Research graph
References from A pyridone-fused imidazo[1,2-a]pyridine hybrid binds to tubulin at the vinblastine site, depolymerizes microtubules and inhibits Cancer cell proliferation. Local targets link to admitted publications; unresolved targets remain external evidence.
Microtubule-targeting agents: strategies to hijack the cytoskeleton
10.1016/j.tcb.2018.05.001 · 2018 · External reference
Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function
10.1016/j.bmc.2014.02.035 · 2014 · External reference
Microtubules: evolving roles and critical cellular interactions
10.1177/1535370219867296 · 2019 · External reference
Interplay between microtubule dynamics and intracellular organization
10.1016/j.biocel.2011.11.009 · 2012 · External reference
Microtubule organization is essential for maintaining cellular morphology and function
2022 · External reference
Phase I study of vinblastine in combination with nilotinib in children, adolescents, and young adults with refractory or recurrent low-grade glioma
2020 · External reference
Paclitaxel: application in modern oncology and nanomedicine-based cancer therapy
10.1155/2021/3687700 · 2021 · External reference
Resistance to anti-tubulin agents: from vinca alkaloids to epothilones
2019 · External reference
Recent advances in microtubule targeting agents for Cancer therapy
10.3390/molecules30163314 · 2025 · External reference
Nivolumab and doxorubicin, vinblastine, and Dacarbazine in early-stage unfavorable Hodgkin lymphoma: final analysis of the randomized German Hodgkin study group phase II NIVAHL trial
10.1200/jco.22.02355 · 2023 · External reference
Eribulin’s exclusive binding to microtubule plus ends results from discrimination between GTP and GDP forms of β-tubulin
10.1016/j.abb.2025.110482 · 2025 · External reference
Efficacy and safety of eribulin plus gemcitabine as second-line treatment for recurrent HER2-negative breast cancer: a phase II, single-arm, open-label trial
10.1038/s43856-026-01483-z · 2026 · External reference
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): mechanistic insights into MMAE ADC peripheral neuropathy
10.1016/j.taap.2021.115534 · 2021 · External reference
Structural basis of microtubule destabilization by potent Auristatin anti-mitotics
10.1371/journal.pone.0160890 · 2016 · External reference
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
10.1073/pnas.1408124111 · 2014 · External reference
The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design
10.1002/1873-3468.14003 · 2021 · External reference
Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus
10.4103/0973-7847.156323 · 2015 · External reference
Triazolopyrimidines are microtubule-stabilizing agents that bind the Vinca inhibitor site of tubulin
10.1016/j.chembiol.2017.05.016 · 2017 · External reference
Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: design, multicomponent synthesis and antiproliferative activities
10.1016/j.bioorg.2019.103260 · 2019 · External reference
Cevipabulin induced abnormal tubulin protofilaments polymerization by binding to vinblastine site and the seventh site
10.1002/cm.21813 · 2024 · External reference
Distinct and overlapping binding sites for IKP104 and vinblastine on tubulin
10.1007/bf02780971 · 1998 · External reference
Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions
10.1039/d2ra07056a · 2022 · External reference
Cancer therapies utilizing the camptothecins: a review of the in vivo literature
10.1021/mp900243b · 2010 · External reference
An N-linked imidazo[1,2-a]pyridine benzoheterobicyclic hybrid inhibits mitosis and cancer cell proliferation by targeting tubulin
10.1016/j.bmc.2025.118242 · 2025 · External reference
Imidazo[1,2-a]pyridine derivatives as promising anticancer agents: synthesis and therapeutic potential
10.1002/ardp.70214 · 2026 · External reference
Imidazo[1,2-a]pyridine derivatives as novel dual-target inhibitors of ABCB1 and ABCG2 for reversing multidrug resistance
10.1021/acs.jmedchem.2c01862 · 2023 · External reference
Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism
2024 · External reference
Novel carbazolyl-thiazolyl-chromone and carbazolyl-thiazolyl-pyrazole hybrids: synthesis, cytotoxicity evaluation and molecular docking studies
10.1039/d4ra03188a · 2024 · External reference
Heterocyclic mesomeric betaines. Part 4. Reductive cyclization of derivatives of 7-methyl-2-(2′-nitrophenyl)imidazo[l,2-a]pyridine
10.1039/p19890000961 · 1989 · External reference
C–H activation: a strategic approach toward lactams using transition metals
2022 · External reference
Oxidizing directing groups enable efficient and innovative C-H activation reactions
10.1002/anie.201007241 · 2011 · External reference
Iridium(III)-catalyzed C-H amidation/cyclization of NH-sulfoximines with N-alkoxyamides: formation of thiadiazine 1-oxides
10.1021/acs.orglett.0c00520 · 2020 · External reference
Palladium-catalyzed alkenylation of quinoline-N-oxides via C-H activation under external-oxidant-free conditions
10.1021/ja902762a · 2009 · External reference
Acetyl oximes as transformable directing groups for Pd-catalyzed C-H bond functionalization
10.1021/ol902720d · 2010 · External reference
Synthesis of isoquinolines via Rh(III)-catalyzed C-H activation using hydrazone as a new oxidizing directing group
10.1021/ol402796m · 2013 · External reference
Harnessing sulfilimine as an oxidizing directing group in Cp*co(III)-catalyzed [4+2] annulation with alkynes and 1,3-diynes
10.1039/d5cc01230a · 2025 · External reference
Pd-catalyzed intermolecular ortho-C− H amidation of anilides by N-nosyloxycarbamate
10.1021/ja106364r · 2010 · External reference
Rh(III)-catalyzed directed C-H olefination using an oxidizing directing group: mild, efficient, and versatile
10.1021/ja109676d · 2011 · External reference
N-methoxybenzamide: a versatile directing group for palladium-, rhodium- and ruthenium-catalyzed C−H bond activations
10.1002/adsc.201900405 · 2019 · External reference
Rhodium(III)-catalyzed isoquinolone synthesis: the N-O bond as a handle for C-N bond formation and catalyst turnover
10.1021/ja102571b · 2010 · External reference
Ruthenium-catalyzed isoquinolone synthesis through C-H activation using an oxidizing directing group
10.1002/chem.201102445 · 2011 · External reference
Redox-neutral [4 + 2] annulation of N-methoxybenzamides with alkynes enabled by an osmium(II)/HOAc catalytic system
10.1021/acs.orglett.9b03827 · 2019 · External reference
Directed regioselective arylation of imidazo[1,2-a]pyridine-3-carboxamides using Rh(III) catalysis
10.1039/d4ob01166j · 2024 · External reference
C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules
10.1016/j.bcp.2019.113663 · 2019 · External reference
Sulforhodamine B colorimetric assay for cytotoxicity screening
10.1038/nprot.2006.179 · 2006 · External reference
Sulforhodamine B (SRB) assay in cell culture to investigate cell proliferation
2016 · External reference
C1, a highly potent novel curcumin derivative, binds to tubulin, disrupts microtubule network and induces apoptosis
10.1042/bsr20160039 · 2016 · External reference
Combretastatin-inspired heterocycles as antitubulin anticancer agents
10.1021/acsomega.8b00996 · 2018 · External reference
Introduction to the use of linear and nonlinear regression analysis in quantitative biological assays
10.1002/cpz1.801 · 2023 · External reference
Glutamate-induced polymerization of tubulin: characteristics of the reaction and application to the large-scale purification of tubulin
10.1016/0003-9861(81)90253-8 · 1981 · External reference
CEP41, a ciliopathy-linked centrosomal protein, regulates microtubule assembly and cell proliferation
10.1242/jcs.261927 · 2024 · External reference
Measuring microtubule dynamics
10.1042/ebc20180035 · 2018 · External reference
Rapid profiling cell cycle by flow cytometry using concurrent staining of DNA and mitotic markers
10.21769/bioprotoc.2517 · 2017 · External reference
3,5-bis(styryl)pyrazole inhibits mitosis and induces cell death independent of BubR1 and p53 levels by depolymerizing microtubules
