Research graph
References from SagS and its unorthodox contributions to Pseudomonas aeruginosa biofilm development. Local targets link to admitted publications; unresolved targets remain external evidence.
Pseudomonas aeruginosa lifestyle: a paradigm for adaptation, survival, and persistence
10.3389/fcimb.2017.00039 · 2017 · External reference
PSEUDOMONAS | Pseudomonas aeruginosa, p
2014 · External reference
Bacterial biofilms: a common cause of persistent infections
10.1126/science.284.5418.1318 · 1999 · External reference
Biofilms: an emergent form of bacterial life
10.1038/nrmicro.2016.94 · 2016 · External reference
EPS—then and now
10.3390/microorganisms4040041 · 2016 · External reference
The biofilm matrix
10.1038/nrmicro2415 · 2010 · External reference
Microscopic examination of natural sessile bacterial populations from an alpine stream
10.1139/m77-249 · 1977 · External reference
Bacterial biofilms in nature and disease
10.1146/annurev.mi.41.100187.002251 · 1987 · External reference
Microbial biofilms
10.1146/annurev.mi.49.100195.003431 · 1995 · External reference
Escaping the biofilm in more than one way: desorption, detachment or dispersion
10.1016/j.mib.2016.01.004 · 2016 · External reference
Spatial transcriptomes within the Pseudomonas aeruginosa biofilm architecture
10.1111/mmi.13863 · 2017 · External reference
The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilms
10.1128/jb.00318-13 · 2013 · External reference
Heterogeneity in Pseudomonas aeruginosa biofilms includes expression of ribosome hibernation factors in the antibiotic-tolerant subpopulation and hypoxia-induced stress response in the metabolically active population
10.1128/jb.00022-12 · 2012 · External reference
Understanding biofilm resistance to antibacterial agents
10.1038/nrd1008 · 2003 · External reference
Multidrug tolerance of biofilms and persister cells
2008 · External reference
The effect of the growth phase of Staphylococcus aureus on resistance to disinfectants in a suspension test
10.4315/0362-028x-65.1.124 · 2002 · External reference
Dynamic interactions of biofilms of mucoid Pseudomonas aeruginosa with tobramycin and piperacillin
10.1128/aac.36.6.1208 · 1992 · External reference
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria
10.1093/femsre/fux010 · 2017 · External reference
Mechanisms of biofilm resistance to antimicrobial agents
10.1016/s0966-842x(00)01913-2 · 2001 · External reference
A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance
10.1038/nature02122 · 2003 · External reference
Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria
10.1126/science.1211037 · 2011 · External reference
The ABC of biofilm drug tolerance: the MerR-like regulator BrlR is an activator of ABC transport systems, with PA1874-77 contributing to the tolerance of Pseudomonas aeruginosa biofilms to tobramycin
10.1128/aac.01981-17 · 2018 · External reference
Distribution of bacterial growth activity in flow-chamber biofilms
10.1128/aem.65.9.4108-4117.1999 · 1999 · External reference
Interaction between human polymorphonuclear leucocytes and bacteria released from in-vitro bacterial biofilm models
10.1099/00222615-41-5-359 · 1994 · External reference
ESCMID guideline for the diagnosis and treatment of biofilm infections 2014
10.1016/j.cmi.2014.10.024 · 2015 · External reference
Clinical practice. Infection associated with prosthetic joints
10.1056/nejmcp0905029 · 2009 · External reference
Periprosthetic joint infection
10.1016/s0140-6736(14)61798-0 · 2016 · External reference
Chronic biofilm-based infections: skewing of the immune response
10.1093/femspd/fty023 · 2018 · External reference
Immune responses to Pseudomonas aeruginosa biofilm infections
10.3389/fimmu.2021.625597 · 2021 · External reference
Microbial biofilms and chronic wounds
10.3390/microorganisms5010009 · 2017 · External reference
Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm
10.1128/jb.184.4.1140-1154.2002 · 2002 · External reference
Biofilms as complex differentiated communities
10.1146/annurev.micro.56.012302.160705 · 2002 · External reference
Biofilm dispersion
2011 · External reference
Control of biofilms with the fatty acid signaling molecule cis-2-decenoic acid
