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References from Neuroactive gypenosides from Yunnan Gynostemma pentaphyllum: Nrf2-mediated cytoprotection and cholinesterase inhibition. Local targets link to admitted publications; unresolved targets remain external evidence.
Challenges in the diagnosis of Parkinson's disease
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Alzheimer’s disease
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Neuroprotective effects of gypenosides: a review on preclinical studies in neuropsychiatric disorders
10.1016/j.ejphar.2024.176766 · 2024 · External reference
Catha edulis and Datura stramonium mitigate oxidative stress, mitochondrial dysfunction, and cell death in an SH-SY5Y model of Parkinson's disease
10.1016/j.jep.2026.121223 · 2026 · External reference
Neurotoxicity study of ethyl acetate extract of Zanthoxylum armatum DC
10.1016/j.jep.2023.117321 · 2024 · External reference
Neuroprotective and antioxidant effects of fermented spent coffee ground fractions against Alzheimer's-related oxysterol 27-hydroxycholesterol in SH-SY5Y neuronal cells
10.1016/j.foodchem.2026.149435 · 2026 · External reference
Neuroprotective effects of pepsin-hydrolyzed ovotransferrin on H2O2-induced oxidative damage in SH-SY5Y neuronal cells
10.1016/j.bioorg.2026.109613 · 2026 · External reference
Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity by restoration of mitochondria function
10.1186/s40035-015-0033-1 · 2015 · External reference
NRF2: master regulator of cellular homeostasis and therapeutic vulnerability in cancer
10.1016/j.redox.2026.104050 · 2026 · External reference
Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
10.1016/j.advenzreg.2006.01.007 · 2006 · External reference
New sweet-tasting gypenosides from “Jiaogulan” (Gynostemma pentaphyllum) and their interactions with the homology model of sweet taste receptors
10.1021/acs.jafc.4c03566 · 2024 · External reference
Sensory-guided isolation and identification of new sweet-tasting dammarane-type saponins from Jiaogulan (Gynostemma pentaphyllum) herbal tea
10.1016/j.foodchem.2022.132981 · 2022 · External reference
Further new gypenosides from jiaogulan (Gynostemma pentaphyllum)
10.1021/acs.jafc.7b01477 · 2017 · External reference
Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: a review
10.1016/j.jep.2023.117186 · 2024 · External reference
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota
10.1016/j.jep.2026.121373 · 2026 · External reference
Metabolomics and molecular docking-directed anti-obesity study of the ethanol extract from Gynostemma pentaphyllum (Thunb.) Makino
10.1016/j.jep.2024.118577 · 2024 · External reference
New dammarane-type glycosides from Gynostemma pentaphyllum and their lipid-lowering activity
10.1016/j.bioorg.2021.104843 · 2021 · External reference
Gypenoside L inhibits oral squamous cell carcinoma progression by targeting the AKT signaling pathway
10.1016/j.bioorg.2025.109303 · 2026 · External reference
Identification and mechanism of hepatoprotective saponins and endogenous metabolites in the sweet variant of Gynostemma pentaphyllum
10.1016/j.bioorg.2025.108996 · 2025 · External reference
Gypenoside TN-2 ameliorates scopolamine-induced learning deficit in mice
10.1016/j.jep.2011.02.002 · 2011 · External reference
Neuroprotective effects of Gynostemma pentaphyllum (Jiaogulan): mechanisms, active compounds, and therapeutic potential
10.1016/j.prmcm.2026.100760 · 2026 · External reference
Triterpenoids from the genus Gynostemma: chemistry and pharmacological activities
2021 · External reference
Diploid chromosome-level reference genome and population genomic analyses provide insights into Gypenoside biosynthesis and demographic evolution of Gynostemma pentaphyllum (Cucurbitaceae)
10.1093/hr/uhac231 · 2023 · External reference
Untargeted qualitative and targeted quantitative analysis of saponins reveal differential chemotypes of Gynostemma pentaphyllum and G. longipes from different geographical origins
10.1016/j.foodchem.2024.142412 · 2025 · External reference
Correlation analysis of taste phenotype and Gynostemma pentaphyllum saponins using computer virtual screening and UPLC-(HR)MS/MS metabolomics
10.1016/j.foodchem.2024.142050 · 2025 · External reference
Untargeted qualitative and targeted quantitative analysis of saponins reveal differential chemotypes of Gynostemma pentaphyllum and G. longipes from different geographical origins
10.1016/j.foodchem.2024.142412 · 2025 · External reference
