Research graph
References from Thymol-based derivatives as anticancer agents: design, synthesis, biological evaluation, and molecular docking studies. Local targets link to admitted publications; unresolved targets remain external evidence.
Thymol and thyme essential oil-new insights into selected therapeutic applications
10.3390/molecules25184125 · 2020 · External reference
Thymol as starting material for the development of a biobased material with enhanced antimicrobial activity: synthesis, characterization, and potential application
10.3390/molecules29051010 · 2024 · External reference
Anticancer activity of thymol: A literature-based review and docking study with emphasis on its anticancer mechanisms
10.1002/iub.1935 · 2019 · External reference
Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development
10.3389/fphar.2017.00380 · 2017 · External reference
Regulation of C6 glioma cell migration by thymol
10.3892/ol.2016.4237 · 2016 · External reference
Chemical composition and biological activity of the essential oil from Thymus lanceolatus
10.1515/znc-2016-0005 · 2016 · External reference
Disruption of the PI3K/AKT/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential oil from Monarda citriodora
10.1016/j.fct.2013.08.037 · 2013 · External reference
Antioxidant and antiproliferative activities of the essential oils from Thymbra capitata and thymus species grown in Portugal
10.1155/2015/851721 · 2015 · External reference
Thymol derivatives from the roots of Eupatorium chinense and their cytotoxic activities
10.1016/j.phytol.2018.12.008 · 2019 · External reference
New thymol and isothymol derivatives from Eupatorium fortunei and their cytotoxic effects
10.1016/j.bioorg.2020.103644 · 2020 · External reference
Synthesis and bioactivity of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan
10.2174/1570180811666140220005252 · 2014 · External reference
Bioavailability of thymol incorporated into gastro-resistant self-emulsifying pellets in rabbits
10.3390/ani15223238 · 2025 · External reference
Current knowledge on the bioavailability of thymol as a feed additive in humans and animals with a focus on rabbit metabolic processes
10.3390/ani12091131 · 2022 · External reference
Improvement of thymol properties by complexation with cyclodextrins: in vitro and in vivo studies
10.1016/j.carbpol.2013.10.084 · 2014 · External reference
Thymol has anticancer effects in U-87 human malignant glioblastoma cells
10.1007/s11033-022-07867-3 · 2022 · External reference
Induction of G0/G1 phase cell cycle arrest and apoptosis by thymol through ROS generation and caspase-9/−3 activation in breast and colorectal cancer cell lines
10.4103/jcrt.jcrt_308_22 · 2023 · External reference
Anticancer potential of novel cinnamoyl derivatives against U87MG and SHSY-5Y cell lines
10.2174/0118715206266917231106064937 · 2024 · External reference
Cinnamic acid hybrids as anticancer agents: a mini-review
10.1002/ardp.202200052 · 2022 · External reference
Synthesis of cinnamic acid ester derivatives with antiproliferative and antimetastatic activities on murine melanoma cells
10.1016/j.biopha.2022.112689 · 2022 · External reference
Uncovering the biological applications of cinnamic acid derivatives: a patent review
2024 · External reference
Sensitive detection of mycoplasmas in cell cultures by using two-step polymerase chain reaction
1993 · External reference
Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells
10.1515/znc-2020-0093 · 2020 · External reference
Glycyl-L-prolyl-L-glutamate pseudotripeptides for treatment of Alzheimer's disease
10.3390/biom11010126 · 2021 · External reference
Boron nitride nanoparticles loaded with a boron-based hybrid as a promising drug carrier system for Alzheimer’s disease treatment
10.3390/ijms23158249 · 2022 · External reference
Slow sulfide donor GYY4137 increased the sensitivity of two breast cancer cell lines to paclitaxel by different mechanisms
10.3390/biom14060651 · 2024 · External reference
Role of the sodium/calcium exchanger type 3 in cancer cells
10.1016/j.ejcb.2025.151493 · 2025 · External reference
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
10.1016/s0969-2126(02)00907-3 · 2002 · External reference
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility
10.1002/jcc.21256 · 2009 · External reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings
10.1021/acs.jcim.1c00203 · 2021 · External reference
3D-QSAR and molecular docking studies of aminopyrimidine derivatives as novel three-targeted Lck/Src/KDR inhibitors
10.1016/j.molstruc.2019.02.071 · 2019 · External reference
Atomic-level characterization of the structural dynamics of proteins
10.1126/science.1187409 · 2010 · External reference
Advancing infection therapy: the role of novel menthol-based antimicrobials
10.1080/14756366.2025.2596488 · 2026 · External reference
Evaluation of the effect of compound aqueous solubility in cytochrome P450 inhibition assays
10.4236/abb.2013.45083 · 2013 · External reference
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 · External reference
Relationship between the inhibition constant (ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
10.1016/0006-2952(73)90196-2 · 1973 · External reference
Insights into protein–ligand interactions: mechanisms, models, and methods
10.3390/ijms17020144 · 2016 · External reference
Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models
10.1021/ar000033j · 2000 · External reference
The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities
10.1517/17460441.2015.1032936 · 2015 · External reference
Revealing innovative JAK1 and JAK3 inhibitors: a comprehensive study utilizing QSAR, 3D-pharmacophore screening, molecular docking, molecular dynamics, and MM/GBSA analyses
10.3389/fmolb.2024.1348277 · 2024 · External reference
Identification and validation of prognostic genes and prognostic models associated with cutaneous melanoma and integrative stress response
10.3389/fimmu.2025.1689103 · 2025 · External reference
Synthesis and biological evaluation of novel cinnamic acid-based antimicrobials
10.3390/ph15020228 · 2022 · External reference
Anticancer activity and mechanism of xanthohumol: a prenylated flavonoid from hops (Humulus lupulus L.)
