Research graph
References from Adding a new dimension: Multi-level structure and organization of mixed-species Pseudomonas aeruginosa and Staphylococcus aureus biofilms in a 4-D wound microenvironment. Local targets link to admitted publications; unresolved targets remain external evidence.
Biofilms in chronic wounds
10.1111/j.1524-475x.2007.00321.x · 2008 · External reference
The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data
10.12968/jowc.2017.26.1.20 · 2017 · External reference
Chronic wound biofilms: pathogenesis and potential therapies
10.1309/lmbnswkui4jpn7so · 2015 · External reference
Why chronic wounds will not heal: a novel hypothesis
10.1111/j.1524-475x.2007.00283.x · 2008 · External reference
Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds
10.1111/j.1524-475x.2011.00681.x · 2011 · External reference
Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds
10.1128/jcm.01395-09 · 2009 · External reference
Distribution, organization, and ecology of bacteria in chronic wounds
10.1128/jcm.00501-08 · 2008 · External reference
The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy methods
10.1155/2014/153586 · 2014 · External reference
Microscopy visualisation confirms multi-species biofilms are ubiquitous in diabetic foot ulcers
10.1111/iwj.12777 · 2017 · External reference
Effect of cadexomer iodine on the microbial load and diversity of chronic non-healing diabetic foot ulcers complicated by biofilm in vivo
10.1093/jac/dkx099 · 2017 · External reference
Metataxonomic approach to decipher the polymicrobial burden in diabetic foot ulcer and its biofilm mode of infection
10.1111/iwj.12888 · 2018 · External reference
The zone model: a conceptual model for understanding the microenvironment of chronic wound infection
10.1111/wrr.12841 · 2020 · External reference
A simple polymicrobial biofilm keratinocyte colonization model for exploring interactions between commensals, pathogens and antimicrobials
10.3389/fmicb.2020.00291 · 2020 · External reference
Skin microbiota-host interactions
10.1038/nature25177 · 2018 · External reference
Dermal fibroblast cells interactions with single and triple bacterial-species biofilms
10.1007/s11033-021-06391-0 · 2021 · External reference
Characterization of bacterial communities in venous insufficiency wounds by use of conventional culture and molecular diagnostic methods
10.1128/jcm.00847-11 · 2011 · External reference
“It takes a village”: mechanisms underlying antimicrobial recalcitrance of polymicrobial biofilms
10.1128/jb.00530-19 · 2019 · External reference
Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model
10.1128/iai.02198-14 · 2014 · External reference
Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus
10.1586/14787210.2015.1023291 · 2015 · External reference
An in vivo polymicrobial biofilm wound infection model to study interspecies interactions
10.1371/journal.pone.0027317 · 2011 · External reference
In vivo and in vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp
10.3389/fcimb.2017.00106 · 2017 · External reference
Interactions of methicillin resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in polymicrobial wound infection
10.1371/journal.pone.0056846 · 2013 · External reference
Interaction between Staphylococcus aureus and Pseudomonas aeruginosa is beneficial for colonisation and pathogenicity in a mixed biofilm
10.1093/femspd/fty003 · 2018 · External reference
Current status of in vitro models and assays for susceptibility testing for wound biofilm infections
10.3390/biomedicines7020034 · 2019 · External reference
In vitro and in vivo biofilm wound models and their application
2015 · External reference
Influence of biofilm growth age, media, antibiotic concentration and exposure time on Staphylococcus aureus and Pseudomonas aeruginosa biofilm removal in vitro
10.1186/s12866-020-01947-9 · 2020 · External reference
Study of the impact of cultivation conditions and peg surface modification on the in vitro biofilm formation of Staphylococcus aureus and Staphylococcus epidermidis in a system analogous to the Calgary biofilm device
2021 · External reference
In vitro interaction of chronic wound bacteria in biofilms
10.12968/jowc.2011.20.12.569 · 2011 · External reference
Role of multicellular aggregates in biofilm formation
10.1128/mbio.00237-16 · 2016 · External reference
Iron and Pseudomonas aeruginosa biofilm formation
10.1073/pnas.0504266102 · 2005 · External reference
Distinct roles of extracellular polymeric substances in Pseudomonas aeruginosa biofilm development
10.1111/j.1462-2920.2011.02503.x · 2011 · External reference
Development of three-dimensional tissue-engineered models of bacterial infected human skin wounds
10.1089/ten.tec.2008.0614 · 2009 · External reference
Porcine models of biofilm infections with focus on pathomorphology
10.3389/fmicb.2017.01961 · 2017 · External reference
Production of tissue-engineered skin and oral mucosa for clinical and experimental use
2011 · External reference
Milieu matters: an in vitro wound milieu to recapitulate key features of, and probe new insights into, mixed-species bacterial biofilms
2021 · External reference
Bioengineered platforms for chronic wound infection studies: how can we make them more human-relevant?
