018.0218 · 2019 · External reference

In vivo host environment alters Pseudomonas aeruginosa susceptibility to aminoglycoside antibiotics

10.3389/fcimb.2017.00083 · 2017 · External reference

The effects of active efflux pumps on antibiotic resistance in Pseudomonas aeruginosa

10.1007/s11274-014-1692-2 · 2014 · External reference

Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence

10.1038/s41598-017-11892-9 · 2017 · External reference

Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosa

10.1038/s41598-018-34694-z · 2018 · External reference

Novel inducers of the expression of multidrug efflux pumps that trigger Pseudomonas aeruginosa transient antibiotic resistance

10.1128/aac.01095-19 · 2019 · External reference

Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate

10.1073/pnas.1909831116 · 2019 · External reference

Analysis of the Pseudomonas aeruginosa aminoglycoside differential resistomes allows defining genes simultaneously involved in intrinsic antibiotic resistance and virulence

10.1128/aac.00185-19 · 2019 · External reference

The Pseudomonas aeruginosa pan-genome provides new insights on its population structure, horizontal gene transfer, and pathogenicity

10.1093/gbe/evy259 · 2019 · External reference

Mechanisms and clinical relevance of bacterial heteroresistance

10.1038/s41579-019-0218-1 · 2019 · External reference

Evaluation of heteroresistance to polymyxin B among carbapenem-susceptible and -resistant Pseudomonas aeruginosa

10.1099/jmm.0.059220-0 · 2013 · External reference

Heteroresistance to carbapenems in invasive Pseudomonas aeruginosa infections

10.1016/j.ijantimicag.2017.10.014 · 2018 · External reference

Mechanisms of heteroresistance and resistance to imipenem in Pseudomonas aeruginosa

10.2147/idr.s249475 · 2020 · External reference

Antimicrobial heteroresistance: an emerging field in need of clarity

10.1128/cmr.00058-14 · 2015 · External reference

Heteroresistance: a cause of unexplained antibiotic treatment failure?

10.1371/journal.ppat.1007726 · 2019 · External reference

Carbapenem-resistant Klebsiella pneumoniae exhibiting clinically undetected colistin heteroresistance leads to treatment failure in a murine model of infection

10.1128/mbio.02448-17 · 2018 · External reference

Aminoglycoside heteroresistance in acinetobacter baumannii AB5075

10.1128/msphere.00271-18 · 2018 · External reference

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification

10.1038/s41564-018-0342-0 · 2019 · External reference

Antibiotic combinations that exploit heteroresistance to multiple drugs effectively control infection

10.1038/s41564-019-0480-z · 2019 · External reference

Adaptive resistance to tobramycin in Pseudomonas aeruginosa lung infection in cystic fibrosis

10.1093/jac/37.6.1155 · 1996 · External reference

NtrBC selectively regulates host-pathogen interactions, virulence, and ciprofloxacin susceptibility of Pseudomonas aeruginosa

10.3389/fcimb.2021.694789 · 2021 · External reference

Adaptive resistance to cationic compounds in Pseudomonas aeruginosa

10.1016/j.ijantimicag.2010.11.019 · 2011 · External reference

Multidrug adaptive resistance of Pseudomonas aeruginosa swarming cells

10.1128/aac.01999-19 · 2020 · External reference

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

10.1038/nrmicro.2016.34 · 2016 · External reference

Generation of persister cells of Pseudomonas aeruginosa and Staphylococcus aureus by chemical treatment and evaluation of their susceptibility to membrane-targeting agents

10.3389/fmicb.2017.01917 · 2017 · External reference

Slow and steady wins the race: an examination of bacterial persistence

10.3934/microbiol.2017.2.171 · 2017 · External reference

Observations on the mechanism of action of penicillin

10.3181/00379727-50-13773 · 1942 · External reference

Treatment of staphylococcal infections with penicillin by intermittent sterilisation

10.1016/s0140-6736(00)74210-3 · 1944 · External reference

Understanding ciprofloxacin failure in Pseudomonas aeruginosa biofilm: persister cells survive matrix disruption

10.3389/fmicb.2019.02603 · 2019 · External reference

Identification of a toxin-antitoxin system that contributes to persister formation by reducing NAD in Pseudomonas aeruginosa

10.3390/microorganisms9040753 · 2021 · External reference

Diversity, prevalence, and longitudinal occurrence of type II toxin-antitoxin systems of Pseudomonas aeruginosa infecting cystic fibrosis lungs

10.3389/fmicb.2017.01180 · 2017 · External reference

Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli

10.1016/j.bbrc.2009.11.033 · 2010 · External reference

Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli

10.1371/journal.pbio.1000317 · 2010 · External reference

Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties

10.1371/journal.ppat.1000706 · 2009 · External reference

Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)