10.1093/jb/mvad031 · 2023 · External reference
Mitotic index analysis
10.1007/978-1-0716-2433-3_3 · 2023 · External reference
Novel combretastatin-2-aminoimidazole analogues as potent tubulin assembly inhibitors: exploration of unique pharmacophoric impact of bridging skeleton and aryl moiety
10.1021/acs.jmedchem.6b00101 · 2016 · External reference
Investigating tubulin-drug interaction using fluorescence spectroscopy
10.1007/978-1-0716-1983-4_17 · 2022 · External reference
Fluorescence spectroscopic methods to analyze drug–tubulin interactions
10.1016/s0091-679x(10)95017-6 · 2010 · External reference
Podophyllotoxin as a probe for the colchicine binding site of tubulin
10.1016/s0021-9258(17)40631-4 · 1977 · External reference
Interaction of tubulin with a new fluorescent analogue of vinblastine
10.1021/bi026182m · 2002 · External reference
Illuminating microtubule functions with small molecules: past, present and future of fluorescent tubulin-binding probes
10.1039/d5cb00321k · 2026 · External reference
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
10.1021/jm051256o · 2006 · External reference
Unresolved reference
1989 · External reference
10.1103/physrevb.37.785
10.1103/physrevb.37.785 · 1988 · External reference
Unresolved reference
2019 · External reference
Mitotic spindle assembly in animal cells: a fine balancing act
10.1038/nrm.2016.162 · 2017 · External reference
Microtubule-targeting agents for cancer treatment: seven binding sites and three strategies
2023 · External reference
Kinetic suppression of microtubule dynamic instability by Griseofulvin: implications for its possible use in the treatment of Cancer
10.1073/pnas.0501821102 · 2005 · External reference
Preclinical models of breast cancer metastasis: strengths, limitations, and clinical relevance
10.1038/s41523-026-00928-x · 2026 · External reference
Identification of triple-negative breast cancer cell lines classified under the same molecular subtype using different molecular characterization techniques: implications for translational research
10.1371/journal.pone.0231953 · 2020 · External reference
Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays
10.1371/journal.pone.0046536 · 2012 · External reference
More than apples and oranges--detecting cancer with a fruit fly’s antenna
10.1038/srep03576 · 2014 · External reference
The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design
10.1002/1873-3468.14003 · ExternalCitation · doi-reference
N-methoxybenzamide: a versatile directing group for palladium-, rhodium- and ruthenium-catalyzed C−H bond activations
10.1002/adsc.201900405 · ExternalCitation · doi-reference
Oxidizing directing groups enable efficient and innovative C-H activation reactions
10.1002/anie.201007241 · ExternalCitation · doi-reference
Imidazo[1,2-a]pyridine derivatives as promising anticancer agents: synthesis and therapeutic potential
10.1002/ardp.70214 · ExternalCitation · doi-reference
Ruthenium-catalyzed isoquinolone synthesis through C-H activation using an oxidizing directing group
10.1002/chem.201102445 · ExternalCitation · doi-reference
Cevipabulin induced abnormal tubulin protofilaments polymerization by binding to vinblastine site and the seventh site
10.1002/cm.21813 · ExternalCitation · doi-reference
Introduction to the use of linear and nonlinear regression analysis in quantitative biological assays
10.1002/cpz1.801 · ExternalCitation · doi-reference
Investigating tubulin-drug interaction using fluorescence spectroscopy
10.1007/978-1-0716-1983-4_17 · ExternalCitation · doi-reference
Mitotic index analysis
10.1007/978-1-0716-2433-3_3 · ExternalCitation · doi-reference
Distinct and overlapping binding sites for IKP104 and vinblastine on tubulin
10.1007/bf02780971 · ExternalCitation · doi-reference
Glutamate-induced polymerization of tubulin: characteristics of the reaction and application to the large-scale purification of tubulin
10.1016/0003-9861(81)90253-8 · ExternalCitation · doi-reference