10.3390/ph8040816 · 2015 · External reference
Biofilm dispersion
10.1038/s41579-020-0385-0 · 2020 · External reference
A novel signaling network essential for regulating Pseudomonas aeruginosa biofilm development
10.1371/journal.ppat.1000668 · 2009 · External reference
The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs
10.1111/j.1365-2958.2009.06782.x · 2009 · External reference
LadS is a calcium-responsive kinase that induces acute-to-chronic virulence switch in Pseudomonas aeruginosa
10.1038/nmicrobiol.2016.184 · 2016 · External reference
Microbial biofilms: from ecology to molecular genetics
10.1128/mmbr.64.4.847-867.2000 · 2000 · External reference
Role of exopolysaccharides in Pseudomonas aeruginosa biofilm formation and architecture
10.1128/aem.00637-11 · 2011 · External reference
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants
10.1046/j.1365-2958.2003.03525.x · 2003 · External reference
Indole as an intercellular signal in microbial communities
10.1111/j.1574-6976.2009.00204.x · 2010 · External reference
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
10.1046/j.1365-2958.1998.01062.x · 1998 · External reference
Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis
10.1046/j.1365-2958.1998.00797.x · 1998 · External reference
Glucose-6-Phosphate acts as an extracellular signal of SagS to modulate Pseudomonas aeruginosa c-di-GMP levels, attachment, and biofilm formation
10.1128/msphere.01231-20 · 2021 · External reference
Divide and conquer: the Pseudomonas aeruginosa two-component hybrid SagS enables biofilm formation and recalcitrance of biofilm cells to antimicrobial agents via distinct regulatory circuits
10.1111/1462-2920.13719 · 2017 · External reference
Regulation of biofilm formation in Pseudomonas and Burkholderia species
10.1111/1462-2920.12448 · 2014 · External reference
Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa
10.1111/j.1462-2920.2011.02495.x · 2011 · External reference
Cooperation and conflict in microbial biofilms
10.1073/pnas.0607651104 · 2007 · External reference
BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14
10.1128/jb.00586-07 · 2007 · External reference
SadC reciprocally influences biofilm formation and swarming motility via modulation of exopolysaccharide production and flagellar function
10.1128/jb.00585-07 · 2007 · External reference
SadB is required for the transition from reversible to irreversible attachment during biofilm formation by Pseudomonas aeruginosa PA14
10.1128/jb.186.14.4476-4485.2004 · 2004 · External reference
Inverse regulation of biofilm formation and swarming motility by Pseudomonas aeruginosa PA14
10.1128/jb.01685-06 · 2007 · External reference
How Pseudomonas aeruginosa regulates surface behaviors
2008 · External reference
Roles for flagellar stators in biofilm formation by Pseudomonas aeruginosa
10.1016/j.resmic.2007.04.001 · 2007 · External reference
A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels
10.1073/pnas.0507170102 · 2005 · External reference
Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces
10.1111/j.1365-2958.2007.06008.x · 2007 · External reference
Two-component systems required for virulence in Pseudomonas aeruginosa
2017 · External reference
Two-component signal transduction systems: a major strategy for connecting input stimuli to biofilm formation
10.3389/fmicb.2018.03279 · 2018 · External reference
The novel two-component regulatory system BfiSR regulates biofilm development by controlling the small RNA rsmZ through CafA
10.1128/jb.00387-10 · 2010 · External reference
SagS contributes to the motile-sessile switch and acts in concert with BfiSR to enable Pseudomonas aeruginosa biofilm formation
10.1128/jb.00305-11 · 2011 · External reference
The novel Pseudomonas aeruginosa two-component regulator BfmR controls bacteriophage-mediated lysis and DNA release during biofilm development through PhdA
10.1111/j.1365-2958.2011.07733.x · 2011 · External reference
Microcolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation
10.1111/mmi.12018 · 2012 · External reference
Specificity in two-component signal transduction pathways
10.1146/annurev.genet.41.042007.170548 · 2007 · External reference
Two-component systems in Pseudomonas aeruginosa: why so many?
