Research graph
References from Discovery of benzimidazole derivatives as LDHA inhibitors with antitumor activity. Local targets link to admitted publications; unresolved targets remain external evidence.
Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression
10.1038/s41588-025-02236-9 · 2025 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Clinical significance of tumor-infiltrating lymphocytes in malignant peritoneal mesothelioma: a single-Center study of 143 cases
10.1245/s10434-025-17437-z · 2025 · External reference
Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents
10.1080/1120009x.2023.2300217 · 2024 · External reference
Metastatic recurrence among adolescents and young adults with Cancer
10.1001/jamaoncol.2025.4971 · 2026 · External reference
The landscape of innovative oncology drug targets
10.1016/j.drudis.2025.104571 · 2026 · External reference
Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors
10.1016/j.drudis.2018.05.014 · 2018 · External reference
Targeting the Warburg effect in cancer: where do we stand
10.3390/ijms25063142 · 2024 · External reference
LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells
10.1016/j.cmet.2016.08.011 · 2016 · External reference
Lactate dehydrogenase and its clinical significance in pancreatic and thoracic cancers
10.1016/j.semcancer.2022.09.001 · 2022 · External reference
Structural and functional regulation of lactate dehydrogenase-a in cancer
10.4155/fmc-2019-0287 · 2020 · External reference
Lactate dehydrogenase a (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension
10.1186/s12967-024-05543-7 · 2024 · External reference
Lactate dehydrogenase a: a key player in carcinogenesis and potential target in cancer therapy
10.1002/cam4.1820 · 2018 · External reference
Astrocytic lactate dehydrogenase a regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice
10.1038/s41467-023-36209-5 · 2023 · External reference
Suppression of tumor aggression through metabolic reprogramming via oxamate targeting LDHA
10.3390/ijms27073245 · 2026 · External reference
Discovery of human lactate dehydrogenase a (LDHA) inhibitors as anticancer agents to inhibit the proliferation of MG-63 osteosarcoma cells
10.1039/c7md00222j · 2017 · External reference
FX11 inhibits aerobic glycolysis and growth of neuroblastoma cells
10.1016/j.surg.2016.09.009 · 2017 · External reference
Inhibition of lactate dehydrogenase a induces oxidative stress and inhibits tumor progression
10.1073/pnas.0914433107 · 2010 · External reference
Quinoline 3-sulfonamides inhibit lactate dehydrogenase a and reverse aerobic glycolysis in cancer cells
10.1186/2049-3002-1-19 · 2013 · External reference
Lactate regulates pathological cardiac hypertrophy via histone lactylation modification
10.1111/jcmm.70022 · 2024 · External reference
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition
10.1038/nchembio.2143 · 2016 · External reference
Pyrazole-based lactate dehydrogenase inhibitors with optimized cell activity and pharmacokinetic properties
10.1021/acs.jmedchem.0c00916 · 2020 · External reference
Rationale for LDH-targeted cancer immunotherapy
10.1016/j.ejca.2022.11.032 · 2023 · External reference
Machine-learning-driven discovery of N-Phenylbenzenesulfonamides as a novel chemotype for lactate dehydrogenase a inhibition with anti-pancreatic Cancer activity
10.1021/acs.jmedchem.5c00359 · 2025 · External reference
Benzimidazole as a privileged scaffold in drug design and discovery
10.2174/0115680266314704240522112439 · 2024 · External reference
Repurposing of benzimidazole anthelmintic drugs as cancer therapeutics
10.3390/cancers14194601 · 2022 · External reference
Benzimidazole scaffold as anticancer agent: synthetic approaches and structure-activity relationship
10.1002/ardp.201700040 · 2017 · External reference
Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer
10.1016/j.canlet.2019.03.002 · 2019 · External reference
Recent achievements in the synthesis of benzimidazole derivatives
10.1039/d3ra05960j · 2023 · External reference
Imidazoles and benzimidazoles as tubulin-modulators for anti-cancer therapy
10.2174/0929867322666150114164032 · 2015 · External reference
ABT-888, an orally active poly (ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
10.1158/1078-0432.ccr-06-3039 · 2007 · External reference
Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation
10.1126/scitranslmed.abe8226 · 2021 · External reference
Niraparib for the treatment of ovarian cancer
10.1080/14737140.2018.1490180 · 2018 · External reference
Discovery of novel chalcone derivatives containing benzimidazole possessing anti-tumor potential in vitro and in vivo
10.1016/j.biopha.2025.118912 · 2026 · External reference
Benzimidazole and its derivatives as cancer therapeutics: the potential role from traditional to precision medicine
10.1016/j.apsb.2022.09.010 · 2023 · External reference
Identification of telmisartan's potential as NADH competitive lactate dehydrogenase a inhibitor unlocks its possibility for drug repurposing in cancer therapy
10.1007/s44371-025-00441-3 · 2025 · External reference
Progress in redirecting antiparasitic drugs for cancer treatment
2021 · External reference
Triclabendazole inhibits PKM2 nuclear localization and glycolysis by enhancing HDAC6-mediated deacetylation in lung cancer
10.1186/s12967-025-06905-5 · 2025 · External reference
Discovery and optimization of potent, cell-active pyrazole-based inhibitors of lactate dehydrogenase (LDH)
2018 · External reference
Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-a inhibitor against pancreatic cancer
2024 · External reference
Exploration of a large virtual chemical space: identification of potent inhibitors of lactate dehydrogenase-a against pancreatic cancer
2021 · External reference
Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
Metabolism, a blossoming target for small-molecule anticancer drugs
10.3390/molecules30173457 · 2025 · External reference
Lactate dehydrogenase-a (LDH-A) preserves cancer stemness and recruitment of tumor-associated macrophages to promote breast cancer progression
2021 · External reference
