Research graph
References from Computational targeting of APE1–miRNA interactions in Cancer: Prioritization of candidate modulators. Local targets link to admitted publications; unresolved targets remain external evidence.
The nucleolus: an emerging target for cancer therapy
10.1016/j.molmed.2013.07.005 · 2013 · External reference
Hallmarks of cancer: the next generation
10.1016/j.cell.2011.02.013 · 2011 · External reference
Surveillance of tumour development: the relationship between tumour-associated RNAs and ribonucleases
10.3389/fphar.2019.01019 · 2019 · External reference
Targeting the RNA-binding protein hur as potential thera-peutic approach for neurological disorders: focus on amyotrophic lateral sclerosis (ALS), spinal muscle atrophy (SMA) and multiple sclerosis
10.3390/ijms221910394 · 2021 · External reference
10.1093/eurheartj/ehw567
10.1093/eurheartj/ehw567 · External reference
10.1016/j.dnarep.2017.06.008
10.1016/j.dnarep.2017.06.008 · External reference
Nucleophosmin interaction with APE1: insights into DNA repair regulation
10.1016/j.dnarep.2020.102809 · 2020 · External reference
Revisiting two decades of research focused on targeting APE1 for cancer therapy: the pros and cons
10.3390/cells12141895 · 2023 · External reference
APE1/Ref-1-one target with multiple indications: emerging aspects and new directions HHS public access
2021 · External reference
10.1016/j.tins.2015.02.003
10.1016/j.tins.2015.02.003 · External reference
Apurinic/apyrimidinic endodeoxyribonuclease 1 modulates RNA G-quadruplex folding of miR-92b and controls its expression in cancer cells
10.1073/pnas.2317861121 · 2024 · External reference
A phase I study of the APE1 protein inhibitor APX3330 in patients with advanced solid tumors
10.1200/jco.2019.37.15_suppl.3097 · 2025 · External reference
10.1016/j.drudis.2020.10.015
10.1016/j.drudis.2020.10.015 · External reference
CTC enumeration and characterization as a pharmacodynamic marker in the phase I clinical study of APX3330, an APE1/Ref-1 inhibitor, in patients with advanced solid tumors
10.1200/jco.2019.37.15_suppl.e14531 · 2019 · External reference
Knockout and inhibition of Ape1: roles of Ape1 in base excision DNA repair and modulation of gene expression
10.3390/antiox11091817 · 2022 · External reference
Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing parkin-mediated mitophagy
2019 · External reference
AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
10.1093/nar/gkab1061 · 2022 · External reference
AlphaFold protein structure database 2025: a redesigned interface and updated structural coverage
10.1093/nar/gkaf1226 · 2026 · External reference
AlphaFold protein structure database and 3D-beacons: new data and capabilities
10.1016/j.jmb.2025.168967 · 2025 · External reference
Automated minimization of steric clashes in protein structures
10.1002/prot.22879 · 2011 · External reference
Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: four approaches that performed well in CASP8
10.1002/prot.22570 · 2009 · External reference
Verification of protein structures: patterns of nonbonded atomic interactions
10.1002/pro.5560020916 · 1993 · External reference
PROCHECK: a program to check the stereochemical quality of protein structures
10.1107/s0021889892009944 · 1993 · External reference
Unresolved reference
1997 · External reference
MolProbity: more and better reference data for improved all-atom structure validation
10.1002/pro.3330 · 2018 · External reference
Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism
10.1006/jmbi.2001.4529 · 2001 · External reference
ZINC 15 - ligand discovery for everyone
10.1021/acs.jcim.5b00559 · 2015 · External reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings
10.1021/acs.jcim.1c00203 · 2021 · External reference
The ClusPro web server for protein-protein docking
10.1038/nprot.2016.169 · 2017 · External reference
10.1038/srep42717
10.1038/srep42717 · External reference
DataWarrior: an open-source program for chemistry aware data visualization and analysis
10.1021/ci500588j · 2015 · External reference
admetSAR3.0: a comprehensive platform for exploration, prediction and optimization of chemical ADMET properties