10.1016/s0966-842x(00)01833-3 · 2000 · External reference
Orphan and hybrid two-component system proteins in health and disease
10.1016/j.mib.2009.12.010 · 2010 · External reference
The PA3177 gene encodes an active diguanylate cyclase that contributes to biofilm antimicrobial tolerance but not biofilm formation by Pseudomonas aeruginosa
10.1128/aac.01049-18 · 2018 · External reference
Antimicrobial tolerance of Pseudomonas aeruginosa biofilms is activated during an early developmental stage and requires the two-component hybrid SagS
10.1128/jb.00732-13 · 2013 · External reference
Controlling chronic Pseudomonas aeruginosa infections by strategically interfering with the sensory function of SagS
10.1111/mmi.14215 · 2019 · External reference
Characterization of the histidine-containing phosphotransfer protein B-mediated multistep phosphorelay system in Pseudomonas aeruginosa PAO1
10.1074/jbc.m708836200 · 2008 · External reference
The lemA gene required for pathogenicity of Pseudomonas syringae pv. syringae on bean is a member of a family of two-component regulators
10.1128/jb.174.9.3011-3020.1992 · 1992 · External reference
Global control in Pseudomonas fluorescens mediating antibiotic synthesis and suppression of black root rot of tobacco
10.1073/pnas.89.5.1562 · 1992 · External reference
Genetic evidence that the gacA gene encodes the cognate response regulator for the lemA sensor in Pseudomonas syringae
10.1128/jb.176.24.7468-7475.1994 · 1994 · External reference
A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa
10.1016/j.devcel.2004.08.020 · 2004 · External reference
Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen
10.1101/gad.1739009 · 2009 · External reference
RsmV, a small noncoding regulatory RNA in Pseudomonas aeruginosa that sequesters RsmA and RsmF from target mRNAs
2018 · External reference
RsmW, Pseudomonas aeruginosa small non-coding RsmA-binding RNA upregulated in biofilm versus planktonic growth conditions
10.1186/s12866-016-0771-y · 2016 · External reference
An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa
10.1073/pnas.1307217110 · 2013 · External reference
Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA
10.1111/j.1365-2958.2009.06670.x · 2009 · External reference
Genome-wide mapping of the RNA targets of the Pseudomonas aeruginosa riboregulatory protein RsmN
10.1093/nar/gky324 · 2018 · External reference
Widespread targeting of nascent transcripts by RsmA in Pseudomonas aeruginosa
10.1073/pnas.1917587117 · 2020 · External reference
Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes
10.1073/pnas.0507407103 · 2006 · External reference
The hybrid histidine kinase LadS forms a multicomponent signal transduction system with the GacS/GacA two-component system in Pseudomonas aeruginosa
10.1371/journal.pgen.1006032 · 2016 · External reference
Histidine-containing phosphotransfer protein-B (HptB) regulates swarming motility through partner-switching system in Pseudomonas aeruginosa PAO1 strain
10.1074/jbc.m111.256586 · 2012 · External reference
The diguanylate cyclase HsbD intersects with the HptB regulatory cascade to control Pseudomonas aeruginosa biofilm and motility
2016 · External reference
Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis
10.1111/j.1365-2958.2010.07146.x · 2010 · External reference
Mutational analysis of RetS, an unusual sensor kinase-response regulator hybrid required for Pseudomonas aeruginosa virulence
10.1128/iai.00575-06 · 2006 · External reference
Elevated levels of the second messenger c-di-GMP contribute to antimicrobial resistance of Pseudomonas aeruginosa
10.1111/mmi.12587 · 2014 · External reference
The phosphodiesterase DipA (PA5017) is essential for Pseudomonas aeruginosa biofilm dispersion
10.1128/jb.05346-11 · 2012 · External reference
Diguanylate cyclase NicD-based signalling mechanism of nutrient-induced dispersion by Pseudomonas aeruginosa
10.1111/mmi.12802 · 2014 · External reference
The Yin and Yang of SagS: distinct residues in the HmsP domain of SagS independently regulate biofilm formation and biofilm drug tolerance
10.1128/msphere.00192-18 · 2018 · External reference
Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials
10.1128/jb.183.23.6746-6751.2001 · 2001 · External reference
Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents-how P. aeruginosa can escape antibiotics
10.3389/fmicb.2019.00913 · 2019 · External reference
The MerR-like regulator BrlR impairs Pseudomonas aeruginosa biofilm tolerance to colistin by repressing PhoPQ
10.1128/jb.00834-13 · 2013 · External reference
BrlR from Pseudomonas aeruginosa is a c-di-GMP-responsive transcription factor
10.1111/mmi.12562 · 2014 · External reference
The MerR-like transcriptional regulator BrlR contributes to Pseudomonas aeruginosa biofilm tolerance
10.1128/jb.00765-12 · 2012 · External reference
The phosphodiesterase activity of the HmsP EAL domain is required for negative regulation of biofilm formation in Yersinia pestis
10.1016/j.femsle.2005.04.036 · 2005 · External reference
HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms-dependent biofilm formation in Yersinia pestis
10.1111/j.1365-2958.2004.04253.x · 2004 · External reference