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References from Monoclonal antibodies that target extracellular DNABII proteins or the type IV pilus of nontypeable Haemophilus influenzae (NTHI) worked additively to disrupt 2-genera biofilms. Local targets link to admitted publications; unresolved targets remain external evidence.
Insights on persistent airway infection by non-typeable Haemophilus influenzae in chronic obstructive pulmonary disease
10.1093/femspd/ftx042 · 2017 · External reference
Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling
10.1128/mbio.00102-10 · 2010 · External reference
The biogeography of infection revisited
10.1038/s41579-022-00683-3 · 2022 · External reference
Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media
10.1016/j.prrv.2012.03.001 · 2012 · External reference
Role of interspecies bacterial communication in the virulence of pathogenic bacteria
10.1080/1040841x.2020.1735991 · 2020 · External reference
Biofilm formation and antibiotic susceptibility in dispersed cells versus planktonic cells from clinical, industry and environmental origins
10.1007/s10482-017-0919-2 · 2017 · External reference
Infectious chronic rhinosinusitis
10.1016/j.jaip.2016.04.008 · 2016 · External reference
Antibodies directed against integration host factor mediate biofilm clearance from Nasopore
10.1002/lary.24183 · 2013 · External reference
Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms
10.1111/mmi.12735 · 2014 · External reference
Superbugs: an arms race against bacteria
10.1016/s2213-2600(18)30271-6 · 2018 · External reference
Microbiology of bacterial respiratory infections
10.1097/00006454-199808001-00002 · 1998 · External reference
Susceptibility of Pseudomonas aeruginosa dispersed cells to antimicrobial agents is dependent on the dispersion cue and class of the antimicrobial agent used
10.1128/aac.00846-17 · 2017 · External reference
Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles
10.1038/ncomms5462 · 2014 · External reference
Tolerance and resistance of microbial biofilms
10.1038/s41579-022-00682-4 · 2022 · External reference
Bacterial biofilms: a common cause of persistent infections
10.1126/science.284.5418.1318 · 1999 · External reference
Minimization of bacterial size allows for complement evasion and is overcome by the agglutinating effect of antibody
10.1016/j.chom.2011.09.009 · 2011 · External reference
DNABII proteins play a central role in UPEC biofilm structure
10.1111/mmi.12994 · 2015 · External reference
The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation
10.1172/jci140527 · 2021 · External reference
Adding a new dimension: multi-level structure and organization of mixed-species Pseudomonas aeruginosa and Staphylococcus aureus biofilms in a 4-D wound microenvironment
2022 · External reference
The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease
10.1016/j.jaci.2020.02.040 · 2021 · External reference
Effect of biofilm culture upon the susceptibility of Staphylococcus epidermidis to tobramycin
10.1093/jac/30.6.803 · 1992 · External reference
Bacteria from bronchoalveolar lavage fluid from children with suspected chronic lower respiratory tract infection: results from a multi-center, cross-sectional study in Spain
10.1007/s00431-017-3044-3 · 2018 · External reference
Structure and signal regulation mechanism of interspecies and interkingdom quorum sensing system receptors
10.1021/acs.jafc.1c04751 · 2022 · External reference
A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein
10.1111/omi.12155 · 2017 · External reference
Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins
10.1038/mi.2011.27 · 2011 · External reference
Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo
10.1038/s41598-019-40378-z · 2019 · External reference
Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma
10.1371/journal.pone.0100645 · 2014 · External reference
Quantitative image analysis of microbial communities with BiofilmQ
10.1038/s41564-020-00817-4 · 2021 · External reference
Effect of autoinducer-2 quorum sensing inhibitor on interspecies quorum sensing
2022 · External reference
Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein
10.1128/jb.01935-06 · 2007 · External reference
A humanized monoclonal antibody potentiates killing of diverse biofilm-forming respiratory tract pathogens by antibiotics
10.1128/aac.01877-21 · 2022 · External reference
Interaction with nontypeable Haemophilus influenzae alters progression of Streptococcus pneumoniae from colonization to disease in a site-specific manner
10.1093/infdis/jiz312 · 2019 · External reference
Streptococcus pneumoniae synergizes with nontypeable Haemophilus influenzae to induce inflammation via upregulating TLR2
10.1186/1471-2172-9-40 · 2008 · External reference
Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation
10.1128/iai.00946-07 · 2007 · External reference
Unveiling co-infection in cystic fibrosis airways: transcriptomic analysis of Pseudomonas aeruginosa and Staphylococcus aureus dual-species biofilms
10.3389/fgene.2022.883199 · 2022 · External reference
DNA-Based diagnostic approaches for identification of Burkholderia cepacia complex, Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, and Burkholderia cepacia genomovars I and III