Population genetic structure, migration, and polyploidy origin of a medicinal species Gynostemma pentaphyllum (Cucurbitaceae)
10.1002/ece3.5618 · 2019 · External reference
Synthesis, characterization, crystal structure and evaluation of four carbazole-coumarin hybrids as multifunctional agents for the treatment of Alzheimer’s disease
10.1016/j.molstruc.2020.127897 · 2020 · External reference
Neuroprotective and antioxidant properties of Polygala virgata fractions in a 6-hydroxydopamine-induced neurotoxicity model
10.1016/j.jep.2026.121222 · 2026 · External reference
Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation
10.1016/j.neuroscience.2015.02.053 · 2015 · External reference
Six new triterpenoid glycosides from Gynostemma pentaphyllum
10.1002/hlca.200900100 · 2009 · External reference
A novel kaempferol triglycoside from flower buds of Panax quinquefolium
10.1007/s10600-010-9500-1 · 2009 · External reference
A new phloroglucinol diglycoside derivative from Hypericum japonicum Thunb
10.3390/molecules13112796 · 2008 · External reference
Inhibitory activity of isorhamnetin from Persicaria thunbergii on farnesyl protein transferase
10.1007/bf02977709 · 2005 · External reference
Flavonoid glycosides from cuban Erythroxylum species
10.1016/j.bse.2006.01.003 · 2006 · External reference
The flavonoids of Phragmites australis flowers
10.1016/s0031-9422(00)83831-5 · 1980 · External reference
Iridoids, flavonoids and monoterpene glycosides from Galium verum subsp. verum
2006 · External reference
Emerging of a new neuroprotective isoflavonoid with potent Keap1/Nrf2/ARE pathway activation and AChE inhibition
10.1016/j.bioorg.2025.109336 · 2026 · External reference
Gypenosides protect retinal pigment epithelium cells from oxidative stress
10.1016/j.fct.2017.12.037 · 2018 · External reference
Multi-target drug design in Alzheimer’s disease treatment: emerging technologies, advantages, challenges, and limitations
10.1002/prp2.70131 · 2025 · External reference
Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
10.1016/j.cell.2025.06.035 · 2025 · External reference
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease
10.1016/j.ejphar.2003.11.080 · 2004 · External reference
Food flavonols: nutraceuticals with complex health benefits and functionalities
10.1016/j.tifs.2021.03.030 · 2021 · External reference
Cholinesterase inhibitors from Cleistocalyx operculatus buds
10.1007/s12272-010-1016-5 · 2010 · External reference
Kaempferol plays a neuroprotection role by alleviating oxidative stress via AKT/Nrf2/HO-1 pathway and inhibiting apoptosis in intracerebral hemorrhage
10.1007/s11064-025-04544-2 · 2025 · External reference
Protective effect of kaempferol against cognitive and neurological disturbances induced by d-galactose and aluminum chloride in mice
10.1016/j.jff.2022.105385 · 2023 · External reference
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells
10.1007/s43188-023-00206-z · 2024 · External reference
Quercetin alleviates 6-OHDA-caused apoptosis in SH-SY5Y cells
10.1093/toxres/tfae117 · 2024 · External reference
Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats
10.1002/ptr.2454 · 2008 · External reference
Quercetin-functionalized nanomaterials: innovative therapeutic avenues for Alzheimer’s disease management
10.1016/j.arr.2025.102665 · 2025 · External reference
Neuroprotective effects of quercetin on memory and anxiogenic-like behavior in diabetic rats: role of ectonucleotidases and acetylcholinesterase activities
10.1016/j.biopha.2016.09.069 · 2016 · External reference
Antioxidative properties and effect of quercetin and its glycosylated form (rutin) on acetylcholinesterase and butyrylcholinesterase activities
10.1177/2156587215610032 · 2016 · External reference
Ombuoside from Gynostemma pentaphyllum protects PC12 cells from L-DOPA-induced neurotoxicity
10.1055/a-0595-7899 · 2018 · External reference
Ameliorative effects of ombuoside on dopamine biosynthesis in PC12 cells
10.20307/nps.2018.24.2.99 · 2018 · External reference
Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells
10.1016/j.neuro.2024.07.010 · 2024 · External reference
Nrf2-dependent cytoprotective effects and depletion of gut microbial energy harvesting by chemically defined polyphenol-rich Clerodendrum infortunatum
10.1016/j.fitote.2025.106730 · 2025 · External reference
Rutin attenuates oxidative stress via PHB2-mediated Mitophagy in MPP+-induced SH-SY5Y cells
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