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References from Design, synthesis, biological evaluation and computational investigation of Thiadiazole Benzimidazole derivatives bearing a Chlorophyrimidine pharmacophore as potent CLK2 inhibitors and anticancer agents. Local targets link to admitted publications; unresolved targets remain external evidence.
An overview of recent advancements in targeted cancer therapies and their potential clinical impact
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Oncogenic dysregulation of pre-mRNA processing by protein kinases: challenges and therapeutic opportunities
10.1111/febs.16057 · 2021 · External reference
Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment
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Cdc2-like kinases: structure, biological function, and therapeutic targets for diseases
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Development of Cdc2-like kinase 2 inhibitors: achievements and future directions
10.1021/acs.jmedchem.1c00985 · 2021 · External reference
Characterization and comparison of four serine-and arginine-rich (SR) protein kinases
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Cdc-like kinases (CLKs): biology, chemical probes, and therapeutic potential
10.3390/ijms21207549 · 2020 · External reference
Exploring the roles of the Cdc2-like kinases in cancers
10.1016/j.bmc.2022.116914 · 2022 · External reference
Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability
10.15252/emmm.201708289 · 2018 · External reference
A review on design, synthesis, structure activity relationships, and anticancer activity of benzimidazole derivatives
10.1016/j.molstruc.2026.146543 · 2026 · External reference
Benzimidazole scaffold as a potent anticancer agent with different mechanisms of action (2016–2023)
10.1007/s11030-024-10907-8 · 2025 · External reference
Recent developments in anticancer kinase inhibitors based on the pyrazolo [3, 4-d] pyrimidine scaffold
10.1039/d0md00227e · 2020 · External reference
Synthesis of a series of novel 2-amino-5-substituted 1, 3, 4-oxadiazole and 1, 3, 4-thiadiazole derivatives as potential anticancer, antifungal and antibacterial agents
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Flurbiprofen clubbed schiff’s base derivatives as potent anticancer agents: in vitro and in silico approach towards breast cancer
10.1016/j.molstruc.2024.139743 · 2025 · External reference
Efficient synthesis, anticonvulsant and muscle relaxant activities of new 2-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl)-6-phenyl-4, 5-dihydropyridazin-3 (2H)-one derivatives
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Recent developments of 1,3,4-thiadiazole compounds as anticancer agents
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Identification of 5-amino-1,3,4-thiadiazole appended isatins as bioactive small molecules with polypharmacological activities
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Recent developments of 1,3,4-thiadiazole compounds as anticancer agents
2025 · External reference
A review on recent progress in synthesis and biological activities of thiadiazole and its derivatives
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Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents
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Synthesis, characterization, antimicrobial, antioxidant, and anti-cancer activity of new hybrid structures based on benzimidazole and thiadiazole
10.1590/s2175-97902025e23939 · 2025 · External reference
Novel benzimidazole-1, 3, 4-thiadiazole derivatives as casein kinase-2 inhibitors: synthesis, in vitro and in silico investigations
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Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives and evaluation of their activities against human colon cancer cell lines
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X-ray structures and feasibility assessment of CLK2 inhibitors for Phelan–McDermid syndrome
10.1002/cmdc.201800344 · 2018 · External reference
Synthesis, biological screening and computational analysis of thiazole linked thiazolidinone Schiff bases as anti-Alzheimer’s drug candidates
10.1016/j.bioorg.2025.108812 · 2025 · External reference
Facile indazole-endowed thiadiazole hybrid derivatives as antibacterial, anti-diabetic and thymidine phosphorylase inhibitors: an insight to experimental, in-vitro biological potential and computational approaches
10.1007/s44446-025-00003-9 · 2025 · External reference
Safety assessment of Detarium microcarpum Guil. & Perr.(Leguminosae) root bark extract in rats: Acute, sub-acute toxicity, ADMET, molecular docking, and molecular dynamics simulations approach
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Comprehensive pharmacokinetic profiling and molecular docking analysis of natural bioactive compounds targeting oncogenic biomarkers in breast cancer
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A computational approach to fighting type 1 diabetes by targeting 2C Coxsackie B virus protein with flavonoids
10.1371/journal.pone.0290576 · 2023 · External reference
Investigating the effect of 1, 2-Dibenzoylhydrazine on Staphylococcus aureus using integrated computational approaches
10.1007/s40203-024-00278-1 · 2024 · External reference
Unresolved reference
2023 · External reference
Unveiling the antiviral activity of 2′, 3, 5, 7-Tetrahydroxyflavanone as potential inhibitor of chikungunya virus envelope glycoprotein
10.1016/j.imu.2024.101486 · 2024 · External reference
Synthesis and structural characterization of a new Cu (II) azo–Schiff base complex: ADMET profiling, molecular docking, and in vitro biological activity evaluation
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Innovation, structural inspection for new mixed complexes: DNA binding, biomedical applications and molecular docking approaches
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Synthesis and structural elucidation for new pyrano thiazole complexes: biological screening and effects on DNA through in-vitro and in-silico approaches
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Multiparameter optimization of broad-spectrum thymidine phosphorylase inhibition, ADMET properties, molecular docking, and DFT screening of novel pyrazole-based thiadiazole/thiazole derivatives
2026 · External reference