10.1093/nar/gkae298 · 2024 · External reference
10.1093/bioinformatics/btae416
10.1093/bioinformatics/btae416 · External reference
PLIP: fully automated protein-ligand interaction profiler
10.1093/nar/gkv315 · 2015 · External reference
LigPlot+: multiple ligand-protein interaction diagrams for drug discovery
10.1021/ci200227u · 2011 · External reference
Gromacs: high performance molecular simulations through multi-level parallelism from laptops to supercomputers
10.1016/j.softx.2015.06.001 · 2015 · External reference
Unresolved reference
2025 · External reference
Evaluation and reparametrization of the OPLS-AA force field for proteins via comparison with accurate quantum chemical calculations on peptides
10.1021/jp003919d · 2001 · External reference
Structure and dynamics of the TIP3P, SPC, and SPC/E water models at 298 K
10.1021/jp003020w · 2001 · External reference
Definition and testing of the GROMOS force-field versions 54A7 and 54B7
10.1007/s00249-011-0700-9 · 2011 · External reference
Testing and validation of the automated topology builder (ATB) version 2.0: prediction of hydration free enthalpies
10.1007/s10822-014-9713-7 · 2014 · External reference
A novel approach for deriving force field torsion angle parameters accounting for conformation-dependent solvation effects
10.1021/ct3001987 · 2012 · External reference
The ACPYPE web server for small-molecule MD topology generation
10.1093/bioinformatics/btad350 · 2023 · External reference
G-mmpbsa -a GROMACS tool for high-throughput MM-PBSA calculations
10.1021/ci500020m · 2014 · External reference
Metadynamics as a tool for exploring free energy landscapes of chemical reactions
10.1021/ar040198i · 2006 · External reference
Bioconductor: open software development for computational biology and bioinformatics
10.1186/gb-2004-5-10-r80 · 2004 · External reference
Unresolved reference
2016 · External reference
A review on protein-protein interaction network of APE1/Ref-1 and its associated biological functions
10.1002/cbf.3100 · 2015 · External reference
10.1038/emm.2014.42
10.1038/emm.2014.42 · External reference
The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
10.1089/ars.2005.7.367 · 2005 · External reference
A new APE1/Ref-1-dependent pathway leading to reduction of NF-κB and AP-1, and activation of their DNA-binding activity
10.1093/nar/gkn416 · 2008 · External reference
Identification of apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA
10.1093/nar/gkp275 · 2009 · External reference
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
10.1128/mcb.01337-08 · 2009 · External reference
Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1
10.1111/cbdd.12826 · 2016 · External reference
Remote on–off switching of protein activity by intrinsically disordered region
10.1038/s41594-025-01585-7 · 2025 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
The DNA-repair protein APE1 participates with hnRNPA2B1 to motif-enriched and prognostic miRNA secretion
10.1038/s41388-024-03039-8 · 2024 · External reference
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions
10.1093/nar/gkq691 · 2010 · External reference
APE1 condensation in nucleoli of non-cancer cells depends on rRNA transcription and forming G-quadruplex RNA structures
10.1093/nar/gkaf168 · 2025 · External reference
Apurinic/apyrimidinic endodeoxyribonuclease 1 modulates RNA G-quadruplex folding of miR-92b and controls its expression in cancer cells
10.1073/pnas.2317861121 · 2024 · External reference
Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence
10.1016/j.dnarep.2018.11.010 · 2019 · External reference
The microRNA machinery
10.1007/978-3-319-22380-3_2 · 2015 · External reference
Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress
10.1038/s41598-019-46841-1 · 2019 · External reference
The microRNA biology of the mammalian nucleus
10.1038/mtna.2014.40 · 2014 · External reference
Molecular dynamics simulations: Concept, methods, and applications
2022 · External reference
Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)
10.1080/07391102.2018.1468282 · 2019 · External reference