Eribulin’s exclusive binding to microtubule plus ends results from discrimination between GTP and GDP forms of β-tubulin
10.1016/j.abb.2025.110482 · ExternalCitation · doi-reference
C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules
10.1016/j.bcp.2019.113663 · ExternalCitation · doi-reference
Interplay between microtubule dynamics and intracellular organization
10.1016/j.biocel.2011.11.009 · ExternalCitation · doi-reference
Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: design, multicomponent synthesis and antiproliferative activities
10.1016/j.bioorg.2019.103260 · ExternalCitation · doi-reference
Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function
10.1016/j.bmc.2014.02.035 · ExternalCitation · doi-reference
An N-linked imidazo[1,2-a]pyridine benzoheterobicyclic hybrid inhibits mitosis and cancer cell proliferation by targeting tubulin
10.1016/j.bmc.2025.118242 · ExternalCitation · doi-reference
Triazolopyrimidines are microtubule-stabilizing agents that bind the Vinca inhibitor site of tubulin
10.1016/j.chembiol.2017.05.016 · ExternalCitation · doi-reference
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): mechanistic insights into MMAE ADC peripheral neuropathy
10.1016/j.taap.2021.115534 · ExternalCitation · doi-reference
Microtubule-targeting agents: strategies to hijack the cytoskeleton
10.1016/j.tcb.2018.05.001 · ExternalCitation · doi-reference
Podophyllotoxin as a probe for the colchicine binding site of tubulin
10.1016/s0021-9258(17)40631-4 · ExternalCitation · doi-reference
Fluorescence spectroscopic methods to analyze drug–tubulin interactions
10.1016/s0091-679x(10)95017-6 · ExternalCitation · doi-reference
Imidazo[1,2-a]pyridine derivatives as novel dual-target inhibitors of ABCB1 and ABCG2 for reversing multidrug resistance
10.1021/acs.jmedchem.2c01862 · ExternalCitation · doi-reference
Novel combretastatin-2-aminoimidazole analogues as potent tubulin assembly inhibitors: exploration of unique pharmacophoric impact of bridging skeleton and aryl moiety
10.1021/acs.jmedchem.6b00101 · ExternalCitation · doi-reference
Iridium(III)-catalyzed C-H amidation/cyclization of NH-sulfoximines with N-alkoxyamides: formation of thiadiazine 1-oxides
10.1021/acs.orglett.0c00520 · ExternalCitation · doi-reference
Redox-neutral [4 + 2] annulation of N-methoxybenzamides with alkynes enabled by an osmium(II)/HOAc catalytic system
10.1021/acs.orglett.9b03827 · ExternalCitation · doi-reference
Combretastatin-inspired heterocycles as antitubulin anticancer agents
10.1021/acsomega.8b00996 · ExternalCitation · doi-reference
Interaction of tubulin with a new fluorescent analogue of vinblastine
10.1021/bi026182m · ExternalCitation · doi-reference
Rhodium(III)-catalyzed isoquinolone synthesis: the N-O bond as a handle for C-N bond formation and catalyst turnover
10.1021/ja102571b · ExternalCitation · doi-reference
Pd-catalyzed intermolecular ortho-C− H amidation of anilides by N-nosyloxycarbamate
10.1021/ja106364r · ExternalCitation · doi-reference
Rh(III)-catalyzed directed C-H olefination using an oxidizing directing group: mild, efficient, and versatile
10.1021/ja109676d · ExternalCitation · doi-reference
Palladium-catalyzed alkenylation of quinoline-N-oxides via C-H activation under external-oxidant-free conditions
10.1021/ja902762a · ExternalCitation · doi-reference
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
10.1021/jm051256o · ExternalCitation · doi-reference
Cancer therapies utilizing the camptothecins: a review of the in vivo literature
10.1021/mp900243b · ExternalCitation · doi-reference
Synthesis of isoquinolines via Rh(III)-catalyzed C-H activation using hydrazone as a new oxidizing directing group
10.1021/ol402796m · ExternalCitation · doi-reference
Acetyl oximes as transformable directing groups for Pd-catalyzed C-H bond functionalization
10.1021/ol902720d · ExternalCitation · doi-reference
Sulforhodamine B colorimetric assay for cytotoxicity screening
10.1038/nprot.2006.179 · ExternalCitation · doi-reference