10.3389/fphar.2018.00530 · 2018 · External reference
Metal organic framework coated MnO2 nanosheets delivering doxorubicin and self-activated DNAzyme for chemo-gene combinatorial treatment of cancer
10.1016/j.ijpharm.2020.119513 · 2020 · External reference
Design and synthesis of thiourea-conjugating organic arsenic D-glucose with anticancer activities
10.3390/molecules29122850 · 2024 · External reference
Discovery of novel nucleoside derivatives as selective lysine acetyltransferase p300 inhibitors for cancer therapy
10.1016/j.bmcl.2024.129742 · 2024 · External reference
Thymoquinone glucuronide conjugated magnetic nanoparticle for bimodal imaging and treatment of cancer as a novel theranostic platform
10.2174/2211556009666200413085800 · 2021 · External reference
MCL1 inhibition overcomes the aggressiveness features of triple-negative breast cancer MDA-MB-231 cells
10.3390/ijms241311149 · 2023 · External reference
Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer
10.1158/1535-7163.1585.3.12 · 2004 · External reference
Multiple molecular mechanisms underlying trastuzumab and lapatinib resistance in JIMT-1 breast cancer cells
10.1016/j.canlet.2010.02.002 · 2010 · External reference
Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by annexin A2 antibodies
10.1038/bjc.2014.542 · 2014 · External reference
Cinobufagin loaded Prussian blue-like nanoparticles for chemo/gas therapy of multidrug resistant cancer
10.1186/s12951-025-03728-w · 2025 · External reference
FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells
10.1016/j.celrep.2015.02.056 · 2015 · External reference
PI3K/AKT/mTOR axis in cancer: from pathogenesis to treatment
2020 · External reference
End-point binding free energy calculation with MM/PBSA and MM/GBSA: strategies and applications in drug design
10.1021/acs.chemrev.9b00055 · 2019 · External reference
Multifaceted roles of heparin and its derivatives in inflammation and cancer: mechanisms, clinical applications, and future directions
10.1016/j.ijbiomac.2025.148054 · 2025 · External reference
Thymol and carvacrol derivatives as anticancer agents; synthesis, in vitro activity, and computational analysis of biological targets
10.1039/d4ra03941f · 2024 · External reference
Synthesis, cytotoxicity, apoptotic activity, oxidative stress inductive capacity, and molecular interactions of thymol-derived imines
10.1002/jbt.70601 · 2025 · External reference
Synthesis, anticancer, computational and docking studies of new thymol hybrids as potential EGFR inhibitors
10.1016/j.molstruc.2025.144762 · 2026 · External reference
Design and synthesis of benzofuran-pyrazole-triazole hybrids via click chemistry: antimicrobial, anticancer, ADMET, docking, and DFT studies
10.1080/00397911.2026.2642776 · 2026 · External reference
Synthesis, antimalarial evaluation, molecular docking, molecular dynamics simulation, and ADMET study of novel quinoline-thiazole hybrid derivatives
10.1016/j.molstruc.2026.146343 · 2026 · External reference
CuAAC derived 7-azaindole and 1H-pyridin-2-one linked 1,2,3-triazole based probe for selective Pb2+ sensing endowed with in vitro and in silico antimicrobial potential
2026 · External reference