10.1128/jcm.38.9.3165-3173.2000 · 2000 · External reference
The ecology of nasal colonization of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus: the role of competition and interactions with host's immune response
10.1186/1471-2180-10-59 · 2010 · External reference
Interkingdom signaling induces Streptococcus pneumoniae biofilm dispersion and transition from asymptomatic colonization to disease
10.1128/mbio.00438-13 · 2013 · External reference
Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media
10.1128/iai.71.6.3454-3462.2003 · 2003 · External reference
Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations
10.1136/thoraxjnl-2017-210408 · 2018 · External reference
The immune response to pneumococcal proteins during experimental human carriage
10.1084/jem.20011576 · 2002 · External reference
Type IV pilus expression is upregulated in nontypeable Haemophilus influenzae biofilms formed at the temperature of the human nasopharynx
10.1128/jb.01022-15 · 2016 · External reference
Antibodies against the majority subunit (PilA) of the type IV pilus of nontypeable Haemophilus influenzae disperse Moraxella catarrhalis from a dual-species biofilm
10.1128/mbio.02423-18 · 2018 · External reference
Nontypeable Haemophilus influenzae newly released (NRel) from biofilms by antibody-mediated dispersal versus antibody-mediated disruption are phenotypically distinct
2020 · External reference
Biofilm formation by Streptococcus pneumoniae: role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion
10.1128/jb.00673-06 · 2006 · External reference
Nontypeable Haemophilus influenzae as a pathogen in children
10.1097/inf.0b013e318184dba2 · 2009 · External reference
Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates
10.1016/j.vaccine.2009.08.017 · 2009 · External reference
Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae
10.1038/mi.2011.6 · 2011 · External reference
Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein
10.1371/journal.pone.0067629 · 2013 · External reference
Antibodies against the majority subunit of type IV pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media
10.1111/mmi.12934 · 2015 · External reference
Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo
10.1016/j.ebiom.2016.06.022 · 2016 · External reference
Redirecting the immune response towards immunoprotective domains of a DNABII protein resolves experimental otitis media
10.1038/s41541-019-0137-1 · 2019 · External reference
Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections
10.1016/j.ebiom.2020.102867 · 2020 · External reference
Dynamic changes in the Streptococcus pneumoniae transcriptome during transition from biofilm formation to invasive disease upon influenza A virus infection
10.1128/iai.02225-14 · 2014 · External reference
Antimicrobial resistance: prevalence, economic burden, mechanisms of resistance and strategies to overcome
10.1016/j.ejps.2021.106103 · 2022 · External reference
Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical outcome
10.1016/j.jaci.2015.02.008 · 2015 · External reference
Bacterial coaggregation: an integral process in the development of multi-species biofilms
10.1016/s0966-842x(02)00034-3 · 2003 · External reference
Targeting the HUbeta protein prevents Porphyromonas gingivalis from entering into preexisting biofilms
10.1128/jb.00790-17 · 2018 · External reference
Increased chain length promotes pneumococcal adherence and colonization
10.1128/iai.00587-12 · 2012 · External reference
Nontypeable Haemophilus influenzae infection upregulates the NLRP3 inflammasome and leads to caspase-1-dependent secretion of Interleukin-1beta - a possible pathway of exacerbations in COPD
10.1371/journal.pone.0066818 · 2013 · External reference
The biofilm life cycle: expanding the conceptual model of biofilm formation
10.1038/s41579-022-00767-0 · 2022 · External reference
Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A
10.1128/iai.62.5.2002-2020.1994 · 1994 · External reference
Multiple combination antibiotic susceptibility testing of nontypeable Haemophilus influenzae biofilms
10.1016/j.diagmicrobio.2006.04.012 · 2006 · External reference
Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and diminish established biofilms
10.1128/aac.00607-07 · 2008 · External reference
Non-typeable Haemophilus influenzae, an under-recognised pathogen
10.1016/s1473-3099(14)70734-0 · 2014 · External reference
The antibiotic resistance crisis: part 1: causes and threats
2015 · External reference
Airway host-microbiome interactions in chronic obstructive pulmonary disease
10.1186/s12931-019-1085-z · 2019 · External reference
Quorum sensing: cell-to-cell communication in bacteria
10.1146/annurev.cellbio.21.012704.131001 · 2005 · External reference
The role of non-typeable Haemophilus influenzae biofilms in chronic obstructive pulmonary disease
10.3389/fcimb.2021.720742 · 2021 · External reference
Bacterial community interactions during chronic respiratory disease
10.3389/fcimb.2020.00213 · 2020 · External reference
Extracellular DNA required for bacterial biofilm formation
10.1126/science.295.5559.1487 · 2002 · External reference