Mitotic spindle assembly in animal cells: a fine balancing act
10.1038/nrm.2016.162 · ExternalCitation · doi-reference
Preclinical models of breast cancer metastasis: strengths, limitations, and clinical relevance
10.1038/s41523-026-00928-x · ExternalCitation · doi-reference
Efficacy and safety of eribulin plus gemcitabine as second-line treatment for recurrent HER2-negative breast cancer: a phase II, single-arm, open-label trial
10.1038/s43856-026-01483-z · ExternalCitation · doi-reference
More than apples and oranges--detecting cancer with a fruit fly’s antenna
10.1038/srep03576 · ExternalCitation · doi-reference
Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions
10.1039/d2ra07056a · ExternalCitation · doi-reference
Directed regioselective arylation of imidazo[1,2-a]pyridine-3-carboxamides using Rh(III) catalysis
10.1039/d4ob01166j · ExternalCitation · doi-reference
Novel carbazolyl-thiazolyl-chromone and carbazolyl-thiazolyl-pyrazole hybrids: synthesis, cytotoxicity evaluation and molecular docking studies
10.1039/d4ra03188a · ExternalCitation · doi-reference
Illuminating microtubule functions with small molecules: past, present and future of fluorescent tubulin-binding probes
10.1039/d5cb00321k · ExternalCitation · doi-reference
Harnessing sulfilimine as an oxidizing directing group in Cp*co(III)-catalyzed [4+2] annulation with alkynes and 1,3-diynes
10.1039/d5cc01230a · ExternalCitation · doi-reference
Heterocyclic mesomeric betaines. Part 4. Reductive cyclization of derivatives of 7-methyl-2-(2′-nitrophenyl)imidazo[l,2-a]pyridine
10.1039/p19890000961 · ExternalCitation · doi-reference
C1, a highly potent novel curcumin derivative, binds to tubulin, disrupts microtubule network and induces apoptosis
10.1042/bsr20160039 · ExternalCitation · doi-reference
Measuring microtubule dynamics
10.1042/ebc20180035 · ExternalCitation · doi-reference
Kinetic suppression of microtubule dynamic instability by Griseofulvin: implications for its possible use in the treatment of Cancer
10.1073/pnas.0501821102 · ExternalCitation · doi-reference
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
10.1073/pnas.1408124111 · ExternalCitation · doi-reference
3,5-bis(styryl)pyrazole inhibits mitosis and induces cell death independent of BubR1 and p53 levels by depolymerizing microtubules
10.1093/jb/mvad031 · ExternalCitation · doi-reference
10.1103/physrevb.37.785
10.1103/physrevb.37.785 · ExternalCitation · doi-reference
Paclitaxel: application in modern oncology and nanomedicine-based cancer therapy
10.1155/2021/3687700 · ExternalCitation · doi-reference
Microtubules: evolving roles and critical cellular interactions
10.1177/1535370219867296 · ExternalCitation · doi-reference
Nivolumab and doxorubicin, vinblastine, and Dacarbazine in early-stage unfavorable Hodgkin lymphoma: final analysis of the randomized German Hodgkin study group phase II NIVAHL trial
10.1200/jco.22.02355 · ExternalCitation · doi-reference
CEP41, a ciliopathy-linked centrosomal protein, regulates microtubule assembly and cell proliferation
10.1242/jcs.261927 · ExternalCitation · doi-reference
Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays
10.1371/journal.pone.0046536 · ExternalCitation · doi-reference
Structural basis of microtubule destabilization by potent Auristatin anti-mitotics
10.1371/journal.pone.0160890 · ExternalCitation · doi-reference
Identification of triple-negative breast cancer cell lines classified under the same molecular subtype using different molecular characterization techniques: implications for translational research
10.1371/journal.pone.0231953 · ExternalCitation · doi-reference
Rapid profiling cell cycle by flow cytometry using concurrent staining of DNA and mitotic markers
10.21769/bioprotoc.2517 · ExternalCitation · doi-reference
Recent advances in microtubule targeting agents for Cancer therapy
10.3390/molecules30163314 · ExternalCitation · doi-reference
Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus
10.4103/0973-7847.156323 · ExternalCitation · doi-reference