10.3389/fbioe.2019.00418 · 2019 · External reference
In vitro studies evaluating the effects of biofilms on wound-healing cells: a review
10.1111/apm.12678 · 2017 · External reference
Current in vitro biofilm-infected chronic wound models for developing new treatment possibilities
10.1089/wound.2020.1176 · 2021 · External reference
Multispecies biofilm in an artificial wound bed--A novel model for in vitro assessment of solid antimicrobial dressings
10.1016/j.mimet.2014.05.008 · 2014 · External reference
Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa
10.1073/pnas.1217993109 · 2012 · External reference
Fluorescent reporters for Staphylococcus aureus
10.1016/j.mimet.2009.02.011 · 2009 · External reference
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
10.1038/nprot.2007.521 · 2008 · External reference
Efficacy of ampicillin against methicillin-resistant Staphylococcus aureus restored through synergy with branched poly(ethylenimine)
10.1038/ja.2016.44 · 2016 · External reference
Reduced serum methods for contact-based coculture of human dermal fibroblasts and epidermal keratinocytes
10.2144/btn-2020-0112 · 2020 · External reference
Quantitative image analysis of microbial communities with BiofilmQ
10.1038/s41564-020-00817-4 · 2021 · External reference
BiofilmQ v0.2.1
2020 · External reference
A threshold selection method from gray-level histograms
10.1109/tsmc.1979.4310076 · 1979 · External reference
ParaView: an end-user tool for large-data visualization
2005 · External reference
Unresolved reference
2015 · External reference
Image processing with ImageJ
2004 · External reference
NIH Image to ImageJ: 25 years of image analysis
10.1038/nmeth.2089 · 2012 · External reference
Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization
10.1128/mbio.00745-13 · 2013 · External reference
Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo
10.1039/c9bm00773c · 2019 · External reference
Unresolved reference
2022 · External reference
Bridging the gap: from 2D cell culture to 3D microengineered extracellular matrices
10.1002/adhm.201500427 · 2015 · External reference
3D cell culture—can it Be as popular as 2D cell culture?
10.1002/anbr.202000066 · 2021 · External reference
A novel 2.5D culture platform to investigate the role of stiffness gradients on adhesion-independent cell migration
10.1371/journal.pone.0110453 · 2014 · External reference
Three-dimensional in vitro cell culture models in drug discovery and drug repositioning
10.3389/fphar.2018.00006 · 2018 · External reference
Adding depth to cell culture
10.1126/science.356.6333.96 · 2017 · External reference
Biomaterials for 4D stem cell culture
10.1016/j.cossms.2016.03.002 · 2016 · External reference
4D self-morphing culture substrate for modulating cell differentiation
2020 · External reference
4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues
10.1039/c9mh00665f · 2020 · External reference
A novel 4D cell culture mimicking stomach peristalsis altered gastric cancer spheroids growth and malignance
10.1088/1758-5090/abf6bf · 2021 · External reference
Biofilms and wounds: an overview of the evidence
10.1089/wound.2014.0557 · 2015 · External reference
Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors
10.1046/j.1524-475x.1999.00442.x · 1999 · External reference
Biochemical analysis of wound fluid from nonhealing and healing chronic leg ulcers
10.1046/j.1524-475x.1996.40211.x · 1996 · External reference
Assessing the inflammatory response to in vitro polymicrobial wound biofilms in a skin epidermis model
10.1038/s41522-022-00286-z · 2022 · External reference
In vivo multiphoton microscopy detects longitudinal metabolic changes associated with delayed skin wound healing
10.1038/s42003-018-0206-4 · 2018 · External reference
Development, standardization and testing of a bacterial wound infection model based on ex vivo human skin
10.1371/journal.pone.0186946 · 2017 · External reference
Clinical investigation of biofilm in non-healing wounds by high resolution microscopy techniques
10.12968/jowc.2016.25.sup9.s11 · 2016 · External reference
A tractable, simplified ex vivo human skin model of wound infection
10.1111/wrr.12712 · 2019 · External reference
The importance of both fibroblasts and keratinocytes in a bilayered living cellular construct used in wound healing
10.1111/wrr.12154 · 2014 · External reference
Modelling the interaction of keratinocytes and fibroblasts during normal and abnormal wound healing processes
10.1098/rspb.2012.0319 · 2012 · External reference
Bacteria induced pH changes in tissue-engineered human skin detected non-invasively using Raman confocal spectroscopy
10.1080/05704928.2018.1558232 · 2020 · External reference
The effects of coating culture dishes with collagen on fibroblast cell shape and swirling pattern formation
10.1007/s10867-020-09556-3 · 2020 · External reference
Comparison of human dermal fibroblasts and HaCat cells cultured in medium with or without serum via a generic tissue engineering research platform
10.3390/ijms19020388 · 2018 · External reference
In vitro expansion of keratinocytes on human dermal fibroblast-derived matrix retains their stem-like characteristics
10.1038/s41598-019-54793-9 · 2019 · External reference
Age-related downregulation of CCN2 is regulated by cell size in a YAP/TAZ-Dependent manner in human dermal fibroblasts: impact on dermal aging
2022 · External reference