10.1128/jb.188.1.305-316.2006 · 2006 · External reference

Gene expression in Escherichia coli biofilms

10.1007/s00253-003-1517-y · 2004 · External reference

Bacterial persistence increases as environmental fitness decreases

10.1111/j.1751-7915.2011.00327.x · 2012 · External reference

Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis

10.1128/jb.01651-09 · 2010 · External reference

Persister cells, dormancy and infectious disease

10.1038/nrmicro1557 · 2007 · External reference

Dissociation in Pseudomonas aeruginosa

10.1128/jb.87.5.1003-1010.1964 · 1964 · External reference

Small-colony variants of Pseudomonas aeruginosa in cystic fibrosis

10.1086/598644 · 1999 · External reference

Small colony variants of staphylococcus aureus - review

10.1007/s12223-010-0089-3 · 2010 · External reference

Self-generated diversity produces "insurance effects" in biofilm communities

10.1073/pnas.0407460101 · 2004 · External reference

Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments

2018 · External reference

Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation

10.1038/416740a · 2002 · External reference

Autolysis and autoaggregation in Pseudomonas aeruginosa colony morphology mutants

10.1128/jb.184.23.6481-6489.2002 · 2002 · External reference

Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid

10.1038/325279a0 · 1987 · External reference

Second messenger regulation of biofilm formation: breakthroughs in understanding c-di-GMP effector systems

10.1146/annurev-cellbio-101011-155705 · 2012 · External reference

Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor

10.1111/j.1365-2958.2008.06281.x · 2008 · External reference

The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP

10.1093/nar/gks384 · 2012 · External reference

YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa

10.1371/journal.ppat.1000804 · 2010 · External reference

Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung

10.1128/jb.00119-09 · 2009 · External reference

Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition

10.1126/scisignal.2005943 · 2015 · External reference

Characterization of colony morphology variants isolated from Pseudomonas aeruginosa biofilms

10.1128/aem.71.8.4809-4821.2005 · 2005 · External reference

A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels

10.1073/pnas.0507170102 · 2005 · External reference

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix

2015 · External reference

Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms

10.1038/s41467-019-08733-w · 2019 · External reference

Phenazine redox cycling enhances anaerobic survival in Pseudomonas aeruginosa by facilitating generation of ATP and a proton-motive force

2014 · External reference

Agmatine accumulation by Pseudomonas aeruginosa clinical isolates confers antibiotic tolerance and dampens host inflammation

10.1099/jmm.0.000928 · 2019 · External reference

Novel aminoglycoside-tolerant phoenix colony variants of Pseudomonas aeruginosa

10.1128/aac.00623-20 · 2020 · External reference

Comparison of detection methods for heteroresistant vancomycin-intermediate Staphylococcus aureus, with the population analysis profile method as the reference method

10.1128/jcm.01128-10 · 2011 · External reference

Biofilm development

10.1128/microbiolspec.mb-0001-2014 · 2015 · External reference

Recent perspectives on the molecular basis of biofilm formation by Pseudomonas aeruginosa and approaches for treatment and biofilm dispersal

10.1007/s12223-018-0585-4 · 2018 · External reference

Pseudomonas aeruginosa biofilms: host response and clinical implications in lung infections

10.1165/rcmb.2017-0321tr · 2018 · External reference

PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa

10.1074/jbc.m117.812842 · 2017 · External reference

Psl produced by mucoid Pseudomonas aeruginosa contributes to the establishment of biofilms and immune evasion

10.1128/mbio.00864-17 · 2017 · External reference

Cyclic di-GMP: second messenger extraordinaire

10.1038/nrmicro.2016.190 · 2017 · External reference

Cyclic-di-GMP and oprF are involved in the response of Pseudomonas aeruginosa to substrate material stiffness during attachment on polydimethylsiloxane (PDMS)

10.3389/fmicb.2018.00110 · 2018 · External reference

Light-Mediated decreases in cyclic di-GMP levels inhibit structure formation in Pseudomonas aeruginosa biofilms

10.1128/jb.00117-20 · 2020 · External reference

The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer

10.1371/journal.ppat.1006504 · 2017 · External reference

Evolution of the Pseudomonas aeruginosa quorum-sensing hierarchy

10.1073/pnas.1819796116 · 2019 · External reference

Contributions of antibiotic penetration, oxygen limitation, and low metabolic activity to tolerance of Pseudomonas aeruginosa biofilms to ciprofloxacin and tobramycin

10.1128/aac.47.1.317-323.2003 · 2003 · External reference

The extracellular matrix protects Pseudomonas aeruginosa biofilms by limiting the penetration of tobramycin

10.1111/1462-2920.12155 · 2013 · External reference

Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin

10.1371/journal.pgen.1003144 · 2013 · External reference

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria

10.1126/science.1211037 · 2011 · External reference

Reaction-diffusion theory explains hypoxia and heterogeneous growth within microbial biofilms associated with chronic infections

10.1038/npjbiofilms.2016.12 · 2016 · External reference

Catheter associated urinary tract infections

2014 · External reference

The effect of infection control nurses on the occurrence of Pseudomonas aeruginosa healthcare-acquired infection and multidrug-resistant strains in critically ill children

2015 · External reference

Pseudomonas aeruginosa biofilms in disease

2014 · External reference

Mechanisms of antibiotic resistance in bacterial biofilms

10.1078/1438-4221-00196 · 2002 · External reference

Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit; a critical review

10.1016/j.gendis.2019.04.001 · 2019 · External reference

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

10.1016/j.biotechadv.2018.11.013 · 2019 · External reference

Diagnosis of biofilm infections in cystic fibrosis patients

10.1111/apm.12689 · 2017 · External reference