Unresolved reference
1999 · External reference
Involucrin synthesis is correlated with cell size in human epidermal cultures
10.1083/jcb.90.3.738 · 1981 · External reference
Roughness threshold for cell attachment and proliferation on plasma micro-nanotextured polymeric surfaces: the case of primary human skin fibroblasts and mouse immortalized 3T3 fibroblasts
10.1088/0022-3727/49/30/304002 · 2016 · External reference
Determination of cell nucleus-to-cytoplasmic ratio using imaging flow cytometry and a combined ultrasound and photoacoustic technique: a comparison study
10.1117/1.jbo.24.10.106502 · 2019 · External reference
A designer cell culture insert with a nanofibrous membrane toward engineering an epithelial tissue model validated by cellular nanomechanics
10.1039/d1na00280e · 2021 · External reference
3D microniches reveal the importance of cell size and shape
10.1038/s41467-017-02163-2 · 2017 · External reference
On the origin of shape fluctuations of the cell nucleus
10.1073/pnas.1702226114 · 2017 · External reference
New insights into mechanisms and functions of nuclear size regulation
2016 · External reference
Pseudomonas aeruginosa biofilms perturb wound resolution and antibiotic tolerance in diabetic mice
10.1007/s00430-012-0277-7 · 2013 · External reference
Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits in vivo -like characteristics
10.1128/aem.00113-17 · 2017 · External reference
Bacterial aggregate size determines phagocytosis efficiency of polymorphonuclear leukocytes
10.1007/s00430-020-00691-1 · 2020 · External reference
Bacterial aggregates establish at the edges of acute epidermal wounds
10.1089/wound.2017.0770 · 2018 · External reference
Planktonic aggregates of Staphylococcus aureus protect against common antibiotics
10.1371/annotation/08d0f2a8-0c40-4a0c-b546-0025648e73f0 · 2012 · External reference
Pseudomonas aeruginosa PAO1 preferentially grows as aggregates in liquid batch cultures and disperses upon starvation
10.1371/journal.pone.0005513 · 2009 · External reference
Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm
10.1371/journal.pone.0027943 · 2011 · External reference
Staphylococcus aureus floating biofilm formation and phenotype in synovial fluid depends on albumin, fibrinogen, and hyaluronic acid
10.3389/fmicb.2021.655873 · 2021 · External reference
Staphylococcus aureus aggregation and coagulation mechanisms, and their function in host–pathogen interactions
2016 · External reference
Non-surface attached bacterial aggregates: a ubiquitous third lifestyle
10.3389/fmicb.2020.557035 · 2020 · External reference
Shaping the growth behaviour of biofilms initiated from bacterial aggregates
2015 · External reference
Exogenous alginate protects Staphylococcus aureus from killing by Pseudomonas aeruginosa
10.1128/jb.00559-19 · 2020 · External reference
A novel chronic wound biofilm model sustaining coexistence of Pseudomonas aeruginosa and Staphylococcus aureus suitable for testing of antibiofilm effect of antimicrobial solutions and wound dressings
10.1111/wrr.12944 · 2021 · External reference
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants
10.1046/j.1365-2958.2003.03525.x · 2003 · External reference
Spatial organization of bacterial populations in response to oxygen and carbon counter-gradients in pore networks
10.1038/s41467-018-03187-y · 2018 · External reference
Cellular function of elastase in Pseudomonas aeruginosa: role in the cleavage of nucleoside diphosphate kinase and in alginate synthesis
10.1046/j.1365-2958.1998.01121.x · 1998 · External reference
Pseudomonas aeruginosa elastase and its role in pseudomonas infections
10.1093/clinids/5.supplement_5.s998 · 1983 · External reference
Pseudomonas aeruginosa virulence proteins pseudolysin and protease IV impede cutaneous wound healing
10.1038/s41374-020-00478-1 · 2020 · External reference
Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum
10.1038/srep43321 · 2017 · External reference
Treatment of hypertrophic scar in human with autologous transplantation of cultured keratinocytes and fibroblasts along with fibrin glue
2015 · External reference
Vimentin and cytokeratin: good alone, bad together
2021 · External reference
Polydopamine-on-liposomes: stable nanoformulations, uniform coatings and superior antifouling performance
10.1039/c9nr07770g · 2020 · External reference
Analysis by confocal laser scanning microscopy of the MDPB bactericidal effect on S. mutans biofilm CLSM analysis of MDPB bactericidal effect on biofilm
10.1590/s1678-77572012000500013 · 2012 · External reference
The use of microscopy and three-dimensional visualization to evaluate the structure of microbial biofilms cultivated in the calgary biofilm device
10.1251/bpo127 · 2006 · External reference
Biofilm matrixome: extracellular components in structured microbial communities
10.1016/j.tim.2020.03.016 · 2020 · External reference
Pseudomonas aeruginosa transcriptome adaptations from colonization to biofilm infection of skin wounds
2021 · External reference
RNA-seq transcriptomic responses of full-thickness dermal excision wounds to Pseudomonas aeruginosa acute and biofilm infection
10.1371/journal.pone.0165312 · 2016 · External reference
Genome sequences of two Pseudomonas aeruginosa isolates with defects in type III secretion system gene expression from a chronic ankle wound infection
10.1128/spectrum.00340-21 · 2021 · External reference
